A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20261 results in Negative / Null Result Report · page 582 of 676
Poisson CL, Green IK, Stemmler GM et al. · 2024 · Preprint
To navigate dynamic environments, animals must rapidly integrate sensory information and respond appropriately to gather rewards and avoid threats. It is well established that dopamine (DA) neurons in the ventral tegmental area (VTA) and…
Matsushima T, Toji N, Wada K et al. · 2024 · Preprint
Embryonic exposure to valproic acid (VPA) and imidacloprid (IMI, a neonicotinoid insecticide) impairs filial imprinting in hatchlings, and the deteriorating effects of VPA are mitigated by post-hatch injection of bumetanide, a blocker of…
Zheng H, Chen W · 2026 · Frontiers in pediatrics
Background and aims Exclusive enteral nutrition is an established induction therapy for pediatric Crohn's disease, but biochemical response varies across patients. We assessed whether baseline gut microbiome features were associated with…
Che Y, Yuan J, Guo J · 2025 · Archives of dermatological research
Observational studies have shown that the risk of developing herpes zoster (HZ) increases with the use of statins. However, there are many confounding factors in observational studies. Therefore, our Mendelian randomization (MR) study…
Tu Y, Xie D, Qian H · 2025 · Medicine
Observational studies have suggested associations between circulating creatine kinase (CK) levels and gastric cancer (GC), yet causality remains uncertain. To evaluate whether genetically predicted CK levels are causally related to GC…
van Lennep JPA, van Middendorp H, Leong OV et al. · 2025 · Scandinavian journal of pain
Objectives To understand how different individuals respond to placebo effects, it is relevant to disentangle the influence of someone's personality and genetic variations. The aim of this exploratory study was to investigate the role of…
Salehi-Reyhani SM, Saadat M · 2024 · Molecular biology reports
Background It is well known that telomerase activity is suppressed in normal human tissues and reactivated in tumors, suggesting that the human telomerase reverse transcriptase (hTERT, MIM: 187270) gene may be involved in carcinogenesis. A…
Naito R, Hiwa R, Inaba R et al. · 2025 · Modern rheumatology case reports
Vesiculobullous dermatomyositis (VD) is a rare manifestation of dermatomyositis (DM) and has been suggested to be associated with malignancy. Although the myositis-specific autoantibodies are associated with distinct clinical presentations…
O'Connor LE, Thoerig RC, Leta CN et al. · 2026 · Advances in nutrition (Bethesda, Md.)
Infants may be exposed to contaminants from environmental and food sources, including human milk (HM) or infant formula (IF). The objective of this series of systematic reviews (PROSPERO: CRD42024530332, CRD42024530336, CRD42024530339, and…
Wade TD, Jabs M, Keegan E et al. · 2024 · The International journal of eating disorders
Objective We examine the small amount of research to date that describes and/or evaluates waitlist interventions as a precursor to treatment for an eating disorder (ED) with the intent to provide recommendations for future research that…
Contente J, Ferreira C, Silva M et al. · 2025 · Journal of bone and joint infection
Introduction : Debridement, antibiotics, and implant retention (DAIR) is recommended for early acute postoperative and late acute periprosthetic joint infections (PJIs). The KLIC and CRIME-80 scores have been proposed to predict DAIR…
Li MS, Wu XQ, Zhou YJ et al. · 2024 · Ying yong sheng tai xue bao = The journal of applied ecology
Species range size is closely related to its ability to migrate and adapt to environmental change. Rapoport's rule predicts that species range size would become larger with increasing latitude or elevation. Empirical evidence for…
Rodriguez-Merchan EC · 2025 · The archives of bone and joint surgery
Periarticular multimodal drug injection (PMDI) is better than FNB (femoral nerve block) in pain relief after total knee arthroplasty (TKA). PMDI of bupivacaine [20 mL 0.5% bupivacaine hydrochloride - HCl (100 mg) following implantation…
Weger HG, Polasek AK, Wright DM et al. · 2024 · The Journal of eukaryotic microbiology
Twenty species/isolates of cyanobacteria and green algae were isolated from cyanobacterial bloom samples in lakes associated with the upper Qu'Appelle River drainage system in southern Saskatchewan, Canada. Three amoebae species…
Wiesenthal J, Schredl M · 2026 · Journal of sleep research
Although about 5% of the German population report having nightmares at least once a week, nightmares are inadequately diagnosed and treated. We therefore examined how people in the general population cope with nightmares in everyday life.…
Stark BC, Alexander JM, Stockrahm E et al. · 2026 · American journal of speech-language pathology
Purpose This study examined the role of inner speech-defined here as the subjective experience of covert lexical access-in naming recovery following semantic feature analysis (SFA) treatment in individuals with aphasia. Specifically, it…
Ercan P, Firlatan Yazgan B, Sendur SN et al. · 2026 · Pituitary
Purpose Long-term renal consequences of acromegaly remain poorly characterized. We assessed prevalence and independent predictors of renal cysts, chronic kidney disease (CKD), and the frequency of urinary-system malignancies, in a large…
Swaid TK, Hamzeh LR, Bukasa LL et al. · 2026 · Intestinal research
Background/aims To determine time to diagnosis (TTD) and its impact on surgery and advanced therapy (AT) burden in inflammatory bowel disease (IBD) in a multi-ethnic United Arab Emirates (UAE) cohort, a region in the acceleration phase of…
Hajibandeh S, Hajibandeh S, Mckittrick H et al. · 2026 · World journal of gastrointestinal surgery
Background Early skeletal muscle wasting has been demonstrated to be associated with chemotherapy-related toxicity in patients with cancer. Hounsfield unit average calculation (HUAC) or psoas muscle index (PMI) can be used to diagnose…
Kurasz Z, Krzyżowski M, Baran B et al. · 2026 · Preprint
Loneliness is increasingly prevalent in emerging adults and is theorised to engage threat-related biology that overlaps with nociceptive processing. We tested whether social connectedness and related cognitive-affective traits predict…
Iler AM, CaraDonna PJ, Petry WK · 2026 · Preprint
Most plants require animal pollination to reproduce, prompting concern that pollinator declines immediately threaten plant populations. This concern is warranted if pollinator-mediated seed losses cause declines in plant population growth…
Derégnaucourt S, Le Maguer L, Geberzahn N · 2026 · Animal cognition
Vocal learning in songbirds requires the integration of auditory perception, sensorimotor learning, and performance monitoring, yet its relationship to general cognitive abilities remains unclear. We tested whether interindividual…
Guan M, Yang Q, Carey P et al. · 2026 · Health communication
Despite its significant implications for public health and individual decision-making, research on information avoidance remains limited. In this study, we applied and extended the model of planned risk information avoidance (PRIA) to…
Wai KM, Parajuli RP, Umezaki M · 2026 · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
Telomeres are repetitive non-coding DNA sequences at chromosome ends that progressively shorten with each cell division, serving as markers of cellular aging. Recent studies have suggested that prenatal and postnatal exposure to…
Anderson C, Linardon J · 2026 · Body image
Previous research suggests that body appreciation and social anxiety are likely intertwined, such that a more accepting and respectful orientation toward one's body may attenuate fears of negative evaluation in socially salient contexts.…
Moreau AL, Li LY, White J et al. · 2026 · Journal of anxiety disorders
Intolerance of uncertainty (IU) is an individual difference dimension reflecting difficulty in tolerating aversive responses triggered by uncertainty. IU is an important etiological and maintaining mechanism of social anxiety disorder…
Berry DS, Cosentino S, Louis ED · 2026 · Neuro-degenerative diseases
Background Elders with essential tremor (ET) are at a heightened risk for incident dementia. Although the consequences of this diagnosis are formidable, we know little about what factors elevate the risk of ET-dementia. We analyzed data…
Sun J, Lawrence A, King B et al. · 2026 · Preprint
Abstract Altered cerebral blood flow (CBF) is associated with first episode psychosis (FEP) and may relate to early treatment response. We investigated CBF using arterial spin labelling (ASL) MRI in 56 individuals experiencing FEP from two…
Das AS, Mallela J, Kalkundrikar GU · 2026 · Annals of African medicine
Background Cardiac involvement in dengue ranges from transient, self-limited changes to life-threatening dysfunction. In children with severe dengue, early identification of electrocardiographic (ECG) abnormalities may inform risk and…
Ho D, Tan K, Li NP et al. · 2026 · Journal of personality
Objective "Simps" are individuals (primarily men) who engage in costly or extravagant gestures toward a romantic interest without receiving reciprocation. As its first empirical validation, the current study newly operationalizes simping…