A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19786 results in Negative / Null Result Report · page 60 of 660
Fabien Gaud, Baptiste Lepers, Jérémie Decouchant et al. · 2014 · Open Repository and Bibliography (University of Luxembourg)
Application virtual address space is divided into pages, each requiring a virtual-to-physical translation in the page table and the TLB. Large working sets, common among modern applications, necessitate a lot of translations, which…
Rocío Montes de, Paul R. Andreassen, Katherine L. Wilson · 2011 · Nucleus
Defects in the nuclear envelope or nuclear 'lamina' networks cause disease and can perturb histone posttranslational (epigenetic) regulation. Barrier-to-Autointegration Factor (BAF) is an essential but enigmatic lamina component that binds…
Larry L. Wang, Renée Zon Filippi, David Zurakowski et al. · 2010 · The American Journal of Surgical Pathology
Neoadjuvant chemotherapy followed by resection has become the mainstay in the treatment of hepatoblastoma (HB). The changes after chemotherapy typically result in tumor necrosis and a fibrohistiocytic response. We have observed that…
Ulas D. Bayraktar, Emerson Chen, Soley Bayraktar et al. · 2010 · Cancer
BACKGROUND: It is unclear whether delays in commencing adjuvant chemotherapy after surgical resection of colon adenocarcinoma adversely impact survival. METHODS: Patients with stage II-III colon adenocarcinoma who received adjuvant…
Annette Langer‐Gould, Robyn Lucas, Anny H. Xiang et al. · 2018 · Nutrients
Multiple sclerosis (MS) incidence and serum 25-hydroxyvitamin D (25OHD) levels vary by race/ethnicity. We examined the consistency of beneficial effects of 25OHD and/or sun exposure for MS risk across multiple racial/ethnic groups. We recruited incident MS cases and controls (blacks 116 cases/131 controls; Hispanics 183/197; whites 247/267) from the membership of Kaiser Permanente Southern California into the MS Sunshine Study to simultaneously examine sun exposure and 25OHD, accounting for genetic ancestry and other factors. Higher lifetime ultraviolet radiation exposure (a rigorous measure o
Daniel S. Tsze, Gerrit Hirschfeld, Carl L. von Baeyer et al. · 2015 · Academic Emergency Medicine
OBJECTIVES: The objective was to determine the minimum and ideal clinically significant differences (MCSD, ICSD) in pain intensity in children for the Faces Pain Scale-Revised (FPS-R) and the Color Analog Scale (CAS) and to identify any…
Wilson Sui, Justin T. Matulay, Maxwell B. James et al. · 2016 · Bladder Cancer
Introduction: Micropapillary bladder cancer (MPBC) is a variant histology of urothelial carcinoma (UC) that is associated with poor outcomes however given its rarity, little is known outside of institutional reports. We sought to use a…
Zaid Zoumot, Afroditi Boutou, Simon Gill et al. · 2014 · Respirology
BACKGROUND AND OBJECTIVE: Reliable markers of disease progression or stability to assist in management decisions are lacking in patients with non-cystic fibrosis bronchiectasis and Mycobacterium avium complex (MAC) infection. METHODS: Data…
Shabih U. Hasan, Jim Potenziano, Girija G. Konduri et al. · 2017 · JAMA Pediatrics
Importance: Bronchopulmonary dysplasia (BPD) occurs in approximately 40% of infants born at younger than 30 weeks' gestation and is associated with adverse pulmonary and neurodevelopmental outcomes. Objective: To test whether…
Byoung Geol Choi, Seung‐Woon Rha, Seong Gyu Yoon et al. · 2019 · Journal of the American Heart Association
Background Significant coronary artery disease has a well‐known association with long‐term adverse cardiovascular events. In this study, we aimed to evaluate its association with long‐term major adverse clinical events ( MACE ) up to 5…
Vincent Uyttendaele, Jennifer L. Dickson, Geoffrey M. Shaw et al. · 2017 · Critical Care
BACKGROUND: Hyperglycaemia is associated with adverse outcomes in the intensive care unit, and initial studies suggested outcome benefits of glycaemic control (GC). However, subsequent studies often failed to replicate these results, and they were often unable to achieve consistent, safe control, raising questions about the benefit or harm of GC as well as the nature of the association of glycaemia with mortality and clinical outcomes. In this study, we evaluated if non-survivors are harder to control than survivors and determined if glycaemic outcome is a function of patient condition and eve
Helena J Teede, Mahnaz Bahri Khomami, Rachel Morman et al. · 2026 · The Lancet
Polyendocrine metabolic ovarian syndrome (PMOS), previously named polycystic ovary syndrome (PCOS), affects one in eight women. However, the term PCOS is inaccurate, implying pathological ovarian cysts, obscuring diverse endocrine and metabolic features, and contributing to delayed diagnosis, fragmented care, and stigma, while curtailing research and policy framing. Building on an international mandate for change, we outline an unprecedented, rigorous, multistep global consensus process for the name change. Funding and governance were established with engagement of 56 leading academic, clinica
Marta Walentynowicz, Stefan Schneider, Arthur A. Stone · 2018 · PLoS ONE
BACKGROUND: The degree to which episodic and semantic memory processes contribute to retrospective self-reports have been shown to depend on the length of reporting period. Robinson and Clore (2002) argued that when the amount of accessible detail decreases due to longer reporting periods, an episodic retrieval strategy is abandoned in favor of a semantic retrieval strategy. The current study further examines this shift between retrieval strategies by conceptually replicating the model of Robinson and Clore (2002) for both emotions and symptoms and by attempting to estimate the exact moment of
John M. Griffin, Richard Lowery, Alessio Saretto · 2014 · Review of Financial Studies
Conventional wisdom suggests that high-reputation banks will generally produce good securities to maintain their long-run reputation. We show with a simple model that, when securities are complex a high-reputation bank may produce assets…
Simone Riis Porsborg, Allan Stensballe, Jeppe Emmersen et al. · 2016 · Stem Cell Research & Therapy
BACKGROUND: Adipose-derived stem cells (ASCs) are being increasingly recognized for their potential to promote tissue regeneration and wound healing. These effects appear to be partly mediated by paracrine signaling pathways, and are enhanced during hypoxia. Mass spectrometry (MS) is a valuable tool for proteomic profiling of cultured ASCs, which may help to reveal the identity of the factors secreted by the cells under different conditions. However, serum starvation which is essentially required to obtain samples compatible with secretome analysis by MS can have a significant influence on ASC
Fabian Ramseyer · 2019 · Psychotherapy Research
Objectives: A methodological obstacle for the assessment of psychotherapy process concerns the compatibility between nomothetic versus idiographic approaches. Using quantitative methodology at an idiographic level, we seek to narrow this…
Gregor Perich, Mehmet Özgür Türkoglu, Lukas Valentin Graf et al. · 2023 · Field Crops Research
Mapping and predicting crop yield on a large scale is increasingly important for use cases such as policy-making, risk insurance and precision agriculture applications at farm and field scale. The higher spatial resolution of Sentinel-2 compared to Landsat allows for satellite-based crop yield mapping even in relatively small scaled agricultural settings such as found in Switzerland and other central European regions. In this study, five years (2017–2021) of cereal crop yield data from a combine harvester were used to model crop yield within-field, on a spatial scale corresponding to the Senti
Brandon J. Erickson, Joshua D. Harris, Brian J. Cole et al. · 2014 · Orthopaedic Journal of Sports Medicine
BACKGROUND: Anterior cruciate ligament (ACL) rupture is a significant injury in male National Hockey League (NHL) players. PURPOSE: To determine (1) the return to sport (RTS) rate in the NHL following ACL reconstruction, (2) performance on…
Jennifer E. Nyland, Nazia Raja‐Khan, Kerstin Bettermann et al. · 2021 · Diabetes
Patients with type 2 diabetes mellitus (T2DM) are at increased risk of severe coronavirus disease 2019 (COVID-19) outcomes possibly because of dysregulated inflammatory responses. Glucose-regulating medications, such as glucagon-like…
Raffaella Schneider, Rosa Valiante, Alessandro Trinca et al. · 2023 · Monthly Notices of the Royal Astronomical Society
ABSTRACT JWST is unveiling for the first time accreting black holes (BHs) with masses of 106 − 107 M⊙ at z > 4, with the most distant residing in GNz11 at z = 10.6. Are we really surprised to find them in the nuclei of z ≃ 5 − 11…
Chingping Wan, Charles A. Herzog, Wojciech Zaręba et al. · 2013 · Annals of Noninvasive Electrocardiology
BACKGROUND: The survival outcome following a sudden cardiac arrest (SCA) in hemodialysis (HD) patients is poor regardless of whether an event takes place in or out of a dialysis center. The characteristics of SCA and post-SCA survival with HD patients using a wearable cardioverter defibrillator (WCD) are unknown. METHODS: All HD patients who were prescribed a WCD between 2004 and 2011 and experienced at least one SCA event were included in this study. Demographics, clinical background, characteristics of SCA events were identified from the manufacturer's database. An SCA event was defined as a
Tien Hoang, Suzanne E. Dahlberg, Joan H. Schiller et al. · 2012 · Journal of Clinical Oncology
PURPOSE: The primary objective of this study was to compare the survival of patients with unresectable stage III non-small-cell lung cancer (NSCLC) treated with combined chemoradiotherapy with or without thalidomide. PATIENTS AND METHODS:…
Erik C. Olsson, Meghan Jobson, Moe R. Lim · 2015 · Orthopedics
Dysphagia is a relatively common complication of anterior cervical spine surgery. Smoking has not been definitively assessed as a risk factor for dysphagia. This study examined risk factors for dysphagia, including smoking and pain…
Takeshi Ueno, Yasuko Asahina, Akio Tanaka et al. · 2013 · Clinical Pharmacology & Therapeutics
Although the number of global clinical trials (GCTs) conducted in multiple countries including Japan has increased recently, it is not clear how much these GCTs help in reducing the lag in drug development (LDD: difference between the…
Maria Azrad, Robin T. Vollmer, John F. Madden et al. · 2013 · Journal of Medicinal Food
Enterolactone and enterodiol, mammalian lignans derived from dietary sources such as flaxseed, sesame seeds, kale, broccoli, and apricots, may impede tumor proliferation by inhibiting activation of nuclear factor kappa B (NFκB) and…
Chaoyuan Kuang, Yongseok Park, Ryan C. Augustin et al. · 2022 · Clinical Epigenetics
Abstract Background DNA mismatch repair proficient (pMMR) metastatic colorectal cancer (mCRC) is not responsive to pembrolizumab monotherapy. DNA methyltransferase inhibitors can promote antitumor immune responses. This clinical trial investigated whether concurrent treatment with azacitidine enhances the antitumor activity of pembrolizumab in mCRC. Methods We conducted a phase 2 single-arm trial evaluating activity and tolerability of pembrolizumab plus azacitidine in patients with chemotherapy-refractory mCRC (NCT02260440). Patients received pembrolizumab 200 mg IV on day 1 and azacitidine 1
Karol Sadowski, Adrianna Jażdżewska, Jan Kozłowski et al. · 2024 · International Journal of Molecular Sciences
Glioblastoma is the most common malignant primary brain tumor in the adult population, with an average survival of 12.1 to 14.6 months. The standard treatment, combining surgery, radiotherapy, and chemotherapy, is not as efficient as we would like. However, the current possibilities are no longer limited to the standard therapies due to rapid advancements in biotechnology. New methods enable a more precise approach by targeting individual cells and antigens to overcome cancer. For the treatment of glioblastoma, these are gamma knife therapy, proton beam therapy, tumor-treating fields, EGFR and
Nathan J. Brown · 2013 · Journal of Democracy
Abstract: Egypt’s mass uprising of 2011 gave birth to tremendous hopes that a new era of democratic politics could be built in the Arab world. But the process of transition to a democracy was badly designed, providing strong incentives for…
Ted Wun, Denis Soulières, Andrew L. Frelinger et al. · 2013 · Journal of Hematology & Oncology
BACKGROUND: Platelet activation has been implicated in the pathogenesis of sickle cell disease (SCD) suggesting antiplatelet agents may be therapeutic. To evaluate the safety of prasugrel, a thienopyridine antiplatelet agent, in adult patients with SCD, we conducted a double-blind, randomized, placebo-controlled study. METHODS: The primary endpoint, safety, was measured by hemorrhagic events requiring medical intervention. Patients were randomized to prasugrel 5 mg daily (n = 41) or placebo (n = 21) for 30 days. Platelet function by VerifyNow® P2Y12 and vasodilator-stimulated phosphoprotein as
Lavinia Rech, Mahmoud Abdellatif, Maria Pöttler et al. · 2021 · Life Sciences
AIMS: Myocardial infarction (MI) is a major global cause of death. Massive cell death leads to inflammation, which is necessary for ensuing wound healing. Extensive inflammation, however, promotes infarct expansion and adverse remodeling. The DNA sensing receptor cyclic GMP-AMP synthase and its downstream signaling effector stimulator of interferon genes (cGAS-STING) is central in innate immune reactions in infections or autoimmunity. Cytosolic double-strand DNA activates the pathway and down-stream inflammatory responses. Recent papers demonstrated that this pathway is also active following M