Negative / Null Result ReportMedicine
Leslie E, Gonzalez Bosc LV, Specht J et al. · 2024 · Medicine and science in sports and exercise
Purpose Chronic, high-altitude hypoxic exposure increases the risk of high-altitude pulmonary hypertension (PH). Emerging evidence shows maternal exercise may improve offspring resistance to disease throughout life. The purpose of this…
View details →DOI: 10.1249/mss.0000000000003479 Negative / Null Result ReportOpen accessMedicine
Contrada M, Pignolo L, Vatrano M et al. · 2024 · Brain sciences
Purpose Cognitive dysfunctions are still very common in the chronic phase of stroke when patients are discharged from neurorehabilitation centers. Even individuals who appear to have made a full clinical recovery may exhibit new…
View details →DOI: 10.3390/brainsci15010011 Negative / Null Result ReportOpen accessMedicine
Nieto-Felipe J, Macias-Diaz A, Alvarado S et al. · 2025 · Scientific reports
Store-operated Ca²⁺ entry (SOCE) is a major pathway for Ca²⁺ entry that regulates several cellular functions. SOCE remodeling mediated by changes in the expression and/or function of the Orai channels results in the reorganization of…
View details →DOI: 10.1038/s41598-025-33071-x Negative / Null Result ReportOpen accessMedicine
Bulgarella M, Reason A, Baty JW et al. · 2025 · Insects
Double-stranded RNA (dsRNA) biopesticides offer the potential for highly targeted pest control with minimal off-target impacts. Varroa mites ( Varroa destructor ) are an important pest of honey bees ( Apis mellifera ) that are primarily…
View details →DOI: 10.3390/insects16030317 Negative / Null Result ReportMedicine
Gunn D, Yeldho C, Hoad C et al. · 2024 · Neurogastroenterology and motility
Background Lactulose is a laxative which accelerates transit and softens stool. Our aim was to investigate its mechanism of action and use this model of diarrhea to investigate the anti-diarrheal actions of ondansetron. Methods A…
View details →DOI: 10.1111/nmo.14754 Negative / Null Result ReportOpen accessMedicine
Mattar D, Cheewasopit W, Samir M et al. · 2023 · Reproduction & fertility
Kisspeptin, a hypothalamic neuropeptide encoded by the KISS1 gene, has a pivotal role in promoting GnRH secretion in mammals. Kisspeptin and its receptor (KISS1R) are also expressed in certain peripheral tissues including gonads,…
View details →DOI: 10.1530/raf-22-0088 Negative / Null Result ReportOpen accessMedicine
Ivanov YV, Ivanova AI, Kartashov AV et al. · 2026 · Biology
Manganese (Mn) is a crucial micronutrient for plants. The impaired function of the oxygen-evolving complex in Photosystem II (PSII) due to Mn deficiency is believed to result in the overproduction of reactive oxygen species and the…
View details →DOI: 10.3390/biology15010101 Negative / Null Result ReportOpen accessMedicine
Fondevila G, Fatmi H, Fernando P et al. · 2025 · Insects
The effects of Lys and Ile supplementation in a barley-based substrate on growth performance and nutrient deposition in Tenebrio molitor larvae were evaluated. Six trays per treatment containing sixty larvae were assigned to five…
View details →DOI: 10.3390/insects16090989 Negative / Null Result ReportMedicine
Brongers K, Hoekstra T, Wilming L et al. · 2024 · Disability and rehabilitation
Purpose As the effect evaluation of our randomized controlled trial the "Comprehensive Approach of Reintegration for clients with Multiple problems" (CARm) showed no superior effect on re-integration into paid employment of the clients…
View details →DOI: 10.1080/09638288.2023.2264765 Negative / Null Result ReportOpen accessMedicine
Hoevenaar-Blom MP, Shourick J, van Dalen JW et al. · 2025 · Alzheimer's & dementia : the journal of the Alzheimer's Association
Introduction We explored which dementia risk factors in two multidomain prevention trials mediate beneficial, neutral, or counteracting effects on dementia incidence. Methods We pooled data from the multidomain MAPT (Multidomain Alzheimer…
View details →DOI: 10.1002/alz.14557 Negative / Null Result ReportOpen accessMedicine
Pizarro J, Walker MC, Sheybani L · 2025 · Epilepsia
Generalized epileptiform discharges (GEDs) in idiopathic generalized epilepsy (IGE) are classically considered symmetrical in amplitude, although this has not been formally tested. This is a major knowledge gap, since asymmetry is…
View details →DOI: 10.1111/epi.18509 Negative / Null Result ReportOpen access
Ford BE, Chachra SS, Alshawi A et al. · 2024 · Preprint
ABSTRACT Glucokinase activators (GKAs) have been developed as blood glucose lowering drugs for type 2 diabetes. Despite good short-term efficacy, several GKAs showed a decline in efficacy chronically during clinical trials. The underlying…
View details →DOI: 10.1101/2024.07.24.604910 Negative / Null Result ReportOpen accessMedicine
Mogensen DG, Aanaes K, Andersen IB et al. · 2025 · The Laryngoscope
Objectives Olfactory training is a recommended treatment in patients with olfactory dysfunction after COVID-19. However, the effectiveness of olfactory training in COVID-19-induced olfactory dysfunction has been studied; only a few studies…
View details →DOI: 10.1002/lary.32275 Negative / Null Result ReportOpen accessMedicine
Sehgal I, Eells K, Hudson I · 2024 · Pharmacy (Basel, Switzerland)
Small interfering RNA (siRNA)-based medications offer the ability to target previously undruggable targets and have now received FDA approval in five instances for orphan or uncommon diseases. The current siRNA "-sirans" are directed…
View details →DOI: 10.3390/pharmacy12020058 Negative / Null Result ReportMedicine
Goldschmied N, Lambrecht J, Castro A et al. · 2023 · Scandinavian journal of medicine & science in sports
Hockey is a sport known for its violent nature. Specifically, hockey fights have consistently been an integral part of the National Hockey League. Past research has demonstrated that players are likely to be involved in fighting as a…
View details →DOI: 10.1111/sms.14432 Negative / Null Result ReportOpen accessMedicine
Riise HS, Simpson MR, Espnes KA et al. · 2026 · Headache
Objective To explore the adherence, effectiveness, safety, tolerability, and acceptability of frequently used oral migraine preventive drugs in a real-world setting. Background Oral migraine preventives are previously mainly explored in…
View details →DOI: 10.1111/head.70061 Negative / Null Result ReportOpen accessMedicine
Sonnhoff M, Oyur M, Becker JN et al. · 2026 · Radiation oncology (London, England)
BACKGROUND: Despite the favorable toxicity profiles of whole breast radiotherapy, there are subgroups that tend to experience high toxicity. This study examines anatomical and physiological characteristics that can predict the induction of…
View details →DOI: 10.1186/s13014-026-02833-w Negative / Null Result ReportOpen accessMedicine
Hunter-Cooper SD, Rahimi M, Millet P et al. · 2026 · European journal of nutrition
Introduction High sodium intake has been associated with greater pressor responses in Black compared with White adults. While the acute effects of sodium on BP have been studied in Black adults, to our knowledge, no studies have explored…
View details →DOI: 10.1007/s00394-026-03994-w Negative / Null Result ReportOpen accessMedicine
Kreko-Pierce T, Chen L, Qu G et al. · 2026 · Membranes
HIV-associated neurocognitive disorders (HAND) persist despite combination antiretroviral therapy (cART) and can be exacerbated by repeated cocaine (COC) exposure. Because COC, HAND, and cART independently disrupt medial prefrontal cortex…
View details →DOI: 10.3390/membranes16040115 Negative / Null Result Report
Bracci EL, Barnett AG, Brown C et al. · 2023 · Preprint
Background: Non-beneficial treatment affects a considerable proportion of older people in hospital, and some will choose to decline invasive treatments when they are approaching the end of their life. The Intervention for Appropriate Care…
View details →DOI: 10.21203/rs.3.rs-3268081/v1 Negative / Null Result ReportOpen accessMedicine
Krittaphol W, Martin LW, Walker GF et al. · 2025 · Pathogens (Basel, Switzerland)
Chronic infections of Pseudomonas aeruginosa are commonly treated with tobramycin. During infections, the bacteria can exist under conditions of oxygen deprivation that render them less susceptible to this antibiotic. The aims of this…
View details →DOI: 10.3390/pathogens14020187 Negative / Null Result ReportOpen accessMedicine
Newman MS, Smeaton J · 2025 · Menopause (New York, N.Y.)
Objectives 3,3'-diindolylmethane (DIM) is a supplement, investigational drug, and the primary in vivo product of indole-3-carbinol. DIM is sometimes recommended to postmenopausal women by functional or integrative medicine providers. Some…
View details →DOI: 10.1097/gme.0000000000002542 Negative / Null Result ReportOpen accessMedicine
Vega-Trejo R, Sanghvi K, Todorova B et al. · 2024 · Scientific reports
Mate availability and social information can influence mating behaviour in both males and females. Social information obtained from conspecifics can influence mate choice, particularly shown by studies on mate choice copying. However, the…
View details →DOI: 10.1038/s41598-024-83465-6 Negative / Null Result ReportOpen accessMedicine
Hemmingsen MG, Zhang GF, Ma Y et al. · 2025 · JCI insight
Methylmalonic acidemia (MMA) is a severe metabolic disorder affecting multiple organs because of a distal block in branched-chain amino acid (BCAA) catabolism. Standard of care is limited to protein restriction and supportive care during…
View details →DOI: 10.1172/jci.insight.187758 Negative / Null Result ReportOpen accessMedicine
Rolig AS, Ziglari T, McGee GH et al. · 2026 · Scientific reports
The tumor microenvironment (TME), which heavily influences immune checkpoint blockade (ICB) efficacy, is shaped by host-microbe interactions. Endogenous intratumoral bacteria have been implicated in efficacy of ICB, such as anti-PD-1…
View details →DOI: 10.1038/s41598-026-39758-z Negative / Null Result ReportOpen accessMedicine
Hauber MM, Nordahl O, Todisco V et al. · 2026 · PloS one
Many coregonine species have declined drastically across the Northern Hemisphere, including populations of Coregonus maraena (whitefish) in the Baltic Sea, and the mechanisms leading to these declines are not well investigated. An abrupt…
View details →DOI: 10.1371/journal.pone.0344576 Negative / Null Result ReportOpen accessMedicine
Marquis-Gravel G, Tong G, Dodd M et al. · 2025 · Journal of the Society for Cardiovascular Angiography & Interventions
Background Coronary artery bypass grafting (CABG) improves survival compared with optimal medical therapy (OMT) alone in patients with ischemic left ventricular systolic dysfunction (iLVSD), but percutaneous coronary intervention (PCI) did…
View details →DOI: 10.1016/j.jscai.2025.103820 Negative / Null Result ReportOpen accessMedicine
Shahid N, Kim CH, Jabilona KB et al. · 2026 · PloS one
Tyrosine kinase inhibitors (TKI) are often used in combination with other chemotherapeutic nucleoside/nucleobase analogues, such as gemcitabine and 6-mercaptopurine, in the treatment of various cancers. Past studies have shown that several…
View details →DOI: 10.1371/journal.pone.0348426 Negative / Null Result ReportOpen accessMedicine
Lubineau M, Watkins CP, Glasel H et al. · 2023 · Proceedings. Biological sciences
Does word flickering facilitate reading? Despite a lack of scientific evidence, flickering glasses and lamps for dyslexia are being marketed in various countries. We conducted four experiments to assess their efficacy. Two experiments…
View details →DOI: 10.1098/rspb.2023.1665 Negative / Null Result ReportOpen accessMedicine
Salerno JW, Xu S, Rainforth M et al. · 2026 · Medicina (Kaunas, Lithuania)
Background and Objectives : Cardiovascular disease (CVD) is the leading cause of death globally. The World Health Organization has called for investigations into traditional systems of medicine for CVD prevention. Ayurveda includes a…
View details →DOI: 10.3390/medicina62050972 