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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19895 results in Negative / Null Result Report · page 571 of 664

Negative / Null Result ReportMedicine

Posttraumatic cognitions and PTSD symptom change in massed prolonged exposure: The impact of treatment delivery on mechanisms of change.

Burton M, Haft S, Fiskeaux M et al. · 2026 · Journal of anxiety disorders

Background Prolonged Exposure (PE) is an effective treatment for PTSD and clarification of mechanisms of change can inform training and continued improvements. Posttraumatic cognitions have been shown to predict subsequent symptom change…

View details →DOI: 10.1016/j.janxdis.2026.103186
Negative / Null Result ReportMedicine

Thalamic Volume Asymmetry as a Potential Predictor of Vagus Nerve Stimulation Outcomes in Refractory Epilepsy.

Ujihara M, Kawabori M, Nakajima M et al. · 2026 · Neurologia medico-chirurgica

Vagus nerve stimulation is an established treatment for refractory epilepsy, but predictors of treatment response remain unclear. Given that left-sided vagus nerve stimulation preferentially modulates the left thalamus and that epileptic…

View details →DOI: 10.2176/jns-nmc.2025-0409
Negative / Null Result ReportMedicine

Longitudinal profiles of parental self- and child-focused emotion regulation.

Jordan G, Stockinger K, Schiltz C et al. · 2026 · Communications psychology

Parenting is an emotion-eliciting experience that requires parents to navigate the dual demands of regulating their own and their children's emotions, drawing on regulatory strategies such as reappraisal and rumination. However, patterns…

View details →DOI: 10.1038/s44271-026-00469-w
Negative / Null Result ReportMedicine

Assessing Knowledge About Living Kidney Donation Among Transplant Candidates and Relationship to Seeking a Living Donor.

Werenski H, Stratta R, McCracken E et al. · 2026 · Clinical transplantation

Introduction Despite well-established advantages of living-donor kidney transplantation (LDKT), LDKT growth has stagnated. Barriers to seeking a living donor include insufficient knowledge among candidates and discomfort discussing LDKT.…

View details →DOI: 10.1111/ctr.70591
Negative / Null Result ReportMedicine

Risk Factors, Biomarkers, and Risk Assessment Models for Prediction of Venous Thromboembolism in Ambulatory Patients with Advanced Lung Cancer.

Ay L, Moik F, Füreder T et al. · 2026 · Hamostaseologie

Summary BACKGROUND: Patients with lung cancer are at high risk of developing venous thromboembolism (VTE). Although several risk assessment models (RAMs) for cancer-associated VTE exist, their performance in advanced lung cancer is…

View details →DOI: 10.1055/a-2882-0557
Negative / Null Result ReportMedicine

Associations among maternal prenatal depression, maternal autism traits, and child autism traits in the Environmental Influences on Child Health Outcome (ECHO) program.

Nutor C, Dunlop AL, Brennan PA · 2026 · Journal of neurodevelopmental disorders

Background Maternal depression during pregnancy has been associated with increased risk of offspring autism spectrum disorder (ASD) - a highly heritable neurodevelopmental disorder. However, no study to date has taken into account maternal…

View details →DOI: 10.1186/s11689-026-09709-w
Negative / Null Result ReportMedicine

A simple clinical risk score can predict frailty in HNSCC patients.

Kunz V, Wald T, Gaenzle M et al. · 2026 · Cancer treatment and research communications

Introduction Frailty is a predictor of adverse outcomes in cancer patients, but its assessment in head and neck squamous cell carcinoma (HNSCC) patients is often limited due to time-consuming questionnaires being required for comprehensive…

View details →DOI: 10.1016/j.ctarc.2026.101253
Negative / Null Result ReportMedicine

Trajectories of physical fitness following paediatric burn injury: A two-year longitudinal and predictive analysis.

Basha MA, Elnaggar RK, Aloraini SM et al. · 2026 · Clinical rehabilitation

ObjectiveTo analyse physical fitness trajectories in paediatric burn survivors from discharge to 2 years post-injury, compare them with an age- and gender-matched control group, and identify baseline demographic and clinical…

View details →DOI: 10.1177/02692155261459618
Negative / Null Result Report

Gendered Interest Structures Exist and Persist Throughout Adolescence: A Latent Profile and Transition Analysis of Academic and Vocational Interests in German Students

Welling J, Ehrtmann L, Malapally A et al. · 2026 · Preprint

Gendered interests are an important driver of gendered academic and vocational decisions and thus contribute to sustaining gender inequalities in the European labor market. Therefore, in order to counteract these inequalities, it is…

View details →DOI: 10.31234/osf.io/zv6yt_v1
Negative / Null Result ReportMedicine

The interplay between feedback literacy and feedback engagement in writing tasks for multilingual higher education students.

Boudouaia A, Mouas S, Mohamed AM et al. · 2026 · Acta psychologica

Understanding feedback is critical for students to cope with the complexities of multilingual development and transfer across languages. While it is crucial that students possess feedback literacy (FL) as a tool for engagement growth in…

View details →DOI: 10.1016/j.actpsy.2025.106110
Negative / Null Result ReportMedicine

Development of a new disseminated intravascular coagulation score tailored for patients with chronic liver disease: a prospective observational study.

Scarlatescu E, Lisman T · 2026 · Journal of thrombosis and haemostasis : JTH

Background Diagnosing disseminated intravascular coagulation (DIC) in patients with chronic liver disease is challenging because cirrhosis-related hemostatic abnormalities mimic DIC laboratory features, leading to frequent overdiagnosis…

View details →DOI: 10.1016/j.jtha.2026.05.024
Negative / Null Result ReportMedicine

Genetic and Environmental Associations Between Processing Speed and Executive Functions Across Adolescence and Established Adulthood.

Karhadkar MA, Friedman NP, Reynolds CA et al. · 2026 · Behavior genetics

Processing speed (PS), the rate at which an individual can perform basic cognitive tasks, and executive functions (EFs), cognitive abilities regulating thoughts and action, are key cognitive abilities related to important life outcomes. We…

View details →DOI: 10.1007/s10519-026-10271-3
Negative / Null Result Report

Longitudinal brain structural changes during clozapine treatment: associations with neuroreceptor architecture and clinical response

King B, Cannon DM, Crossley NA et al. · 2026 · Preprint

In treatment-resistant schizophrenia, clozapine treatment has been associated with longitudinal reductions in subcortical volumes, ventricular enlargement, and widespread cortical thinning. However, it is unknown how these structural…

View details →DOI: 10.64898/2026.06.06.26354980
Negative / Null Result ReportMedicine

Long-term outcomes after recovery from pediatric acute sinusitis with orbital complications.

Phung C, Wei K, Rizzi MD et al. · 2026 · International journal of pediatric otorhinolaryngology

Objective This study aims to assess whether an occurrence of acute sinusitis with orbital complications in childhood is associated with the development of long-term complications, including the development of chronic rhinosinusitis (CRS),…

View details →DOI: 10.1016/j.ijporl.2026.112881
Negative / Null Result ReportMedicine

Nightmares, insomnia, and suicide within a trauma-exposed sample.

West Staples V, Angle E, Pickering A et al. · 2026 · Psychological trauma : theory, research, practice and policy

Objective The literature is mixed regarding the relationship between nightmares and suicide, with some suggesting that the variance in nightmares is explained by fear of sleep (FoS), insomnia, and/or obstructive sleep apnea (OSA). We add…

View details →DOI: 10.1037/tra0002202
Negative / Null Result ReportMedicine

Do Child Communicative Abilities Predict Subjective Wellbeing and Satisfaction With Family Life in Caregivers of Minimally Verbal Children?

Saul J, McGuinness L, Cooke M et al. · 2026 · Journal of autism and developmental disorders

Purpose Caregivers of children with neurodevelopmental conditions often experience poor mental wellbeing, which may be influenced by their child's behavioural or communicative profile. Few studies have focussed exclusively on caregivers of…

View details →DOI: 10.1007/s10803-026-07351-y
Negative / Null Result ReportMedicine

Exposure to Feline Viruses in European Wildcats (<i>Felis s. silvestris</i>) in Germany: Spatial Patterns and Environmental Risk Factors.

Heddergott M, Pikalo J, Müller F et al. · 2026 · Viruses

While viral diseases of domestic cats ( Felis catus ) can threaten the recovery of the European wildcat ( Felis s. silvestris ), their epidemiology in wildcat populations remains poorly understood. Here, we analyzed 428 road-killed…

View details →DOI: 10.3390/v18060627
Negative / Null Result Report

Predictive Value of Polypharmacy and Inappropriate Medication Use in Older Emergency Department Patients: A Retrospective Observational Study

Holstein R, Hongisto M, Jämsen E et al. · 2026 · Preprint

Abstract Background. Polypharmacy and potentially inappropriate medication (PIM) use are well-known risk factors for drug-related problems among older adults, but their association with clinical outcomes of older emergency department (ED)…

View details →DOI: 10.21203/rs.3.rs-9326583/v1
Negative / Null Result ReportMedicine

The temporal interplay between physical activity, emotional well-being, and health-related quality of life in individuals with recently diagnosed type 2 diabetes mellitus: a cross-lagged panel analysis.

Kristoffersen SF, Domazet SL, Pouwer F et al. · 2026 · Diabetes research and clinical practice

Aims We investigated longitudinal, bidirectional associations between objectively measured moderate to vigorous physical activity (MVPA), health-related quality of life (HRQoL), and emotional well-being (EWB) in individuals recently…

View details →DOI: 10.1016/j.diabres.2026.113185