A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20261 results in Negative / Null Result Report · page 594 of 676
Cheng MH, Goh KK, Lu ML et al. · 2026 · Asian journal of psychiatry
Background Schizophrenia is characterized by social cognition deficits, yet the neurobiological mechanisms of moral reasoning remain poorly understood. In particular, self-other differentiation and contextual sensitivity, reflected in…
Yazdy GM, Workowski KA, Ghanem KG et al. · 2026 · American journal of obstetrics and gynecology
Bacterial vaginosis, the most common cause of vaginal complaints among reproductive-aged women, is highly recurrent and often challenging to treat. Whether bacterial vaginosis is sexually transmissible has long been questioned by patients,…
Xue J, Ye J, Han P et al. · 2025 · The journal of gene medicine
Background Synovial mesenchymal stem cell-derived exosomes (SMSC-Exos) can regulate macrophage polarization and alleviate knee osteoarthritis (KOA). However, the underlying mechanisms remain unclear. This study explored the role of…
Diener HC · 2025 · Brain : a journal of neurology
A number of neuropeptides, including pituitary adenylate cyclase-activating polypeptide (PACAP), play an important role in the pathophysiology of migraine. Infusions of PACAP in patients with migraine can provoke migraine attacks. A…
Park SK, Chung Y, Oh CM et al. · 2026 · Global heart
Background There have been inconsistent findings regarding the effects of high sodium intake on coronary artery disease (CAD). This study therefore aimed to investigate the relationship between sodium intake and the coronary artery calcium…
Ichimura Y, Niiyama S, Hirata A · 2026 · Case reports in dermatology
Introduction Basal cell carcinoma (BCC) is the most common skin cancer, with a rising incidence globally. We encountered a patient with the nonpigmented adenoid subtype of BCC. The nonpigmented subtype of BCC accounts for only a small…
Spyropoulou N, Diamantopoulou S, Patrinos S et al. · 2025 · Preprint
OBJECTIVE: The purpose of this study was to examine and compare the clinical be-havior of indirect onlays/overlays made of lithium disilicate and composite resin and to investigate risk factors associated with restorations failures.…
Hayat F, Chiu S, Stuart A et al. · 2025 · Journal of gastrointestinal oncology
Background Tobacco smoking accounts for 22% of the pancreatic cancer burden in Australia. Smoking may increase therapy-related adverse effects and was associated with shorter survival in the previous analysis of all stages of pancreatic…
Dubin A · 2025 · Annals of intensive care
Background Fluids are a key component of shock resuscitation. Nevertheless, their microvascular effects are complex. In fluid responsive patients, fluids may increase tissue perfusion because of the increase in cardiac output. Since shock…
Wregg JF, Hofer A, Gruber-Wackernagel A et al. · 2026 · Experimental dermatology
Water-filtered infrared-A (wIRA) has been proposed to enhance tissue perfusion and modulate fibrosis, but clinical evidence in morphea (localised scleroderma) is limited. We conducted a prospective, intra-individual pilot split-study in 10…
Cradeur A, Abshire M, Schichtel M et al. · 2025 · Preprint
Objectives: This prospective study aimed to assess noise levels in otolaryngology operating rooms (OR), explore noise variation across subspecialties, and examine the correlation between noise, verbal communication, and surgery complexity.…
Acikgoz NB, Toplu-Hocaoglu A, Yildirim BA et al. · 2026 · Epilepsy research
Purpose The ketogenic diet has long been used in epilepsy treatment, particularly in drug-resistant cases, but its efficacy in idiopathic generalized epilepsy, including absence epilepsy, remains less studied. This study aimed to evaluate…
SAW YH, CHAI HI, YAHYA NA et al. · 2026 · Preprint
Abstract Background Energy drinks are widely consumed acidic beverages that may compromise the longevity of resin composite restorations. However, limited evidence exists regarding the use of swept-source optical coherence tomography…
Pettenuzzo T, Sella N, Zarantonello F et al. · 2026 · Preprint
Abstract Background. High-flow nasal cannula (HFNC) is a promising respiratory support modality that improves oxygenation, alveolar recruitment, and comfort while reducing dead space compared to conventional oxygen therapy. Recently, a…
Dağlı E, Çapar ÖF, Sert S · 2026 · Scientific reports
This study examines the effects of freeze-thaw (F-T) cycles on the unconfined compressive strength (UCS) of untreated and stabilized soils using fly ash, lime, and lime-fly ash mixtures (30% FA, 5% L, and 30% FA + 5% L). Specimens were…
Ryou S, Jung Y, Kim DS et al. · 2026 · The Korean journal of internal medicine
Background/aims Few studies have compared modified endoscopic mucosal resection (EMR) techniques for small rectal neuroendocrine tumors (NETs). This study evaluated the clinical outcomes of ligation-assisted EMR (EMR-L) and precutting EMR…
Liu L, Shen Y, Yang S et al. · 2026 · Journal of biotechnology
As an enzyme cofactor, antioxidant, and stabilizer of cellular structures, Mn²⁺is essential for microbial growth, metabolism, and environmental adaptation. In this work, the impact of varying Mn²⁺ levels on caproic acid formation and…
Pina L, Eufemio CM, Dove J et al. · 2025 · Surgical endoscopy
Introduction Laparoscopic Sleeve Gastrectomy (LSG) and Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) constitute the most commonly performed bariatric metabolic surgery (BMS) procedures in the USA. The number of robotic-assisted BMS cases…
Gonzalez PA, Zamora-Abrahan G, Roa F et al. · 2024 · Preprint
Background: A 32-year-old Filipino female with rheumatoid arthritis and lichen planus of low activity was admitted following a five-week period of painful oral mucosal and cutaneous bullae and erosions over her prior lichen planus lesions…
Sharath S, Sardana K, Khurana A et al. · 2025 · Archives of dermatological research
Background Although there are several reports on use of tofacitinib in lichen planus (LP), its usage in hypertrophic LP is sparse with no data on tissue cytokine expression. Methods We retrospectively analyzed the records of recalcitrant…
Culliton K, Au K, Undurraga S et al. · 2026 · Hand (New York, N.Y.)
Background TDetection of distal radioulnar joint (DRUJ) instability has proven inconsistent despite numerous examination maneuvers. Computed tomography (CT) has been suggested as a modality for evaluating DRUJ instability; however, without…
Karaki Z, Chemaly C, Kotaich J et al. · 2025 · Annals of medicine and surgery (2012)
Introduction and importance Aplastic anemia (AA) is a rare but potentially fatal hematologic disorder in children, marked by bone marrow failure and pancytopenia. Early diagnosis and access to curative treatment such as hematopoietic stem…
Muir R, O’Shea B, Iniesta R et al. · 2024 · Preprint
Objectives Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder, affecting both upper and lower motor neurons. High-density surface electromyography is a non-invasive measure of muscle fasciculations, a phenomenon prevalent…
Mansouri M, Rockne KJ · 2026 · ACS environmental Au
Gas ebullition plays a critical role in facilitating contaminant transport from the sediment to the water column. Predicting gas ebullition accurately is necessary for managing sediments and assessing sediment/water flux, and many…
Ahmed A, Ahmed A, Zahra Z et al. · 2025 · Physiology & behavior
Introduction Despite emerging evidence on oxytocin's role in eating disorders,there is a need for a comprehensive review to integrate findings across neurobiological, genetic, hormonal, and therapeutic dimensions. This scoping review…
Ingram I, Hughes MA · 2024 · Journal of laparoendoscopic & advanced surgical techniques. Part A
Background: Surgeons are exposed to unavoidable distractions while operating. Distractions can cause stress, and stress can impair cognition and motor skills to the detriment of surgeon performance. This study assessed the impact of…
Zhang Y, Wen Z, Xia C et al. · 2024 · Heliyon
Dyslipidemia has been implicated in autoimmunity; however, its association with myasthenia gravis (MG) prognosis is unclear. We aimed to investigate the correlation between baseline lipid profiles and risk of MG worsening. This 7-year…
Williams KJ · 2025 · Current opinion in lipidology
Purpose of review For many years, inflammation has been a major concept in basic research on atherosclerosis and in the development of potential diagnostic tools and treatments. The purpose of this review is to assess the performance of…
Demir S, KÖYLÜ MT · 2023 · Preprint
INTRODUCTION To examine the ability of changes in optical coherence tomography angiography (OCTA) values to predict progression in the visual field (GA) and retinal nerve fiber layer (RNFL) in patients with glaucoma progression. METHODS…
Basu S, Gupta S, De R et al. · 2024 · Preprint
ABSTRACT Background and Objectives Microcytic hypochromic anemia is the most common feature of alpha-thalassemia and depends on the number of alpha genes deleted. Therefore, in this study, we aim to determine the most common deletion…