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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19902 results in Negative / Null Result Report · page 598 of 664

Negative / Null Result ReportMedicine

The Surgical Outcomes of Brachiocephalic Vein Transection Versus Reconstruction for Locally Advanced Thymic Epithelial Tumors.

Sun J, Xiong Y, Qiu J et al. · 2026 · Annals of surgical oncology

Background Locally advanced thymic epithelial tumors (TETs) may extend into the adjacent brachiocephalic vein (BCV), creating major technical challenges for resection. While BCV reconstruction is traditionally considered after tumor…

View details →DOI: 10.1245/s10434-026-19935-0
Negative / Null Result Report

Challenging the standard: Comparison of outcomes between Laparoscopically Assisted Anorectoplasty (LAARP) and Posterior Sagittal Anorectoplasty (PSARP) in the correction of rectobulbar fistula in Pediatric Patients

Sanchez MAC, Ruiz J, Siffredi J et al. · 2026 · Preprint

Abstract Background: Posterior sagittal anorectoplasty (PSARP) remains the standard surgical approach for rectobulbar fistula in patients with anorectal malformations (ARM). Laparoscopically assisted anorectoplasty (LAARP) has emerged as…

View details →DOI: 10.21203/rs.3.rs-9556600/v1
Negative / Null Result ReportMedicine

Levels of acylated and deacylated ghrelin are elevated in unmedicated patients with major depressive disorder and obesity: a cross-sectional study.

Lis M, Miłuch T, Krupa R et al. · 2026 · Scientific reports

Major depressive disorder (MDD) frequently co-occurs with obesity, suggesting shared neuroendocrine mechanisms. Ghrelin, a hormone involved in appetite regulation, stress response, and reward processing, has been proposed as a biological…

View details →DOI: 10.1038/s41598-026-54095-x
Negative / Null Result ReportMedicine

Clinical and radiographic outcomes of cannulated cancellous screw osteosynthesis with and without side-plate for nondisplaced femoral neck fractures: a multicenter propensity score-matched study.

Maeda K, Funahashi H, Tokutake K et al. · 2026 · International orthopaedics

Purpose This study aimed to evaluate postoperative outcomes, including clinical results, radiological assessments, and complications, in patients over 50 years old with nondisplaced femoral neck fractures (Garden classification I-II)…

View details →DOI: 10.1007/s00264-026-06870-8
Negative / Null Result ReportMedicine

Efficacy and Safety of Denosumab versus Zoledronic Acid in the Treatment of Hypercalcemia in Primary Hyperparathyroidism: A Retrospective Comparative Study.

Liu Y, Liu L, Wang J et al. · 2026 · Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

Objective Nephrotoxicity of bisphosphonates limits their utility in the management of severe hypercalcemia among patients with primary hyperparathyroidism (PHPT) and impaired renal function. It remains unclear whether denosumab is an…

View details →DOI: 10.1016/j.eprac.2026.05.034
Negative / Null Result ReportMedicine

Clinical outcomes of a Locator-bilateral segmental bar concept versus a conventional rigid bar concept for maxillary implant-supported overdentures: a retrospective cohort study.

Zheng J, Chen M, Fu J · 2026 · BMC oral health

Background This retrospective cohort study evaluated a Locator-bilateral segmental bar concept (LBSB) for maxillary implant-supported overdentures and compared it with a conventional rigid bar concept (CRB) in terms of implant survival,…

View details →DOI: 10.1186/s12903-026-08764-y
Negative / Null Result ReportMedicine

Effectiveness of Audiovisual Distraction During Dental Treatment Under Nitrous Oxide/Oxygen Conscious Sedation in Paediatric Patients: A Randomized Crossover Clinical Trial.

Gentile T, Vanacore S, Caputo M et al. · 2026 · Children (Basel, Switzerland)

Background/objectives Dental anxiety represents a major challenge in paediatric dentistry and is a frequent cause of non-cooperative behaviour during dental treatment. Nitrous oxide/oxygen inhalation conscious sedation is widely used to…

View details →DOI: 10.3390/children13060812
Negative / Null Result Report

Functional Outcome and Discharge Destination in Elderly Patients with Spinal Cord Injury: A Retrospective Cohort Study Manuscript Type: Original Article

Kurz S, Habich O, Brauer K et al. · 2026 · Preprint

Abstract Purpose To evaluate whether patients aged > 75 years with spinal cord injury (SCI) benefit from specialized inpatient rehabilitation, focusing on functional outcomes and discharge destination. Methods This retrospective…

View details →DOI: 10.21203/rs.3.rs-9332195/v1
Negative / Null Result ReportMedicine

The trajectories of relative concentrations of antirhodococcal immunoglobulin A differ from those of immunoglobulin G subisotypes in bronchoalveolar lavage fluid but not serum of foals.

Aucoin AA, Zhidkov V, Legere RM et al. · 2026 · American journal of veterinary research

Objective To characterize age-related trajectories of the relative concentrations of anti-virulence-associated protein A (VapA) immunoglobulin (Ig)-G1, IgG3/5, IgG4/7, and IgA in serum and bronchoalveolar lavage fluid (BALF) as indicators…

View details →DOI: 10.2460/ajvr.25.11.0402
Negative / Null Result ReportMedicine

Combined Pain Neuroscience Education and Progressive Muscle Relaxation for Post-Thoracoscopic Pain.

Wang X, Li W, Wang F et al. · 2026 · Pain management nursing : official journal of the American Society of Pain Management Nurses

Purpose The objective of this study was to evaluate whether combining pain neuroscience education (PNE) with progressive muscle relaxation (PMR) could reduce acute pain after thoracoscopic lung resection, alleviate psychological distress,…

View details →DOI: 10.1016/j.pmn.2026.03.024
Negative / Null Result ReportMedicine

Comparing Spinal and General Anesthesia for Prone Percutaneous Nephrolithotomy: A Propensity Score-Matched Study.

Chen L, Xu D, Hou L · 2026 · Medical principles and practice : international journal of the Kuwait University, Health Science Centre

Background/objective Prone percutaneous nephrolithotomy (PCNL) is commonly performed under general anesthesia (GA); however, increasing evidence supports the feasibility of PCNL under spinal anesthesia (SA). This study presents our…

View details →DOI: 10.1159/000552326
Negative / Null Result ReportMedicine

Development and Preliminary Clinical Evaluation of a Multifunctional Operative Support Arm in Reproductive Laparoscopic Surgery: A Randomized Controlled Study.

Mao W, Lu N · 2026 · Journal of investigative surgery : the official journal of the Academy of Surgical Research

Objective To evaluate short-term clinical outcomes, surgeon-reported fatigue, and staff user experience associated with a multifunctional operative support arm in reproductive laparoscopic surgery. Design Single-center, parallel-group…

View details →DOI: 10.1080/08941939.2026.2668806
Negative / Null Result ReportMedicine

Marginal and internal fit and fracture resistance of lithium disilicate laminate veneers for teeth with proximal cavities: an in-vitro comparative study.

Taş MO, Güleryüz A · 2026 · BMC oral health

Background The management of proximal cavities under porcelain laminate veneers remains a clinical challenge. Conventional strategies-such as placing an intermediate composite restoration or extending the preparation-require additional…

View details →DOI: 10.1186/s12903-026-08841-2
Negative / Null Result ReportMedicine

Comparison of visual performance among three higher-order aspheric enhanced monofocal intraocular lenses and a standard aspheric monofocal lens.

Hayashi S, Yoshida M, Hayashi K et al. · 2025 · Journal of cataract and refractive surgery

Purpose To compare visual performance among 3 types of higher-order aspheric enhanced monofocal intraocular lenses (IOLs) and a standard aspheric monofocal IOL. Setting Hayashi Eye Hospital, Fukuoka, Japan. Design Randomized comparative…

View details →DOI: 10.1097/j.jcrs.0000000000001734
Negative / Null Result ReportMedicine

Comparative outcomes of Mini-PCNL and suction-assisted flexible ureteroscopy in patients with renal stones ≥2 cm.

Durak HM, Sancı A, Hepşen E et al. · 2026 · Actas urologicas espanolas

Introduction To compare the efficacy and perioperative outcomes of miniaturized percutaneous nephrolithotomy (mini-PCNL) and flexible ureteroscopy with flexible and navigable suction ureteral access sheath (FANS-UAS) in the management of…

View details →DOI: 10.1016/j.acuroe.2026.501997
Negative / Null Result ReportMedicine

Sleep and emotional memory of preschool children adopted from foster care: a comparison with a community sample.

Rusin K, Myers A, Rech ME et al. · 2026 · Journal of pediatric psychology

Objective Children who spend time in foster care are at risk for adverse developmental outcomes, including sleep problems. Yet, research examining sleep and emotional memory has primarily focused on children with no history of foster care…

View details →DOI: 10.1093/jpepsy/jsag039
Negative / Null Result Report

Increasing clinical utility of prenatal exome sequencing: the potential power of phenotype-driven Artificial Intelligence analysis

Suerink M, Hoffer M, Dingemans A et al. · 2026 · Preprint

Abstract Prenatal exome sequencing (pES) is challenging due to rapid turnaround requirements and limited phenotype information. Analysis strategies span gene panels through exome-wide review, with Artificial Intelligence (AI) as optional…

View details →DOI: 10.21203/rs.3.rs-9634215/v1
Negative / Null Result ReportMedicine

Day-case versus conventional inpatient artificial urinary sphincter implantation: A single-center comparative study of 177 patients.

Youssef MW, Perrin L, Denormandie AC et al. · 2026 · The French journal of urology

Purpose Ambulatory artificial urinary sphincter (AUS) implantation has been proposed as an alternative to conventional inpatient surgery, but comparative data remain limited. We aimed to compare early postoperative outcomes between…

View details →DOI: 10.1016/j.fjurol.2026.103135
Negative / Null Result ReportOpen accessMedicine

Residential radon exposure and lung cancer histology and stage: a population-based ecological study in Central Germany.

Ernst P, Rachow T, Henn S et al. · 2026 · Journal of cancer research and clinical oncology

Purpose Residential radon exposure is recognised as one of the leading environmental risk factors for lung cancer and acts synergistically with tobacco smoking. Thuringia, Germany, exhibits high geogenic radon potential; however,…

View details →DOI: 10.1007/s00432-026-06524-7
Negative / Null Result ReportMedicine

The impact of drains on postoperative seroma and infection after mastectomy: A retrospective study in Danish women with breast cancer.

Palshof FK, Korsholm RHR, Duriaud HM et al. · 2026 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Introduction Postoperative drains are commonly used after mastectomy to reduce seroma formation, but evidence of the benefit remains unclear. We evaluated the effect of postoperative drains on seroma formation and infection after…

View details →DOI: 10.1016/j.ejso.2026.111970
Negative / Null Result ReportMedicine

Hematopoietic progenitor cells (HPCs) mobilization following high-intensity interval exercise in cancer patients undergoing bone marrow transplantation: preliminary results from a randomized controlled trial.

Zarekar T, Ahmadizad S, Hajifathali A et al. · 2026 · Stem cell research & therapy

Background and objective Hematopoietic progenitor cells (HPCs) mobilization is essential for successful bone marrow transplantation but may be impaired in cancer patients due to prior treatments. High-intensity interval exercise (HIIE) has…

View details →DOI: 10.1186/s13287-026-05084-4
Negative / Null Result ReportMedicine

Amplicon sequencing reveals impact of imidacloprid residues on diversity profile of grape fructosphere microbiota.

Deore P, Upadhyay A, Thekkumpurath AS et al. · 2026 · World journal of microbiology & biotechnology

In grape, fructosphere microbiota play an important role in nutrient cycling, pathogen suppression, berry quality, and fermentation processes. Insecticide imidacloprid (IM) is used to manage several insect pests of grape. However, the…

View details →DOI: 10.1007/s11274-026-05095-6
Negative / Null Result ReportMedicine

Reliability and readability of five AI chatbots for concussion health advice across retrieval augmented and pretrained models.

Huang H, Zhang C, Hu H et al. · 2026 · Scientific reports

Generative AI is rapidly entering patient education workflows, yet its safety profile for concussion management remains undefined. Utilizing the CHART framework, this cross-sectional audit assessed five platforms, specifically isolating…

View details →DOI: 10.1038/s41598-026-51281-9
Negative / Null Result ReportMedicine

Clinical Outcome of EMG-Based Pelvic Floor Biofeedback in Patients With Constipation-Impact of Prior Anorectal Manometry/Balloon Expulsion Test for Patient Selection. A Retrospective Study.

Kochhar S, Channapragada T, Shenoy V et al. · 2026 · Neurogastroenterology and motility

Introduction Pelvic floor biofeedback therapy (BFT) is the mainstay treatment for dyssynergic defecation, a condition defined by the Rome criteria. This retrospective study compares outcomes between patients referred for EMG-based BFT…

View details →DOI: 10.1111/nmo.70373