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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20261 results in Negative / Null Result Report · page 610 of 676

Negative / Null Result Report

The relationships between cochlear nerve health and AzBio sentence scores in quiet and noise in postlingually deafened adult cochlear implant users

Gao Z, Yuan Y, Oleson JJ et al. · 2024 · Preprint

ABSTRACT Objectives This study investigated the relationships between the cochlear nerve (CN) health and sentence-level speech perception outcomes measured in quiet and noise in postlingually deafened adult cochlear implant (CI) users.…

View details →DOI: 10.1101/2024.11.16.24317332
Negative / Null Result ReportOpen accessMedicine

Descriptive Epidemiology and Prognostic Significance of Diaphragm Thickness in the General Population: The Nagahama Study.

Tabara Y, Matsumoto T, Murase K et al. · 2025 · Journal of cachexia, sarcopenia and muscle

Background Diaphragm thickness is a potential marker of sarcopenia in addition to muscle mass and strength at extremities. We aimed to clarify the descriptive epidemiology and prognostic significance of diaphragm thickness in the general…

View details →DOI: 10.1002/jcsm.13690
Negative / Null Result ReportOpen accessMedicine

Outcomes of ACL Reconstruction with Quadriceps Tendon Graft Based on Graft Diameter Relative to Notch Width.

Dadoo S, Vieider RP, Grandberg C et al. · 2026 · Orthopaedic journal of sports medicine

Background While quadriceps tendon (QT) autograft is being increasingly utilized for primary anterior cruciate ligament reconstruction (ACLR), there remains limited evaluation of how QT autograft diameter and the ratio of graft diameter to…

View details →DOI: 10.1177/23259671261433007
Negative / Null Result ReportOpen accessMedicine

Youth Soccer Participation and Brain Health Outcomes in Adolescent Athletes.

Koerte IK, Wiegand TLT, Bonke EM et al. · 2026 · JAMA network open

Importance Repetitive head impacts (RHIs) are associated with later-life neurodegeneration. Because soccer is the most widely played sport among youth worldwide, identifying early changes associated with RHI is important. Objective To…

View details →DOI: 10.1001/jamanetworkopen.2026.19569
Negative / Null Result ReportOpen accessMedicine

Lack of association of the calpain-10 Indel-19 variant with chronic diseases in a Mexican population.

Meza-Espinoza JP, Zavala-Rubio JD, Leal-Ugarte E et al. · 2025 · BMC research notes

Objective The CAPN10 gene encodes a protein that regulates insulin secretion and glucose uptake. Its variant Indel-19 has been associated with an increased risk of type 2 diabetes mellitus, diabetes-related traits, and some chronic…

View details →DOI: 10.1186/s13104-025-07184-5
Negative / Null Result ReportOpen accessMedicine

Behavioral Inhibition Places Preschoolers at Risk for Reduced Social Competence, but Only in the Context of Other Temperamental Traits.

Fleece H, Teglasi H · 2025 · Children (Basel, Switzerland)

Background/Objectives : Behavioral inhibition (BI) has been extensively studied as an early-appearing risk factor for adverse developmental outcomes. One pathway through which BI may confer risk is via reduced competence to interact…

View details →DOI: 10.3390/children13010042
Negative / Null Result ReportMedicine

Plasma omega-3 fatty acids are not associated with muscle strength, regardless of age or protein intake: National Health and Nutrition Examination Survey 2011-12.

Nehme R, Sponchiado IM, Limirio LS et al. · 2025 · Clinical nutrition ESPEN

Background & aims Muscle strength is a key predictor of both quality of life and mortality. Although numerous studies have investigated the relationship between omega-3 (ω-3) intake and muscle strength, the evidence remains inconclusive.…

View details →DOI: 10.1016/j.clnesp.2024.12.025
Negative / Null Result ReportOpen accessMedicine

Genetic Variants in Vitamin-D Metabolism Genes (rs1155563, rs12785878 and rs10500804) among Females with Type-2 Diabetes Mellitus in Saudi Arabia.

Alharazy S · 2024 · Pakistan journal of medical sciences

Background & objective Hypovitaminosis D has shown to be linked with T2DM development and control in numerous studies. The association of SNPs in genes related to VitD metabolism with T2DM has not been sufficiently studied. Consequently,…

View details →DOI: 10.12669/pjms.40.8.9318
Negative / Null Result ReportOpen accessMedicine

Computationally efficient whole-genome quantile regression at biobank scale.

Wang F, Wang C, Wang T et al. · 2025 · Proceedings of the National Academy of Sciences of the United States of America

Genotype-phenotype associations can be context-dependent and dynamic in nature leading to heterogeneity of genetic effects across different parts of the phenotype distribution. Quantile regression, an alternative to linear regression for…

View details →DOI: 10.1073/pnas.2513007122
Negative / Null Result ReportOpen accessMedicine

Lack of Association Between Intraoperative Hypotension and Postoperative Acute Kidney Injury in Patients Undergoing Pancreaticoduodenectomy: A Retrospective Cohort Study.

Gu Y, Zhang W, Zhou J et al. · 2025 · International journal of nephrology

Background: Acute kidney injury (AKI) is a common postoperative event. Previous research suggests that intraoperative hypotension (IOH) is associated with postoperative AKI. This connection, however, has not been studied in patients…

View details →DOI: 10.1155/ijne/5568151
Negative / Null Result ReportOpen accessMedicine

<i>XPO5</i> Polymorphism in Colon Cancer Patients: A Cross-Sectional Study.

Agbektas T, Genc HC, Zontul C et al. · 2025 · International journal of molecular sciences

(1) This cross-sectional study aims to elucidate the association between the XPO5 gene polymorphism (rs11544382) and colon cancer (CC). (2) Genotyping of XPO5 (rs11544382) was performed in 120 individuals (60 CC patients and 60 controls)…

View details →DOI: 10.3390/ijms27010345
Negative / Null Result ReportMedicine

Comparison of susceptibility of Pseudomonas aeruginosa isolated from keratitis to antibiotics and multipurpose disinfecting solutions.

Itoi M, Willcox MDP · 2024 · Contact lens & anterior eye : the journal of the British Contact Lens Association

Purpose This study aimed to assess the susceptibility of ocular isolates of Pseudomonas aeruginosa to two multi-purpose disinfectant solutions (MPDS) and to determine if there was a relationship with resistance to antibiotics. Methods…

View details →DOI: 10.1016/j.clae.2024.102288
Negative / Null Result ReportOpen accessMedicine

Relationship between the anxiety of labor companion and labor satisfaction among laboring women.

Nasirzadeh A, Mohammadzadeh F, Kazeminia S et al. · 2025 · Scientific reports

The presence of a known labor companion was shown to improve childbirth satisfaction. However, a companion's anxiety might affect the satisfaction of laboring women. Therefore, this study aimed to evaluate the relationship between the…

View details →DOI: 10.1038/s41598-025-04754-2
Negative / Null Result ReportMedicine

Lack of Association Between Immunotherapy and Improvement of Survival for Non-small Cell Lung Cancer Patients With Hemodialysis: A Nationwide Retrospective Cohort Study.

Sawa K, Ihara Y, Imai T et al. · 2024 · Clinical lung cancer

Background The number of patients undergoing hemodialysis continues to increase globally, and the incidence of cancer is high among these patients. Immune checkpoint inhibitors are widely used in patients with advanced cancer, especially…

View details →DOI: 10.1016/j.cllc.2023.11.003
Negative / Null Result ReportOpen accessMedicine

Peripheral immune system activity in young psychiatry patients.

Seizer L, Löchner J, Renner TJ · 2026 · Brain, behavior, & immunity - health

The interaction between the immune system and the central nervous system has been implicated in the development of psychiatric disorders in adult patients. However, comprehensive data regarding pediatric psychiatry are still lacking. This…

View details →DOI: 10.1016/j.bbih.2025.101143
Negative / Null Result ReportOpen accessMedicine

Implicit Bias and Recognition of Biases Among Vascular Surgeons.

Howard KA, Witrick B, Clark A et al. · 2026 · The Journal of surgical research

Introduction Implicit bias can influence behavior and decision-making, such as treatment decisions in clinical settings. Given documented Black-White disparities in vascular care, the purpose of this study was to describe the prevalence…

View details →DOI: 10.1016/j.jss.2026.02.004
Negative / Null Result ReportOpen accessMedicine

Mechanosensitivity and Adipose Thickness as Determinants of Pressure to Reach Deep Fasciae in Cervical and Thoracolumbar Regions.

Pires S, Freitas M, Pinho F et al. · 2025 · Sensors (Basel, Switzerland)

Objective We aimed to quantify the mechanical pressure required to reach the deep cervical and thoracolumbar fasciae, to examine its association with pressure pain threshold (PPT) and adipose tissue thickness, and to determine whether PPT…

View details →DOI: 10.3390/s25165073
Negative / Null Result ReportOpen accessMedicine

Lack of association between breastfeeding duration and body mass index in children and adolescents - A Swedish cohort study.

Haahr Vad O, Önnestam L, Bengtsson Boström K et al. · 2025 · PloS one

Aims The aim of the study was to investigate the association between breastfeeding duration and body mass index (BMI), overweight and obesity in children during follow-up until 16 years of age. Methods Observational cohort study of mothers…

View details →DOI: 10.1371/journal.pone.0319502
Negative / Null Result ReportOpen accessMedicine

<i>IL4</i> Gene Variants rs2243250 and rs2243248 and Their Association with Clinical Phenotypes of Severe Asthma in the Mexican Population: In Silico Functional Analysis and Regulatory Implications.

Montoya-Delgado IB, Ochoa-García IV, Escobedo-Salcedo ZL et al. · 2026 · International journal of molecular sciences

Severe asthma (SA) is a chronic respiratory disease characterized by clinical heterogeneity and poor therapeutic response. Variants in the IL4 gene, including rs2243250 and rs2243248, have been associated with asthma susceptibility and…

View details →DOI: 10.3390/ijms27114711
Negative / Null Result ReportOpen accessMedicine

Lack of association between food insecurity, eating disorders, and orthorexia nervosa: findings from a cross-sectional study in Lebanon.

Sacre H, Haddad C, Rizk R et al. · 2025 · Frontiers in public health

Objectives To investigate the association between food insecurity (FI), eating disorders (EDs), and orthorexia nervosa (ON) among Lebanese university students. Methods This cross-sectional study, conducted between 2021 and 2022, enrolled…

View details →DOI: 10.3389/fpubh.2025.1572654
Negative / Null Result ReportOpen accessMedicine

Lack of Association Between Sodium Intake and Cytokine Levels.

Wistrand H, Kaartinen NE, Jousilahti P et al. · 2024 · Integrated blood pressure control

Purpose The complex pathogenesis of hypertension, potentially involving inflammatory pathways, remains elusive. This study aimed to evaluate the relationship between 24-hour urinary sodium excretion and inflammatory cytokines alongside…

View details →DOI: 10.2147/ibpc.s483495
Negative / Null Result ReportOpen accessMedicine

Accounting for Time-Varying Confounding in a Self-Controlled Case Series of Fluoroquinolone Treatment for Uncomplicated Urinary Tract Infections and Risk of Collagen-Related Events.

Schultze A, Ju S, Drysdale M et al. · 2025 · Pharmacology research & perspectives

We report findings from three SCCS conducted to quantify the association between fluoroquinolone (FQ) use for the treatment of uncomplicated urinary tract infection (uUTI) and tendon rupture, retinal detachment, and uveitis. Female…

View details →DOI: 10.1002/prp2.70124
Negative / Null Result ReportOpen accessMedicine

Lack of association of ABO and RhD blood groups with COVID-19 mortality: A 2-center cross-sectional study in Saudi Arabia.

Halawani AJ, Alhamoud AH, Kabrah SM et al. · 2024 · Medicine

Several diseases, including both noninfectious diseases and bacterial and viral diseases, are associated with the ABO and RH blood group systems. Previous studies have shown a link between blood type and the probability of coronavirus…

View details →DOI: 10.1097/md.0000000000039673
Negative / Null Result ReportOpen accessMedicine

Lack of association between prior or concurrent malignancies and overall survival in gastroesophageal cancer: evidence from a large European single-center cohort.

Puhr HC, Berchtold L, Zingerle L et al. · 2026 · Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

Background History of malignant disease is a common exclusion criterion in clinical cancer trials, yet data on the impact of cancer survivorship on outcome in gastroesophageal cancer patients are scarce. Methods Retrospective association…

View details →DOI: 10.1007/s12094-025-04036-3
Negative / Null Result ReportOpen accessMedicine

Impact of Prediabetes on In-Hospital Mortality and Clinical Outcomes in Acute Pancreatitis: Insights from a Nationwide Inpatient Sample.

Dakkak T, Silin N, Mahmood R et al. · 2025 · Journal of clinical medicine

Background/Objectives : Prediabetes is characterized by insulin resistance and systemic inflammation, which may increase susceptibility to acute pancreatitis (AP). However, limited data exist on how prediabetes influences in-hospital…

View details →DOI: 10.3390/jcm14124271