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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19895 results in Negative / Null Result Report · page 561 of 664

Negative / Null Result Report

Identification of a Pathogenic BRCA2 Variant by Multigene Panel Testing in a Blood Group Chimera/Mosaic Case Unclassifiable by Conventional BRCA1/2 Testing

GONDA K, Ozaki A, Ito S et al. · 2026 · Preprint

Abstract In the setting of blood group chimerism/mosaicism, conventional BRCA1/2 genetic testing may yield inconclusive results. Multigene panel testing (MGPT) may overcome this limitation. We report a case in which BRCA2 pathogenic…

View details →DOI: 10.21203/rs.3.rs-8494624/v1
Negative / Null Result ReportMedicine

Biomagnetism of oral tissues and external magnetic field interactions with cell membranes, oral microflora, and orthodontic magnetic therapies: A review.

Itabaiana Sobrinho S, Meira-Belo LC, Mohallem NDS · 2026 · Progress in biophysics and molecular biology

Various rare earth magnets have been successfully applied in clinical orthodontics; however, their interactions with the oral environment remain only partially understood. Various controversies remain regarding magnetic fields (MFs) in…

View details →DOI: 10.1016/j.pbiomolbio.2026.01.003
Negative / Null Result ReportMedicine

Effects of Glucagon-Like Peptide-1 Receptor Agonists (Mono and Combination Therapy) on Energy Expenditure: A Scoping Review.

Vieira FT, Deng Z, Muller MJ et al. · 2026 · Obesity reviews : an official journal of the International Association for the Study of Obesity

Introduction Weight loss results in reduced energy expenditure (EE) due to body composition alterations (e.g., fat-free mass and fat mass losses) and mass-independent adaptations in EE (e.g., hormones). Glucagon-like peptide-1 receptor…

View details →DOI: 10.1111/obr.70116
Negative / Null Result ReportMedicine

Intraoperative biopsy challenges: Cavernous sinus meningioma mimic.

Pérez Serena A, Martínez Betancourt DP · 2026 · Neurocirugia

We report the case of a 56-year-old female patient with controlled Human Immunodeficiency Virus (HIV) who presented with binocular diplopia and a known sixth cranial nerve palsy. Imaging revealed a lesion centered in the right cavernous…

View details →DOI: 10.1016/j.neucie.2025.500739
Negative / Null Result ReportMedicine

Lost in submission? Investigating publication bias in regional anaesthesia: A pilot case study of the erector spinae plane block.

De Cassai A, Dost B, Karapinar YE et al. · 2026 · Revista espanola de anestesiologia y reanimacion

Background The Erector Spinae Plane (ESP) block is a regional anaesthesia technique with a growing range of clinical applications due to its short learning curve, low complication rate, and effectiveness. However, publication bias can…

View details →DOI: 10.1016/j.redare.2026.501995
Negative / Null Result ReportMedicine

Radiation necrosis mimicking tumor recurrence after chemoradiation for vaginal squamous cell carcinoma.

Di Noia D, Maiorano MFP, Sanasi A et al. · 2026 · Journal of gynecology obstetrics and human reproduction

Radiation necrosis is a rare but serious complication of pelvic chemoradiotherapy that may closely mimic tumor recurrence on both imaging and clinical examination. We describe the case of a 43-year-old woman with FIGO stage II vaginal…

View details →DOI: 10.1016/j.jogoh.2026.103129
Negative / Null Result ReportOpen accessMedicine

Glomerular Yield in Ultrasound-Guided Native Kidney Biopsies in Pediatric and Adult Populations With Age-Stratified Subgroups.

Ravizzini PC, Lino HA, de Faria Castro Fleury E et al. · 2025 · Cureus

Background This study compares the glomerular yield, mean number of biopsy cores, and complication rates between pediatric and adult populations undergoing ultrasound-guided native kidney biopsies. Additionally, the adult population was…

View details →DOI: 10.7759/cureus.91202
Negative / Null Result ReportMedicine

Association between hemodynamically significant patent ductus arteriosus and fluid intake in the first week of life in a cohort of very low birth weight preterm infants: the COOL study.

Mayer A, Bresesti I, Francescato G et al. · 2025 · European journal of pediatrics

The amount of fluid to give in preterm infants with patent ductus arteriosus (PDA) is still highly debated, with no robust evidence that fluid restriction provides a clear benefit. The aim of the study is to evaluate if spontaneous closure…

View details →DOI: 10.1007/s00431-025-06651-2
Negative / Null Result ReportMedicine

Assessing Blood Pressure, Mental Health, and HRV Responses to Integrated Acupuncture in Hypertensive Patients: A Pilot Randomized Controlled Trial.

Singh D, Kodali PB, Sharma G et al. · 2025 · Medical acupuncture

Abstract This study aimed to investigate the effects of an integrated acupuncture (IA) protocol on blood pressure (BP), depression, anxiety, stress scores, and heart rate variability (HRV) in hypertensive patients. Abstract The study was a…

View details →DOI: 10.1089/acu.2024.0065
Negative / Null Result ReportMedicine

The VGLUT3 positive neurons of the median raphe region promote long-term spatial memory through time-dependent mechanisms.

Fazekas CL, Török B, Szabó A et al. · 2026 · Progress in neurobiology

Episodic memory and related forms of learning depend critically on the hippocampus, whose activity is regulated by brainstem inputs that remain incompletely understood. The midbrain median raphe region (MRR) is a key regulator of forebrain…

View details →DOI: 10.1016/j.pneurobio.2026.102904
Negative / Null Result ReportOpen accessMedicine

Value of endoscopic submucosal dissection in diagnosing gastric mucosa-associated lymphoid tissue lymphoma: A case report.

Li SH, Niu WW, Huo XX et al. · 2025 · World journal of gastroenterology

Background Gastric mucosa-associated lymphoid tissue (MALT) lymphoma presents with various clinical presentations and endoscopic features. While gastric lesions are primarily assessed via endoscopic forceps biopsy, pathological…

View details →DOI: 10.3748/wjg.v31.i38.111549
Negative / Null Result ReportOpen accessMedicine

Post-Traumatic Chest Wall Abscess Associated with <i>Gordonia sputi</i> in an Immunocompetent Patient: A Case Report.

Soda M, Motoyama H, Adachi T et al. · 2026 · Surgical case reports

Introduction Gordonia species are rare aerobic Gram-positive actinomycetes and opportunistic pathogens. Their clinical manifestations and optimal management remain poorly defined. Gordonia sputi is an especially uncommon cause of…

View details →DOI: 10.70352/scrj.cr.26-0054
Negative / Null Result ReportOpen accessMedicine

Nationwide seroprevalence of SARS-CoV-2 during the COVID-19 pandemic and prepandemic periods in Lao PDR.

Phommasone K, Souksakhone C, Chanthongthip A et al. · 2025 · PloS one

Background Lao PDR reported a low number of confirmed SARS-CoV-2 cases until the introduction of COVID-19 vaccines in April 2021. This raised doubts about whether the reported number reflected the true situation and questioned about…

View details →DOI: 10.1371/journal.pone.0336239
Negative / Null Result ReportOpen accessMedicine

Impact of 18F-choline PET-CT or PET-MRI on surgical strategy in patients with primary hyperparathyroidism.

Carrillo Lizarazo JL, Cecchin D, Camozzi V et al. · 2025 · BJS open

Background Accurate preoperative localization is essential for successful, focused, minimally invasive surgery in primary hyperparathyroidism (PHPT). New imaging techniques have recently been proposed. This study evaluated the impact of…

View details →DOI: 10.1093/bjsopen/zraf069
Negative / Null Result ReportMedicine

Serum 25-Hydroxyvitamin D Levels and Longitudinal Changes in Muscle Mass and Function in Peritoneal Dialysis Patients: A Prospective Cohort Study.

Wang L, Xue C, Zhu B et al. · 2026 · Journal of nutritional science and vitaminology

Data regarding to how serum 25 hydroxyvitamin D (25(OH)D) levels affect muscle mass and function in end-stage renal disease (ESRD) patients have led to inconclusive results. The main goal of this research was to examine the relationship…

View details →DOI: 10.3177/jnsv.72.1
Negative / Null Result Report

Optimizing C14120-based LNPs for in vitro and in vivo mRNA delivery

Song P, Su J, Vraa CLK et al. · 2025 · Preprint

Lipid nanoparticles (LNPs) have proven to be an effective delivery system for RNA therapeutics. The chemical composition of LNPs determines their functional delivery efficiency and targeting properties, which vary between in vitro and in…

View details →DOI: 10.1101/2025.09.02.673705
Negative / Null Result ReportMedicine

Methionine PET Findings in the Diagnosis of Brain Tumors and Nontumorous Mass Lesions: A Single-Center Report on 426 Cases.

Shiba Y, Aoki K, Ohka F et al. · 2025 · AJNR. American journal of neuroradiology

Background and purpose Differentiating between a brain tumor and a nontumorous lesion remains a diagnostic challenge, particularly when conventional imaging modalities such as CT and MRI provide inconclusive results. While 11 C-methionine…

View details →DOI: 10.3174/ajnr.a8871
Negative / Null Result ReportOpen accessMedicine

Diagnostic Performance of the α-Synuclein Seed Amplification Assay for Dementia With Lewy Bodies: A Comparison Across 4 Laboratories.

Kumar R, Gravett S, Jelic V et al. · 2026 · Neurology

Background and objectives The α-synuclein (α-syn) seed amplification assay (SAA) has shown promising results for diagnosing dementia with Lewy bodies (DLB) using CSF samples. A barrier to implementing α-syn SAA clinically is the use of…

View details →DOI: 10.1212/wnl.0000000000214614
Negative / Null Result ReportMedicine

Associations between menstrual cycle phases and sexuality, well-being and mood in young healthy women.

Tornvall S, Blomberg L, Hirschberg AL · 2025 · Psychoneuroendocrinology

The objective of this study was to investigate the association of menstrual cycle phases on sexual function, well-being, and mood in young healthy women. Previous research has shown inconclusive results likely due to using non-validated…

View details →DOI: 10.1016/j.psyneuen.2025.107613
Negative / Null Result ReportOpen accessMedicine

Capsule Endoscopy-Guided Diagnosis of Small Bowel Lymphoma Presenting as Protein-Losing Enteropathy: Complementary Role of Peripheral Blood Flow Cytometry.

Abdulrasak M, Axler O, Kapás B et al. · 2026 · Diagnostics (Basel, Switzerland)

Protein-losing enteropathy (PLE) is an uncommon and often underrecognized manifestation of lymphoproliferative disorders and may be difficult to diagnose when conventional gastrointestinal investigations are unrevealing. We present an…

View details →DOI: 10.3390/diagnostics16071006
Negative / Null Result ReportMedicine

The Role of Circulating Tumor DNA in Patients Treated with Adjuvant Immune Checkpoint Inhibitors: Clinical Reality or Distant Horizon?

Maffezzoli M, Nagpal R, Elewaily M et al. · 2025 · Current oncology reports

PURPOSE OF REVIEW: Adjuvant immunotherapy has improved outcomes in several cancers, although patient selection and toxicity remain challenges. Circulating tumor DNA (ctDNA) has emerged as a biomarker for minimal residual disease (MRD)…

View details →DOI: 10.1007/s11912-025-01701-2
Negative / Null Result ReportOpen accessMedicine

Impact of therapeutic exercises on pain-related outcomes in patients with knee osteoarthritis: an umbrella review of 116 systematic reviews.

Viderman D, Kalikanov S, Mazhibiyeva A et al. · 2026 · Frontiers in pain research (Lausanne, Switzerland)

Background and objectives Chronic knee pain is highly prevalent in various knee diseases. It significantly decreases patients' quality of life. Among non-surgical interventions, exercise is considered a promising approach for alleviating…

View details →DOI: 10.3389/fpain.2026.1717540
Negative / Null Result ReportOpen accessMedicine

Assessing the impact of exome sequencing on diagnostic yield in a large cohort of Brazilian patients.

Planello AC, Loureiro T, Alencar-Cupertino D et al. · 2025 · Revista da Associacao Medica Brasileira (1992)

Objective This study aimed to evaluate whether the increased use of exome sequencing as a primary next-generation sequencing test provides a higher diagnostic yield compared to multi-gene panels for various clinical indications within a…

View details →DOI: 10.1590/1806-9282.20250086
Negative / Null Result ReportMedicine

Third-generation computed tomography angiography after coronary chronic total occlusion intervention in ruling out significant in-stent restenosis at long-term follow-up.

Mansikkaniemi L, Stewart JA, Sinisalo J et al. · 2025 · Scandinavian cardiovascular journal : SCJ

Background. Invasive coronary angiography (ICA) is the gold standard in evaluating stent patency after percutaneous coronary intervention (PCI), but it carries a risk of potentially life-threatening complications. Third-generation coronary…

View details →DOI: 10.1080/14017431.2025.2550280