A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21742 results · page 601 of 725
Buck AN, Fleiner T, Rosskothen-Kuhl N et al. · 2026 · Trends in hearing
It is widely known that users of cochlear implants (CIs) often show deficits in binaural hearing. In particular, interaural time difference (ITD) discrimination tends to be substantially worse in CI users. However, only very few studies…
Chen Y, Gao J, Wang X et al. · 2024 · Frontiers in nutrition
Background Evidence from observational studies on the association between folate and metabolic dysfunction-associated steatotic liver disease (MASLD) is conflicting. Aims This study aimed to investigate the association between serum folate…
Castillo L, Berrozpe-Villabona C, Miserachs-García S et al. · 2024 · Acta ophthalmologica
Purpose The role of the choroid in Leber hereditary optic neuropathy (LHON) remains unclear. The literature is scarce, with conflicting results and lacks axial length measurements. Therefore, we aimed to analyse the choriocapillaris (CC)…
Ding L, Reiher M · 2026 · Journal of chemical theory and computation
Neural quantum states (NQS) are a promising ansatz for solving many-body quantum problems due to their inherent expressiveness. Yet this expressiveness can only be harnessed efficiently for treating identical particles if the suitable…
Brunekreef J · 2024 · Journal of imaging informatics in medicine
The cited article reports on a convolutional neural network trained to predict response to neoadjuvant chemotherapy from pre-treatment breast MRI scans. The proposed algorithm attains impressive performance on the test dataset with a mean…
Loos E, Van Stiphout L, Lucieer F et al. · 2025 · Scientific reports
Little is known about the evolution of vestibular dysfunction and health-related quality of life in bilateral vestibulopathy patients over time. Furthermore, it is unknown whether etiology influences the evolution. A retrospective study…
Ahmadi Somaghian S, Pajouhi N, Dezfoulian O et al. · 2024 · Archives of physiology and biochemistry
Objective Improvement of cell survival is essential for achieving better clinical outcomes in stem cell therapy. We investigated the effects of hyperoxic pre-treatment (HP) on the viability of human adipose stromal stem cells (ASCs).…
Liao C, Nie J, Xu XJ et al. · 2024 · Leukemia & lymphoma
Two hundred and thirty-one acute lymphoblastic leukemia (ALL) children with 1376 high-dose methotrexate (HD-MTX) courses (3-5 g/m 2 ) were enrolled to analyze the influence of the plasma MTX concentration ( C MTX ) in ALL. The 24-h target…
Chen W, Yoshida S, Fujii Y · 2026 · Cancer reports (Hoboken, N.J.)
Background Androgen receptor signaling inhibitors (ARSI) combined with androgen deprivation therapy (ADT) have demonstrated significant survival benefits in metastatic hormone-sensitive prostate cancer (mHSPC) in several clinical trials.…
Findlay MC, Tenhoeve S, Alt J et al. · 2024 · Neurosurgery
Background and objective Cushing disease (CD) affects mortality and quality of life along with limited long-term remission, underscoring the need to better identify recurrence risk. The identification of surgical or imaging predictors for…
Pot MT, Visser ME, Helm B et al. · 2024 · Biology letters
Whether avian migrants can adapt to their changing world depends on the relative importance of genetic and environmental variation for the timing and direction of migration. In the classic series of field experiments on avian migration, A.…
Diao Z, Zhang Y, Chen Y et al. · 2023 · Clinical chemistry
Background Laboratory-developed metagenomic next-generation sequencing (mNGS) assays are increasingly being used for the diagnosis of infectious disease. To ensure comparable results and advance the quality control for the mNGS assay, we…
Yu J, Lu Y, Zhao L · 2026 · Frontiers in public health
Purpose Health inequalities rooted in social stratification remain a persistent structural public-health challenge. While physical activity is recognized as a health-enhancing behavior, limited longitudinal evidence exists on how its…
Krasieva K, Gencer B, Locatelli I et al. · 2024 · Circulation. Cardiovascular quality and outcomes
Background Long-term control of cardiovascular risk factors after acute coronary syndrome (ACS) is the cornerstone for preventing recurrence. We investigated the extent of cardiovascular risk factor management in males and females with and…
Bloch RJ, Traficante M, Mariot V et al. · 2025 · Neuromuscular disorders : NMD
Facioscapulohumeral muscular dystrophy is a progressive muscle disorder that is likely linked to aberrant DUX4 expression. Losmapimod, a p38 kinase inhibitor, was utilized to suppress DUX4 and its downstream effects. Phase I/II clinical…
de Barros B, Sultana F, Maximus N et al. · 2026 · Preprint
ABSTRACT Background Erythema nodosum leprosum (ENL) is a severe inflammatory complication of leprosy that often requires prolonged corticosteroid therapy which is associated with adverse effects. Methotrexate is an affordable…
Garg AX · 2026 · Annals of internal medicine
Clinical impact ratings GIM/FP/GP: [Formula: see text] Critical Care: [Formula: see text] Nephrology: [Formula: see text].
Dodd TS, Borzak S · 2026 · Annals of internal medicine
Clinical impact ratings GIM/FP/GP: [Formula: see text] Cardiology: [Formula: see text] Hematology: [Formula: see text].
Jain S, Jha AK, Chawla D et al. · 2026 · Indian journal of pediatrics
OBJECTIVES: To determine the effect of prone positioning on the duration of respiratory support in neonates receiving non-invasive mode of ventilation. METHODS: This open label randomized controlled trial was conducted in the NICU of a…
Brasher MI, Patil MS · 2026 · Acta paediatrica (Oslo, Norway : 1992)
The LAKANA trial: a randomized control trial evaluating the impact of mass administration of azithromycin to infants 1 to 11 months of age in Mali showed no reduction in mortality.
Legnani C, Ventura A, Oriani G · 2026 · Journal of clinical practice and research
A retrospective study was conducted to evaluate the need for perioperative autotransfusions and the amount of blood loss by comparing patients receiving different tranexamic acid (TXA) regimens following total joint replacement (TJR). A…
Holl CK, Bonilla Yanez M, Finley JM et al. · 2026 · Preprint
Background and Purpose Walking after stroke is often characterized by persistent biomechanical impairments and reduced walking capacity. While visual biofeedback can improve gait mechanics and fast walking can enhance capacity, it is…
Greenway RR, Coulter AA, Zhang D et al. · 2026 · Journal of medicinal food
Gallic acid, a catechin polyphenol in tea, completely inhibited angiogenesis in assays of human tissue at 10 -3 M. Psoriasis is a skin disease caused by excessive secretion of angiogenenic factors by keratinocytes and stromal skin cells.…
Fantasia ME, Penick CA · 2026 · Journal of economic entomology
Climate change intensifies drought frequency, posing risks to pollinators both directly and indirectly through changes in floral resource availability. We tested how water limitation alters pollinator-relevant floral traits, visitation,…
Kasige RH, Johnson SN, Frew A · 2026 · Preprint
Abstract Background and aims. Plant susceptibility to insect herbivores is shaped by interacting soil-based biotic and abiotic factors, particularly arbuscular mycorrhizal (AM) fungi and silicon (Si) availability. AM fungi influence plant…
Ge H, Calero C, Costas R · 2026 · Preprint
Abstract Global scientific mobility is central to the circulation of knowledge, skills and opportunities, but its recent evolution remains unclear. Using the Dimensions database, we reconstruct publication-based career trajectories for…
Wick B, Sahibzada O, Cherner A et al. · 2026 · Journal of vascular surgery. Venous and lymphatic disorders
Objective The optimal clinical management of isolated distal deep venous thrombosis (IDDVT) remains controversial as the benefits of routine anticoagulant therapy are not clearly defined amid the risk of bleeding events. Our study aimed to…
Hetherington A, Bauer L, Rablin S et al. · 2026 · Australasian emergency care
Background Acute wheeze is a common emergency department presentation among pre-school aged children. Innovative models of care that safely optimise treatment and streamline patient flow are needed. A nurse-led stretching of inhaled…
Agweyu A, Mwaniki P, Menon V et al. · 2026 · Nature medicine
Rigorous evidence on the performance of large language models (LLMs) in real-world, low-resource clinical settings remains limited. Here we conducted a pragmatic, cluster-randomized trial in 16 primary care facilities in Kenya. Clinical…
Khan S, Simmons KL, Khan S et al. · 2026 · Orbit (Amsterdam, Netherlands)
Purpose To determine whether prophylactic antibiotic administration following the development of an orbital floor fracture or after orbital floor fracture repair is associated with a reduced risk of orbital or periorbital cellulitis.…