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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20261 results in Negative / Null Result Report · page 598 of 676

Negative / Null Result ReportOpen accessMedicine

Postoperative C-Reactive Protein Trajectories in Spine Surgery - Influence of Vancomycin Powder: A Secondary Analysis of a Prospective Randomized Controlled Trial.

Panzenböck LF, Abdel Nour G, Dürrschnabel DL et al. · 2026 · Global spine journal

Study DesignRandomized controlled trial.ObjectivesTo characterize postoperative C-reactive protein (CRP) trajectories as predictors of surgical site infection (SSI) following lumbar spine surgery, to determine optimal CRP thresholds, and…

View details →DOI: 10.1177/21925682261450878
Negative / Null Result ReportMedicine

Chronic ozone exposure does not alter sexual behavior but modulates oxidative stress and early testicular apoptosis in adult male rats.

Yardimci A, Ertugrul NU, Akkoc RF et al. · 2026 · Reproductive biology

Ozone (O₃) has been used to treat various diseases for many years, with most preclinical studies focusing on its effects in conditions such as testicular torsion and ischemia-reperfusion injury; however, its impact on male reproductive…

View details →DOI: 10.1016/j.repbio.2026.101185
Negative / Null Result ReportMedicine

The potential of cell-free supernatants from Lacticaseibacillus paracasei B1 and Lactiplantibacillus plantarum O24 as antioxidant and antimicrobial agents

Kęska P, Zielińska D, Karbowiak M et al. · 2025 · Food Chemistry

The aim of this study was to evaluate the effectiveness of cell-free supernatants (CFS) produced by selected lactic acid bacteria (LAB) strains: Lacticaseibacillus paracasei B1 and Lactiplantibacillus plantarum O24 as antioxidant and…

Negative / Null Result ReportOpen accessMedicine

Understanding the impact of growth hormone on ventilatory control stability in children with Prader-Willi syndrome.

Patoglu OR, Horne RSC, Mann DL et al. · 2026 · European journal of pediatrics

A hallmark of Prader-Willi syndrome (PWS) is hypothalamic-pituitary axis dysfunction, which can result in reduced growth hormone (GH) production. While GH replacement therapy is common in children with PWS, it has also been implicated in…

View details →DOI: 10.1007/s00431-026-06857-y
Negative / Null Result ReportMedicine

Subacute ivermectin-induced affective dysregulation: Evidence for hippocampal microglial and astrocytic activation.

Eser M, Yazıcı C, Kandemir Ü et al. · 2026 · Research in veterinary science

Ivermectin (IVR) is a semi-synthetic macrocyclic lactone widely used against nematodes. Under physiological conditions, its central nervous system (CNS) penetration is limited by P-glycoprotein-mediated efflux at the blood-brain barrier…

View details →DOI: 10.1016/j.rvsc.2026.106105
Negative / Null Result ReportMedicine

High dose methyl donor nutrient supplementation fails to prevent the adverse effects of a maternal Western-style diet on depression-related behavior and results in stress-dependent effects on learning.

Farber C, Jackson C, Renteria K et al. · 2026 · Nutrition (Burbank, Los Angeles County, Calif.)

Background Exposure to a Western diet during gestation and lactation adversely impacts offspring mood, learning, and memory. We determined if high dose maternal methyl donor nutrient (MDN) supplementation ameliorated the effects of a high…

View details →DOI: 10.1016/j.nut.2026.113149
Negative / Null Result ReportMedicine

Platelet-derived mitochondrial preparation did not alter early inflammatory markers in a bilateral lipopolysaccharide-induced model of equine synovitis.

Khaliji E, Marycz K, Horna M et al. · 2025 · American journal of veterinary research

Objective To evaluate IA autologous platelet-derived mitochondrial preparation versus vehicle control in a bilateral lipopolysaccharide (LPS)-induced model of equine synovitis. Methods 2 ng of LPS was injected into bilateral intercarpal…

View details →DOI: 10.2460/ajvr.25.05.0187
Negative / Null Result ReportMedicine

Effects of dietary alpha-ketoglutaric acid on growth performance and intestinal barrier function in Lateolabrax maculatus fed a high soybean meal diet

Quan F, Ma J, Zhao Y et al. · 2025 · Aquaculture international

This study investigated the effects of supplementing high soybean meal diets with alpha-ketoglutaric acid (AKG) on the intestinal health and growth performance of spotted sea bass (Lateolabrax maculatus). A total of 270 fish (average…

Negative / Null Result ReportMedicine

Opposing Effects of Dietary Nitrate on Muscle Contractile Function in Fast and Slow Human Muscles.

Zoughaib WS, Fry MJ, Singhal A et al. · 2026 · Medicine and science in sports and exercise

Purpose Increasing nitric oxide bioavailability via nitrate (NO 3- ) ingestion enhances muscle contractility, which may be due to phosphorylation of the regulatory light chain of myosin. If so, there should be an interaction between NO 3-…

View details →DOI: 10.1249/mss.0000000000003932
Negative / Null Result Report

Functional and evolutionary evidence from a widely used molluscan model reveals the absence of ecdysone signaling in lophotrochozoans

Svigruha R, Yañez-Guerra LA, Caña-Bozada VH et al. · 2025 · Preprint

Abstract Ecdysone-controlled pathways regulate ecdysozoan development through both a nuclear (nEcR) and a membrane receptor (mEcR). Ecdysone signaling was long thought to be exclusive to ecdysozoans; however, studies since 2010 have…

View details →DOI: 10.21203/rs.3.rs-8193722/v1
Negative / Null Result ReportMedicine

Heparin in peripherally inserted central catheters did not alter elective removal and complication rates in preterm infants.

Wackernagel D, Gavelli V, Nydert P · 2025 · Clinical nutrition ESPEN

Background & aims In preterm and sick newborn infants, peripherally inserted central catheters (PICC) are used for the delivery of concentrated parenteral nutrition and other high risk drugs. Despite the precaution issued by the ESPGHAN…

View details →DOI: 10.1016/j.clnesp.2025.03.024
Negative / Null Result ReportMedicine

Vacuolar Protein Sorting 35 Controls Hepatocellular Proliferation Through SRC Signaling and Promotes Diethyl Nitrosamine-Induced Tumor Initiation.

Barbosa MG, Vos DY, Verzijl CRC et al. · 2026 · Cellular and molecular gastroenterology and hepatology

Background & aims Hepatocellular carcinoma is the third leading cause of cancer-related mortality worldwide. Therapeutic options for hepatocellular carcinoma remain limited, and the mechanisms underlying hepatocellular carcinoma are not…

View details →DOI: 10.1016/j.jcmgh.2026.101788
Negative / Null Result ReportMedicine

Organic carbon loss from agricultural soil is accelerated by biodegradable microplastics and mitigated by mineral nitrogen addition.

Wooliver R, Neupane A, DeBruyn JM et al. · 2026 · Journal of environmental quality

Microplastics derived from agricultural plastic films accumulate in soils, potentially impacting ecosystem functions such as soil organic carbon (SOC) storage. Microbial degradation of biodegradable plastics, which are intentionally tilled…

View details →DOI: 10.1002/jeq2.70135
Negative / Null Result ReportMedicine

Use of blood micro-samples in forensic thanatology.

Bertrand-Ndoye M, Girard H, Hakim F et al. · 2026 · Forensic science international

In forensic thanatology, post-mortem blood is often stored for long periods, leading to in vitro variations in drug concentrations. This study evaluated the use of dried blood microsampling supports dried (Dried Blood Spot - DBS and…

View details →DOI: 10.1016/j.forsciint.2025.112798
Negative / Null Result ReportOpen accessMedicine

Impact of Emergency Surgery for Acute Type A Aortic Dissection on Postoperative Renal Function in Patients With Autosomal Dominant Polycystic Kidney Disease.

Fukunaga N, Takanishi T, Wakami T et al. · 2026 · Circulation reports

Background The impact of emergency surgery for acute type A aortic dissection (ATAAD) on renal function in patients with autosomal dominant polycystic kidney disease (ADPKD) remains unclear. Methods and results The renal function of 4…

View details →DOI: 10.1253/circrep.cr-25-0255
Negative / Null Result ReportMedicine

Effects of percussive massage vs. foam rolling on hamstring function: a comparative study using shear wave elastography, tensiomyography, and MyotonPro.

Fischer J, Seguel JM, Drole K et al. · 2026 · BMC sports science, medicine & rehabilitation

Background This study investigated the comparative acute effects of 3 × 30 s of vibration foam rolling (VFR) or percussive massage (PM) on the hamstring muscles, specifically range of motion (ROM), maximum voluntary isometric contraction…

View details →DOI: 10.1186/s13102-026-01732-7
Negative / Null Result ReportMedicine

Core Temperature Estimation Using Wearable Earbud-Type Thermometer and Machine Learning During Light-Intensity Cycling Under Varying Indoor Ambient Temperatures.

Fujii N, Katagiri A, Nakagome K et al. · 2026 · Scandinavian journal of medicine & science in sports

Continuous monitoring of core temperature is crucial for optimizing exercise performance, promoting health, and ensuring safety. Here, we evaluated the validity of a machine learning-based earbud-type core temperature sensor during…

View details →DOI: 10.1111/sms.70315
Negative / Null Result ReportMedicine

Development and validation of the OMERACT juvenile idiopathic arthritis MRI- sacroiliac joint score (OMERACT JAMRIS-SIJ): Phase 3.

Maksymowych WP, Weiss PF, Francavilla ML et al. · 2026 · Seminars in arthritis and rheumatism

Objective The OMERACT JAMRIS working group has defined a spectrum of MRI lesions in the sacroiliac joint (SIJ) in pediatric cases with spondyloarthritis (SpA) that match domains for inflammation and structural damage. We aimed to assess…

View details →DOI: 10.1016/j.semarthrit.2026.153018