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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19902 results in Negative / Null Result Report · page 596 of 664

Negative / Null Result ReportOpen accessMedicine

The murine Irs1 knockout model, generated by the spontaneous Irs1<sup>S57X</sup> mutation in homozygosity, exhibits high embryonic lethality, limiting studies of adult hematopoiesis.

Fenerich BA, Fernandes JC, Silva CLA et al. · 2026 · Hematology, transfusion and cell therapy

Introduction Insulin Receptor Substrate 1 (IRS1) is differentially expressed in hematological neoplasms suggesting a role in hematopoiesis and neoplastic transformation. Irs1 knockout mice represent a tool to investigate IRS1 function.…

View details →DOI: 10.1016/j.htct.2026.106465
Negative / Null Result ReportMedicine

Common Divalent Cations Elicit Sublethal Effects of Negatively Charged Nanoplastics on <i>Shewanella oneidensis</i> by Compromising Membrane Protein Functionality.

Zhang S, Jia B, Huang W et al. · 2025 · ACS nano

The toxicity of negatively charged nanoplastics (NNP) to bacteria is generally subtler than that of positively charged counterparts, owing to limited NNP-cell interaction. This study hypothesized that common environmental cations (Na + ,…

View details →DOI: 10.1021/acsnano.5c04610
Negative / Null Result ReportMedicine

Combination of Exercise and Group Occupational Therapy for Behavioural and Psychological Symptoms of Dementia: A Pilot Randomised Controlled Trial.

Yoshiura K, Murata M, Hamasuna M et al. · 2025 · Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society

Background The behavioural and psychological symptoms of dementia (BPSD) increase the burden for the caregiver, often leading to difficulties in maintaining home care and triggering psychiatric hospitalisation. Effective management of BPSD…

View details →DOI: 10.1111/psyg.70085
Negative / Null Result ReportMedicine

Oxidation of Platina(II)corrole to Platina(IV)corrole.

Kato S, Miwa K, Takano H et al. · 2025 · Inorganic chemistry

Recently, the aromaticity and antiaromaticity of organometallacycles have received much attention to understand the cyclic electronic delocalization through d orbitals on the metal center. Here, we prepared a Pd(II) platina(II)corrole…

View details →DOI: 10.1021/acs.inorgchem.5c00942
Negative / Null Result ReportMedicine

Retrospective analysis of early functional and radiological outcomes between robotic, navigated and conventional total knee arthroplasty: A single Surgeon's series.

Leong JWK, Lee BH, Haniball J et al. · 2025 · Journal of clinical orthopaedics and trauma

Background Achieving a neutral mechanical axis alignment (MAA) in Total Knee Arthroplasty (TKA) is associated with increased implant longevity and patient satisfaction, and robot-assisted (robotic) TKA is touted to improve implant…

View details →DOI: 10.1016/j.jcot.2025.103145
Negative / Null Result Report

A Comprehensive Null Search for Prompt Radio Bursts Associated with 218 Gravitational Wave Events: The Strongest Constraints on Pre-Merger Fast Radio Burst Emission

Prajapati S · 2026 · Preprint

Abstract Binary neutron star mergers are known to produce gravitational waves and panchromatic electromagnetic afterglow emission hours to days after coalescence. However, a fundamental question remains unanswered: do these mergers…

View details →DOI: 10.21203/rs.3.rs-9595477/v1
Negative / Null Result ReportMedicine

Experimental and clinical evidence on radiofrequency electromagnetic field effects on the blood-brain barrier: a scoping review.

Simsek ET, Sumser K, Mansourinezhad P et al. · 2026 · Physics in medicine and biology

Objective. This scoping review evaluates evidence on whether radiofrequency electromagnetic field (RF-EMF) exposure influences blood-brain barrier (BBB) permeability. Given inconsistent findings across decades of research and expanding…

View details →DOI: 10.1088/1361-6560/ae6e17
Negative / Null Result ReportMedicine

Can ovarian cancer screening work? A secondary analysis of the UK collaborative trial of ovarian cancer screening.

Lange JM, Ahmad I, Dengos IJ et al. · 2026 · British journal of cancer

Background The UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS; 2001-2020) showed no reduction in disease mortality in its primary intervention arm using multimodal screening (MMS) with longitudinal Cancer Antigen 125 (CA125)…

View details →DOI: 10.1038/s41416-026-03490-2
Negative / Null Result ReportMedicine

Spectroscopic analysis of the N<sub>2</sub> B<sup>3</sup>Π<sub>g</sub>-A<sup>3</sup>Σ+u in radiation-induced air ionization.

Murzyn CM, Jans ER, Marshall GJ · 2026 · Physical chemistry chemical physics : PCCP

This article presents experimental results from probing atmospheric air irradiated by a Polonium-210 alpha particle source using both optical emission spectroscopy and continuous wave cavity ring down absorption spectroscopy to study the…

View details →DOI: 10.1039/d5cp03971a
Negative / Null Result Report

Assessing Brain-Behaviour Coupling in Non-invasive Brain Stimulation Using Reliable Change Indices: Evidence from pre-Supplementary Motor Area – right Inferior Frontal Gyrus transcranial Alternating Current Stimulation

Fujiyama H, Wansbrough K, Lebihan B et al. · 2026 · Preprint

Non-invasive brain stimulation (NiBS) studies frequently report exploratory correlations between individual-level changes in neurophysiological and behavioural measures. However, these analyses are typically underpowered and rely on…

View details →DOI: 10.64898/2026.03.24.714072
Negative / Null Result Report

Collaborative registered replication of Griskevicius et al. (2010): Can pro-environmental behavior be promoted by priming status motivation?

Lazarevic LB, Wagge JR, Balci BB et al. · 2025 · Preprint

The present study presents the results of a collaborative registered replication of Griskevicius et al. (2010, Experiment 1). As part of the Collaborative Replication and Education Project, 24 student groups from six countries (N = 3,774)…

View details →DOI: 10.31234/osf.io/sfmz8_v5
Negative / Null Result Report

Collaborative registered replication of Griskevicius et al. (2010): Can pro-environmental behavior be promoted by priming status motivation?

Lazarevic LB, Wagge JR, Balci BB et al. · 2025 · Preprint

The present study presents the results of a collaborative registered replication of Griskevicius et al. (2010, Experiment 1). As part of the Collaborative Replication and Education Project, 24 student groups from six countries (N = 3,774)…

View details →DOI: 10.31234/osf.io/sfmz8_v3
Negative / Null Result Report

Collaborative registered replication of Griskevicius et al. (2010): Can pro-environmental behavior be promoted by priming status motivation?

Lazarevic LB, Wagge JR, Buchanan EM et al. · 2025 · Preprint

The present study presents the results of a collaborative registered replication of Griskevicius et al. (2010, Experiment 1). As part of the Collaborative Replication and Education Project, 24 student groups from six countries (N = 3,774)…

View details →DOI: 10.31234/osf.io/sfmz8_v2
Negative / Null Result ReportOpen accessMedicine

A case-control neuroimaging investigation of chronic Zika virus-infected adults.

Jun S, Bido-Medina R, Oviedo J et al. · 2026 · Frontiers in human neuroscience

Background Systemic viral infections with neurotropic potential pose significant global health challenges. The Zika virus (ZIKV) is known for its pronounced neurotropism, with recent infectious clusters raising renewed public health…

View details →DOI: 10.3389/fnhum.2026.1710905
Negative / Null Result ReportMedicine

Does affective processing require awareness? On the use of the Perceptual Awareness Scale in response priming research.

Wentura D, Rohr M, Kiefer M · 2025 · Journal of experimental psychology. General

Masked priming paradigms are frequently used to shine light on the processes of nonconscious cognition. Introducing a new method to this field, Lähteenmäki et al. (2015) claimed that affective priming requires awareness. Specifically, they…

View details →DOI: 10.1037/xge0001648
Negative / Null Result ReportOpen accessMedicine

Biological Therapy Leads to a Reduction in Systemic Inflammation but Leaves Serum Uric Acid Unmodified in Moderate-to-Severe Plaque Psoriasis: A Prospective Longitudinal Cohort Study.

Suiu LI, Vreju FA, Turcu-Stiolica A et al. · 2026 · Journal of clinical medicine

Background/Objective: Psoriasis is a systemic inflammatory disease often associated with metabolic comorbidities, including hyperuricemia. While biological therapies effectively target inflammatory pathways, their specific impact on serum…

View details →DOI: 10.3390/jcm15103817
Negative / Null Result ReportOpen accessMedicine

Are Atrial Fibrillation Risk Loci Universally Applicable? Insights from Whole-Genome Sequencing in a Polish Population.

Wasiak M, Sypniewski M, Dobosz P et al. · 2026 · Medical sciences (Basel, Switzerland)

Background: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia worldwide and has a substantial genetic component. Genome-wide association studies (GWASs) have identified more than 100 susceptibility loci; however,…

View details →DOI: 10.3390/medsci14010155
Negative / Null Result Report

Fallacy of the Absolute Speed of Light

Hajra S · 2024 · Preprint

In this article, we have rationally analyzed the null result of the Michelson-Morley experiment, along with the unique observation that all electrodynamic phenomena, whether terrestrial, solar, or astral, are independent of the motion of…

View details →DOI: 10.32388/rfu29h
Negative / Null Result ReportOpen accessMedicine

No substantial causal effect of genetic liability to viral infections on subacute thyroiditis: A large-scale Mendelian randomization analysis.

Zeng S, Cheng W · 2026 · Medicine

The association between viral infections and subacute thyroiditis (SAT) has been recognized, yet whether a genetic causal relationship exists between them remains unclear. To address this, we conducted a two-sample Mendelian randomization…

View details →DOI: 10.1097/md.0000000000048696
Negative / Null Result ReportOpen accessMedicine

Investigating if changing the wording of a study invitation letter increased recruitment in a project promoting tobacco cessation in a town with high smoking rates.

Schell C, Godinho A, Cunningham JA · 2026 · Substance abuse treatment, prevention, and policy

BACKGROUND: Invitation letters can be the first point of contact between research staff and potential participants and a number of modifiable variables have been studied to improve their effectiveness. The aim of this analysis was to…

View details →DOI: 10.1186/s13011-026-00704-x