A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20261 results in Negative / Null Result Report · page 570 of 676
Vandenbossche V, Valcke M, Maldoy M et al. · 2026 · Anatomical sciences education
Digital media have reshaped anatomy education through the integration of virtual three-dimensional models. Techniques such as surface scanning, enable the development of highly photorealistic anatomical models; however, evidence regarding…
Yahata A, Nakamoto N, Oiwa H · 2026 · Rheumatology international
To investigate the clinical characteristics of muscle-dominant ANCA-associated vasculitis (muscle-dominant AAV) in a consecutive single-center cohort. We retrospectively analyzed consecutive patients newly diagnosed with microscopic…
León-Lloreda A, Muñoz-Sánchez B, Polonio-González M et al. · 2026 · Preprint
INTRODUCTION: Delayed initiation of mepolizumab may influence long-term disease control and the achievement of clinical and functional outcomes in patients with uncontrolled severe asthma (SUA), but no definitive conclusions have yet been…
Jaramillo Quiceno GA, Sarmiento Riveros PA, Arias Perez RD et al. · 2026 · Journal of ISAKOS : joint disorders & orthopaedic sports medicine
Introduction/objectives Residual rotational laxity remains a relevant clinical concern after anterior cruciate ligament (ACL) reconstruction. Combined ACL and anterolateral ligament (ALL) reconstruction has been proposed to improve control…
Eren Hİ, Takım U · 2026 · Clinical psychology & psychotherapy
Adjustment disorder (AD) is characterized by disproportionate emotional and behavioural responses to stressors, often leading to significant functional impairment; however, the psychological mechanisms underlying this impairment remain…
Akter T, Aziz MA, Shahid AB et al. · 2026 · BMC research notes
Objectives Breast cancer is a complex malignancy influenced by both genetic and environmental mechanisms. The WDFY4 gene, predominantly expressed in immune tissues, plays a role in immune regulation. However, its application in relation to…
Uesato Y, Inamine S · 2026 · Journal of laparoendoscopic & advanced surgical techniques. Part A
Background The umbilical port is routinely used for camera insertion and specimen retrieval in laparoscopic cholecystectomy (LC). However, the umbilicus is anatomically vulnerable and may be associated with an increased risk of surgical…
Di Lorenzo G, Melluso M, Rodolico A et al. · 2026 · The journal of allergy and clinical immunology. In practice
Background Allergen immunotherapy (AIT) is the only disease-modifying treatment for grass pollen-induced allergic rhinoconjunctivitis (ARC). Three delivery routes-subcutaneous (SCIT), sublingual drops (SLIT-D), and sublingual tablets…
Baulier C, Zappella N, Grall N et al. · 2026 · Anaesthesia, critical care & pain medicine
Background Recent studies have increasingly questioned the efficacy and safety of piperacillin-tazobactam (TZP) in septic patients, particularly those with healthcare-associated intra-abdominal infections (hcIAI). This study assessed…
Ariza-Torrado IP, Groman-Lupa S, Martínez-Córdoba CJ et al. · 2026 · Journal of vitreoretinal diseases
Purpose: To evaluate functional and structural outcomes after application of a single intravitreal dose of faricimab in patients with chronic retinal diseases. Methods: In this observational, longitudinal, prospective study, best-corrected…
Kavgacı A, Kaya Ö, Örün UA et al. · 2026 · Journal of clinical medicine
Background : Congenital heart disease (CHD) represents a major cause of perinatal morbidity and mortality, and fetal echocardiography is essential for its early diagnosis and management. Maternal smoking has been suggested as a potential…
Nassif ND, Roberts EK, Vu SN et al. · 2026 · Future microbiology
Background Lung nodule evaluation is a vital practice in pulmonary medicine. While biopsy remains the diagnostic gold standard, it carries procedural risks. In regions endemic for fungal disease, low-cost, noninvasive testing may help…
Kampel L, Oestreicher-Kedem Y, Horowitz G et al. · 2026 · International journal of oral and maxillofacial surgery
Immunotherapy has brought new hope to patients with locally advanced, recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). This study aimed to evaluate the outcomes at our institution, focusing on the response to…
Krzepkowski HA, Ząbkowski T, Walędziak M et al. · 2026 · Journal of clinical medicine
Background/Objectives : An accurate preoperative assessment of prostate cancer malignancy is crucial for risk stratification and selection of the optimal treatment strategy. This study assessed the concordance of Gleason scores between…
Woo JMP, Chen D, Yarosh R et al. · 2026 · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Background Thyroid disease (TD), and its treatments, are suspected risk factors for breast cancer (BC), attributed primarily to alterations in thyroid hormone-related metabolism. Prior literature is inconsistent, in part, due to small…
Lin Q, Li S, Zhang W et al. · 2026 · BMC pediatrics
Objective To investigate the clinical efficacy and safety of single-port transscrotal laparoscopic orchiopexy combined with a hernia needle (SPLT-Orchiopexy) in children with palpable middle- and low-position undescended testes. Methods A…
Gonzalez W, Riquelme JP, Arellano J et al. · 2026 · BMC musculoskeletal disorders
Background Unicompartmental knee arthroplasty (UKA) is an established procedure for selected patients with unicompartmental osteoarthritis. Robotic-assisted UKA (RA-UKA) has been introduced to improve accuracy of implant positioning.…
Balcan B, Vezir D, Ocal R et al. · 2026 · Biomedicines
Background : Anemia and obstructive sleep apnea (OSA) are prevalent comorbidities in bronchiectasis and may share overlapping pathophysiological mechanisms. However, their combined impact on clinical outcomes in bronchiectasis remains…
Narusawa E, Katayama A, Koibuchi Y et al. · 2026 · Breast cancer (Tokyo, Japan)
Background Bevacizumab is an anti-angiogenic agent that inhibits tumor vascularization and thereby suppresses tumor growth. Tumor-infiltrating lymphocytes (TILs), particularly CD8-positive TILs, play a critical role in the antitumor immune…
Park JH, Kwon SU · 2026 · Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Background Total cerebral small-vessel disease (cSVD) score is a well-established predictor of vascular risks. However, the specific type of recurrent stroke associated with cSVD scores remains unclear in hemorrhage-prone patients-those…
Tahsin S, Murat K, Gözde OK et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
OBJECTIVE: To investigate the potential interaction between the vestibular and olfactory systems by evaluating olfactory identification performance in patients with BPPV. METHODS: Fifty-two patients with BPPV and 50 age-matched healthy…
Arrayales-Millán EM, Rodal M, González-Macías ME et al. · 2026 · Bioengineering (Basel, Switzerland)
This study investigated balance control during the half squat by analyzing the relationship between the center of mass (CoM) and the center of pressure (CoP) in five experienced male weightlifters performing segmented squats at five load…
Xu Z, Tang J · 2026 · Preprint
Abstract Background Wilson disease (WD) is an autosomal recessive disorder caused by pathogenic variants in ATP7B, resulting in impaired copper transport and progressive copper accumulation, most prominently affecting the liver. With the…
Song H · 2026 · LGBT health
Purpose The purpose of this study was to reexamine the association between marriage and health among partnered gay and lesbian adults, comparing married individuals with those in unmarried couples. Methods Using a decade of large-scale,…
Ritchie M, Speed D · 2025 · Journal of religion and health
The experience of discrimination is associated with worse health outcomes. Religious attendance associated with positive health is theorized to buffer the harmful effect of stressors (e.g., discrimination). Using data from the 2020…
Gagné N, Ditlecadet D, Hébert K et al. · 2026 · Journal of fish diseases
Infectious salmon anaemia virus (ISAV) can cause disease and mortality in Atlantic salmon (Salmo salar). The virus is endemic in several regions including the Atlantic coast of Canada. Lumpfish (Cyclopterus lumpus) are increasingly…
Müller CL, Ehring T, Kustermann A et al. · 2026 · Journal of psychopathology and clinical science
Cognitive-behavioral theories propose that attentional biases contribute to the development and maintenance of obsessive-compulsive disorder (OCD). However, research findings have been inconsistent, with some studies supporting vigilance…
Sullivan ADW, Barrett ES, Sullivan A et al. · 2026 · Biopsychosocial science and medicine
Objective Placental corticotropin-releasing hormone (pCRH) is a peptide essential for fetal development and birth timing. Prenatal programming frameworks position maternal pCRH as a primary neuroendocrine mediator underlying the…
Kidwell-Chandler A, Jeng B, Motl RW · 2026 · Multiple sclerosis and related disorders
Background Obesity is cited as a relevant factor in multiple sclerosis (MS). To date, there is inconsistent evidence regarding the relationship between total body fat and frequently studied outcomes in MS. Body fat distribution, or the…
Gibson AK, Peng L, Batterton T et al. · 2026 · Preprint
ABSTRACT Defense is the ability of a host to minimize fitness loss to parasites. It is among the most variable phenotypes in host populations, and this variation facilitates rapid adaptation under parasite-mediated selection. We do not,…