A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19786 results in Negative / Null Result Report · page 61 of 660
Michael Craig, G.E.St.J. Hardy, Joseph B. Fontaine et al. · 2012 · Journal of Applied Ecology
Summary 1. There is increasing evidence that passive faunal recolonisation of restored areas can take decades or even centuries, reducing benefits to biodiversity from restoration. Thus, there is a need to develop restoration and…
Yinsong Wang, Yinsong Wang, Yajie Zou et al. · 2017 · PLoS ONE
Roadway elevation data is critical for a variety of transportation analyses. However, it has been challenging to obtain such data and most roadway GIS databases do not have them. This paper intends to address this need by proposing a method to extract roadway elevation data from Google Earth (GE) for transportation applications. A comprehensive accuracy assessment of the GE-extracted elevation data is conducted for the area of conterminous USA. The GE elevation data was compared with the ground truth data from nationwide GPS benchmarks and roadway monuments from six states in the conterminous
Jochen B. Fiebach, Yasir Al‐Rawi, Max Wintermark et al. · 2012 · Stroke
BACKGROUND AND PURPOSE: Desmoteplase is a novel and highly fibrin-specific thrombolytic agent. Evidence of safety and efficacy was obtained in 2 phase II trials (Desmoteplase In Acute Ischemic Stroke [DIAS] and Desmoteplase for Acute…
Orhan Sivrikaya, Enar Tunc · 2013 · The Open Transportation Journal
introduction Patients have the right to influence the care they receive, but their wish to participate in care decision-making is unclear. Aim This study investigates whether participation in nursing documentation influences patient participation in care decision-making, mastery, self-esteem, empowerment and depressive feelings among adult in-patients with chronic disease. Materials and Methodology Adult patients (n=39) with chronic diseases were randomized. The intervention group participated in nursing documentation. Upon departure, patients filled in questionnaires about participation in ca
Junyi Xin, Xia Jiang, Shuai Ben et al. · 2022 · BMC Medicine
BACKGROUND: The association between vitamin E and cancer risk has been widely investigated by observational studies, but the findings remain inconclusive. Here, we aimed to evaluate the causal effect of circulating vitamin E on the risk of ten common cancers, including bladder, breast, colorectal, esophagus, lung, oral and pharynx, ovarian, pancreatic, prostate, and kidney cancer. METHODS: A Mendelian randomization (MR) analytic framework was applied to data from a cancer-specific genome-wide association study (GWAS) comprising a total of 297,699 cancer cases and 304,736 controls of European a
Ignácio F. Mata, Dora Yearout, Victoria Álvarez et al. · 2011 · Movement Disorders
Recent genome-wide association studies of Parkinson's disease have nominated 3 new susceptibility loci (PARK16-18) and confirmed 2 known risk genes (MAPT and SNCA) in populations of European ancestry. We sought to replicate these findings.…
Manamba Epaphra · 2017 · Journal of Mathematical Finance
Policy makers need accurate forecasts about future values of exchange rates. This is due to the fact that exchange rate volatility is a useful measure of uncertainty about the economic environment of a country. This paper applies univariate nonlinear time series analysis to the daily (TZS/USD) exchange rate data spanning from January 4, 2009 to July 27, 2015 to examine the behavior of exchange rate in Tanzania. To capture the symmetry effect in exchange rate data, the paper applies both ARCH and GARCH models. Also, the paper employs exponential GARCH (EGARCH) model to capture the asymmetry in
Aaron Tkaczynski, Robin Stokes · 2010 · Event Management
As a service quality measurement tool, SERVPERF has gained an increasing level of prominence among marketing theorists. However, despite the apparent usefulness of this "performance-only"measure of quality in various settings, research is…
Jayashree Nath, Anupam Chowdhury, Swapan Kumar Dolui · 2018 · Advances in Polymer Technology
Abstract Synthesis of hydrogel with multifunctional properties still remains a challenge within the scientific community. Hydrogels having stimulus‐responsive properties are a few of the desired properties for real‐life applications. This…
Dylan J. Jester, Ellen Rozek, Ryan A. McKelley · 2018 · Aging & Mental Health
OBJECTIVES: Two decades of heart rate variability (HRV) biofeedback research have focused on adolescent and adult populations with a variety of symptoms and conditions at the exclusion of older adults. This study explores HRV biofeedback…
Zahra Shahrokh, Louise Royle, Radka Saldova et al. · 2010 · Molecular Pharmaceutics
Recombinant human erythropoietin has been used to treat anemia associated with chronic renal disease. This paper provides a comprehensive comparative analysis of Dynepo and three other commercial erythropoiesis stimulating agents, Eprex,…
Monica Rydén‐Aulin, Dimitrios T. Boumpas, Irene E. M. Bultink et al. · 2016 · Lupus Science & Medicine
OBJECTIVES: Rituximab (RTX) is a biological treatment used off-label in patients with systemic lupus erythematosus (SLE). This survey aimed to investigate the off-label use of RTX in Europe and compare the characteristics of patients…
Nikolaos A. Trikalinos, Amy Zhou, Maria B. Majella Doyle et al. · 2018 · Journal of the National Comprehensive Cancer Network
Background: Combined hepatocellular-cholangiocarcinoma tumors (cHCC-CCA) are a heterogeneous group of rare malignancies that have no established optimal treatment. Patients and Methods: We identified patients with cHCC-CCA treated at a…
Bart A. Mulder, Dirk J. van Veldhuisen, Harry J.G.M. Crijns et al. · 2012 · European Journal of Heart Failure
AIMS: Beneficial effects of beta-blockade remain unclear in heart failure patients who have atrial fibrillation (AF), especially in the elderly. We evaluated the effect of nebivolol on cardiovascular outcomes in elderly patients with heart…
Ahmed M Abou-Setta, Brett L. Houston, Hesham Al-Inany et al. · 2013 · Cochrane Database of Systematic Reviews
BACKGROUND: Various options exist for treating endometriosis, including surgical, medical, such as ovarian suppression, or a combination of these strategies. Surgical treatment of endometriosis aims to remove visible areas of…
Marianna Adamo, Matteo Pagnesi, Giulia Ghizzoni et al. · 2022 · European Journal of Heart Failure
AIM: To evaluate short-term changes in tricuspid regurgitation (TR) after transcatheter edge-to-edge mitral valve repair (M-TEER) in secondary mitral regurgitation (SMR), their predictors and impact on mortality. METHODS AND RESULTS: This…
Ambra Bisio, Natale Stucchi, Marco Jacono et al. · 2010 · PLoS ONE
Automatic imitation is the tendency to reproduce observed actions involuntarily. Though this topic has been widely treated, at present little is known about the automatic imitation of the kinematic features of an observed movement. The present study was designed to understand if the kinematics of a previously seen stimulus primes the executed action, and if this effect is sensitive to the kinds of stimuli presented. We proposed a simple imitation paradigm in which a dot or a human demonstrator moved in front of the participant who was instructed either to reach the final position of the stimul
Bharti Mangla, Pankaj Kumar, Shamama Javed et al. · 2025 · Nanomedicine
Over the past decade, nanomedicines have witnessed significant advancements, with various nanocarriers being introduced into clinical practice. Despite this progress, the absence of a well-defined regulatory framework presents major…
on behalf of the Vx-001-201 trial team, Cesare Gridelli, Tudor–Eliade Ciuleanu et al. · 2020 · British Journal of Cancer
BACKGROUND: CD8 + cytotoxic T cells; this immune response is associated with improved overall survival (OS) in patients with advanced/metastatic non-small cell lung cancer (NSCLC). METHODS: A randomised, double blind, phase 2b trial, in HLA-A*201-positive patients with metastatic, TERT-expressing NSCLC, who did not progress after first-line platinum-based chemotherapy were randomised to receive either Vx-001 or placebo. The primary endpoint of the trial was OS. RESULTS: Two hundred and twenty-one patients were randomised and 190 (101 and 89 patients in the placebo and the Vx-001 arm, respectiv
Pénélope Paradis‐Deschênes, Denis R. Joanisse, François Billaut · 2017 · Frontiers in Physiology
Prior peripheral hypoxia induced via remote ischemic preconditioning (IPC) can improve physical performance in male athletes through improved O2 delivery and utilization. Since females may have an innate protective mechanism against ischemia-reperfusion injury, and since muscle metabolism during contraction differs between sexes, it is relevant to examine the impact of sex in response to IPC to determine whether it is also ergogenic in females. In a randomized, crossover, single-blind study, we investigated muscle performance, hemodynamic and O2 uptake in strength-trained males (n=9) and femal
Markus Schlegel, Vivanne Dubach, Larissa von Buol et al. · 2016 · FEMS Microbiology Ecology
While Hymenoscyphus fraxineus causes dieback of the European ash (Fraxinus excelsior), flowering ash (F. ornus) appears resistant to the pathogen. To date, contributions of endophytic fungi to host resistance are unknown. The following…
Mukul S. Bansal, Yi-Chieh Wu, Eric J. Alm et al. · 2014 · Bioinformatics
MOTIVATION: The accurate inference of gene trees is a necessary step in many evolutionary studies. Although the problem of accurate gene tree inference has received considerable attention, most existing methods are only applicable to gene families unaffected by horizontal gene transfer. As a result, the accurate inference of gene trees affected by horizontal gene transfer remains a largely unaddressed problem. RESULTS: In this study, we introduce a new and highly effective method for gene tree error correction in the presence of horizontal gene transfer. Our method efficiently models horizonta
Martha Cárdenas, Alejandro Grajales, Roberto Sierra et al. · 2011 · BMC Genetics
BACKGROUND: Phytophthora infestans (Mont.) de Bary, the causal agent of potato late blight, is responsible for tremendous crop losses worldwide. Countries in the northern part of the Andes dedicate a large proportion of the highlands to the production of potato, and more recently, solanaceous fruits such as cape gooseberry (Physalis peruviana) and tree tomato (Solanum betaceum), all of which are hosts of this oomycete. In the Andean region, P. infestans populations have been well characterized in Ecuador and Peru, but are poorly understood in Colombia and Venezuela. To understand the P. infest
Evan J. Fishman, Hilda Borko, Jonathan Osborne et al. · 2017 · Journal of Science Teacher Education
Considerable evidence suggests that dialogical interaction in the classroom promotes students’ scientific knowledge building and reasoning. Hence, scientific argumentation is recognized as a central component of the Next Generation Science…
Edmund K. M. Chang, Cheng Zheng, Patrick Lanigan et al. · 2015 · Geophysical Research Letters
Abstract Extratropical cyclones give rise to much of the precipitation over California. Observed California winter precipitation is highly correlated to a metric of extratropical cyclone activity over the Eastern Pacific. The lack of…
Yun‐Ming Tian, Mingzhu Liu, Lei Zeng et al. · 2018 · Head & Neck
PURPOSE: To analyze the long-term outcome and pattern of failure for patients with nasopharyngeal carcinoma (NPC) after intensity-modulated radiotherapy (IMRT). METHODS AND MATERIALS: Patients with NPC after IMRT from 2001 to 2008 were…
Dorothea Buck, Sabine Cepok, Steve Hoffman et al. · 2011 · Archives of Neurology
OBJECTIVE: To determine relevant HLA-DRB1 alleles associated with the susceptibility of anti-interferon beta antibody development in a large patient cohort. DESIGN: In a case-control study, HLA-DRB1 genotyping was performed in a discovery…
Christopher R Romero, Daniela S Herzig, A.O. Etogo et al. · 2010 · Journal of Leukocyte Biology
Several studies indicate that IFN-γ facilitates systemic inflammation during endotoxin-induced shock. However, the pathobiology of IFN-γ in clinically relevant models of septic shock, such as CLP, is not well understood. In this study, the…
Ara Cho, Yoosoo Chang, Jiin Ahn et al. · 2018 · British Journal of Cancer
BACKGROUND: We evaluated the association between smoking status and thyroid cancer risk and whether this association is mediated by body mass index (BMI) and thyroid-stimulating hormone (TSH). METHODS: We performed a cohort study of 96,855 Korean adults who were followed annually or biennially for a median of 5.9 years. RESULTS: During 511,052.9 person-years of follow-up, 1,250 participants developed thyroid cancer. In men, we observed a dose-dependent inverse association between current smoking, pack-years, and thyroid cancer. After adjustment for confounders, adjusted hazard ratios (95% conf
Adam de Belder, Aung Myat, Jonathan Blaxill et al. · 2021 · EuroIntervention
BACKGROUND: Historically the elderly have been under-represented in non-ST-elevation myocardial infarction (NSTEMI) management trials. AIMS: The aim of this trial was to demonstrate that an intervention-guided strategy is superior to optimal medical therapy (OMT) alone for treating NSTEMI in elderly individuals. METHODS: Patients (≥80 years, chest pain, ischaemic ECG, and elevated troponin) were randomised 1:1 to an intervention-guided strategy plus OMT versus OMT alone. The primary endpoint was a composite of all-cause mortality and non-fatal myocardial reinfarction at 1 year. Ethics approval