e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19895 results in Negative / Null Result Report · page 577 of 664

Negative / Null Result ReportOpen accessMedicine

MRI findings of an incidental ectopic posterior pituitary gland in an adult: Case report and review of T1 hyperintense lesions in the literature.

Hashem S, Murhega RB, Migabo PA · 2026 · Radiology case reports

The ectopic posterior pituitary represents a rare congenital malformation attributable to aberrant embryogenesis of the neurohypophysis. Although it may occur as an isolated anomaly, it is frequently concomitant with other congenital…

View details →DOI: 10.1016/j.radcr.2026.03.050
Negative / Null Result ReportOpen accessMedicine

Variations in transcranial doppler among pediatric patients with sickle cell disease in the Brazilian Northeast: a cross-sectional study.

de Oliveira Castro Marques TR, Vidal SA, da Costa HA et al. · 2026 · Hematology, transfusion and cell therapy

Background Stroke, the most severe neurological complication of sickle cell disease, can result in irreversible sequelae and death. Transcranial Doppler combined with periodic blood transfusions reduces the chances of stroke by 90 %. In…

View details →DOI: 10.1016/j.htct.2026.106458
Negative / Null Result ReportMedicine

The impact of a second embryo biopsy for preimplantation genetic testing for monogenic diseases (PGT-M) with inconclusive results on pregnancy potential: results from a matched case-control study.

Guarneri C, Reschini M, Pinna M et al. · 2024 · Journal of assisted reproduction and genetics

Purpose To evaluate whether a second biopsy, following a first diagnostic failure on blastocysts tested for preimplantation genetic testing for monogenic diseases (PGT-M), allows to obtain genetic diagnosis and to what extent this…

View details →DOI: 10.1007/s10815-024-03078-w
Negative / Null Result Report

Diagnostic impact of secondary findings from whole genome or whole exome sequencing in patients diagnosed with genetic eye disorders

Mehta SP, Antonio Aguirre B, See WYN et al. · 2025 · Preprint

Purpose Whole exome or genome sequencing (WES and WGS, respectively) can be valuable in identifying the molecular basis of inherited retinal disorders (IRD), particularly when panel-based testing yields negative or inconclusive results.…

View details →DOI: 10.1101/2025.03.03.25322102
Negative / Null Result ReportOpen accessMedicine

Hormonal and reproductive factors and risk of nasopharyngeal carcinoma in Chinese women: a case-control study.

Su XY, Schroder A, Tse LA et al. · 2025 · BMC research notes

Background Sex hormones may play a role in the development of nasopharyngeal carcinoma (NPC), but the evidence is limited. Methods This case-control study collected information on sex hormonal and reproductive factors of 99 female incident…

View details →DOI: 10.1186/s13104-025-07471-1
Negative / Null Result ReportOpen accessMedicine

Pre-Analytical and Analytical Challenges in Whole-Exome Sequencing of Formalin-Fixed Paraffin-Embedded Breast and Prostate Cancer Tissue: A Real-World Multicenter Study.

Rosa ML, Bordignon C, Schuch JB et al. · 2026 · Diagnostics (Basel, Switzerland)

Background/Objectives : Formalin-fixed paraffin-embedded tissue is widely used in pathology and molecular diagnostics, yet its variable quality can critically influence the accuracy of sequencing-based analyses. This study investigated…

View details →DOI: 10.3390/diagnostics16111595
Negative / Null Result ReportOpen accessMedicine

Comprehensive assessment of invalid and indeterminate results in Truenat MTB-RIF testing across sites under the national TB elimination program of India.

Gopalaswamy R, Kumar N, Vashistha H et al. · 2023 · Frontiers in public health

Introduction Truenat MTB-RIF assay (Truenat), a nucleic acid amplification test (NAAT), is a real-time polymerase chain reaction (RT-PCR) chip-based assay that can detect Mycobacterium tuberculosis ( Mtb ) and rifampicin (RIF) drug…

View details →DOI: 10.3389/fpubh.2023.1255756
Negative / Null Result ReportMedicine

Foodborne pathogens in the plastisphere: Can microplastics in the food chain threaten microbial food safety?

Tavelli R, Callens M, Grootaert C et al. · 2024 · Trends in Food Science & Technology.

Microplastics (MPs) contaminate the global marine and terrestrial ecosystems. This environmental contamination can enter the food chain, with MPs found in drinking water, fishery products and other food categories. Consequently, ingestion…

View details →DOI: 10.1016/j.tifs.2022.08.021
Negative / Null Result ReportMedicine

Should embryo rebiopsy be considered a regular strategy to increase the number of embryos available for transfer?

Nohales M, Coello A, Martin A et al. · 2023 · Journal of assisted reproduction and genetics

Purpose To investigate whether embryo rebiopsy increases the yield of in vitro fertilization (IVF) cycles. Methods Retrospective study including 18,028 blastocysts submitted for trophectoderm biopsy and preimplantation genetic testing for…

View details →DOI: 10.1007/s10815-023-02875-z
Negative / Null Result ReportOpen accessMedicine

Analysis of Pregnancy Outcomes in Women with Polycystic Ovary Syndrome (PCOS): A Retrospective Study.

Salgotra M, Bharti N, Sinha V et al. · 2024 · Journal of pharmacy & bioallied sciences

Introduction Although PCOS affects reproductive health, its consequences on the outcome of pregnancies are still up for discussion. Comparing the pregnancy outcomes of women with PCOS to a control group was the goal of this retrospective…

View details →DOI: 10.4103/jpbs.jpbs_233_24
Negative / Null Result ReportMedicine

GWAS shows the genetics behind cell-free DNA and highlights the importance of p.Arg206Cys in DNASE1L3 for non-invasive testing.

Linthorst J, Nivard M, Sistermans EA · 2024 · Cell reports

The properties of cell-free DNA (cfDNA) are intensely studied for their potential as non-invasive biomarkers. We explored the effect of common genetic variants on the concentration and fragmentation properties of cfDNA using a genome-wide…

View details →DOI: 10.1016/j.celrep.2024.114799
Negative / Null Result ReportMedicine

Dietary Iron Intake and Risk of Gastric Cancer.

Pham YT, Nguyen BN, Nguyen TG et al. · 2026 · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Background Iron is one of the essential elements for human life. Prior studies provided inconclusive results about the association between dietary iron intake and gastric cancer risk. We determined the association between dietary iron…

View details →DOI: 10.1158/1055-9965.epi-25-1167
Negative / Null Result ReportMedicine

Single-exon fetal RHD genotyping: a 31-month follow up in the obstetric population of Western Sweden.

Pardi C, Hellberg Å, Isakson P · 2024 · Blood transfusion = Trasfusione del sangue

Background The Rh blood group system is highly complex, polymorphic, and immunogenic. The presence of RHD gene variants in RhD negative pregnant women is a challenge in fetal RHD genotyping as it may influence the antenatal management of…

View details →DOI: 10.2450/bloodtransfus.741
Negative / Null Result ReportOpen accessMedicine

Rare Occurrence of Myxoma in Heart Transplant Recipient: A Case Report.

Gutowska A, Bohdan M, Radtke-Łysek A et al. · 2026 · The American journal of case reports

BACKGROUND Cardiac myxomas are the most common primary cardiac tumors in the general population but are exceedingly rare in orthotopic heart transplant recipients. Fewer than 5 cases have been reported. Their pathogenesis in the setting of…

View details →DOI: 10.12659/ajcr.949982
Negative / Null Result ReportMedicine

Scoping review of the music-based movement therapy Ronnie Gardiner Method.

Harjunen L, Östman K, Pohl P · 2025 · Disability and rehabilitation

Purpose Ronnie Gardiner Method (RGM) is a music-based movement therapy that has long been used within rehabilitation. There is a need to (1) identify the scope of the use of RGM, (2) explore potential benefits, (3) examine qualitative…

View details →DOI: 10.1080/09638288.2024.2392037
Negative / Null Result ReportOpen accessMedicine

Effect of total knee arthroplasty on the spinopelvic parameters: A systemic review and metanalysis.

Jain M, Pal DK, Narayan Sahu R et al. · 2025 · World journal of orthopedics

Background Sagittal spinopelvic alignment (SSA) is essential for preserving a stable and effective upright posture and locomotion. Although alterations in the SSA are recognised to induce compensatory modifications in the pelvis, hips, and…

View details →DOI: 10.5312/wjo.v16.i7.107869
Negative / Null Result ReportOpen accessMedicine

External quality assessments for SARS-CoV-2 genome detection in Austria : A comparison of the first postpandemic round with results from the pandemic era.

Buchta C, Aberle SW, Görzer I et al. · 2024 · Wiener klinische Wochenschrift

Background External quality assessment (EQA) schemes provide objective feedback to participating laboratories about the performance of their analytical systems and information about overall regional analytical performance. The EQAs are…

View details →DOI: 10.1007/s00508-024-02353-1
Negative / Null Result ReportOpen accessMedicine

Developmental Outcomes in Children With Clubfoot: A Twin Study Comparing Affected and Unaffected Siblings.

Katz A, Kreiner M, Korain Blank P et al. · 2025 · Journal of pediatric orthopedics

Background Clubfoot is a congenital condition affecting 1 to 2 per 1000 live births, with treatment primarily involving the Ponseti method and/or surgical intervention. It is important to ascertain whether children affected by clubfoot are…

View details →DOI: 10.1097/bpo.0000000000003049
Negative / Null Result ReportMedicine

Efficacy and tolerability of valproate versus topiramate in migraine prevention, a randomized controlled multi-center trial.

Zeinhom MG, Elsayed Khalil MF, Omar Youssif TY et al. · 2025 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Although topiramate and valproate are antiseizure medications that have many contraindications and could produce many side effects, they are still used as migraine preventive therapy in middle- and low-income countries. Several trials…

View details →DOI: 10.1016/j.jocn.2025.111156
Negative / Null Result ReportOpen accessMedicine

Different interpretations of inconclusive results of SARS-CoV-2 real-time RT PCR.

La Jeon Y, Lee SG, Lee EH et al. · 2023 · Diagnostic microbiology and infectious disease

We investigated whether inconclusive results could be interpreted differently depending on the situation. First, data from retesting of the initial samples from subjects without a confirmed COVID-19 history were analyzed. And by analyzing…

View details →DOI: 10.1016/j.diagmicrobio.2022.115888
Negative / Null Result ReportOpen accessMedicine

Original article: novelty of Canadian manufacture nasopharyngeal swabs for collection of samples being tested for SARS-CoV-2 in a pandemic setting.

Palomino-Padilla S, Caceres-Cardenas G, Calderon R et al. · 2024 · Frontiers in public health

Objectives The COVID-19 pandemic caused a global shortage of nasopharyngeal (NP) swabs, required for RT-PCR testing. Canadian manufacturers were contacted to share NP swab innovations. The primary objective was to determine whether novel…

View details →DOI: 10.3389/fpubh.2024.1344295
Negative / Null Result ReportMedicine

The association between changes in muscle mass and function and mortality in individuals receiving peritoneal dialysis.

Wang L, Xue C, Zhu B et al. · 2025 · Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis

Background/objective Data in terms of how dynamic changes of muscle mass and function affect mortality in end-stage kidney disease (ESKD) patients undergoing dialysis have led to inconclusive results. The main goal of this research was to…

View details →DOI: 10.1177/08968608241288958