A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19902 results in Negative / Null Result Report · page 603 of 664
DeGrado J, Devlin JW · 2025 · Critical care clinics
Antipsychotics are an attractive option for adjunctive sedation in critically ill adults given their sedating effects, short duration of action, lack of effect on respiratory drive, and multiple routes of administration but high-quality…
Wattacheril J, Kleinstein SE, Shea PR et al. · 2024 · Preprint
Background and Aims Nonalcoholic Fatty Liver Disease (NAFLD) is a complex human disease. Common genetic variation in the patatin-like phospholipase domain containing 3 ( PNPLA3 ) and transmembrane 6 superfamily member 2 ( TM6SF2 ) genes…
Curtis A, Skvarc D, Brittain N et al. · 2025 · Drug and alcohol review
Introduction Substance use has been associated with child-to-parent violence (CPV), yet little is known about the contributing factors. This study investigated the association between parental substance use and substance involved child to…
D'Marco L, Checa-Ros A, Locascio A et al. · 2025 · Frontiers in medicine
Background Several studies suggest that C-peptide (CP) is involved in regulating lipolysis, adipokine release, and other functions in the adipose tissue. On the other hand, organ-specific adipose tissues, such as the epicardial adipose…
Nguyen TT, Pineda R, Reynolds S et al. · 2026 · Physical & occupational therapy in pediatrics
Aim To examine the relationship between feeding therapy and the timing of independent oral feeding (IOF) in preterm infants in the neonatal intensive care unit (NICU). Study design A retrospective analysis of 536 preterm infants ( Results…
Stankovic M, Weber C, Koser M et al. · 2025 · Journal of frailty, sarcopenia and falls
Objectives While chronological aging does not necessarily impair oncological outcomes after radical prostatectomy, the role of frailty remains less clear. This study aimed to evaluate whether frailty significantly affects early continence…
Keser CS, Erdemir M, Yilmaz M et al. · 2025 · BMC nephrology
Background Hemodynamic instability related to renal replacement therapy (HIRRT) is a serious complication of continuous renal replacement therapy (CRRT) in critically ill patients with acute kidney injury (AKI), significantly increasing…
Smith CM, Spalt EW, Gallo LC et al. · 2026 · Journal of urban health : bulletin of the New York Academy of Medicine
Neighborhood-scale environmental factors, including disinvestment in infrastructure, may impact cardiometabolic disease risk. To our knowledge, no prior studies have investigated the association between neighborhood disinvestment and…
Ihle-Hansen H, Walle-Hansen MM, Berge T et al. · 2026 · BMJ open
Background Current expert consensus statements generally suggest cardiovascular risk assessment, including atrial fibrillation (AF) screening, on detection of covert brain infarctions (CBIs). However, evidence to guide management of CBI…
Abdalla M · 2026 · Frontiers in medicine
Background Hormone replacement therapy (HRT) is widely prescribed for managing menopausal symptoms, yet its effects on the endometrium remain clinically important. While large-scale studies have established that estrogen-only HRT increases…
O'Brien EA, Wypij D, Rofeberg V et al. · 2026 · Journal of perinatology : official journal of the California Perinatal Association
Objective Investigate the association between placental vascular abnormalities and regional brain volumes in congenital heart disease (CHD) fetuses with and without genetic abnormalities. Study design Secondary analysis of brain magnetic…
Girişgen İ, Altıncık SA, Avcı E et al. · 2025 · Journal of clinical research in pediatric endocrinology
Objective To compare serum mitochondrial open reading frame of 12S rRNA-c (MOTS-c) levels, a new potential biomarker for oxidative stress, in children with type 1 diabetes mellitus (T1DM) and healthy children. A further aim was to…
Tristani-Firouzi B, Pappas L, Joseph M et al. · 2026 · BJOG : an international journal of obstetrics and gynaecology
Objective Maternal genotypes may be useful to customise foetal growth assessment, but generalisability across diverse racial and ancestral groups remains uncertain. We assessed the generalisability of a genetic risk score for birth weight…
Posada-López A, Duque JD, Pineda-Tamayo RA et al. · 2023 · Reumatologia clinica
Background and objective Periodontitis and rheumatoid arthritis (RA) have been associated in a bidirectional way. The objective of this study was to determine the association between clinical parameters of periodontitis and RA. Materials…
Zhang X, Goldberg SB, Baldwin SA et al. · 2025 · Journal of consulting and clinical psychology
Objective This study applied a machine-learning-based skill assessment system to investigate the association between supportive counseling skills (empathy, open questions, and reflections) and treatment outcomes. We hypothesized that…
Sznitman S, Mabouk C, Said Z et al. · 2023 · BMJ supportive & palliative care
Background Various jurisdictions have legalised medical cannabis (MC) for use in chronic pain treatment. The objective of this study was to determine if the use of MC is related to a reduction in the use of prescription opioids and other…
Ellenardóttir V, Coronel R, Folke F et al. · 2024 · Open heart
Aim Conflicting results have been reported regarding the association between fluoroquinolones (FQs) and the risk of out-of-hospital cardiac arrest (OHCA). In particular, it has not become clear whether OHCA in FQ users is related to the…
Nacar MC, Yigit S · 2023 · Nucleosides, nucleotides & nucleic acids
Background Osteoporosis (OP) is a common systemic, metabolic bone disease that affects 40% of postmenopausal women. Oxidative stress (OS) ìs caused by reactive oxygen species (ROS), inhibits osteoblast differentiation and causes apoptosis…
Sato K, Arasaki N, Agena S et al. · 2025 · JMA journal
Introduction Increased muscle mass may positively influence the recovery of balance function. In this study, we aimed to investigate the relationship between changes in muscle mass and improved balance in patients with cerebral infarction.…
Lozano-Meca JA, Gacto-Sánchez M, Montilla-Herrador J · 2024 · European journal of pain (London, England)
Introduction Knee Osteoarthritis (KOA) is mainly characterized by pain. The assessment of KOA-related pain frequently focuses on different constructs subject to sources of bias or drawbacks, as the classical Pain at Rest (PAR).…
Daniel S, Hou R, Galea I et al. · 2025 · Brain, behavior, & immunity - health
Background Subarachnoid haemorrhage (SAH) is a severe type of intracranial bleed that causes significant morbidity. One of the most overlooked yet commonly reported symptom is persistent fatigue. Fatigue in the general population has been…
Gonçalves TR, Cunha DB, Mediano MFF et al. · 2025 · BMC public health
Background Low back pain (LBP) is a leading cause of years lived with disability. However, the association of non-chronic LBP with levels of daily physical activity (PA) remains poorly explored. This study investigated the association…
Wierzbiński P, Henzler M, Hubska J · 2022 · Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
Suicidal behaviour is a major public health problem in Poland. There is compelling evidence that genetic factors contribute to the risk for suicidal behavior. Studies suggest a link between single nucleotide polymorphism (SNP) rs1049353…
Gümüş CY, Özer Y, Kaşko Arıcı Y · 2026 · Medical science monitor : international medical journal of experimental and clinical research
BACKGROUND Vitamin D deficiency is common in pediatric obesity and has been proposed to contribute to metabolic-associated fatty liver disease (MAFLD). This retrospective study aimed to evaluate serum 25-hydroxyvitamin D (25[OH]D) levels…
Barber LE, Maliniak ML, Moubadder L et al. · 2024 · JAMA network open
Importance Neighborhood deprivation has been associated with increased breast cancer mortality among White women, but findings are inconsistent among Black women, who experience different neighborhood contexts. Accounting for interactions…
Xin Y, Qian X, Yang Y · 2025 · BMC public health
Background This study aimed to prospectively assess the relationship between systolic blood pressure (SBP) trajectories and successful aging in middle-aged and elderly Chinese individuals. Methods A total of 1,960 participants from the…
Rabizadeh S, Seyedi SA, Nabipoorashrafi SA et al. · 2023 · Chronic diseases and translational medicine
Background High concentrations of low-density lipoprotein cholesterol (LDL-C) have been a known risk factor for cardiovascular diseases. Also, the role of oxidized LDL (ox-LDL) in forming atherosclerosis plaque has been proven. However, it…
Lange AV, Hess E, Barón AE et al. · 2026 · Journal of palliative medicine
Background Providing and measuring goal-concordant care is a priority. Objective Determine the effect of a nurse and social worker palliative telecare team intervention on goal concordance and participants' understanding of care focus.…
Soeda K, Komaba H, Nakagawa Y et al. · 2024 · Journal of nephrology
Background Hyponatremia is implicated in pathological bone resorption and has been identified as a risk factor for bone fracture in the general population. However, there are limited data on the association between serum sodium levels and…
Lampousi AM, Zeng J, Löfvenborg JE et al. · 2026 · Diabetologia
Aims/hypothesis The role of red meat in type 1 diabetes risk remains unclear. We examined whether maternal and early-life red meat intake is associated with the development of type 1 diabetes and whether such associations are modified by…