A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19902 results in Negative / Null Result Report · page 597 of 664
Struja T, Hansen LH, Matos J et al. · 2026 · BMJ open
Importance Clinical trials have produced inconclusive results regarding the optimal glucose range for a patient with sepsis in the intensive care unit (ICU) receiving insulin treatment. Objective To investigate the optimal glucose range in…
Droste MJ, Remeijer M, Planqué R et al. · 2024 · Preprint
A bstract In isothermal chemical reaction networks, reaction rates depend solely on the reactant concentrations setting their thermodynamic driving force. Living cells can, in addition, alter reaction rates in their enzyme-catalysed…
Klim L, Michalik M, Cichocka-Jarosz E et al. · 2025 · Nutrients
Background: Diagnosing food allergy (FA) typically involves a detailed clinical history and confirmation of allergen-specific IgE. Oral food challenges (OFCs) remain the gold standard in FA diagnosis. This study aimed to present our…
Jain M, Pal DK, Narayan Sahu R et al. · 2025 · World journal of orthopedics
Background Sagittal spinopelvic alignment (SSA) is essential for preserving a stable and effective upright posture and locomotion. Although alterations in the SSA are recognised to induce compensatory modifications in the pelvis, hips, and…
Buchta C, Aberle SW, Görzer I et al. · 2024 · Wiener klinische Wochenschrift
Background External quality assessment (EQA) schemes provide objective feedback to participating laboratories about the performance of their analytical systems and information about overall regional analytical performance. The EQAs are…
Katz A, Kreiner M, Korain Blank P et al. · 2025 · Journal of pediatric orthopedics
Background Clubfoot is a congenital condition affecting 1 to 2 per 1000 live births, with treatment primarily involving the Ponseti method and/or surgical intervention. It is important to ascertain whether children affected by clubfoot are…
Zeinhom MG, Elsayed Khalil MF, Omar Youssif TY et al. · 2025 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Although topiramate and valproate are antiseizure medications that have many contraindications and could produce many side effects, they are still used as migraine preventive therapy in middle- and low-income countries. Several trials…
La Jeon Y, Lee SG, Lee EH et al. · 2023 · Diagnostic microbiology and infectious disease
We investigated whether inconclusive results could be interpreted differently depending on the situation. First, data from retesting of the initial samples from subjects without a confirmed COVID-19 history were analyzed. And by analyzing…
Palomino-Padilla S, Caceres-Cardenas G, Calderon R et al. · 2024 · Frontiers in public health
Objectives The COVID-19 pandemic caused a global shortage of nasopharyngeal (NP) swabs, required for RT-PCR testing. Canadian manufacturers were contacted to share NP swab innovations. The primary objective was to determine whether novel…
Wang L, Xue C, Zhu B et al. · 2025 · Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis
Background/objective Data in terms of how dynamic changes of muscle mass and function affect mortality in end-stage kidney disease (ESKD) patients undergoing dialysis have led to inconclusive results. The main goal of this research was to…
Bevilacqua C, Boscarato V, Pieroni G et al. · 2024 · Preprint
Background: developmental dysplasia of the hip (DDH) is a condition characterized by abnormal hip development in infancy. Early diagnosis allows for effective treatment, while late presentation often necessitates complex surgical…
Rajamanickam SK, Prades Morera E, Agarwal A et al. · 2025 · Cureus
Background Fine needle aspiration cytology (FNAC) is widely used to evaluate head and neck masses, with both ultrasound (US)-guided and freehand techniques being employed. While US-guided FNAC is thought to enhance accuracy, freehand FNAC…
Fortier A, Zouaoui I, Dumais A et al. · 2024 · Psychiatric services (Washington, D.C.)
Objective Recreational cannabis legalization (RCL) is expanding rapidly. RCL's effects on mental health issues are of particular concern because cannabis use is more frequent among people receiving psychiatric care and is associated with…
Rodrigo C, Gnanathasan A · 2024 · Transactions of the Royal Society of Tropical Medicine and Hygiene
Globally, snakebites cause an estimated 80 000-140 000 deaths annually. While there are evidence-based recommendations for managing snakebite victims, recommendations on the prevention of snakebites are limited to expert opinions. We…
Paisant A, Faroche E, Fouche A et al. · 2024 · Abdominal radiology (New York)
Purpose Preoperative imaging is now recommended in patients with suspected acute appendicitis (AA) by the World Society of Emergency Surgery. Our aims were (i) to describe our local practice and (ii) to evaluate the efficiency of…
Hinney B, Wiedermann S, Vaneev X et al. · 2024 · Parasites & vectors
The population of South American camelids (SAC) has been steadily growing in Europe, where they are confronted with the regional endoparasite population of ruminants. As there are no anthelmintic drugs registered for use against nematode…
Shen C, Zhu Z, Zhang X et al. · 2024 · Preprint
Purpose: Numerous epidemiological studies have explored the association between the components of metabolic syndrome (MetS) and risk of prostate cancer (PCa). However, to date, the findings have yielded inconclusive results. This study…
Mildner FO, Sykora MM, Hackl H et al. · 2024 · Lung cancer (Amsterdam, Netherlands)
Background Cancer immune evasion is critical in non-small cell lung cancer (NSCLC) and has been targeted by immunotherapy. High soluble (s)PD-L1 is associated with reduced survival and treatment failure in advanced stages. Here we…
Johnson MS, Adams VM, Byrne J · 2024 · Preprint
Abstract Effective adaptation to climate risks requires identifying and realizing community beliefs about which locations require management attention. Environmental planners and asset managers, especially those in rural and regional…
Le NT, Nguyen TG, Huynh NYN et al. · 2025 · Scientific reports
Dietary calcium's role in human health and disease prevention is inconclusive. We examined the associations between dietary calcium intake and the risk of overall and specific causes of mortality. A prospective cohort study was performed…
Manni G, Pambianco M, Sicuro C et al. · 2025 · International journal of molecular sciences
Hepatic actinomycosis (HA) and IgG4-related inflammatory pseudotumors are rare and often overlooked causes of liver mass, which can easily be misdiagnosed as primary liver cancer or metastasis. Diagnosis is arduous due to unspecified…
Borz-Baba L, Aydin A, Parvin R · 2026 · Cureus
Metabolic-associated steatotic liver disease (MASLD) is a common medical condition that can progress to metabolic-associated steatohepatitis (MASH) and advanced fibrosis, leading to severe outcomes. Liver biopsy continues to be the…
Sakuma K, Yoshimura K · 2026 · Journal of environmental radioactivity
Tritium ( 3 H) is the principal radionuclide remaining in ALPS-treated water discharged from the Fukushima Dai-ichi Nuclear Power Plant (FDNPP), and its potential environmental impact has drawn considerable attention. To evaluate possible…
Jhaveri k, Mai N, Anjos CHd et al. · 2024 · Preprint
Abstract After disease progression on endocrine therapy (ET) plus a CDK4/6 inhibitor, there is no standardized sequence for subsequent treatment lines for estrogen receptor positive (ER+) metastatic breast cancer (MBC). CDK4/6i retrial as…
Needle R, Yu Y, Soualhine H et al. · 2025 · Biomedicines
Background/Objectives : The diagnosis of Mycobacterium tuberculosis complex (MTBC) and nontuberculous mycobacterial (NTM) infections is accomplished by three main diagnostics methods: smear microscopy, culture, and molecular testing.…
Kirby C, Baldwin JA, Elwell K et al. · 2026 · Healthcare (Basel, Switzerland)
Background The literature shows inconclusive results from utilizing motivational interviewing (MI) in indigenous populations to address early childhood caries (ECC). Great Beginnings for Healthy Native Smiles (GBHNS) (NIDCR U01DE028508), a…
Fan J, Zeng F, Zhong H et al. · 2024 · Preprint
Abstract Cigarette smoking is posited as a potential factor in disrupting the balance of the human gut microbiota. However, existing studies with limited sample size have yielded inconclusive results. Here, we assessed the association…
Zhang Y, Baharani J, Ajayi B et al. · 2025 · BMC nephrology
Background Fibrillary glomerulonephritis (FGN) is a rare immune complex-mediated glomerulonephritis characterised by the deposition of anomalous fibrillary structures within the glomeruli. The prognosis for patients with FGN is usually…
Gobishangar S, Abiharan P, Jenil A et al. · 2026 · Cureus
Background The appendix is a vermiform structure with a variable position, length, and thickness. Imaging plays a critical role in diagnosing an inflamed appendix, with non-contrast computed tomography (NCCT) being an effective modality…
Bronkhorst H, Kalaykova S, Huysmans MC et al. · 2024 · Journal of dentistry
Objective This study presents a scoping review to determine the association between tooth wear and bruxism. Data A protocol was developed a priori (Open Science Framework (DOI 10.17605/OSF.IO/CS7JX)). Established scoping review methods…