Negative / Null Result ReportOpen accessMedicine
Wang X, Dowty ME, Tripathy S et al. · 2024 · European journal of drug metabolism and pharmacokinetics
Background and objective Abrocitinib is an oral small-molecule Janus kinase (JAK)-1 inhibitor approved for the treatment of moderate-to-severe atopic dermatitis. In vitro studies indicated that abrocitinib is a weak time-dependent…
View details →DOI: 10.1007/s13318-024-00893-5 Negative / Null Result ReportOpen accessMedicine
Austin DK, Amador LMD, Li LM et al. · 2025 · Neuropsychopharmacology reports
Aim Selective serotonin reuptake inhibitors are thought to exert a clinical effect through various mechanisms, including through alteration in synaptic plasticity. Repetitive transcranial magnetic stimulation can induce temporary changes…
View details →DOI: 10.1002/npr2.12493 Negative / Null Result ReportMedicine
Leslie E, Gonzalez Bosc LV, Specht J et al. · 2024 · Medicine and science in sports and exercise
Purpose Chronic, high-altitude hypoxic exposure increases the risk of high-altitude pulmonary hypertension (PH). Emerging evidence shows maternal exercise may improve offspring resistance to disease throughout life. The purpose of this…
View details →DOI: 10.1249/mss.0000000000003479 Negative / Null Result ReportOpen accessMedicine
Contrada M, Pignolo L, Vatrano M et al. · 2024 · Brain sciences
Purpose Cognitive dysfunctions are still very common in the chronic phase of stroke when patients are discharged from neurorehabilitation centers. Even individuals who appear to have made a full clinical recovery may exhibit new…
View details →DOI: 10.3390/brainsci15010011 Negative / Null Result ReportOpen accessMedicine
Nieto-Felipe J, Macias-Diaz A, Alvarado S et al. · 2025 · Scientific reports
Store-operated Ca²⁺ entry (SOCE) is a major pathway for Ca²⁺ entry that regulates several cellular functions. SOCE remodeling mediated by changes in the expression and/or function of the Orai channels results in the reorganization of…
View details →DOI: 10.1038/s41598-025-33071-x Negative / Null Result ReportOpen accessMedicine
Bulgarella M, Reason A, Baty JW et al. · 2025 · Insects
Double-stranded RNA (dsRNA) biopesticides offer the potential for highly targeted pest control with minimal off-target impacts. Varroa mites ( Varroa destructor ) are an important pest of honey bees ( Apis mellifera ) that are primarily…
View details →DOI: 10.3390/insects16030317 Negative / Null Result ReportMedicine
Gunn D, Yeldho C, Hoad C et al. · 2024 · Neurogastroenterology and motility
Background Lactulose is a laxative which accelerates transit and softens stool. Our aim was to investigate its mechanism of action and use this model of diarrhea to investigate the anti-diarrheal actions of ondansetron. Methods A…
View details →DOI: 10.1111/nmo.14754 Negative / Null Result ReportOpen accessMedicine
Mattar D, Cheewasopit W, Samir M et al. · 2023 · Reproduction & fertility
Kisspeptin, a hypothalamic neuropeptide encoded by the KISS1 gene, has a pivotal role in promoting GnRH secretion in mammals. Kisspeptin and its receptor (KISS1R) are also expressed in certain peripheral tissues including gonads,…
View details →DOI: 10.1530/raf-22-0088 Negative / Null Result ReportOpen accessMedicine
Ivanov YV, Ivanova AI, Kartashov AV et al. · 2026 · Biology
Manganese (Mn) is a crucial micronutrient for plants. The impaired function of the oxygen-evolving complex in Photosystem II (PSII) due to Mn deficiency is believed to result in the overproduction of reactive oxygen species and the…
View details →DOI: 10.3390/biology15010101 Negative / Null Result ReportOpen accessMedicine
Fondevila G, Fatmi H, Fernando P et al. · 2025 · Insects
The effects of Lys and Ile supplementation in a barley-based substrate on growth performance and nutrient deposition in Tenebrio molitor larvae were evaluated. Six trays per treatment containing sixty larvae were assigned to five…
View details →DOI: 10.3390/insects16090989 Negative / Null Result ReportMedicine
Brongers K, Hoekstra T, Wilming L et al. · 2024 · Disability and rehabilitation
Purpose As the effect evaluation of our randomized controlled trial the "Comprehensive Approach of Reintegration for clients with Multiple problems" (CARm) showed no superior effect on re-integration into paid employment of the clients…
View details →DOI: 10.1080/09638288.2023.2264765 Negative / Null Result ReportOpen accessMedicine
Hoevenaar-Blom MP, Shourick J, van Dalen JW et al. · 2025 · Alzheimer's & dementia : the journal of the Alzheimer's Association
Introduction We explored which dementia risk factors in two multidomain prevention trials mediate beneficial, neutral, or counteracting effects on dementia incidence. Methods We pooled data from the multidomain MAPT (Multidomain Alzheimer…
View details →DOI: 10.1002/alz.14557 Negative / Null Result ReportOpen accessMedicine
Pizarro J, Walker MC, Sheybani L · 2025 · Epilepsia
Generalized epileptiform discharges (GEDs) in idiopathic generalized epilepsy (IGE) are classically considered symmetrical in amplitude, although this has not been formally tested. This is a major knowledge gap, since asymmetry is…
View details →DOI: 10.1111/epi.18509 Negative / Null Result ReportOpen access
Ford BE, Chachra SS, Alshawi A et al. · 2024 · Preprint
ABSTRACT Glucokinase activators (GKAs) have been developed as blood glucose lowering drugs for type 2 diabetes. Despite good short-term efficacy, several GKAs showed a decline in efficacy chronically during clinical trials. The underlying…
View details →DOI: 10.1101/2024.07.24.604910 Negative / Null Result ReportOpen accessMedicine
Mogensen DG, Aanaes K, Andersen IB et al. · 2025 · The Laryngoscope
Objectives Olfactory training is a recommended treatment in patients with olfactory dysfunction after COVID-19. However, the effectiveness of olfactory training in COVID-19-induced olfactory dysfunction has been studied; only a few studies…
View details →DOI: 10.1002/lary.32275 Negative / Null Result ReportOpen accessMedicine
Sehgal I, Eells K, Hudson I · 2024 · Pharmacy (Basel, Switzerland)
Small interfering RNA (siRNA)-based medications offer the ability to target previously undruggable targets and have now received FDA approval in five instances for orphan or uncommon diseases. The current siRNA "-sirans" are directed…
View details →DOI: 10.3390/pharmacy12020058 Negative / Null Result ReportMedicine
Boss M, Pels F, Kleinert J · 2023 · PsyCh journal
The purpose of this study was to analyze whether the social compensation of performance drops in a team setting depends on the relationship quality. Two experiments were conducted. Experiment 1: In a team-building condition, the…
View details →DOI: 10.1002/pchj.662 Negative / Null Result Report
Rivest D, Martin-Guay M · 2023 · Preprint
Well-designed temperate tree-based intercropping (TBI) systems can enhance soil nutrient cycling compared to conventional agricultural systems. To improve the TBI designs and their subsequent wide-scale adoption, greater understanding is…
View details →DOI: 10.21203/rs.3.rs-3398528/v1 Negative / Null Result ReportOpen accessMedicine
Başeğmez M, Eryavuz A, Demirel HH · 2025 · Journal of biochemical and molecular toxicology
This study aims to determine the effect of orally administered vitamin C (Vit C) supplementation on physiological and histopathological changes in aged rats of different genders. A total of 28 Sprague-Dawley aged male and female rats were…
View details →DOI: 10.1002/jbt.70324 Negative / Null Result Report
Ehinger BV, Bonasch H · 2023 · Preprint
Abstract 1 Some participants consistently show large, and others small activations in Electroencephalography (EEG) and other neuroimaging studies. Similarly, decoding accuracies in Brain-Computer-Interface (BCI) vary between subjects, in…
View details →DOI: 10.1101/2023.05.21.541632 Negative / Null Result ReportOpen accessMedicine
Scott MB, Kammermeier PJ · 2024 · Pharmaceuticals (Basel, Switzerland)
The gabapentenoids such as gabapentin (GP) and pregabalin are approved for the treatment of chronic pain, but their utility is limited by persistent side effects. These adverse effects result from GPs affecting many types of neurons and…
View details →DOI: 10.3390/ph17091237 Negative / Null Result ReportOpen accessMedicine
Choneva M, Delchev S, Hrischev P et al. · 2024 · International journal of molecular sciences
Diabetic cardiomyopathy is a major etiological factor in heart failure in diabetic patients, characterized by mitochondrial oxidative metabolism dysfunction, myocardial fibrosis, and marked glycogen elevation. The aim of the present study…
View details →DOI: 10.3390/ijms251810027 Negative / Null Result ReportMedicine
Ebrahimi F, Kangari H, Akbarzadeh-Bagheban A et al. · 2025 · International journal of ophthalmology
Aim To evaluate the effects of polarized and non-polarized sunglasses on visual functions, including distance and near visual acuity, phoria, stereopsis and contrast sensitivity across five spatial frequencies (1.5, 3, 6, 12, 18…
View details →DOI: 10.18240/ijo.2025.12.14 Negative / Null Result ReportOpen accessMedicine
Zeng X, Chen Y, Lin S et al. · 2026 · Frontiers in surgery
Purpose This study aimed to investigate the influence of previous percutaneous renal procedures on the outcome of ultrasound (US)-guided percutaneous nephrolithotomy (PCNL) in patients with upper urinary tract stones. Patients and methods…
View details →DOI: 10.3389/fsurg.2026.1721410 Negative / Null Result Report
Lartey NL, Nyarko ENY, Asare-Anane H et al. · 2023 · Preprint
ABSTRACT Background and aim The lack of standardization and scientific validation of the use of most plant extracts leads to toxicity problems. The stem bark extract of Annickia polycarpa has been shown to possess antioxidant,…
View details →DOI: 10.1101/2023.09.14.557718 Negative / Null Result ReportOpen accessMedicine
Kazmi S, Sanford E, Rammaha ZA et al. · 2025 · International journal of molecular sciences
Oral squamous cell carcinoma (OSCC) is marked by profound differences in survival between the localized and disseminated disease, estimated to result in a 70% and less than a 40% five-year survival rate with surgical and/or radiation…
View details →DOI: 10.3390/ijms262110651 Negative / Null Result ReportMedicine
Dicker D, Tamir O, Lieberman-Segal G et al. · 2023 · The Israel Medical Association journal : IMAJ
Background In 2019, 1 mg subcutaneous semaglutide was registered for the treatment of diabetes in Israel. Recognition of its effect on weight has led to its use as a treatment for obesity. Objectives To explore physicians' pre-therapy…
Negative / Null Result ReportOpen accessMedicine
Rolig AS, Ziglari T, McGee GH et al. · 2026 · Scientific reports
The tumor microenvironment (TME), which heavily influences immune checkpoint blockade (ICB) efficacy, is shaped by host-microbe interactions. Endogenous intratumoral bacteria have been implicated in efficacy of ICB, such as anti-PD-1…
View details →DOI: 10.1038/s41598-026-39758-z Negative / Null Result ReportOpen accessMedicine
Hauber MM, Nordahl O, Todisco V et al. · 2026 · PloS one
Many coregonine species have declined drastically across the Northern Hemisphere, including populations of Coregonus maraena (whitefish) in the Baltic Sea, and the mechanisms leading to these declines are not well investigated. An abrupt…
View details →DOI: 10.1371/journal.pone.0344576 Negative / Null Result ReportOpen accessMedicine
Marquis-Gravel G, Tong G, Dodd M et al. · 2025 · Journal of the Society for Cardiovascular Angiography & Interventions
Background Coronary artery bypass grafting (CABG) improves survival compared with optimal medical therapy (OMT) alone in patients with ischemic left ventricular systolic dysfunction (iLVSD), but percutaneous coronary intervention (PCI) did…
View details →DOI: 10.1016/j.jscai.2025.103820 