A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20261 results in Negative / Null Result Report · page 576 of 676
Plaikner A, Ploner M, Sewald Z et al. · 2026 · Preprint
Protein Language Models (pLMs) have significantly advanced computational biology. Yet their scale and reliance on redundant training data raise a fundamental question: do pLMs generalize the statistical grammar of proteins, or do they…
Shan J, Yu J, Zhao L et al. · 2026 · BMC cancer
Background Dose reduction during concurrent chemoradiotherapy (cCRT) is frequently required in patients with limited-stage small-cell lung cancer (LS-SCLC) because of treatment-related toxicities or poor tolerance. However, the impact of…
Mohammed S, Kyei L, Okyere F et al. · 2026 · Preprint
Abstract Background: PAM50 molecular subtype is an established prognostic factor in breast cancer, yet unmeasured heterogeneity may persist within and between subtypes. We evaluated whether shared frailty modeling provides additional…
Alkhalifah OF, Ali Shah S, Tareen SUK et al. · 2026 · Cureus
Background Achieving a lifelike color match for anterior restorations is a persistent challenge because tooth appearance is heavily influenced by illumination and observer-dependent choices. While visual matching with VITA-type guides…
Kiplimo D, Sperber S, Nata’ala MK et al. · 2026 · Preprint
Abstract Background Antimicrobial resistance (AMR) in plant-associated microbiomes is increasingly recognized as One-Health concern. Apples are widely consumed, yet little is known about how agricultural practices and geography shape its…
Matsumoto T, Yamamoto Y, Kotaka M et al. · 2024 · Targeted oncology
Background Non-inferiority of trifluridine/tipiracil (FTD/TPI) plus bevacizumab (BEV) to irinotecan/fluoropyrimidine plus BEV in metastatic colorectal cancer was investigated in the phase III TRUSTY study, and we conducted a phase II study…
Halpin M, Lerner A, Sagar M et al. · 2023 · Preprint
The systemic inflammatory response seen in patients with severe COVID-19 shares many similarities with the changes observed in hemophagocytic lymphohistiocytosis (HLH); a disease characterized by excessive immune activation. Many patients…
Webers C, Ortolan A, Sepriano A et al. · 2023 · Annals of the rheumatic diseases
Objective To update the evidence on efficacy and safety of biological disease-modifying antirheumatic drugs (bDMARDs) in patients with axial spondyloarthritis (axSpA) to inform the 2022 update of the Assessment of SpondyloArthritis…
Ma XT, Yao GY, Li JL et al. · 2025 · World journal of clinical oncology
Background Human epidermal growth factor receptor 2 (HER2)-positive gastric cancer (GC) represents a distinct molecular cancer subtype that is often associated with a poor prognosis. While perioperative chemotherapy regimens are currently…
Çam Ö, Ateş MO, Keleş A · 2026 · BMC oral health
BACKGROUND: The aim of this study was to evaluate the association of buccolingual width (BLW), age, and gender with the detection of a lingual canal in mandibular anterior teeth using cone-beam computed tomography (CBCT). METHODS: CBCT…
Mohammed ABAERAAK, Abdallah AM · 2026 · Preprint
Abstract Background: The thyroid gland is a vital endocrine organ responsible for the secretion of triiodothyronine (T3) and thyroxine (T4), hormones that regulate metabolism, growth, and tissue development. Thyroid dysfunction, including…
Szablewska AW, Zając B · 2026 · Scientific reports
Gestational diabetes mellitus (GDM) is associated with various perinatal complications and may affect neonatal acid-base status. Umbilical cord arterial blood gas (ABG) analysis provides an objective measure of fetal well-being at birth,…
Mohamed NS, Abdel Aziz NAS · 2026 · Cutaneous and ocular toxicology
Purpose To quantitatively assess the macular microvasculature after intravenous chemotherapy (IVC) for retinoblastoma (RB) using optical coherence tomography angiography (OCTA). Methods A case control study compared the OCT and OCTA…
Soenarti S, Sitorus S, Nugroho MB et al. · 2026 · Rehabilitacion
Sarcopenia represents a leading cause of functional decline in older adults. This randomized controlled trial examined whether the addition of ankle weights to a Nordic walking protocol yields superior outcomes compared with standard…
Bader S, Magnuson A, Brorsson C et al. · 2026 · European journal of trauma and emergency surgery : official publication of the European Trauma Society
Background Haemorrhagic shock (HS) is frequently associated with secondary cerebral injury due to compromised cerebral perfusion. Resuscitative endovascular balloon occlusion of the aorta (REBOA) is an effective haemorrhage control…
Iyiol AR · 2026 · Cureus
Background Intestinal ischemia-reperfusion (I/R) injury represents a critical clinical condition characterized by oxidative stress, inflammatory activation, and impairment of intestinal mucosal integrity. Although restoration of blood flow…
Mizushima Y, Whaley C, Kaimal A et al. · 2026 · JAMA network open
Importance Noneconomic damage caps, a form of medical malpractice law, remain controversial, as several states have enacted such laws since 2010, whereas others have repealed them. The clinical consequences of repealing these caps are…
Longo UG, Mazzola A, Stelitano G et al. · 2026 · Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine
Objective The aim of this study was to evaluate, in runners participating in the 2019 Rome Marathon, the interaction between resilience and coping and how they are influenced by sex, age, body weight, height, number of weekly training…
Eke H, Toprak B, Bozkurt ED · 2026 · Journal of cardiothoracic surgery
BACKGROUND: Laryngoscopy and intubation provoke strong sympathetic activation and may cause hemodynamic instability in cardiovascular surgery patients. Maintaining adequate hypnotic depth and cerebral oxygenation during induction is…
Mujayridi M, Matinlinna J, Silikas N · 2026 · Materials (Basel, Switzerland)
Three-dimensional (3D) printing is increasingly used for the fabrication of definitive crowns; however, whether specific post-curing hardware is mandatory for clinical success remains a practical concern. This study provided a practical…
Duc TA, Ha NTT, Toan NK et al. · 2026 · La Clinica terapeutica
Background Labor induction is commonly performed in high-risk pregnancies, but can also be beneficial in low-risk populations, as shown in the ARRIVE trial. This study aimed to compare the effectiveness and pregnancy outcomes of labor…
Ayesh W, Houry E, Hodges G · 2026 · The neurologist
Objective Optimal timing of initiation of pharmacologic venous thromboembolism (VTE) prophylaxis following intracerebral hemorrhage is controversial. This study aims to assess the association between the timing of pharmacologic VTE…
Novikova L, Lang C, Tumani H et al. · 2026 · Brain communications
Weight loss, partially caused by hypermetabolism, represents a well-documented and therapeutically relevant feature of the amyotrophic lateral sclerosis phenotype worldwide. In this study, we retrospectively analysed the association…
Gür S, Soyal M · 2026 · BMC sports science, medicine & rehabilitation
BACKGROUND: Resistance training plays a crucial role in the planning and implementation of all sports requiring optimal performance. The literature on resistance exercise encompasses many different methods. The aim of this study is to…
Türk B, Metin G, Fencki SM et al. · 2026 · Journal of bodywork and movement therapies
Background Type 2 diabetes mellitus (T2DM) can impair musculoskeletal function, affecting the shoulder's mobility, proprioception, and functional stability. Despite its growing prevalence, shoulder involvement in T2DM remains largely…
Yıldırım D, Zorluoğlu SL, Navruz ES et al. · 2026 · BMC oral health
Background Oral and dental health education is typically delivered using visual methods on jaw models. However, these methods are insufficient for individuals with visual impairments. This study aims to contribute to the oral and dental…
Sousa MM, Vieira LP, Pinho AR et al. · 2026 · JSES reviews, reports, and techniques
Background Radial head fractures are among the most common elbow injuries in adults. The choice between osteosynthesis and radial head arthroplasty (RHA) remains controversial, particularly in comminuted or unstable fracture patterns. This…
Angenent A, Maaskant JM, Nieland L et al. · 2026 · European journal of pediatrics
This study evaluates the effect of a comfort assessment using focus language compared with pain assessment using the Numeric Rating Scale (NRS) on postoperative length of stay (LOS), analgesic use and patient and parental satisfaction.…
Azmy Basiouny HM, Shafik AA, Elbarmelgi MY et al. · 2026 · BMC surgery
Background While current surgical approaches for obstructed defecation syndrome (ODS) primarily target rectocele and rectal intussusception, excessive perineal descent (PD) may contribute to persistent symptoms and suboptimal surgical…
Al-Eitan LN, Alasmar MK, Alorjani MS et al. · 2026 · Frontiers in medicine
Background Vitamin D exerts a protective role in carcinogenesis by regulating signaling pathways implicated in tumor growth and progression. Variants in CYP2R1, CYP24A1, CYP27B1, and DBP have been reported to influence circulating 25(OH)D…