A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20261 results in Negative / Null Result Report · page 568 of 676
Krieglstein F, Jansen S, Meusel F et al. · 2024 · Acta psychologica
A growing body of research focuses on optimizing retrieval processes to help learners recall information from memory. The context-dependent memory effect suggests that information retrieval is more effective when the retrieval context…
Shimizu Y, Kudo Y, Karasawa K · 2024 · Acta psychologica
Identifying and improving existing morality perceptions regarding older adults is crucial for fostering intergenerational cooperation and constructing an inclusive society. In this study, we conducted two online experiments with Japanese…
Veshchitskii A, Shkorbatova P, Efimova E et al. · 2024 · The Journal of comparative neurology
Rat strains differ in physiology, behavior, and recovery after central nervous system injury. To assess these differences, we compared the gross and local anatomy and neuromorphology of the lumbar spinal cord of the Wistar and Dark Agouti…
Melkevik O, Jeppesen LS, Folke S et al. · 2025 · European journal of psychotraumatology
Background : Posttraumatic stress disorder (PTSD) is a serious and debilitating condition among military veterans. Exposure to potentially traumatic events (PTEs) may lead to PTSD and PTE sensitivity may be influenced by the personality…
Carrera-Aubesart A, Li J, Contreras E et al. · 2024 · Preprint
Antimicrobial peptides (AMPs) are regarded as a promising alternative to traditional antibiotics in the face of ever-increasing resistance. Our research has focused on crotalicidin (Ctn), an AMP from a snake venom, and a fragment thereof,…
Awaluddin K, Mayfield AB, Tew KS et al. · 2025 · Marine environmental research
Ocean acidification (OA) and warming pose significant threats to marine ecosystems, particularly by reducing calcium carbonate availability for marine calcifiers. Given that seagrasses can capture and store excess carbon, this study aimed…
Vardarli E, Bhattarai N, El Ayadi A et al. · 2025 · PloS one
Introduction Major burns results in the rapid and profound accumulation of lipid in peripheral tissues, but its impact on muscle metabolic function is unclear. Given previous reports demonstrating that lipid oversupply compromises…
Legrand FD, Jeandet P, Polidori G et al. · 2025 · Psychology of sport and exercise
This randomized controlled trial investigated the impact of a brief session of group-based running on feelings of energy and fatigue, comparing exercise in a local nature reserve versus an outdoor built environment, and a sedentary control…
Kwon M, Kim SA, Kim J · 2025 · Healthcare (Basel, Switzerland)
Background/Objectives : This study investigated the mediating effects of instrumental activities of daily living (IADL) and depression on the relationship between the ability to perform movements and death preparation among older adults…
paban v, Feraud L, Weills A et al. · 2024 · Preprint
In the context of an aging population, concerns surrounding memory function become increasingly prevalent, particularly as individuals transition into middle age and beyond. This study investigated neurofeedback (NFB) as a potential early…
Borden JB, Gibbs JP, Vanek JP et al. · 2024 · Preprint
As the fastest-growing form of land use, urbanization drives profound environmental change that reshapes biodiversity. Studies often characterize biodiversity patterns along urban-rural gradients with statistical models that include one or…
Gordon G, Nadar T, Green A · 2026 · Journal of functional morphology and kinesiology
Background : Sprint performance, including acceleration, maximal velocity and deceleration, is crucial for athletic success in field and court-based sports; however, deceleration remains understudied despite its role in change of direction…
Nemcova Y, Knotek P, Jadrná I et al. · 2024 · Journal of phycology
Mallomonas thrive primarily in freshwaters and dominate plankton communities, especially in oligotrophic waters. The cells have a siliceous cell covering of regularly arranged scales. Despite their ecological importance, the intricate…
Wang J, Lan X, Chen P et al. · 2024 · Crop Protection
Unmanned Aerial Spraying Systems (UASS) have garnered substantial market attention as efficient tools for applying Plant Protection Products (PPPs). However, their application has primarily focused on low-growing crops such as rice and…
Lamouille-Hébert M, Arthaud F, Besnard A et al. · 2024 · Preprint
Abstract Climate change is one of the main drivers of species erosion. Rapidly changing climate in the form of warming, drying, and habitat isolation causes freshwater species to change their spatial extent, as most species have little…
Albuquerque-Silva MM, Oliveira MTd, de Oliveira AFM et al. · 2024 · Preprint
This study explored the correlation between concentrations of phenolic compounds (phenols, tannins, and flavonoids) and the versatility of woody medicinal plants in the Caatinga, a seasonally dry forest region in Brazil. We examined…
Cederholm C, Nilsson M, Oliva D · 2026 · Preprint
Abstract It is well established that patients undergoing chemotherapy for cancer experience reduced Quality of Life (QoL) across physical, cognitive, emotional, and social dimensions. The relationship between cancer and QoL is complex;…
Kramer MR, Bartolome S, Saggar R et al. · 2026 · Preprint
Abstract Background Combination therapy is recommended for pulmonary arterial hypertension (PAH), part of which generally includes prostanoids, which affect both the vascular tone and vessel remodeling seen in PAH. This study tested…
Pahwa R, Elble R, Hauser RA et al. · 2026 · Parkinsonism & related disorders
Introduction Effective treatments for essential tremor (ET) are needed. EveresT (NCT05122650) examined the efficacy and safety of suvecaltamide in patients with moderate to severe ET. Methods In this phase 2 b, 12-week, double-blind,…
Atthakitmongkol T, Chotiyaputta W, Lertwattanarak R et al. · 2026 · Journal of the Formosan Medical Association = Taiwan yi zhi
Background Tenofovir disoproxil fumarate (TDF) is an important drug to treat chronic hepatitis B (CHB) patients. However, long-term TDF therapy decreases renal function and bone mineral density (BMD). This study compared bone turnover…
Ozer BH, Lindhorst SM, Merrell RT et al. · 2026 · Preprint
Background GBM is one of the most common and most aggressive brain tumors in adults, and upfront standard of care treatment has limited efficacy. Immune checkpoint inhibitor strategies have significantly improved outcomes in various solid…
· 2026 · Cancer discovery
The NHS-Galleri trial, the first randomized, controlled trial of the multi-cancer early detection test Galleri, found that the test from GRAIL did not meet its primary endpoint, a reduction in late-stage cancers. Researchers say the result…
Kircik L, Tsianakas A, Valenzuela F et al. · 2025 · The British journal of dermatology
Background Atopic dermatitis (AD), the most common inflammatory skin disorder, carries a significant public health burden. Many patients with moderate-to-severe AD are unable to achieve adequate disease control with topical treatment and…
Roupret M, Bertaut A, Pignot G et al. · 2026 · Annals of oncology : official journal of the European Society for Medical Oncology
Background Standard treatment of high-risk non-muscle-invasive bladder cancer (NMIBC) after transurethral resection of bladder tumor is intravesical instillation with Bacillus Calmette-Guérin (BCG) (induction and maintenance regimens);…
Falkenhorst J, Ivanyi P, Schulz T et al. · 2025 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose Imatinib resistance is conferred by secondary mutations within the ATP-binding pocket or the activation loop of KIT in gastrointestinal stromal tumors (GIST). Ponatinib is active against KIT secondary activation loop and the…
Sahebjam S, Bazer DA, Rhun EL et al. · 2026 · Neuro-oncology advances
Background Abemaciclib is a selective cyclin-dependent kinase 4 and 6 inhibitor that penetrates the blood-brain barrier, resulting in comparable concentrations in tissue and plasma. The primary objective of this nonrandomized Simon…
Kim DW, Kim RD, Jimenez MM et al. · 2025 · The oncologist
Background Ramucirumab plus paclitaxel after progression on fluoropyrimidine/platinum in metastatic gastric (GA) and gastroesophageal junction adenocarcinoma (GEJC) has shown improvement in overall survival over paclitaxel alone. However,…
Leelahawong P, Ketsuwan C · 2026 · Journal of clinical medicine
Background/Objectives : To evaluate whether adjunctive silodosin improves the stone-free rate (SFR) and clinical outcomes of extracorporeal shock wave lithotripsy (ESWL) for renal calculi. Methods : In this prospective randomised…
Chibaudel B, Dourthe LM, André T et al. · 2026 · Signal transduction and targeted therapy
Managing unresectable metastatic colorectal cancer (mCRC) requires a comprehensive strategy. While chemotherapy, anti-angiogenic, and anti-epidermal growth factor receptor (EGFR) agents are available, strategy trials are needed to optimize…
Wheless MC, Stockton S, Soares HP et al. · 2025 · The oncologist
Background Mutations in TP53 are common in gastroesophageal cancer and portend a poor prognosis. Tumor cells with TP53 mutations increasingly rely on ataxia-telangiectasia and Rad3-related (ATR) protein to respond to and repair DNA damage…