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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20261 results in Negative / Null Result Report · page 587 of 676

Negative / Null Result ReportOpen accessMedicine

Effect of 940 nm diode laser adjunct to mechanical debridement on S100A8 levels and clinical parameters in peri-implantitis treatment.

Nalbant A, Olgun HE, Hendek M et al. · 2026 · Lasers in medical science

The aim of this study was to compare the effectiveness of diode laser and combined treatment protocols, applied in addition to mechanical debridement, in the treatment of peri-implantitis on clinical periodontal parameters and S100A8…

View details →DOI: 10.1007/s10103-026-04925-1
Negative / Null Result ReportMedicine

Incidence and clinical impact of cystic changes in interpositional grafts following arthroscopy-assisted lower trapezius tendon transfer: A retrospective comparative clinical study.

Baek CH, Lim C, Kim JG et al. · 2026 · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

Background Cystic changes within interpositional grafts used for arthroscopy-assisted lower trapezius tendon transfer (aLTT) are occasionally detected on postoperative magnetic resonance imaging (MRI); however, their clinical significance…

View details →DOI: 10.1016/j.jos.2026.04.009
Negative / Null Result ReportMedicine

Exploring the Expression Changes of Immune Genes in Alzheimer's Disease: A Study on ANXA1, VCAM1, and CCL2.

Fattahi F, Abed S, Kouchakali G et al. · 2026 · Molecular neurobiology

Introduction Alzheimer's disease (AD) is a progressive neurological disorder associated with high prevalence. Numerous studies have been conducted to regulate the expression of inflammatory genes, indicating that any changes may ultimately…

View details →DOI: 10.1007/s12035-026-05821-z
Negative / Null Result ReportOpen accessMedicine

Serum biomarkers remain stable after transitioning from intravenous to subcutaneous natalizumab in multiple sclerosis.

Muñoz-Vendrell A, Arroyo-Pereiro P, León I et al. · 2026 · Journal of neurology

Background Subcutaneous natalizumab offers greater convenience than intravenous administration, but pharmacokinetic differences have raised concerns about potential subclinical disease activity. Serum neurofilament light chain (sNfL) and…

View details →DOI: 10.1007/s00415-026-13949-0
Negative / Null Result ReportMedicine

Mandibular setback by bilateral sagittal split osteotomy: a two-year three-dimensional study of condylar positional and morphological changes.

Al-Mohana RAAM, Jianping H, Alhammadi MS et al. · 2026 · Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

Objective To elucidate the pattern and extent of long-term condylar adaptation within the temporomandibular joint (TMJ) following mandibular setback by bilateral sagittal split osteotomy (BSSO) in patients with mandibular prognathism, with…

View details →DOI: 10.1016/j.jcms.2026.104622
Negative / Null Result ReportMedicine

Assessment of eyeball findings on two sequential post-mortem computed tomography (PMCT) : no reliable marker for post-mortem interval.

Kubota H, Makino Y, Yoshida M et al. · 2026 · International journal of legal medicine

Background It is important to understand post-mortem changes in post-mortem computed tomography (PMCT) image interpretation. Only a few studies have focused on the eyeballs. This study aimed to clarify the changes in eyeball findings on…

View details →DOI: 10.1007/s00414-026-03829-7
Negative / Null Result ReportOpen accessMedicine

Ethanol infusion of the vein of Marshall reduces localized voltage but preserves mitral isthmus conduction velocity.

Lu Y, Shu L, Liu C et al. · 2026 · Frontiers in cardiovascular medicine

Background Ethanol infusion of the vein of Marshall (EIVOM) has emerged as a promising adjunct to pulmonary vein isolation (PVI) for atrial fibrillation (AF). Methods Patients undergoing catheter ablation for persistent AF (>3 months) were…

View details →DOI: 10.3389/fcvm.2026.1807237
Negative / Null Result ReportMedicine

CLINICAL FEATURES AND PROGNOSIS ANALYSIS OF RHEGMATOGENOUS RETINAL DETACHMENT IN PATIENTS WITH IMPLANTABLE COLLAMER LENS.

Lin YJ, Chen QY, Zhao SY et al. · 2026 · Retina (Philadelphia, Pa.)

Purpose This study investigated the clinical characteristics and prognosis of rhegmatogenous retinal detachment (RRD) in patients with implantable collamer lens (ICL). Methods A retrospective review was conducted of medical records from…

View details →DOI: 10.1097/iae.0000000000004772
Negative / Null Result ReportMedicine

A randomized controlled trial comparing two processes of exposure therapy: Extinction learning and habituation.

Treanor M, Zbozinek TD, Rosenberg BM et al. · 2025 · Journal of consulting and clinical psychology

Objective To investigate the role of extinction learning and habituation by comparing inhibitory retrieval to habituation-focused exposure for social anxiety and panic disorder. Method In this assessor-blinded, parallel-group, two-arm…

View details →DOI: 10.1037/ccp0000970
Negative / Null Result ReportMedicine

Prognostic and Predictive Factors in Metastatic Breast Cancer Patients Treated with CDK4/6 Inhibitors.

Demirel N, Yildiz B, Demir M · 2026 · Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

Objective To evaluate the safety and efficacy of CDK4/6 inhibitors in combination with hormone therapy, and to investigate potential predictive markers of treatment in metastatic breast cancer (MBC). Study design An observational study.…

View details →DOI: 10.29271/jcpsp.2026.05.614
Negative / Null Result Report

Impact of vitamin D supplementation on disease severity and visual acuity in pediatric vernal keratoconjunctivitis (VKC) Vitamin D Supplementation in Vernal Keratoconjunctivitis

K S, V KC, S AK et al. · 2026 · Preprint

Abstract Background: Vernal keratoconjunctivitis (VKC) is a chronic, recurrent allergic ocular disorder predominantly affecting children and adolescents. Vitamin D deficiency has been implicated in allergic conditions; however, its…

View details →DOI: 10.21203/rs.3.rs-9278495/v1
Negative / Null Result ReportMedicine

Feasibility assessment of integrated oral health care pathways designed for pediatric and adult patients referred to School of Dentistry.

Hashemi TM, Khami MR, Razeghi S et al. · 2026 · BMC oral health

Introduction Transitioning from a treatment-oriented model to a prevention-focused approach is essential for improving oral health outcomes. This study aimed to assess the feasibility and implementation outcomes of Integrated Oral Health…

View details →DOI: 10.1186/s12903-026-08622-x
Negative / Null Result ReportMedicine

Long-term Clinical and Radiographic Outcomes After Salto Talaris Total Ankle Arthroplasty: Long-term Follow-up of a Previously Published Cohort.

Slowinski J, Lutnick E, Frappa N et al. · 2026 · Foot & ankle international

Background This study aimed to demonstrate long term clinical follow-up and implant survivorship of Salto Talaris-type primary total ankle arthroplasty (TAA) by 1 foot and ankle-trained surgeon at a single institution. Methods Patients…

View details →DOI: 10.1177/10711007261443281
Negative / Null Result ReportMedicine

Temperature Effects on the Impact Attenuation Performance of American Football Helmets and Padding Materials.

Ghiri AA, Cavanaugh SJ, Nuñez AA et al. · 2026 · Annals of biomedical engineering

While American football games are played across a wide range of temperatures, current helmet rating protocols assess performance primarily at room temperature. This study evaluates how temperature influences impact attenuation performance…

View details →DOI: 10.1007/s10439-026-04161-2
Negative / Null Result ReportOpen accessMedicine

Evaluation of Rabeprazole for Gastrointestinal Protection in Acute Coronary Syndrome Patients Treated with Aspirin and Ticagrelor: A Pilot Study.

Hyun HK, Lee OH, Roh JW et al. · 2026 · Yonsei medical journal

Purpose Patients with acute coronary syndrome (ACS) on ticagrelor-based dual antiplatelet therapy (DAPT) have an increased risk of gastrointestinal (GI) bleeding. However, evidence supporting the protective role of proton pump inhibitors…

View details →DOI: 10.3349/ymj.2025.0232
Negative / Null Result ReportMedicine

Endoscopic three-layer graft myringoplasty without tympanomeatal flap elevation for repairing subtotal and total perforations.

Lou Z, Yang H · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

OBJECTIVE: The objective of this study was to evaluate the graft success rate, hearing outcomes, and complications associated with three-layer graft myringoplasty for repairing subtotal and total perforations. MATERIALS AND METHODS:…

View details →DOI: 10.1007/s00405-026-10223-x
Negative / Null Result ReportMedicine

Outcomes from a structured conflict management programme implemented at three paediatric healthcare sites: a mixed-methods evaluation.

Phillipson J, Menson E, Barclay S et al. · 2026 · Archives of disease in childhood

Objective Evaluation of the Medical Mediation Foundation's Conflict Management Programme (CMP)-a structured process for managing conflict. Design Mixed-methods evaluation using Kirkpatrick's framework, a four-level model for evaluating…

View details →DOI: 10.1136/archdischild-2025-329335
Negative / Null Result ReportMedicine

Daily-life posttraumatic stress symptoms, posttraumatic cognitions, and affect following the processing of positive memories technique: An open-label case-control daily diary study.

Greene T, Dicker-Oren SD, Sznitman SR et al. · 2026 · Journal of traumatic stress

The processing of positive memories technique (PPMT) is a promising new treatment for posttraumatic stress disorder (PTSD) involving the detailed narration and processing of specific positive autobiographical memories. This study used an…

View details →DOI: 10.1002/jts.70066
Negative / Null Result ReportMedicine

Intravitreal pegfilgrastim for indirect traumatic optic neuropathy: a first-in-human phase 1/2a study.

Huang CT, Wen YT, Liu PK et al. · 2026 · QJM : monthly journal of the Association of Physicians

Background Indirect traumatic optic neuropathy (TON) is associated with severe vision loss and no proven treatment. Aim To evaluate the safety and exploratory functional outcomes of intravitreal pegfilgrastim in patients with indirect TON.…

View details →DOI: 10.1093/qjmed/hcag129
Negative / Null Result ReportOpen accessMedicine

Investigation of the effects of radiotherapy and chemotherapy on brain volume in cancer patients: brain tumor study.

Deniz B, Arpaci MF, Pekmez H et al. · 2026 · Journal of neuro-oncology

Purpose Brain tumors, characterized by the uncontrolled proliferation of abnormal cells within cerebral tissue, remain clinically challenging entities. Radiotherapy and chemotherapy constitute fundamental therapeutic modalities; however,…

View details →DOI: 10.1007/s11060-025-05366-6
Negative / Null Result ReportOpen accessMedicine

The Effect of Ocrelizumab on Anti-JC Virus Antibody Index.

Virupakshaiah A, Gill AJ, Schoeps VA et al. · 2026 · Brain and behavior

Purpose/introduction The anti-JC virus (JCV) antibody index is used to stratify the risk of progressive multifocal leukoencephalopathy (PML) in multiple sclerosis (MS), particularly with natalizumab therapy. B-cell-depleting therapies may…

View details →DOI: 10.1002/brb3.71386