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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20261 results in Negative / Null Result Report · page 571 of 676

Negative / Null Result Report

From Silos to Flows by Redesigning Regional Care for System-Wide Coordination: A Qualitative Study of Organizational Capabilities and Governance in Sweden

Carlsson KS, Brommels M, Ohrling M · 2026 · Preprint

Abstract Background Decentralised and market-inspired health system reforms have increased organisational plurality and local autonomy but often intensify fragmentation and complicate system-wide coordination. This study explored how…

View details →DOI: 10.21203/rs.3.rs-8703981/v1
Negative / Null Result ReportMedicine

Association Between Plasma Pentosidine and Skeletal Muscle-Related Indices in Older Adults Without Diabetes.

Shida T, Hatanaka S, Ohta T et al. · 2026 · Geriatrics & gerontology international

Aim This study examined the association between plasma pentosidine concentrations-an advanced glycation end-product marker-and skeletal muscle morphometric indices, physical function, and sarcopenia among community-dwelling older adults…

View details →DOI: 10.1111/ggi.70515
Negative / Null Result ReportMedicine

Prevention or relief? Voters' support for disaster policies.

Kim HH, Cragun J, DeScioli P · 2026 · Disasters

Researchers have argued that preventing disasters is more efficient than providing relief. Yet, previous scholarship has found that voters in the United States reward politicians more for relief than for prevention policies. It is unclear,…

View details →DOI: 10.1111/disa.70016
Negative / Null Result ReportMedicine

Educational Interventions to Improve Student Pharmacists' Empathy and Attitudes Toward Older Adults or Aging: A Scoping Review.

Gray SL, Liberman M, Onukwufor E et al. · 2026 · American journal of pharmaceutical education

Objectives Ageism remains a pervasive barrier to delivering high-quality health care to older adults. The objective of this scoping review is to describe studies on educational interventions aimed at improving the empathy and attitudes of…

View details →DOI: 10.1016/j.ajpe.2026.101960
Negative / Null Result ReportMedicine

ADHD symptoms and problematic digital media use in emerging adults: Investigating the role of cognitive deficits as mediators.

Todorovic L, Baumer J, Larsen H · 2026 · Addictive behaviors

This study examined the relationship between ADHD symptoms and problematic social media use (PSMU) and problematic gaming (PG) in a community sample of emerging adults. Cognitive deficits underlying ADHD - inhibitory control deficits,…

View details →DOI: 10.1016/j.addbeh.2026.108608
Negative / Null Result ReportMedicine

A Diagnostic Dilemma: Concurrent Diagnosis of Cystic Fibrosis and Definitive Kabuki Syndrome Type 1.

Vasilyeva T, Kashirskaya N, Mukhina A et al. · 2026 · International journal of molecular sciences

The article presents a clinical case involving a patient with presumptive coexistence of two hereditary disorders, confirmed by molecular genetic analyses. Clinical evaluation of the proband, a 9-year-old girl, revealed features…

View details →DOI: 10.3390/ijms27052510
Negative / Null Result ReportMedicine

Causal relationship between chronic kidney disease and senile cataract: a bidirectional two-sample Mendelian randomization study.

Jin S, Huang J, Wang Y et al. · 2026 · Molecular and cellular biochemistry

Despite observed epidemiological associations, the direct causality between chronic kidney disease (CKD) and senile cataract remains unclear. This bidirectional Mendelian randomization (MR) study assessed the causal associations between…

View details →DOI: 10.1007/s11010-026-05482-5
Negative / Null Result ReportMedicine

Plasma neurotransmitter-related metabolite alterations in adolescent major depressive disorder with and without psychotic features.

Luo J, Huang H, Shao W et al. · 2026 · Journal of affective disorders

Background Whether adolescent major depressive disorder (MDD) with psychotic features has a distinct peripheral metabolite signature remains uncertain. We compared targeted plasma neurotransmitter-related metabolites in psychotic MDD,…

View details →DOI: 10.1016/j.jad.2026.121436
Negative / Null Result ReportOpen accessMedicine

Public support of and attitudes toward decriminalization of possession of illegal drugs among the general population in British Columbia.

Imtiaz S, Russell C, Ali F et al. · 2025 · Substance abuse treatment, prevention, and policy

BACKGROUND: Decriminalization of possession of illegal drugs was implemented in British Columbia, Canada for a three-year period starting from January 31, 2023. As public sentiment played a large role in the outcome of a similar reform in…

View details →DOI: 10.1186/s13011-025-00680-8
Negative / Null Result ReportMedicine

Exploring Dimensions of Posttraumatic Stress in Young Children.

Mulligan DJ, Grasso DJ, Greene CA et al. · 2026 · Research on child and adolescent psychopathology

The latent structure of posttraumatic stress symptoms (PTSS) in early childhood remains poorly understood. This study aimed to assess PTSS in young children, identify underlying latent constructs, and evaluate their construct validity.…

View details →DOI: 10.1007/s10802-025-01396-w
Negative / Null Result ReportOpen accessMedicine

Validation of the Leuven Postprandial Distress Scale According to the Rome IV Criteria for Functional Dyspepsia.

Van de Bruaene C, Carbone F, Van den Houte K et al. · 2026 · Journal of neurogastroenterology and motility

Background/aims : The Leuven Postprandial Distress Scale (LPDS) is a validated patient reported outcome (PRO) measure for functional dyspepsia (FD)/postprandial distress syndrome (PDS) patients according to Rome III criteria. However,…

View details →DOI: 10.5056/jnm25108
Negative / Null Result ReportMedicine

The role of allopurinol in metabolic dysfunction-associated steatotic liver disease: A randomized clinical trial.

Khani E, Khoshbaten M, Jafarabadi MA et al. · 2026 · Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology

Background and study aims Despite being the leading cause of liver-related mortality, the treatment of metabolic dysfunction-associated steatotic liver disease (MASLD) remains challenging. This study aimed to assess the effects of…

View details →DOI: 10.1016/j.ajg.2025.11.004
Negative / Null Result ReportMedicine

BDNF Val66Met polymorphism is linked to elevated levels of serotonin-transporter in the medial prefrontal cortex but not to altered eating behavior.

McLeod A, Rullmann M, Hinderberger P et al. · 2026 · Neuroscience

A single nucleotide polymorphism in the brain derived neurotrophic factor (BDNF)-encoding gene leads to diminished BDNF signaling resulting from Val66Met and has been linked to obesity. Previous imaging studies regarding the impact of BDNF…

View details →DOI: 10.1016/j.neuroscience.2026.03.008
Negative / Null Result ReportMedicine

Presence and correlation of potentially toxic elements in honey, pollen, and soil samples in Kosovo.

Kastrati G, Sopaj F, Bytyqi V et al. · 2025 · Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering

The study involved the determination of the concentrations of 11 potentially toxic elements (PTEs) in soil, honey, and pollen samples collected in the territory of Kosovo, followed by a statistical analysis. Inductively coupled…

View details →DOI: 10.1080/10934529.2025.2594372
Negative / Null Result Report

Personality disorder traits and impression formation: Individuals higher in detachment and antagonistic traits are perceived as less likable and trustworthy

Niedtfeld I, Störkel L, Didushok V et al. · 2025 · Preprint

The first impression a person makes can substantially influence whether and how they areapproached and treated by others. Prior research on this process suggests that individualsexhibiting higher levels of maladaptive personality traits…

View details →DOI: 10.31234/osf.io/k9sdg_v1
Negative / Null Result ReportMedicine

Peer victimization and emotion regulation strategies in adolescents: A cross-lagged panel model.

Alexander KN, Turner MS, Salazar JP et al. · 2025 · Journal of research on adolescence : the official journal of the Society for Research on Adolescence

Many adolescents experience peer victimization during this critical period for development. Emotion regulation strategies, including cognitive reappraisal and emotional suppression, can help adolescents cope with such experiences. Although…

View details →DOI: 10.1111/jora.70119
Negative / Null Result Report

Acute and chronic dosing of the GABA A alpha 2,3 selective agonist BAER-101 do not alter behavior but may impact auditory-evoked EEG responses in adults with fragile X syndrome

DeStefano L, Kim H, Erickson C et al. · 2025 · Preprint

Abstract Background: Fragile X syndrome (FXS) is characterized by sensory hypersensitivity and neural hyperexcitability linked to GABAergic dysfunction. BAER-101, formerly known as AZD7325, is a positive allosteric modulator of GABA A…

View details →DOI: 10.21203/rs.3.rs-8123031/v1
Negative / Null Result Report

Daily and Weekly Fluctuations in the Microbiome of the Urinary Tract of Postmenopausal Women with No History of Urinary Tract Infections

Hogins J, Mekala S, Resendiz J et al. · 2025 · Preprint

At least half of all women will experience a urinary tract infection (UTI) in their lifetime. Age, sexual activity, hormonal status, and the urinary tract microbiome (urobiome) contribute to the probability of infection. While studies have…

View details →DOI: 10.1101/2025.11.04.686513
Negative / Null Result ReportMedicine

Lion-Tiger-Stripes: Delimiting the Semantic Association Effect on Working Memory With Mediated Association.

Ishiguro S, Guitard D, Saint-Aubin J · 2025 · Quarterly journal of experimental psychology (2006)

Semantic relatedness of items improves working memory performance. We targeted one type of semantic relatedness, semantic association. The beneficial effect of association is often explained by the spreading-activation process:…

View details →DOI: 10.1177/17470218251392562