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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19902 results in Negative / Null Result Report · page 587 of 664

Negative / Null Result ReportMedicine

The activation of thematic semantic relation representations is intrusive but modulated by thematic association strength: evidence from the Think/No-Think paradigm.

Shi K, Li J · 2026 · Psychological research

This study adopts the Think/No-Think (TNT) paradigm for the first time to examine whether activation of thematic semantic relation representations is intrusive. In Experiment 1, during the learning phase, participants memorized cue–target…

View details →DOI: 10.1007/s00426-025-02226-w
Negative / Null Result ReportMedicine

Effects of inpatient and outpatient cardiac rehabilitation on the 5-year prognosis in patients with acute myocardial infarction.

Suematsu Y, Minei A, Sumita Y et al. · 2026 · European journal of preventive cardiology

Aims Cardiac rehabilitation (CR) has been shown to improve the prognosis of patients with acute myocardial infarction (AMI). In Japan, the duration of hospitalization has shortened, resulting in a lower participation rate in CR among…

View details →DOI: 10.1093/eurjpc/zwaf705
Negative / Null Result ReportMedicine

When Randomization Is Not Enough: Divergent Beta-Blocker Trials and the Illusion of Universal Causality.

Omerovic E, Råmunddal T, Jha S et al. · 2026 · European heart journal. Cardiovascular pharmacotherapy

Two contemporary randomized trials of β-blocker therapy after myocardial infarction (MI) reached apparently conflicting conclusions. REBOOT, conducted in Spain and Italy, found no reduction in death or major cardiovascular events among…

View details →DOI: 10.1093/ehjcvp/pvag037
Negative / Null Result ReportMedicine

Rescue of conjunctival lymphatics after mitomycin C induced inhibition in rat eyes: An experimental study.

Mittal H, Thattaruthody F, Akella M et al. · 2026 · Indian journal of ophthalmology

Abstract This experiment was designed to study the effect of mitomycin C (MMC) on conjunctival lymphatics and the lymphangiogenesis potential of synthetic retinoic acid (ec23) in rat eyes. This prospective animal experimental study…

View details →DOI: 10.4103/ijo.ijo_1929_25
Negative / Null Result ReportMedicine

Accommodative changes after implantation of a foldable iris-fixated phakic intraocular lens for the correction of myopic astigmatism.

Royo M, Jiménez Á, Molina-Martin A et al. · 2026 · European journal of ophthalmology

PurposeTo analyze the amplitude of accommodation and its changes at a 6-month follow-up in healthy subjects implanted with an anterior chamber pIOL, assessing whether accommodative function is affected. Additionally, changes in visual…

View details →DOI: 10.1177/11206721261462300
Negative / Null Result ReportOpen accessMedicine

The effect of omalizumab treatment on inflammatory parameters in urticarial diseases: a retrospective study.

Temizel KA, Dursun P, Ikizoglu G · 2026 · Postepy dermatologii i alergologii

Introduction Chronic spontaneous urticaria (CSU) and urticarial vasculitis (UV) are chronic inflammatory skin disorders. Monoclonal anti-IgE therapy is widely approved for CSU and is increasingly investigated for its broader…

View details →DOI: 10.5114/ada.2026.161026
Negative / Null Result Report

Stigmasterol from Pluchea indica Leaves Reduces Spermatogenesis and Alters Sperm Morphology in Male Rat: In Vivo and In Silico Study

Wahyono P, Ariesaka KM, Susetyarini E et al. · 2026 · Preprint

Background Limited male contraception choices have prompted the hunt for natural antifertility drugs. This experimental study investigates the antifertility effects of stigmasterol extracted from Pluchea indica leaves in male rats ( Rattus…

View details →DOI: 10.12688/f1000research.180671.2
Negative / Null Result ReportOpen accessMedicine

Return to play is reliable, but market value declines after proximal hamstring repair in elite soccer players.

Ciccarelli G, Monaco E, Nasso V et al. · 2026 · Journal of experimental orthopaedics

Purpose The purpose of this study was to quantify return-to-play (RTP) time, post-operative performance and market-value trends after proximal hamstring repair in top-tier European league soccer players. It was hypothesized that surgery…

View details →DOI: 10.1002/jeo2.70775
Negative / Null Result ReportMedicine

[Metformin for the prevention of hyperemesis gravidarum: From a GDF15-based rationale to early clinical evidence].

Deruelle P, Arcieri F, Martineau R · 2026 · Gynecologie, obstetrique, fertilite & senologie

Background Hyperemesis gravidarum (HG) remains one of the most disabling complications of the first trimester, with a high risk of recurrence after a prior episode that weighs heavily on family planning and on patients' mental health.…

View details →DOI: 10.1016/j.gofs.2026.06.002
Negative / Null Result ReportMedicine

A Randomized Controlled Trial of an iCBT Program to Reduce Infertility-Related Stress: A Novel Digital Approach.

Haflidadottir S, Helgadottir FD, Sighvatsson MB · 2026 · Scandinavian journal of psychology

The global burden of infertility and its associated psychological distress is substantial, yet many individuals face barriers to accessing psychological support. A scalable, low-cost online intervention presents a promising solution. A…

View details →DOI: 10.1111/sjop.70126
Negative / Null Result Report

Efficacy of painting wind turbine blades as a mitigation measure to reduce bird collisions in a Mediterranean wind farm

May R, Hernández Gómez MÁ, Aguirre Martínez JL et al. · 2026 · Preprint

One of the most notable impacts of wind energy is bird mortality due to collisions with wind turbines, making it necessary to adopt measures to prevent or mitigate this impact. In recent years, studies have been carried out to test the…

View details →DOI: 10.22541/authorea.15003733/v1
Negative / Null Result ReportOpen accessMedicine

Efficacy of 8% arginine associated with low-level laser therapy in the treatment of dentin hypersensitivity: randomized double-blind clinical trial.

Leal Barbosa V, Westenhofen D, Scherdien Silva P et al. · 2026 · Lasers in medical science

Purpose To evaluate the efficacy of 8% arginine-based desensitizing toothpaste and photobiomodulation (PBM), used alone or in combination, in the treatment of dentin hypersensitivity (DH). Materials and methods This randomized,…

View details →DOI: 10.1007/s10103-026-04927-z
Negative / Null Result ReportMedicine

Diagnostic assessment of artificial intelligence reconstruction on accelerated prostate MRI: a retrospective, paired, multi-reader multi-case study.

van Lohuizen Q, Fransen SJ, Yiasemis G et al. · 2026 · European radiology

Objectives To determine whether AI-reconstructed prostate MRI at reduced acquisition times maintains prostate cancer (PCa) detection performance comparable to conventional scans. Materials and methods This multicenter, retrospective,…

View details →DOI: 10.1007/s00330-026-12479-7
Negative / Null Result ReportMedicine

Comparison of incision and drainage procedure with drainage and ligation of the intersphincteric fistula tract in the treatment of deep perianal abscess.

Akay T, Arslan RS · 2026 · Scientific reports

Patients with deep perianal abscess (DPA) and transsphincteric fistula typically require incision and drainage as emergency treatment. However, recurrent abscesses and fistulas are common. This study aimed to evaluate the impact of…

View details →DOI: 10.1038/s41598-026-59144-z
Negative / Null Result ReportMedicine

Prevention of adhesive small bowel obstruction by anti-adhesion barriers: do they really work?

Verhulst E, Ten Broek R, Bislenghi G et al. · 2026 · Techniques in coloproctology

Postoperative intraabdominal adhesions remain one of the most common and clinically significant complications following abdominal and pelvic surgery. Adhesions contribute to adhesive small bowel obstruction (aSBO), chronic abdominal pain,…

View details →DOI: 10.1007/s10151-026-03350-4
Negative / Null Result ReportMedicine

Age-related susceptibility to paraquat-induced neurotoxicity in male wistar rats: effects on neurobehaviour, substantia nigra cytoarchitecture, and alpha-synuclein levels.

Ichie K, Asomugha A, Okafor I · 2026 · BMC neuroscience

Background Parkinson's disease (PD) is a progressive neurodegenerative disorder strongly associated with dopaminergic neuronal degeneration and alpha-synuclein pathology. Paraquat (PQ) has been implicated in Parkinsonian neurodegeneration;…

View details →DOI: 10.1186/s12868-026-01019-0
Negative / Null Result ReportMedicine

Feasibility, Acceptability, and Preliminary Efficacy of a Medication Intervention for Older Adults.

Somerville E, Bollinger RM, Haxton M et al. · 2026 · OTJR : occupation, participation and health

Interventions to address polypharmacy and improve adherence are insufficient for community-dwelling older adults. To examine the feasibility, acceptability, and preliminary efficacy of a tailored medication management intervention (TIMM)…

View details →DOI: 10.1177/15394492261442163
Negative / Null Result ReportMedicine

Short-term outcomes of selective laser trabeculoplasty in pseudophakic primary angle-closure glaucoma after iridotomy: a retrospective pilot comparison with primary open-angle glaucoma.

Hsieh YC, Lu WY, Chen YL et al. · 2026 · BMC ophthalmology

Background Selective laser trabeculoplasty (SLT) is a widely accepted treatment for primary open-angle glaucoma (POAG), but its role in primary angle-closure glaucoma (PACG) remains less defined. This study aimed to evaluate the short-term…

View details →DOI: 10.1186/s12886-026-05058-3
Negative / Null Result Report

Efficacy of Ergothioneine Supplementation on Postpartum Fatigue, Sleep Quality, and Quality of Life: A Randomized, Double-Blind, Placebo-Controlled Trial

Liu W, Guo C, Ding W et al. · 2026 · Preprint

Background Postpartum asthenia, characterized by severe fatigue, sleep disturbances, and physiological stress, lacks effective targeted interventions. Ergothioneine (EGT) is a unique, naturally occurring antioxidant that actively…

View details →DOI: 10.64898/2026.06.08.26355132
Negative / Null Result ReportMedicine

Impact of ERAS on morbidity and length of stay in elderly patients undergoing elective laparoscopic colorectal cancer surgery: a two-center comparative study.

Verbo A, Verbo I · 2026 · Langenbeck's archives of surgery

Background Enhanced Recovery After Surgery (ERAS) protocols are widely implemented in colorectal surgery to improve postoperative recovery and reduce hospital stay. However, their impact on postoperative morbidity in elderly and clinically…

View details →DOI: 10.1007/s00423-026-04120-4