e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20261 results in Negative / Null Result Report · page 562 of 676

Negative / Null Result ReportMedicine

Video-Based Study of the Progression of Pediatric Emergency Medicine Fellows' Tracheal Intubation Performance During Training.

Thomas P, Kerrey B, Edmunds K et al. · 2024 · Pediatric emergency care

Background The lower clinical exposure of Pediatric Emergency Medicine (PEM) fellows to critical procedures may impede skill acquisition. We sought to determine the tracheal intubation learning curve of PEM fellows during training and…

View details →DOI: 10.1097/pec.0000000000003204
Negative / Null Result ReportOpen accessMedicine

Spectators lead to overconfidence and risk-taking in males in a motor task.

Pelzer F, Leisge K, Kaczmarek C et al. · 2025 · Scientific reports

We often perform motor tasks in front of other people, and this may help or hinder our performances. Previous research mainly focused on changes in motor performance, and less is known about spectator influences on performance predictions.…

View details →DOI: 10.1038/s41598-025-18048-0
Negative / Null Result ReportOpen accessMedicine

Daytime sleep following observational practice does not enhance a visual-spatial and a motor representation.

Panzer S, Hofstetter N, Schreiber M et al. · 2026 · Experimental brain research

The present study examined if a daytime nap of 90 min can further improve skill memory afforded by observation and physical practice. Moreover, we determined if a 'nap' benefit was restricted to a particular representational form (spatial…

View details →DOI: 10.1007/s00221-026-07281-2
Negative / Null Result ReportMedicine

The impact of self-assessment and surveyor assessment on site visit performance under the National General Practice Accreditation scheme.

McNaughton DT, Mara P, Jones MP · 2024 · Australian health review : a publication of the Australian Hospital Association

Objective There is a need to undertake more proactive and in-depth analyses of general practice accreditation processes. Two areas that have been highlighted as areas of potential inconsistency are the self-assessment and surveyor…

View details →DOI: 10.1071/ah23235
Negative / Null Result ReportOpen accessMedicine

Self-Soothing Touch Reduces Momentary Stress, Fatigue, and Loneliness Comparable to Brief Meditation: A Randomised Controlled Trial.

Maier F, Luttenberger I, Dreisoerner A et al. · 2026 · Stress and health : journal of the International Society for the Investigation of Stress

Chronic stress has well-documented adverse effects on physical and psychological health. Beyond contributing to the development of fatigue, its impact is intensified by social stressors such as loneliness, making the development of…

View details →DOI: 10.1002/smi.70145
Negative / Null Result Report

Comparative CNS Pharmacology of the Bruton’s Tyrosine Kinase (BTK) Inhibitor Tolebrutinib Versus Other BTK Inhibitor Candidates for Treating Multiple Sclerosis

Turner TJ, Brun P, Gruber R et al. · 2024 · Preprint

Tolebrutinib is a covalent BTK inhibitor designed and selected for potency and CNS exposure to optimize impact on BTK-dependent signaling in CNS-resident cells. We applied a translational approach to evaluate three BTK inhibitors in Phase…

View details →DOI: 10.1101/2024.03.25.586667
Negative / Null Result ReportOpen accessMedicine

Investigating the Effect of Algal Inclusions in Broiler Chickens.

Al-Khalaifah H, Al-Nasser A, Al-Surrayai T · 2025 · Life (Basel, Switzerland)

There is growing interest in adding marine algae to poultry feed rations. The aim of the present study is to examine the effect of various inclusions of Sargassum sp., Gracilaria sp., and Spirulina sp. on productive performance, serum…

View details →DOI: 10.3390/life15040670
Negative / Null Result ReportOpen accessMedicine

Procalcitonin and CRP as Predictors of Anastomotic Dehiscence in Adult Patients.

Zamora Veliz HY, Paredes Cabanillas RY, Gomez Trejo JE et al. · 2025 · Cureus

Introduction Intestinal anastomotic leakage is a serious postoperative complication associated with high morbidity and mortality. Although acute-phase reactants such as procalcitonin (PCT) and CRP have been proposed as early biomarkers,…

View details →DOI: 10.7759/cureus.88190
Negative / Null Result ReportOpen accessMedicine

Achieving target plasma concentrations of beta-lactam antibiotics in critically ill patients: a retrospective study of full-dose administration in the first 24 hours.

Halačová M, Mieresová M, Kubele J et al. · 2026 · Pharmacological reports : PR

BACKGROUND: Beta-lactams are the cornerstone of therapy for the treatment of the most serious infections in the intensive care unit (ICU) setting. However, individualization of dosing remains challenging because pharmacokinetics are highly…

View details →DOI: 10.1007/s43440-026-00836-8
Negative / Null Result ReportOpen accessMedicine

Impaired Cognitive Flexibility With Preserved Learning in an Amyloid Precursor Protein Knock-In Mouse Model of Amyloidopathy.

Dumont JR, Sheppard PAS, Fodor C et al. · 2025 · Genes, brain, and behavior

Alzheimer's disease is a debilitating neurodegenerative condition characterized by amyloid beta plaques and tau neurofibrillary tangles, which leads to progressive cognitive decline. Several new mouse models of fast amyloid deposition have…

View details →DOI: 10.1111/gbb.70024
Negative / Null Result ReportMedicine

Moving from the clinic to telehealth during the COVID-19 pandemic - a pilot clinical trial comparing in-clinic rehabilitation versus telerehabilitation for persisting symptoms following a mild Traumatic brain injury.

Langevin P, Frémont P, Fait P et al. · 2024 · Disability and rehabilitation

Purpose The objective of this study was to compare the effects of an in-clinic cervicovestibular rehabilitation program (education, home exercises, manual techniques, sub-symptom threshold aerobic exercise [STAE] program) to a similar…

View details →DOI: 10.1080/09638288.2023.2236016
Negative / Null Result ReportMedicine

Ovulatory cycle shifts in human motivational prioritisation of sex and food.

Schleifenbaum L, Stern J, Driebe JC et al. · 2024 · Hormones and behavior

Previous research on the endogenous effects of ovarian hormones on motivational states in women has focused on sexual motivation. The Motivational Priority Shifts Hypothesis has a broader scope. It predicts a shift from somatic to…

View details →DOI: 10.1016/j.yhbeh.2024.105542
Negative / Null Result ReportMedicine

Evaluating nutrition in advanced ovarian cancer: which biomarker works best?

Fumagalli D, Sonik R, De Vitis LA et al. · 2024 · Gynecologic oncology

Background Advanced epithelial ovarian cancer (OC) patients often present with malnutrition; however, the ideal nutritional evaluation tool is unclear. We aimed to evaluate the role of preoperative albumin, Prognostic Nutritional Index…

View details →DOI: 10.1016/j.ygyno.2024.06.021
Negative / Null Result ReportOpen accessMedicine

Trajectory of COVID-related tinnitus over the pandemic timeline.

Figueiredo RR, de Azevedo AA, Figueiredo GMR et al. · 2026 · Brazilian journal of otorhinolaryngology

Objectives COVID-19 is a respiratory disease caused by the coronavirus SARS-CoV-2. Previous studies reported cases of tinnitus following COVID infection, most of them mild and with similar characteristics to other forms of tinnitus. Our…

View details →DOI: 10.1016/j.bjorl.2026.101857
Negative / Null Result ReportOpen accessMedicine

Measuring differences in the ERG in myopia using the RETeval device with skin electrodes.

Stapley V, Anderson RS, Saunders K et al. · 2025 · Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

Introduction Previous research suggests that the electroretinogram (ERG) is reduced and delayed in non-pathological myopia. However, the invasive nature of the electrode and cumbersome equipment required has prevented the widescale uptake…

View details →DOI: 10.1111/opo.13460
Negative / Null Result ReportOpen accessMedicine

Cleft Laterality Dental Arch Relationship Outcomes for Children with Unilateral Cleft Lip and Palate in New Zealand.

Fowler PV, Keall H, Kennedy D et al. · 2025 · The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

ObjectivesTo investigate cleft laterality dental arch relationship outcomes of children with non-syndromic complete unilateral cleft lip and palate (UCLP) in New Zealand.DesignA retrospective nationwide study.SettingsVirtual 3D orthodontic…

View details →DOI: 10.1177/10556656241234599
Negative / Null Result ReportOpen accessMedicine

Pre-operative planning for reverse shoulder arthroplasty in low-resource centres: A modified Delphi study in South Africa.

Rachuene PA, Dey R, Kauta NJ et al. · 2024 · SICOT-J

Background Pre-operative planning for reverse shoulder arthroplasty (RSA) poses challenges, particularly when dealing with glenoid bone loss. This modified Delphi study aimed to assess expert consensus on RSA planning processes and…

View details →DOI: 10.1051/sicotj/2024021
Negative / Null Result ReportOpen accessMedicine

The Localization Accuracy of Electrically Evoked Dental Sensations.

Ashaibi NA, Mason AG, Hector MP et al. · 2025 · Clinical and experimental dental research

Objectives Dental pain of odontogenic origin can be difficult to accurately locate to a specific tooth. This study aimed to determine how effectively volunteers could locate electrical stimuli applied to teeth in both the anterior and…

View details →DOI: 10.1002/cre2.70012
Negative / Null Result Report

Bluetooth Noise-Canceling Headphones Improve the Quality of Ophthalmic Exam in Hearing-Loss Patients – A Randomized Controlled Trial

Glanzer BM, Ladki MS, Chea M et al. · 2023 · Preprint

This study tests the utilization of Bluetooth noise-canceling headphones in improving the quality of eye exams in patients with hearing loss. University of Texas Medical Branch patients above 55 years of age were screened for hearing loss…

View details →DOI: 10.20944/preprints202310.1157.v1
Negative / Null Result ReportOpen accessMedicine

The association between Nutrient-Rich food score (NRFS) and the odds of lung cancer risk: a case-control study in Iran.

Mohammadzadeh M, Abdi F, Hadi S et al. · 2026 · BMC nutrition

Background A high-quality diet is an important strategy for preventing chronic diseases, including cancer. The Nutrient Rich Food Score (NRFS) is a very useful index that can compare the value of key micronutrients and macronutrients per…

View details →DOI: 10.1186/s40795-026-01243-1
Negative / Null Result ReportOpen accessMedicine

Refining the clinical utility of [<sup>177</sup>Lu]Lu/[<sup>225</sup>Ac]Ac-PSMA tandem RLT in patients with metastatic castration resistant prostate cancer.

Widjaja L, Hornfeck J, Siegmund SC et al. · 2026 · European journal of nuclear medicine and molecular imaging

Purpose This study aimed to evaluate the efficacy and safety of Lutetium-177/Actinium-225 prostate-specific membrane antigen tandem radioligand therapy ([ 177 Lu]Lu/[ 225 Ac]Ac-PSMA tandem RLT) and to explore clinical and imaging-based…

View details →DOI: 10.1007/s00259-025-07632-1
Negative / Null Result ReportMedicine

Potential benefits of therapeutic drug monitoring for beta-lactam antibiotics in augmented renal clearance patients: a case report.

El-Haffaf I, Laverdière J, Albert M et al. · 2024 · Canadian journal of physiology and pharmacology

Augmented renal clearance (ARC) is commonly described in critically ill patients, making drug pharmacokinetics even harder to predict in this population. This case report displays the value of therapeutic drug monitoring (TDM) of…

View details →DOI: 10.1139/cjpp-2023-0109
Negative / Null Result ReportOpen accessMedicine

Nuclear protein 1 is a cell death regulator in primary human airway epithelial cells and reduced in idiopathic pulmonary fibrosis.

Zöller M, Mastalerz M, Dick E et al. · 2026 · Scientific reports

The airway epithelium is the first site of injury from cigarette smoke (CS), a major risk factor for chronic lung disease including idiopathic pulmonary fibrosis (IPF). Here, we report the first intracellular proteomic analysis of CS…

View details →DOI: 10.1038/s41598-026-51510-1
Negative / Null Result ReportOpen accessMedicine

Rapid response to BRAF/MEK inhibitor therapy within 2 weeks for high-grade glioma with leptomeningeal metastasis: illustrative case.

Kawaguchi Y, Hana T, Hasegawa H et al. · 2025 · Journal of neurosurgery. Case lessons

Background High-grade gliomas, particularly isocitrate dehydrogenase-wildtype glioblastomas (GBMs), are highly aggressive brain tumors with limited treatment options and poor outcomes. A subset of these tumors, including epithelioid GBM,…

View details →DOI: 10.3171/case25247
Negative / Null Result ReportMedicine

Gender-Affirming Hormone Therapy Is Associated with Increased Odds of Screening for Sexually Transmitted Infections in a Clinical Cohort of Transgender and Nonbinary Adults.

Pletta DR, Mayer KH, Chen JT et al. · 2024 · Transgender health

Purpose Transgender and nonbinary adults (TNB) are disproportionately burdened by sexually transmitted infections (STI) and the human immunodeficiency virus (HIV). This study investigated whether gender-affirming hormone therapy was…

View details →DOI: 10.1089/trgh.2023.0159