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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20261 results in Negative / Null Result Report · page 573 of 676

Negative / Null Result ReportMedicine

Effect of High-Dose vs Standard-Dose Vitamin D Supplementation in Pregnancy on Bone Mineralization in Offspring Until Age 6 Years: A Prespecified Secondary Analysis of a Double-Blinded, Randomized Clinical Trial.

Brustad N, Garland J, Thorsen J et al. · 2020 · JAMA pediatrics

Importance Studies suggest an association between maternal vitamin D status during pregnancy and offspring anthropometry and bone mineralization, but investigations are few and with mixed results. Objective To investigate the effect of a…

View details →DOI: 10.1001/jamapediatrics.2019.6083
Negative / Null Result ReportOpen accessMedicine

Cholesterol efflux capacity of high-density lipoprotein was not associated with cognitive decline and brain structures in older people with diabetes mellitus.

Wu Y, Tan KC, Shiu SW et al. · 2022 · Journal of diabetes investigation

Aims/introduction To examine the association between cholesterol efflux capacity (CEC) of serum high-density lipoprotein (HDL) and cognitive function and brain structures in older people with diabetes mellitus. Materials and methods…

View details →DOI: 10.1111/jdi.13875
Negative / Null Result ReportMedicine

Pediatric ondansetron hypersensitivity: Clinical features and a preliminary diagnostic approach.

Genis C, Torun Ozel C, Selmanoglu A et al. · 2025 · Allergy and asthma proceedings

Background: Ondansetron is a common antiemetic that rarely causes hypersensitivity. Skin-prick testing (SPT) and intradermal testing (IDT) may assist in diagnosing ondansetron hypersensitivity; however, their sensitivity, specificity, and…

View details →DOI: 10.2500/aap.2025.46.250057
Negative / Null Result ReportMedicine

Three ways to find a fluke: Evaluating diagnostic methods for Fasciola hepatica surveillance in Swedish sheep.

Felländer M, Grandi G, Juremalm M et al. · 2026 · Veterinary parasitology, regional studies and reports

Infections with Fasciola hepatica are most prevalent in south-western Sweden, but climate change may facilitate further spread, as both the parasite and its snail host thrive in humid, mild conditions. Sheep are particularly susceptible,…

View details →DOI: 10.1016/j.vprsr.2026.101469
Negative / Null Result ReportMedicine

[The Simplest Scheme for Detection of "Asian-Type" DEL in Clinical Blood Transfusion Laboratories].

Yi P, Ou ZY, Wang MM et al. · 2026 · Zhongguo shi yan xue ye xue za zhi

Objective To explore the simplest scheme for detection of "Asian-type" DEL in clinical blood transfusion and its application effectiveness. Methods 100 pregnant women who tested Rh(D) negative by the saline method were selected. Their…

View details →DOI: 10.19746/j.cnki.issn1009-2137.2026.02.023
Negative / Null Result Report

Environmental Sensitivity and Digit Ratio (2D:4D): Negative Results

Iimura S, Nishaat A · 2025 · Preprint

The current study explored the associations between different levels of developmental plasticity factors—specifically, prenatal androgen exposure and the personality trait related to environmental sensitivity. We recruited participants…

View details →DOI: 10.31234/osf.io/563nm_v2
Negative / Null Result ReportMedicine

Reassessing negative 24 h pH impedance tests for hidden gastroesophageal reflux disease using multi feature anomaly detection.

Lee S, Lee J, Park D et al. · 2026 · NPJ digital medicine

Gastroesophageal reflux disease (GERD) diagnosis traditionally relies on acid exposure time (AET) obtained from 24-h multichannel intraluminal impedance-pH (MII-pH) monitoring, the gold standard for GERD diagnosis. However, a negative…

View details →DOI: 10.1038/s41746-026-02796-y
Negative / Null Result ReportMedicine

Testing Multiple Tissues Improves Performance of Diagnostic Assays for Chronic Wasting Disease in Elk (Cervus canadensis).

Galloway NL, Sargeant GA, Powers JG et al. · 2026 · Journal of wildlife diseases

Effective wildlife disease management and research rely on trustworthy disease diagnostics. For chronic wasting disease (CWD), immunohistochemistry (IHC) is recognized as the gold standard, and ELISA is a reliable high-throughput screening…

View details →DOI: 10.7589/jwd-d-25-00164
Negative / Null Result ReportMedicine

[The challenge of delabeling antibiotic allergy in Colombian children: do parents trust the negative result of the drug provocation test with the implicated antibiotic?]

Rincón-González AM, Galeano-Tamayo DC, Zuluaga LSD · 2025 · Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)

Objective To explore the factors associated with the use of the antibiotic implicated in an adverse reaction following a negative challenge test in pediatric patients in a clinical allergology service of a health institution in Medellin.…

View details →DOI: 10.29262/ram.v72i3.1465
Negative / Null Result ReportMedicine

Cervical length and fetal fibronectin for the identification of true spontaneous onset of labor.

Warintaksa P, Youkhong C, Trikasemmart M et al. · 2026 · The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

Introduction True labor is characterized by regular uterine contractions and cervical changes. However, the precise diagnosis of the "onset" of true labor is challenging, as the examination of cervical changes requires multiple timepoints,…

View details →DOI: 10.1080/14767058.2026.2670757
Negative / Null Result ReportMedicine

Suspicious bands in serum and urine protein immunofixation electrophoresis tests in patients with and without a history of monoclonal gammopathies: a retrospective database study.

Dincer M, Aydin O, Karakus V et al. · 2026 · Laboratory medicine

Introduction Electrophoresis tests are reported as negative, positive, or-rarely-as suspicious for monoclonal band (SfMB). This study aimed to determine the fate of patients with SfMB findings in long-term follow-up. Methods Patients with…

View details →DOI: 10.1093/labmed/lmag013
Negative / Null Result ReportMedicine

Circulating Tumor High Risk HPV DNA as the HPV-Specific Test in Oropharyngeal Squamous Cell Carcinoma Patients.

Hidalgo CM, Yin LX, Bogan AW et al. · 2026 · Head and neck pathology

Purpose The uses for circulating tumor high risk human papillomavirus DNA (ctHPVDNA) in the diagnostic work-up and treatment of HPV-associated oropharyngeal squamous cell carcinoma (HPV( +)OPSCC) patients are actively being investigated.…

View details →DOI: 10.1007/s12105-026-01911-5
Negative / Null Result ReportOpen accessMedicine

Stage IV Rectal Adenocarcinoma After Negative Multitarget Stool DNA-Fecal Immunochemical Test in a Symptomatic Patient: Misapplication of a Screening Test in a Diagnostic Context.

Omari Y, Nohomovich B, Sallam D et al. · 2026 · Cureus

Multitarget stool DNA-fecal immunochemical testing (mt-sDNA-FIT) is validated for colorectal cancer (CRC) screening in asymptomatic, average-risk adults. However, its application in symptomatic patients represents a misuse of a screening…

View details →DOI: 10.7759/cureus.110890
Negative / Null Result ReportOpen accessMedicine

Use of the dual tyrosine kinase inhibitor lapatinib for the treatment of vulvovaginal squamous cell carcinoma in a dog.

Vardanega MJ, Longo T, Aceino A et al. · 2026 · Journal of veterinary internal medicine

Vulvovaginal squamous cell carcinoma (SCC) is an uncommon neoplasm in dogs. An 11-year-old female spayed German Shepherd dog presented with a history of excessive peri-vulvar grooming and a 3 cm × 3 cm irregular mass involving the vagina…

View details →DOI: 10.1093/jvimsj/aalag116
Negative / Null Result ReportMedicine

A comprehensive multicenter study assessing the impact of abelacimab, asundexian and milvexian on coagulation assays.

Goubeau L, Curis E, Delavenne X et al. · 2026 · Blood advances

Phase 3 trials evaluating inhibitors of coagulation factor (F) XI and/or its activated form (FXIa) as novel anticoagulant drugs are ongoing. These agents include parenteral monoclonal antibody (abelacimab) and oral small molecules…

View details →DOI: 10.1182/bloodadvances.2026020472
Negative / Null Result ReportOpen accessMedicine

Phenotypic spectrum and molecular characteristics of variants of uncertain significance in copy number variations associated with fetal cardiac malformations: a case series of 9 patients.

Yin J, Wang Q, Lan T et al. · 2026 · Frontiers in pediatrics

Background Copy number variants of uncertain significance (VUS-CNVs) pose significant challenges in prenatal counseling for congenital heart malformations (CHMs). Their clinical relevance remains poorly defined, particularly in the absence…

View details →DOI: 10.3389/fped.2026.1696089
Negative / Null Result ReportOpen accessMedicine

Overall Diagnostic Efficiency of a Noninvasive Diagnostic Strategy Aimed at Early Detection of Advanced Liver Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease Cases.

Iwata K, Mori N, Ogasawara K · 2025 · Cureus

Introduction Noninvasive methods for assessing liver fibrosis are increasingly important for early detection of advanced liver fibrosis (ALF), particularly in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).…

View details →DOI: 10.7759/cureus.93549
Negative / Null Result ReportOpen accessMedicine

The Effect of Oral Supplementation with a Multi-Strain Probiotic Preparation on Group B Streptococcus (GBS) Carriage in Pregnant Women-A Pilot Study.

Zych-Krekora K, Sylwestrzak O, Krekora M · 2026 · Journal of clinical medicine

Background/Objectives : Maternal rectovaginal carriage of Group B Streptococcus (GBS, Streptococcus agalactiae ) is a major risk factor for vertical transmission and early-onset neonatal infection. Intrapartum antibiotic prophylaxis…

View details →DOI: 10.3390/jcm15031113
Negative / Null Result ReportOpen accessMedicine

Comparative analysis of third-generation dual-energy CT and IVUS for in-stent restenosis detection.

Eldeeb MEA, Mostafa MA, Nagiub TA et al. · 2025 · BMC cardiovascular disorders

Purpose Prior studies have assessed in-stent diameter restenosis (ISDR) in coronary arteries using 64-slice multidetector computed tomography coronary angiography (MDCT-CA) compared to invasive coronary angiography (ICA), which is the gold…

View details →DOI: 10.1186/s12872-025-04836-z
Negative / Null Result ReportMedicine

Cardiac Channelopathies in the Pediatric Patient: Long QT Syndrome.

Follansbee CW, Landstrom AP, Aziz PF · 2025 · Cardiac electrophysiology clinics

Congenital long QT syndrome is the most common inherited arrhythmia syndrome and is characterized by prolongation of the QT interval in the absence of structural heart disease or external factors. Disease will often manifest during…

View details →DOI: 10.1016/j.ccep.2025.07.011
Negative / Null Result ReportOpen accessMedicine

Utility and clinical relevance of multiplex PCR panels for diagnosis of central nervous system infections.

Gürler M, Karaoğlu Ç, Yurtcu EE et al. · 2026 · The Indian journal of medical research

Background and objectives Multiplex molecular panels for meningitis and encephalitis (M&E) allow rapid detection of multiple pathogens directly from cerebrospinal fluid (CSF) samples. Although their use is expanding, real-world data on…

View details →DOI: 10.25259/ijmr_2107_2025
Negative / Null Result ReportOpen accessMedicine

Clinical predictors of enzyme immunoassay accuracy in Clostridioides difficile infection: the impact of immune status and infection predisposing factors.

Duan S, Lv T, Zheng L et al. · 2026 · BMC infectious diseases

BACKGROUND: Clostridioides difficile infection (CDI) is a major cause of healthcare-associated diarrhea, with increasing prevalence in China and the Asia-Pacific region. Despite its limited sensitivity, the enzyme immunoassay (EIA) is…

View details →DOI: 10.1186/s12879-026-13252-3
Negative / Null Result ReportOpen accessMedicine

Progressive Supranuclear Palsy (PSP): An Orthoptic Assessment.

Burdon D, Mullin S, Harris C · 2026 · The British and Irish orthoptic journal

Aim Progressive supranuclear palsy (PSP) is an atypical Parkinsonian disorder which, like other atypical Parkinsonian disorders, displays neurological motor and oculomotor signs at different stages along the disease course. The overlap in…

View details →DOI: 10.22599/bioj.505