A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20261 results in Negative / Null Result Report · page 586 of 676
Sadek A, Rey NL, Kunka A et al. · 2026 · Preprint
Alpha-synuclein (aSyn) aggregation into amyloid fibrils is a hallmark of synucleinopathies, a group of neurodegenerative disorders that includes Parkinson’s disease. Beyond the central role of fibrils in disease pathology and propagation,…
Jaffery Z, Nohria A · 2026 · Preprint
Abstract Background HER 2 targeted therapy is a used in a large number of cancer patients with HER 2 receptors positivity. There are reports suggesting HER 2 targeted therapy can cause pulmonary hypertension (PH) and treatment…
Gul E, Doğan ÖT, Taş N et al. · 2026 · Medicina (Kaunas, Lithuania)
Background and Objectives: It is well established that obstructive sleep apnea syndrome (OSAS) is associated with functional lung volumes. The aim of this study was to investigate the relationship between morphological lung volume and the…
Cristobal M, Utterback PL, Stein HH et al. · 2025 · Poultry Science
The objective was to evaluate the nutritional value of conventional soybean meal (SBM-CV), fermented SBM-CV (FSBM), full-fat soybeans (FFSB), and fermented FFSB (FFFSB). In Experiments 1 and 2, two precision-fed rooster assays were…
Massie S, Léguillette R, Jones JH et al. · 2026 · Journal of veterinary internal medicine
Background Maximal intensity exercise in equine athletes induces pulmonary capillary stress failure and exercise-induced pulmonary hemorrhage (EIPH) secondary to excessive transmural pressure (Ptm). Furosemide decreases EIPH severity and…
Orr L, Golding H, O'Brien E et al. · 2026 · Genetics
Autophagy has emerged as a potential drug target for enhancing the efficacy of radiotherapy, but its precise role in cellular responses to ionizing radiation (IR) remains incompletely understood. To address this, we conducted a focused RNA…
Koska D, Biermann N, Maiwald C · 2026 · Journal of biomechanics
Generalized Procrustes Analysis (GPA) is used for rigid alignment in statistical shape modeling to remove positional and size variation prior to Principal Component Analysis (PCA). GPA assumes isotropic variation, which is violated in…
Bonatto IDC, Cavali M, Belli IM et al. · 2026 · Waste management & research : the journal of the International Solid Wastes and Public Cleansing Association, ISWA
The generation of municipal solid waste (MSW) has risen sharply, posing increasingly complex environmental challenges, particularly in its final disposal in landfills. Among the various contaminants present in MSW, emerging pollutants such…
Silva GA, Reis-Silva LL, Gomes-de-Souza L et al. · 2026 · Pflugers Archiv : European journal of physiology
The lateral hypothalamus (LH) is a key brain region involved in integrating cardiovascular and autonomic components of the stress response, yet the local neurochemical mechanisms governing these functions remain poorly understood. This…
Yang B, Guo Z, Zhou Q et al. · 2026 · Animals : an open access journal from MDPI
The lateral line is a highly differentiated skin sensory organ in fish, but few studies have explored the relationship between stocking density and the physiological responses of the lateral line in different species. In this study, grass…
Post B, Chowhury P, Harris A et al. · 2026 · Medical care
Objectives To determine if hospital-orthopedist integration is associated with larger or smaller race and ethnicity gaps in the utilization of total knee arthroplasty (knee replacement) and physical therapy among Medicare beneficiaries.…
Yasutake YC, Donelson JM · 2026 · Preprint
Abstract Many coral reef fish spawn during summer, when marine heatwaves (MHWs) could impose extreme temperatures on vulnerable early-life stages. Most experimental studies expose reef fish to warming from the parental generation (thereby…
Hu W, Shimoda H, Hayasaka D · 2026 · Research in veterinary science
Animal gastrointestinal coronaviruses such as porcine epidemic diarrhea virus (PEDV) and transmissible gastroenteritis virus (TGEV) can cause oral infection despite being enveloped viruses, implying that they are capable of passing through…
Banga A, Valentine V, Zhang S et al. · 2026 · American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Despite more complex procurement logistics under Continuous Distribution (CD), lung transplant (LT) outcomes appear better. The current analysis sought to investigate the potential contributors to these trends observed under the CD…
Evsyukova VS, Sorokin IE, Kulikov PA et al. · 2026 · Bulletin of experimental biology and medicine
The removal of the cuticular membrane (chorion) in developing Danio rerio embryos was used as a model of mild and long-acting influences to study their consequences for adult D. rerio. We studied the effect of dechorionation 12 h after…
Sargent C, Halson SL, Morrison M et al. · 2026 · Sensors (Basel, Switzerland)
There is some evidence to indicate that lower-body compression garments aid recovery from exercise by improving sleep quality, but this evidence is based on measures derived from self-reports and accelerometers. The aim of this study was…
Wheeler GL, Steinman SA · 2026 · Frontiers in psychology
Introduction According to cognitive models, individuals with social anxiety place excessive importance on gaging others' reactions to their social performance. This may lead to misinterpretation of facial expression. Facial interpretation…
Orekhova E, Fadeev K, Morozova M et al. · 2026 · Preprint
ABSTRACT Temporal and spectral regularities characteristic of vowels are preferentially encoded by the auditory system, giving rise to a prolonged enhancement of a negative electromagnetic response in the auditory cortex - sustained…
Tanaka Y, Ishikawa K, Okubo M · 2026 · Psychological research
Previous studies using gaze-cueing tasks have reported mixed findings regarding how face masks affect gaze-triggered attentional processes. However, in those tasks, participants were explicitly instructed to ignore gaze and face stimuli,…
Cozzi NV · 2026 · Naunyn-Schmiedeberg's archives of pharmacology
The aim of this study was to investigate the effects of deuterium substitution on the in vitro pharmacology of the psychedelic drug 2-(4-bromo-2,5-dimethoxyphenyl)ethan-1-amine (2C-B). Two deuterated isotopologues of 2C-B, namely…
Lidborg LH, Kohen Tuncer D, Burton AM et al. · 2026 · Biological psychology
Theoretical models of face processing incorporate within-pool inhibition - a mechanism by which representations compete with one another to support recognition. However, direct evidence for these inhibitory mechanisms is sparse in studies…
Alex L, Klutho PJ, Song L et al. · 2026 · Preprint
Genetic inhibition of cyclophilin D (CypD) delays the opening of the mitochondrial permeability transition pore (MPTP) and therefore reduces necrotic cell death. Elucidation of factors that impact CypD activity is therefore key to…
Trexler RV, Bruns MA, Borton MA et al. · 2026 · Preprint
Soil microbial inoculants have the potential to improve crop yield, enhance agricultural sustainability, and support soil restoration, but they often display unpredictable in-field performance across varied soil conditions.…
Wiechert S, de Groot E, Rutjens BT et al. · 2026 · Preprint
Over the past decade, psychology has embraced transparency and reproducibility reforms to address the replication crisis, raising the question of whether these signals help legal decision-makers identify which psychological evidence is…
Boxer B, Zhang Z, Folland JP et al. · 2026 · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Impact and resistance exercise have potent osteogenic effects and may positively affect cartilage through tissue deformation. These effects may be mediated through inhibitors of Wnt signaling, such as sclerostin and Dickkopf WNT signaling…
Ashmore S, Russo D, Hornbach A et al. · 2026 · Urogynecology (Philadelphia, Pa.)
Importance Surgeons traditionally place the synthetic midurethral sling (MUS) after completing the apical suspension procedure during surgical procedures for pelvic organ prolapse (POP) and stress urinary incontinence (SUI). We hypothesize…
Çetin OG, Gülgöz S · 2026 · Memory (Hove, England)
The role of agency in collective memory is largely unexplored, and evidence that schema-congruent collective events are more readily integrated than incongruent ones remains largely correlational. Studying these factors experimentally is…
Moreno-Druet M, Pardaens S, Soudzilovskaia NA et al. · 2026 · Preprint
Climate change is reshaping soil microbial communities, yet the impact of warming in bacterial-fungal interactions (BFIs) remains underexplored. We investigated whether heatwave temperature influence BFIs and the mechanism supporting the…
Kawasaki Y, Suzuki Y, Miyazaki K et al. · 2026 · Fukushima journal of medical science
Aim To clarify the change in characteristics and body mass index standard deviation (BMI-SD) after guanfacine extended-release (GXR) administration for attention-deficit/hyperactivity disorder (ADHD) children, we undertook a clinical…
Pugina G, Tardivo C, Monus B et al. · 2026 · Scientific reports
Citrus production in Florida has declined drastically due to Huanglongbing (HLB), a bacterial disease associated with Candidatus Liberibacter asiaticus. This disease significantly reduces fruit yield and quality and shortens the tree's…