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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21350 results · page 576 of 712

Negative / Null Result Report

The individual and combined impacts of school-based water, sanitation, and hygiene (WASH) education and infrastructure operation and maintenance (O&M): A factorial cluster-randomized controlled trial in Uttar Pradesh, India

Hornsby G, Pu C, Badamikar A et al. · 2025 · Preprint

ABSTRACT Introduction While improving water, sanitation, and hygiene (WASH) service delivery in schools supports the Sustainable Development Goals, rigorous trials have recently reported inconsistent effects of WASH in schools (WinS)…

View details →DOI: 10.1101/2025.10.23.25338677
Negative / Null Result ReportMedicine

Replicating the use of motivational interviewing and facilitated contraceptive access to reduce repeat adolescent pregnancy: A randomized trial.

Harding JF, Walzer J, Piatt R et al. · 2025 · Contraception

Objectives It is important to identify programs that can work in multiple contexts to support adolescent parents in achieving their reproductive health goals. A randomized controlled trial in Ohio in 2012 found that the Teen Options to…

View details →DOI: 10.1016/j.contraception.2025.111200
Negative / Null Result ReportMedicine

Independent effects of sex and ear-canal size on auditory brainstem response amplitudes in young adults.

Guest H, Plack CJ, Munro KJ et al. · 2026 · International journal of audiology

Objective Adult auditory brainstem response (ABR) amplitudes are employed by both researchers and clinicians, but exhibit substantial between-subject variability, reducing their sensitivity as measures of underlying auditory health. One…

View details →DOI: 10.1080/14992027.2025.2530713
Negative / Null Result ReportOpen accessMedicine

Foetal Exposure to Phthalates and Endocrine Effects on the Leydig Cell.

Nielsen SP, Mathiesen L, Møller P · 2025 · Basic & clinical pharmacology & toxicology

This review examines the association between early life exposure to phthalates in human males and Leydig cell endocrine function. A systematic search was performed in PubMed and EMBASE, identifying 17 studies for analysis. Association…

View details →DOI: 10.1111/bcpt.70035
Negative / Null Result ReportOpen accessMedicine

Causal effects of single-carbon metabolism and vitamin levels on autism spectrum disorder risk: a bidirectional Mendelian randomized study.

Zhu J, Yi Y, Ma L et al. · 2026 · Italian journal of pediatrics

BACKGROUND: Observational epidemiology studies suggested a relationship between single-carbon metabolism and vitamin levels with autism spectrum disorder (ASD) risk. We aimed to explore the causal relationship between them at the genetic…

View details →DOI: 10.1186/s13052-026-02254-1
Negative / Null Result Report

Return of Threat Expectancy Likelihood After an Exposure Exercise as Dynamic Predictor of Intervention Outcome in Fear of Public Speaking

Bouwman V, Pittig A, Engelhard I et al. · 2025 · Preprint

Although exposure-based Cognitive Behavioral Therapy is generally effective for anxiety disorders, many people do not benefit. A better understanding of treatment predictors is required. This study investigated whether the dynamics of…

View details →DOI: 10.31234/osf.io/6s23z_v1
Negative / Null Result ReportMedicine

Exploring the links between functional activation and hallucination proneness.

Alotaibi AM, Alosaimi MH, Orfali RS et al. · 2025 · Brain research bulletin

Hallucinations are often associated with alterations in brain activation, particularly in language-related and sensory processing areas. Existing models suggest different frameworks for understanding the relationship between brain…

View details →DOI: 10.1016/j.brainresbull.2025.111424
Negative / Null Result ReportMedicine

The association between residential natural vegetation exposure at diagnosis and colorectal cancer-specific mortality among colorectal cancer cases in Kentucky.

Newton JD, Ellis T, Ruther M et al. · 2026 · Environmental research

Living near green areas with high vegetation may contribute to an active lifestyle, stress reduction, and enhance social cohesion, and consequently may be associated with improved cancer survival. Epidemiologic studies focused on greenness…

View details →DOI: 10.1016/j.envres.2025.123574
Negative / Null Result ReportOpen accessMedicine

The Effect of Myo-Inositol Supplementation During Pregnancy on Fetal and Maternal Outcomes: Results of the Myo-Inositol for the Prevention of Gestational Diabetes Mellitus (MiGDM) Randomized Double-Blind, Placebo-Controlled Pilot Trial.

Okunoye G, George Samuel C, Abdullahi H et al. · 2026 · Cureus

Gestational diabetes mellitus (GDM) is a common pregnancy complication with significant maternal and neonatal risks, and its prevalence is particularly high in Qatar. Myo-inositol has been proposed as an insulin-sensitizing supplement that…

View details →DOI: 10.7759/cureus.102259
Negative / Null Result ReportOpen accessMedicine

No Support for White Matter Alterations in Adults With Dyslexia: A Fixel-Based Diffusion MRI Study.

Verhelst H, Gerrits R, Karlsson EM · 2025 · Neurobiology of language (Cambridge, Mass.)

Developmental dyslexia is a common learning disability marked by reading and spelling difficulties. While previous imaging studies aiming to elucidate the neurobiological mechanisms of this disorder have reported white matter alterations,…

View details →DOI: 10.1162/nol.a.17
Negative / Null Result ReportMedicine

Effect of different durations of treatment with antihypertensive drugs with anticholinergic effects on the risk of dementia: a target trial emulation study.

Aguado J, Gutierrez L, Forns J et al. · 2025 · American journal of epidemiology

Studying the effect of duration of treatment on prognostic outcomes using real-world data is challenging because only people who survive for a long time can receive a treatment for a long time. Specifying a target trial helps overcome such…

View details →DOI: 10.1093/aje/kwae263
Negative / Null Result ReportMedicine

Losing sleep? The effects of exposure to shootings near one's residence on self-reported sleep quantity in Chicago, 2020-2021.

McLone SG, Coleman CM, Matzke HJ et al. · 2026 · American journal of epidemiology

Firearm violence is a public health crisis in the United States and negatively impacts individuals and communities. We used data from The Healthy Chicago Survey, a citywide survey of 8754 respondents from 2020 to 2021, and police-reported…

View details →DOI: 10.1093/aje/kwaf031
Negative / Null Result ReportOpen accessMedicine

Negative news exposure does not affect risk or ambiguity aversion.

Garcia Campos LS, Lempert KM · 2025 · Frontiers in psychology

Introduction Uncertain decisions can be risky (with known probabilities) or ambiguous (with unknown probabilities). Previous studies have found that negative affect can increase risk aversion and ambiguity aversion, but it is unknown if…

View details →DOI: 10.3389/fpsyg.2025.1485346
Negative / Null Result ReportOpen accessMedicine

Elusive effects of legalized wolf hunting on human-wolf interactions.

Merz LM, von Hohenberg BC, Bergmann NT et al. · 2025 · Science advances

Expanding gray wolf ( Canis lupus ) populations in Europe and North America contribute to increased risks of livestock predation, which can threaten human livelihoods and lead government agencies to target wolves for lethal removal. Public…

View details →DOI: 10.1126/sciadv.adu8945
Negative / Null Result ReportOpen accessMedicine

Psychotherapy Process Dynamics and Their Relation to Treatment Success Do Not Differ Across Diagnoses.

Seizer L, Kratzer L, Löchner J et al. · 2026 · Clinical psychology & psychotherapy

Psychotherapy process research increasingly uses intensive longitudinal monitoring to capture dynamic patterns of change in patients. In this study, 283 psychiatric inpatients diagnosed with depression (n = 70), PTSD (n = 148),…

View details →DOI: 10.1002/cpp.70222
Negative / Null Result ReportMedicine

Speech sounds in larger inventories are not (necessarily) less variable.

Hauser I · 2022 · The Journal of the Acoustical Society of America

This paper reconsiders a classic claim about phonetic variability-that speech sounds in larger phonemic inventories should exhibit less within-category variability in production. Although this hypothesis is intuitive, existing literature…

View details →DOI: 10.1121/10.0014912
Failed Experiment ReportOpen accessMedicine

Effects of transcutaneous electrical stimulation on peripheral nerve regeneration after digital neurorrhaphy: A randomized clinical trial.

de Mattos ESR, Guedes A, Zana Y et al. · 2025 · F1000Research

Background Sensory recovery following digital nerve neurorrhaphy is often incomplete, and strategies to enhance regeneration remain under investigation. Low-frequency transcutaneous electrical stimulation has been proposed as a potential…

View details →DOI: 10.12688/f1000research.169801.3
Negative / Null Result ReportMedicine

Maternal Mediterranean Diet during Pregnancy and Adiposity from Early Childhood through Preadolescence.

Gonzalez-Nahm S, Griffith E, Maguire RL et al. · 2026 · Childhood obesity (Print)

Objective To assess the longitudinal associations between maternal diet during pregnancy and child adiposity between ages 2 and 12 years. Methods Repeated measures linear regression models with autoregressive covariance were used to assess…

View details →DOI: 10.1177/21532176261420979
Negative / Null Result ReportOpen accessMedicine

Examining valproate's potential anticancer effect among patients with bipolar disorder: a territory-wide active-comparator new user study spanning two decades.

Wei C, Ng VWS, Wei Y et al. · 2025 · BMC psychiatry

AIMS: Preclinical studies have suggested potential anticancer effects of valproate, but clinical evidence is limited and inconclusive. This study aims to reexamine the relationship between valproate use and cancer incidence, using lithium…

View details →DOI: 10.1186/s12888-025-07622-5