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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20261 results in Negative / Null Result Report · page 565 of 676

Negative / Null Result ReportMedicine

Modulation of oxidative stress mediates kaempferol induced enhancement of bovine oocyte In Vitro maturation developmental efficiency.

Wang H, Wang W, Li Y et al. · 2026 · Animal reproduction science

This study aimed to examine the protective effects of kaempferol on the in vitro maturation (IVM) of bovine oocytes and their subsequent embryonic development, and to investigate the underlying mechanisms. Bovine oocytes were cultured with…

View details →DOI: 10.1016/j.anireprosci.2026.108252
Negative / Null Result ReportMedicine

Tasting beer based on the tactile thickness of the glass lip

Ariga A, Kubo N, Koizumi T et al. · 2026 · Food Quality and Preference.

Multisensory research has demonstrated that the perceptual characteristics of a receptacle can influence how beverages are experienced, a phenomenon known as sensation transference. Previous studies have shown that the lip thickness of a…

Negative / Null Result Report

Do drugs with biliary toxicity cause cholangiocarcinoma?

Zong C, Lim K, Walker SA et al. · 2026 · Preprint

A bstract Many commonly used therapeutic drugs cause biliary toxicity, but it is unclear if they are directly responsible for the increasing incidence of cholangiocarcinoma (CCA). We tested experimentally and analyzed through a cohort…

View details →DOI: 10.64898/2026.03.31.715688
Negative / Null Result ReportMedicine

Incidence and associated factors of metachronous contralateral cryptorchidism after unilateral cryptorchidism: a retrospective cohort study.

Grande-Moreillo C, Pérez-López C, Vicente-Sánchez N et al. · 2026 · European journal of pediatrics

Acquired cryptorchidism is an increasingly recognized condition and may present bilaterally with a metachronous pattern. The objective of this study was to evaluate the incidence of acquired contralateral metachronous cryptorchidism and to…

View details →DOI: 10.1007/s00431-026-07154-4
Negative / Null Result ReportMedicine

Frequent Ambulatory Care Visits Predict Harmful Diagnostic Errors in High-Risk Hospitalized Patients: a Retrospective Cohort Study.

Goyal A, Konieczny K, Plombon S et al. · 2026 · Journal of general internal medicine

Background Diagnostic errors (DEs) are a major threat to hospital patient safety. Identifying admission-based predictors associated with harmful DEs may help improve diagnostic safety in high-risk populations. Objective To assess the…

View details →DOI: 10.1007/s11606-026-10527-y
Negative / Null Result ReportOpen accessMedicine

Effectiveness of Hyaluronic Acid Gel in Preventing Postoperative Intrauterine Adhesion Formation Following Operative Hysteroscopy.

Ciftci B, Karadag B · 2026 · International journal of women's health

Objective To evaluate the effectiveness of intrauterine hyaluronic acid (HA) gel application in preventing postoperative intrauterine adhesion formation following operative hysteroscopy. Methods This retrospective comparative study was…

View details →DOI: 10.2147/ijwh.s609095
Negative / Null Result ReportOpen accessMedicine

Trend and clinical outcomes of transcatheter aortic valve replacement in connective tissue disease from the national inpatient sample database (2016-2022).

Yasmin F, Rab AU, Asghar MS et al. · 2026 · Journal of cardiothoracic surgery

Purpose Given the systemic nature of connective tissue diseases (CTD), open surgical intervention for aortic stenosis is often considered high risk, making transcatheter aortic valve replacement (TAVR) a potentially preferable alternative.…

View details →DOI: 10.1186/s13019-026-04170-1
Negative / Null Result ReportMedicine

Short-term vaginal prasterone therapy induces steroid receptor modulation and extracellular matrix remodeling in human vaginal mucosa.

Tomczyk K, Yang-Jensen KC, Lorentzen LG et al. · 2026 · Scientific reports

Prasterone (dehydroepiandrosterone, DHEA) is increasingly used in the treatment of genitourinary syndrome of menopause (GSM), although its molecular effects on vaginal tissue remain insufficiently characterized. This prospective study…

View details →DOI: 10.1038/s41598-026-50491-5
Negative / Null Result ReportMedicine

Analysis of patients with hydrogen sulfide poisoning reported to the Taiwan Poison Control Center between 1986 and 2021.

Wen YC, Chu FY, Wang TH et al. · 2026 · Clinical toxicology (Philadelphia, Pa.)

Introduction Hydrogen sulfide exposure is a major cause of occupational poisoning and is frequently associated with life-threatening effects. This study aimed to investigate the patterns, poisoning severity, and predictors of severity in…

View details →DOI: 10.1080/15563650.2026.2675040
Negative / Null Result ReportMedicine

Age at menopause and risk of sarcopenia in postmenopausal women: evidence from the China health and retirement longitudinal study.

Li Y, Qin L, Wang Y et al. · 2026 · Reproductive health

Background Menopausal age is closely associated with women's health, but research on its association with sarcopenia risk remains insufficient. Our study aimed to explore how menopausal age affects the risk of sarcopenia in postmenopausal…

View details →DOI: 10.1186/s12978-026-02358-1
Negative / Null Result ReportMedicine

Nailfold capillaroscopy findings after anthracycline-based chemotherapy and their association with subclinical changes in left ventricular ejection fraction.

Kiracı M, Soytürk G, Köş FT et al. · 2026 · BMC cancer

Background Anthracyclines can induce endothelial and microvascular injury that precedes measurable myocardial dysfunction. However, reliable early markers of such injury are lacking. Nailfold capillaroscopy (NFC) is a noninvasive imaging…

View details →DOI: 10.1186/s12885-026-16187-9
Negative / Null Result ReportMedicine

Changes in female sexual function during the retirement transition.

Virkkunen V, Kero K, Stenholm S et al. · 2026 · Menopause (New York, N.Y.)

Objectives For many women, retirement represents a significant transition in late adulthood, which may result in many alterations in lifestyle habits and behavioral patterns. Several factors known to improve during the retirement…

View details →DOI: 10.1097/gme.0000000000002778
Negative / Null Result ReportOpen accessMedicine

Factors Influencing Interest in Urology Among Osteopathic and Allopathic Medical Students: A Single-Institution Cross-Sectional Survey.

Woodworth E, Sheppard C, Wong R et al. · 2026 · Cureus

Background Following the transition to a single-accreditation residency system, Doctor of Osteopathic Medicine (DO) and Doctor of Allopathic Medicine (MD) students now apply for the same urology residency positions. Despite this…

View details →DOI: 10.7759/cureus.107827
Negative / Null Result ReportMedicine

Differential Factor-Level MADRS Response Associated With Seizure Duration in Electroconvulsive Therapy: Exploratory Findings.

Swierkosz-Lenart K, Ranjbar S, Compagne C et al. · 2026 · The journal of ECT

Background Electroconvulsive therapy (ECT) is a widely used treatment for severe and treatment-resistant depression, with high efficacy but considerable interindividual variability of response. The neurophysiological mechanisms underlying…

View details →DOI: 10.1097/yct.0000000000001264
Negative / Null Result ReportMedicine

Cross-sectional and prospective relations between dysfunctional cognitive beliefs and obsessive-compulsive symptoms during late childhood and early adolescence: a test of two aetiological models.

Barcaccia B, Cervin M, Borrelli DF et al. · 2026 · Journal of child psychology and psychiatry, and allied disciplines

Background Obsessive-compulsive symptoms (OCS) often emerge during childhood and adolescence, and two aetiological models have been proposed. According to the first model, maladaptive cognitive beliefs facilitate the transformation of…

View details →DOI: 10.1111/jcpp.70077
Negative / Null Result ReportOpen accessMedicine

Dyadic Dynamic in Generalized Political Attitudes: Homophily, Relationship Satisfaction, and Convergence.

Miculka A, Imhoff R · 2026 · International review of social psychology

Despite the social nature of generalized political attitudes such as conspiracy mentality, right-wing authoritarianism (RWA), and social dominance orientation (SDO), dyadic phenomena concerning these attitudes have not been comprehensively…

View details →DOI: 10.5334/irsp.1102
Negative / Null Result ReportOpen accessMedicine

The impact of vision care program on the mental health of migrant children in Eastern China: evidence from a cluster-randomized controlled trial.

Wang Y, Li C, Zhang H et al. · 2026 · International journal for equity in health

BACKGROUND: Vision impairment is common among children and is known to affect learning, but its impact on children’s mental health has received less attention, especially in low- and middle-income countries. This study aims to focus on a…

View details →DOI: 10.1186/s12939-026-02854-7
Negative / Null Result ReportMedicine

β2-microglobulin is superior to lactate dehydrogenase and bulky disease for risk stratification in diffuse large B-cell lymphoma patients with IPI 1-2.

Chang H, Hung YS, Kuo MC et al. · 2026 · Annals of hematology

The International Prognostic Index (IPI) is the classical assessment tool to evaluate prognosis of diffuse large B cell lymphoma (DLBCL). Although the IPI is simple, reproducible, well validated and widely utilized, it is not entirely…

View details →DOI: 10.1007/s00277-026-07134-6
Negative / Null Result ReportMedicine

Antidepressant use and worsening of non-suicidal self-injury and suicidality in bipolar disorder: A multicenter retrospective cohort study.

Deng Y, Xu N, Huang J et al. · 2026 · Psychiatry research

The safety of antidepressants in bipolar disorder (BD) remains controversial, particularly regarding the risk of behavioral activation and worsening Non-Suicidal Self-Injury (NSSI). This multi-center retrospective cohort study included 575…

View details →DOI: 10.1016/j.psychres.2026.117301
Negative / Null Result ReportMedicine

Risk of postpartum hemorrhage according to the ultrasound measurement of the lower uterine segment before delivery of women with a prior cesarean delivery: secondary exploratory research of the Lower Uterine Segment Trial.

Jeremy B, Rozenberg P · 2026 · American journal of obstetrics & gynecology MFM

Background Women with a previous cesarean delivery have a higher risk of postpartum hemorrhage, including after successful vaginal birth after cesarean. Mechanisms underlying this excess risk remain unclear and may involve impaired…

View details →DOI: 10.1016/j.ajogmf.2026.101973
Negative / Null Result ReportMedicine

Effects of shoulder rotation and table tilt maneuvers on the lumbar and thoracic paramedian acoustic window in older adults: a quasi-experimental study.

Nunes de Souza MV, Caetano AMM, Duarte NMC et al. · 2026 · Brazilian journal of anesthesiology (Elsevier)

Background Shoulder rotation and table tilt have been reported to increase the acoustic window for spinal ultrasonography. However, evidence in older adults remains scarce. This study evaluated their anatomical effects on lumbar (L3-L4)…

View details →DOI: 10.1016/j.bjane.2026.844769
Negative / Null Result ReportMedicine

Short-term outcomes following reconstruction or direct repair of the ulnar collateral ligament.

Sribhashyam S, Talaski GM, Yazdanpanah S et al. · 2026 · Journal of ISAKOS : joint disorders & orthopaedic sports medicine

Introduction Medial ulnar collateral ligament (UCL) injuries substantially impair athletic performance due to pain, instability, and diminished throwing capabilities. While UCL reconstruction is the primary surgical treatment due to its…

View details →DOI: 10.1016/j.jisako.2026.101153
Negative / Null Result ReportMedicine

Comparison of the illness perception between age-related macular degeneration and glaucoma patients living in a middle-income country.

Germano-Morrel CS, Tomishige KS, Macchione RM et al. · 2026 · Journal of health psychology

The aim of this cross-sectional study was to compare the cognitive and emotional representations of illness in patients with primary open angle glaucoma (POAG) and age-related macular degeneration (AMD) living in a developing country. All…

View details →DOI: 10.1177/13591053261430435
Negative / Null Result ReportMedicine

Bulimia Nervosa in Adolescents: Impact of Childhood and Adolescent Sexual Abuse History and the Mediating Role of Social Media.

Alvarez-Tueros EX, Alcántara-Obando MO, Caycho-Rodríguez T et al. · 2026 · The International journal of social psychiatry

The aim of this study was to analyze whether exposure to esthetic content aligned with beauty standards on social media mediates the relationship between a history of childhood/adolescent sexual abuse and bulimic symptomatology in…

View details →DOI: 10.1177/00207640261438840
Negative / Null Result ReportMedicine

Effect of Continuous Theta-Burst Stimulation on Postoperative Delirium in Older Patients Who Undergo Cardiac Surgery.

Zhang J, Zhu Y, Yin Y et al. · 2026 · Neuromodulation : journal of the International Neuromodulation Society

Objectives Postoperative delirium (POD) is a common complication after cardiac surgery in older patients, associated with higher mortality and prolonged stays. Continuous theta-burst stimulation (cTBS), a noninvasive neuromodulation…

View details →DOI: 10.1016/j.neurom.2026.03.003
Negative / Null Result ReportOpen accessMedicine

Association Between Individual Functional Movement Screen™ Tasks and Sports Injury Occurrence in University Basketball Players: A Prospective Cohort Study.

Kikumoto T, Kobayashi M, Hori S et al. · 2026 · International journal of sports physical therapy

The Functional Movement Screen™ (FMS™) is widely used to evaluate movement quality and attempt to identify athletes at risk of injury. However, the predictive value of the total score is inconsistent, and it remains unclear whether…

View details →DOI: 10.26603/001c.162342