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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20261 results in Negative / Null Result Report · page 578 of 676

Negative / Null Result ReportMedicine

Clinical and forensic evaluation of 66 cases of alcohol intoxication: Insights into substitute alcohols detected by HS-GC/MS.

Bulut C, Arslan Z, Aydoğdu M et al. · 2026 · Forensic science international

Rising global alcohol consumption is a major public health and safety concern. Over the last decade, undeclared alcohol consumption has increasingly come into focus due to high inflation that has led many individuals to resort to unhealthy…

View details →DOI: 10.1016/j.forsciint.2025.112764
Negative / Null Result ReportMedicine

Performance of five mpox antigen-based rapid diagnostic tests tested on lesion swabs from patients with suspected mpox from the Kinshasa province of DR Congo: a diagnostic accuracy study.

Kavunga-Membo H, Chi HF, Emperador DM et al. · 2026 · The Lancet. Infectious diseases

Background Mpox has spread to 36 countries in Africa, yet many face challenges achieving nationwide PCR-based testing due to cost and limited access in remote and rural areas. Point-of-care antigen-based rapid diagnostic tests (RDTs) might…

View details →DOI: 10.1016/s1473-3099(26)00141-6
Negative / Null Result ReportOpen accessMedicine

Hit-and-run hypothesis: revisiting the impact of EBV in malignancies.

Mangiaterra T, Chabay P, Bellan C et al. · 2026 · Frontiers in immunology

Epstein-Barr virus (EBV) infects more than 90% of the global population and is etiologically linked to a wide spectrum of lymphoid and epithelial malignancies. Although its role as an oncogenic virus is well established, the mechanisms…

View details →DOI: 10.3389/fimmu.2026.1742214
Negative / Null Result Report

Percutaneous Transluminal Angioplasty and Stenting for Symptomatic Intracranial Stenosis After SAMMPRIS: Patient Selection and Clinical Outcomes

Mann L, Samp P, Schäefer JH et al. · 2025 · Preprint

Background: / Objectives; After negative results of the SAMMPRIS-trial the indication for endovascular treatment of atherosclerotic intracranial artery stenosis (ICAS) was widely restricted. It was the aim of our study to report whether…

View details →DOI: 10.20944/preprints202511.1539.v1
Negative / Null Result ReportMedicine

Psychological distress and cancer worry in unaffected relatives undergoing cascade testing with multigene panel testing.

Kimura K, Kuwata T, Hiraoka Y et al. · 2026 · Journal of human genetics

Multigene panel testing (MGPT) is increasingly used for diagnosing hereditary cancers; however, its application in cascade testing remains limited, and the psychological impact on unaffected relatives is not well understood. This…

View details →DOI: 10.1038/s10038-026-01464-z
Negative / Null Result ReportOpen accessMedicine

Assessing the Effectiveness of the Human Immunodeficiency Virus Point-of-Care Proficiency Testing Scheme: Analysis of the Data From 2021 to 2022 in South Africa.

Blasich NP, Adelekan AM · 2026 · Health science reports

Background Point-of-care rapid diagnostic testing plays a critical role in HIV detection and timely linkage to care, particularly in decentralized healthcare settings. To support testing reliability, the National Health Laboratory Service…

View details →DOI: 10.1002/hsr2.71521
Negative / Null Result ReportMedicine

Radiation dosimetry of <sup>15</sup>O-water based on dynamic large axial field of view PET.

Lubberink M, Åhlström A, Tolvanen T et al. · 2026 · Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

Purpose Previously published effective dose coefficient estimates for 15 O-water are around 1 μSv/MBq, resulting in an effective dose of around 0.4 mSv for a typically injected activity of 400 MBq in clinical cardiac scans. These estimates…

View details →DOI: 10.1016/j.nuclcard.2026.102775
Negative / Null Result ReportMedicine

Application and Evaluation of a Formative Feedback Rubric on Nontechnical Skills Using Retrospective SIMPL App Data in General Surgery Residents.

Cloonan MR, Maginot ER, Tieken KR et al. · 2026 · Journal of surgical education

To determine the frequency of nontechnical skills (NTS) feedback provided by attending surgeons through narrative comments and assess its effectiveness using a validated formative feedback rubric. This retrospective cross-sectional study…

View details →DOI: 10.1016/j.jsurg.2026.104035
Negative / Null Result ReportOpen accessMedicine

Economic evaluation of the second-line regimen of liposome irinotecan (II) combined with 5-FU/LV versus placebo combined with 5-FU/LV for locally advanced or metastatic pancreatic ductal adenocarcinoma in China.

Huang J, Ye H, Lin J et al. · 2026 · PloS one

Background The cost-effectiveness of liposome irinotecan (II) (HR070803) in combination with 5-fluorouracil and leucovorin as a treatment for patients with locally advanced or metastatic pancreatic ductal adenocarcinoma offering a…

View details →DOI: 10.1371/journal.pone.0351853
Negative / Null Result ReportMedicine

Unfolding prion misfolding and the challenge of identifying effective therapeutics: is there hope on the horizon?

Sabzehei S, Innocenti N, Rigoli M et al. · 2026 · Expert opinion on drug discovery

Introduction Prion diseases are rare, fatal neurodegenerative disorders caused by the conformational conversion of cellular prion protein (PrP) into a pathogenic counterpart called PrP Sc , that replicates by templated misfolding. The…

View details →DOI: 10.1080/17460441.2026.2688321
Negative / Null Result ReportOpen accessMedicine

Vessel diameter as a potential predictor of pulsed dye laser response in port wine stain: a retrospective exploratory reflectance confocal microscopy study.

Ran X, Shang Y, Yang X et al. · 2026 · Lasers in medical science

To investigate whether noninvasive reflectance confocal microscopy (RCM)-derived vascular parameters can serve as objective predictors of therapeutic response to pulsed dye laser (PDL) treatment in patients with port wine stain (PWS),…

View details →DOI: 10.1007/s10103-026-04906-4
Negative / Null Result ReportOpen accessMedicine

The Median Effective Dose of Phenylephrine Infusion for Prevention of Spinal-Induced Hypotension During Cesarean Delivery in the 15° Left-Tilt vs. Supine Positions: A Randomised Control Study.

Yu XQ, Drzymalski DM, Qian J et al. · 2026 · Drug design, development and therapy

Background Left uterine displacement is presumed to decrease vasopressor requirements during cesarean delivery due to decreased aortocaval compression, but studies have been equivocal. Our primary aim was to determine the median effective…

View details →DOI: 10.2147/dddt.s591446
Negative / Null Result ReportMedicine

Investigating the evidence for effective digital skin surveillance methods.

Fabbri F, Albusaidi I, Ntani G et al. · 2026 · Occupational medicine (Oxford, England)

Background Hand dermatitis is a common occupational skin disease and is particularly prevalent among healthcare workers. Aims To identify which digital skin surveillance methods are effective for detecting hand dermatitis. Methods A…

View details →DOI: 10.1093/occmed/kqag028
Negative / Null Result ReportOpen accessMedicine

Drug supply shortages and their perceived consequences for patients: a questionnaire survey of German and Austrian physicians.

Rotter JM, Seifert R · 2026 · European journal of clinical pharmacology

Purpose Drug supply shortages are a recurring issue in developed countries, with consequences for patients even before the COVID-19 pandemic. Questions arise regarding the effectiveness and tolerability of alternative treatments chosen by…

View details →DOI: 10.1007/s00228-026-04052-4
Negative / Null Result ReportMedicine

Genetic Association and Clinical Relevance of TNFSF13B/BAFF and PADI4 Polymorphisms in ANCA-Associated Vasculitis: A Case-Control Study with Genetic Model Analysis in Guangxi Population.

Lu J, Huang S, Wei S et al. · 2026 · Genes

Objective: TNFSF13B , which encodes B-cell-activating factor ( BAFF ) and peptidylarginine deiminase 4 ( PADI4 ), plays crucial roles in the pathogenesis of ANCA-associated vasculitis (AAV). This study investigated the associations of…

View details →DOI: 10.3390/genes17060710
Negative / Null Result ReportMedicine

Clinical characteristics of lung cancer in patients with connective tissue disease associated interstitial lung disease: a brief report.

Zhang G, Zhang L, Jiang M et al. · 2026 · Clinical rheumatology

Patients with connective tissue disease-associated interstitial lung disease (CTD-ILD) have an increased risk of developing lung cancer (LC).This study investigated whether non-receipt of immunosuppressive therapy is associated with LC…

View details →DOI: 10.1007/s10067-026-08231-7
Negative / Null Result ReportOpen accessMedicine

No benefit of adding glucocorticoids to maintenance treatment in reducing the risk of major relapses in ANCA-associated vasculitis: real life data from a longitudinal cohort study.

Chavatza K, Gialouri CG, Drougkas K et al. · 2026 · RMD open

Objective To examine the role of low-dose glucocorticoids (GCs) in major relapse, hospitalisation and damage accumulation risk during maintenance therapy in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAVs). Methods…

View details →DOI: 10.1136/rmdopen-2026-006935
Negative / Null Result ReportMedicine

Replacing stationary time or light physical activity with moderate-to-vigorous physical activity is associated with improved metabolic health in adults with or at risk of knee osteoarthritis.

Halliwell C, Courish M, Moyer R et al. · 2026 · Clinical rheumatology

Background Individuals with knee osteoarthritis are at an increased risk of poor metabolic health. We tested if cross-sectionally replacing stationary time with light or moderate-to-vigorous physical activity would be associated with lower…

View details →DOI: 10.1007/s10067-026-08253-1
Negative / Null Result ReportOpen accessMedicine

Maternal Health and Sociodemographic Characteristics Influence Infant Growth to 24 Months in the Tunza Mwana Cohort: A Prospective Cohort Study.

Hendrixson DT, Tiwari R, James P et al. · 2026 · Maternal & child nutrition

Upstream pathways influencing child growth are complex. Weight-for-age z-score (WAZ) reflects both ponderal and linear growth and can identify children at high mortality risk. Using data from a prospective cohort of 326 mother-child pairs…

View details →DOI: 10.1111/mcn.70195
Negative / Null Result ReportMedicine

Metabolic dysfunction-associated fatty liver disease and its clinical implications in heart failure.

Suzuki Y, Misaka T, Okochi S et al. · 2026 · Fukushima journal of medical science

Background Heart-liver metabolic crosstalk contributes to heart failure pathophysiology. Metabolic dysfunction-associated fatty liver disease (MAFLD) has been proposed as a new disease entity based on positive metabolic criteria. However,…

View details →DOI: 10.5387/fms.26-00009
Negative / Null Result ReportMedicine

Cortisol stress reactivity and cumulative output associations with structural neural network architecture in adolescents.

Guzman JM, Hardi FA, Peckins MK et al. · 2026 · Psychoneuroendocrinology

The hypothalamic-pituitary-adrenal (HPA) axis maintains homeostasis and responds to stressors in the environment, shaping responsivity and behavior at least partly through its effects on the brain. For example, increased cortisol levels…

View details →DOI: 10.1016/j.psyneuen.2026.107938
Negative / Null Result ReportMedicine

Associations between sick leave during pregnancy and after childbirth and future labour force participation: a Dutch cohort study.

Frijmersum ZZ, Van Der Meij E, Huirne JA et al. · 2026 · Occupational and environmental medicine

Objectives Women's labour force participation often declines after childbirth, but the role of sick leave during pregnancy and after childbirth in sustained employment remains unclear. This study examined: (1) the association between sick…

View details →DOI: 10.1136/oemed-2025-110638
Negative / Null Result ReportMedicine

Sociodemographic factors shaping knowledge-attitude-behaviour pathways in postpartum fall prevention.

Yang L, Xu L · 2026 · Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology

Background Postpartum falls threaten maternal and infant safety, yet evidence on postpartum women's fall-prevention knowledge, attitude, and behaviour (KAB) and their sociodemographic correlates remains limited. This study examined…

View details →DOI: 10.1080/01443615.2026.2678173
Negative / Null Result Report

Elevated HbA1c is associated with advanced brain age in severe obesity

Juhasz J, DeFeis B, Britton MK et al. · 2026 · Preprint

ABSTRACT Introduction Brain-predicted age, estimated from structural MRI data, is a machine learning biomarker of biological brain aging. Greater brain age gap (BAG) indicates advanced brain aging and is associated with cognitive decline…

View details →DOI: 10.64898/2026.06.04.26354935
Negative / Null Result ReportMedicine

Diet Quality, Healthy Practices, and Psychosocial Functioning Across School Youth, Students, and Adults in Poland: A Cross-Sectional Online Survey.

Sochacka K, Kotowska A, Lachowicz-Wiśniewska S · 2026 · Nutrients

Background: This study aimed to compare a limited set of predefined diet-, lifestyle-, knowledge-, and psychosocial indicators across school youth, students, and adults in Poland, and to examine their associations with three predefined…

View details →DOI: 10.3390/nu18122022
Negative / Null Result ReportMedicine

Is outcome observed in performance of clinical tests associated with patient-reported outcome measures after patellofemoral pain treatment? Secondary analysis of data from a randomized clinical trial.

Machado EM, Matthews M, Rathleff MS et al. · 2026 · Brazilian journal of physical therapy

Background Clinical functional tests for patellofemoral pain (PFP), such as step-up, step-down and squat, are commonly used in clinic practice, although the extent to which changes in these tests reflect changes in patient-reported outcome…

View details →DOI: 10.1016/j.bjpt.2026.101593
Negative / Null Result ReportMedicine

Phenotypic Heterogeneity in Crohn's Disease-Associated Intestinal Strictures: An Exploratory Retrospective Cohort Study.

Fusco S, Nesseler J, Minn L et al. · 2026 · Diagnostics (Basel, Switzerland)

Background : Crohn's disease-associated intestinal strictures represent a major source of morbidity and frequently require endoscopic or surgical intervention. However, patients with stricturing Crohn's disease demonstrate substantial…

View details →DOI: 10.3390/diagnostics16121841