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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19893 results in Negative / Null Result Report · page 560 of 664

Negative / Null Result ReportMedicine

[Influenza virus infection affects the efficacy of the treatment of dyslipidemia in mice with a polyisoprenoid-based drug].

Makiev EA, Kozhevnikova TN, Pronin AV et al. · 2026 · Voprosy virusologii

Objective To evaluate how influenza infection affects the hypolipidemic effect of a novel combined drug - Prenophytol based on polyisoprenoids (sodium polyprenyl phosphate and beta-sitosterol) in mice with experimental dyslipidemia.…

View details →DOI: 10.36233/0507-4088-343
Negative / Null Result ReportMedicine

Short-term vaginal prasterone therapy induces steroid receptor modulation and extracellular matrix remodeling in human vaginal mucosa.

Tomczyk K, Yang-Jensen KC, Lorentzen LG et al. · 2026 · Scientific reports

Prasterone (dehydroepiandrosterone, DHEA) is increasingly used in the treatment of genitourinary syndrome of menopause (GSM), although its molecular effects on vaginal tissue remain insufficiently characterized. This prospective study…

View details →DOI: 10.1038/s41598-026-50491-5
Negative / Null Result ReportMedicine

Analysis of patients with hydrogen sulfide poisoning reported to the Taiwan Poison Control Center between 1986 and 2021.

Wen YC, Chu FY, Wang TH et al. · 2026 · Clinical toxicology (Philadelphia, Pa.)

Introduction Hydrogen sulfide exposure is a major cause of occupational poisoning and is frequently associated with life-threatening effects. This study aimed to investigate the patterns, poisoning severity, and predictors of severity in…

View details →DOI: 10.1080/15563650.2026.2675040
Negative / Null Result ReportMedicine

Age at menopause and risk of sarcopenia in postmenopausal women: evidence from the China health and retirement longitudinal study.

Li Y, Qin L, Wang Y et al. · 2026 · Reproductive health

Background Menopausal age is closely associated with women's health, but research on its association with sarcopenia risk remains insufficient. Our study aimed to explore how menopausal age affects the risk of sarcopenia in postmenopausal…

View details →DOI: 10.1186/s12978-026-02358-1
Negative / Null Result ReportMedicine

Nailfold capillaroscopy findings after anthracycline-based chemotherapy and their association with subclinical changes in left ventricular ejection fraction.

Kiracı M, Soytürk G, Köş FT et al. · 2026 · BMC cancer

Background Anthracyclines can induce endothelial and microvascular injury that precedes measurable myocardial dysfunction. However, reliable early markers of such injury are lacking. Nailfold capillaroscopy (NFC) is a noninvasive imaging…

View details →DOI: 10.1186/s12885-026-16187-9
Negative / Null Result ReportMedicine

Changes in female sexual function during the retirement transition.

Virkkunen V, Kero K, Stenholm S et al. · 2026 · Menopause (New York, N.Y.)

Objectives For many women, retirement represents a significant transition in late adulthood, which may result in many alterations in lifestyle habits and behavioral patterns. Several factors known to improve during the retirement…

View details →DOI: 10.1097/gme.0000000000002778
Negative / Null Result ReportOpen accessMedicine

Factors Influencing Interest in Urology Among Osteopathic and Allopathic Medical Students: A Single-Institution Cross-Sectional Survey.

Woodworth E, Sheppard C, Wong R et al. · 2026 · Cureus

Background Following the transition to a single-accreditation residency system, Doctor of Osteopathic Medicine (DO) and Doctor of Allopathic Medicine (MD) students now apply for the same urology residency positions. Despite this…

View details →DOI: 10.7759/cureus.107827
Negative / Null Result ReportMedicine

Differential Factor-Level MADRS Response Associated With Seizure Duration in Electroconvulsive Therapy: Exploratory Findings.

Swierkosz-Lenart K, Ranjbar S, Compagne C et al. · 2026 · The journal of ECT

Background Electroconvulsive therapy (ECT) is a widely used treatment for severe and treatment-resistant depression, with high efficacy but considerable interindividual variability of response. The neurophysiological mechanisms underlying…

View details →DOI: 10.1097/yct.0000000000001264
Negative / Null Result ReportMedicine

Cross-sectional and prospective relations between dysfunctional cognitive beliefs and obsessive-compulsive symptoms during late childhood and early adolescence: a test of two aetiological models.

Barcaccia B, Cervin M, Borrelli DF et al. · 2026 · Journal of child psychology and psychiatry, and allied disciplines

Background Obsessive-compulsive symptoms (OCS) often emerge during childhood and adolescence, and two aetiological models have been proposed. According to the first model, maladaptive cognitive beliefs facilitate the transformation of…

View details →DOI: 10.1111/jcpp.70077
Negative / Null Result ReportOpen accessMedicine

Dyadic Dynamic in Generalized Political Attitudes: Homophily, Relationship Satisfaction, and Convergence.

Miculka A, Imhoff R · 2026 · International review of social psychology

Despite the social nature of generalized political attitudes such as conspiracy mentality, right-wing authoritarianism (RWA), and social dominance orientation (SDO), dyadic phenomena concerning these attitudes have not been comprehensively…

View details →DOI: 10.5334/irsp.1102
Negative / Null Result ReportOpen accessMedicine

The impact of vision care program on the mental health of migrant children in Eastern China: evidence from a cluster-randomized controlled trial.

Wang Y, Li C, Zhang H et al. · 2026 · International journal for equity in health

BACKGROUND: Vision impairment is common among children and is known to affect learning, but its impact on children’s mental health has received less attention, especially in low- and middle-income countries. This study aims to focus on a…

View details →DOI: 10.1186/s12939-026-02854-7
Negative / Null Result ReportMedicine

A randomized trial of carbon-dioxide flushing to reduce vascular brain injury in patients undergoing TAVI.

Khawaja SA, Hanna L, Singh A et al. · 2026 · EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

Background Stroke remains a significant concern in patients undergoing Transcatheter Aortic Valve Implantation (TAVI). Despite advances in TAVI technology and techniques, rates have remained unchanged, with trials of Cerebral embolic…

View details →DOI: 10.4244/eij-d-26-00425
Negative / Null Result ReportMedicine

Active-fluidics versus gravity-fluidics system in phacoemulsification for type 2 diabetes mellitus without diabetic retinopathy: a retrospective observational study.

Wang J, Ma Y · 2026 · BMC ophthalmology

Background The efficacy and safety profile of the active-fluidics system (AFS) in diabetic cataract patients remains inadequately characterized. This study specifically evaluated AFS versus gravity-fluidics system (GFS) in type 2 diabetes…

View details →DOI: 10.1186/s12886-026-04927-1
Negative / Null Result ReportMedicine

Jumper's knee risk in elite volleyball: impact of training volume, sex, and position.

Reis AM, Barros AS, Poças PS et al. · 2026 · The Journal of sports medicine and physical fitness

Background Jumper's knee, also known as patellar tendinopathy, is a common overuse injury among athletes involved in sports that require repetitive jumping and high-impact activities, such as volleyball. Understanding the risk factors…

View details →DOI: 10.23736/s0022-4707.26.17195-3
Negative / Null Result ReportMedicine

FLAMSA versus FLAG-IDA as salvage therapy in adults with relapsed/refractory acute myeloid leukemia and acute lymphoblastic leukemia: A single-center real-world retrospective study.

Savaş EM, Bozkurt HH, Kemer NI et al. · 2026 · Leukemia research

Management of relapsed or refractory acute leukemia remains challenging, as allogeneic transplantation is the only curative option. Although targeted therapies are increasingly incorporated as bridge-to-transplant strategies in both AML…

View details →DOI: 10.1016/j.leukres.2026.108271
Negative / Null Result ReportMedicine

Effects of hydroxychloroquine sulfate combined with aspirin and enoxaparin sodium therapy on perinatal outcomes in patients with undifferentiated connective tissue disease-related recurrent miscarriage: a retrospective clinical study.

Pei LC, Wang T, Guo YJ et al. · 2026 · BMC pregnancy and childbirth

Background To evaluate the association between triple therapy (hydroxychloroquine sulfate, aspirin, and enoxaparin sodium) and pregnancy outcomes in patients with undifferentiated connective tissue disease (UCTD)-related recurrent…

View details →DOI: 10.1186/s12884-026-09337-1
Negative / Null Result ReportMedicine

Real-world insights on switching aflibercept dosage for enhanced outcomes in age-related macular degeneration (RISE-AMD): Safety data.

Karunainathan MG, Lee C, Zohalinejad KD et al. · 2026 · Acta ophthalmologica

Purpose To evaluate real-world safety experience with aflibercept 8 mg in a large case series of patients with neovascular age-related macular degeneration (nAMD). Methods Due to a high proportion of patients on short treatment intervals,…

View details →DOI: 10.1111/aos.70160
Negative / Null Result ReportMedicine

Closing gaps in urban trauma systems: Outcomes of an inner-city community emergency department multidisciplinary trauma protocol.

London KS, Cherney A, Neupane S et al. · 2026 · The American journal of emergency medicine

Background Non-trauma center (NTC) emergency departments (EDs) play regular but underappreciated roles in the management of severely injured patients, yet many lack formal protocols to guide care. We describe the implementation and…

View details →DOI: 10.1016/j.ajem.2026.05.032
Negative / Null Result ReportMedicine

Preoperative computed tomography findings of chest wall or mediastinal invasion in pulmonary metastases among children, adolescents, and young adults.

Shirane K, Kitagawa N, Morishima R et al. · 2026 · Journal of pediatric surgery

Background Pulmonary metastasectomy can improve the survival of children with pulmonary metastases from solid tumors. However, preoperative imaging often suggests chest wall and/or mediastinal invasion, raising concerns about…

View details →DOI: 10.1016/j.jpedsurg.2026.163183
Negative / Null Result ReportOpen accessMedicine

Investigating the lasting effects of SARS-CoV-2 infection and the lung microbiome: no persistent microbial alterations in recovered COVID-19 patients with persistent radiological or respiratory abnormalities.

Teng NMY, Vijayakumar B, Smith DJF et al. · 2026 · Access microbiology

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was a global pandemic where infected individuals experienced mild or severe disease. Unfortunately, some patients who experienced severe disease also had lasting abnormalities.…

View details →DOI: 10.1099/acmi.0.001103.v3
Negative / Null Result ReportMedicine

β2-microglobulin is superior to lactate dehydrogenase and bulky disease for risk stratification in diffuse large B-cell lymphoma patients with IPI 1-2.

Chang H, Hung YS, Kuo MC et al. · 2026 · Annals of hematology

The International Prognostic Index (IPI) is the classical assessment tool to evaluate prognosis of diffuse large B cell lymphoma (DLBCL). Although the IPI is simple, reproducible, well validated and widely utilized, it is not entirely…

View details →DOI: 10.1007/s00277-026-07134-6
Negative / Null Result ReportMedicine

Antidepressant use and worsening of non-suicidal self-injury and suicidality in bipolar disorder: A multicenter retrospective cohort study.

Deng Y, Xu N, Huang J et al. · 2026 · Psychiatry research

The safety of antidepressants in bipolar disorder (BD) remains controversial, particularly regarding the risk of behavioral activation and worsening Non-Suicidal Self-Injury (NSSI). This multi-center retrospective cohort study included 575…

View details →DOI: 10.1016/j.psychres.2026.117301
Negative / Null Result ReportMedicine

Risk of postpartum hemorrhage according to the ultrasound measurement of the lower uterine segment before delivery of women with a prior cesarean delivery: secondary exploratory research of the Lower Uterine Segment Trial.

Jeremy B, Rozenberg P · 2026 · American journal of obstetrics & gynecology MFM

Background Women with a previous cesarean delivery have a higher risk of postpartum hemorrhage, including after successful vaginal birth after cesarean. Mechanisms underlying this excess risk remain unclear and may involve impaired…

View details →DOI: 10.1016/j.ajogmf.2026.101973
Negative / Null Result ReportMedicine

Effects of shoulder rotation and table tilt maneuvers on the lumbar and thoracic paramedian acoustic window in older adults: a quasi-experimental study.

Nunes de Souza MV, Caetano AMM, Duarte NMC et al. · 2026 · Brazilian journal of anesthesiology (Elsevier)

Background Shoulder rotation and table tilt have been reported to increase the acoustic window for spinal ultrasonography. However, evidence in older adults remains scarce. This study evaluated their anatomical effects on lumbar (L3-L4)…

View details →DOI: 10.1016/j.bjane.2026.844769
Negative / Null Result ReportMedicine

Short-term outcomes following reconstruction or direct repair of the ulnar collateral ligament.

Sribhashyam S, Talaski GM, Yazdanpanah S et al. · 2026 · Journal of ISAKOS : joint disorders & orthopaedic sports medicine

Introduction Medial ulnar collateral ligament (UCL) injuries substantially impair athletic performance due to pain, instability, and diminished throwing capabilities. While UCL reconstruction is the primary surgical treatment due to its…

View details →DOI: 10.1016/j.jisako.2026.101153
Negative / Null Result ReportMedicine

Comparison of the illness perception between age-related macular degeneration and glaucoma patients living in a middle-income country.

Germano-Morrel CS, Tomishige KS, Macchione RM et al. · 2026 · Journal of health psychology

The aim of this cross-sectional study was to compare the cognitive and emotional representations of illness in patients with primary open angle glaucoma (POAG) and age-related macular degeneration (AMD) living in a developing country. All…

View details →DOI: 10.1177/13591053261430435
Negative / Null Result ReportMedicine

Bulimia Nervosa in Adolescents: Impact of Childhood and Adolescent Sexual Abuse History and the Mediating Role of Social Media.

Alvarez-Tueros EX, Alcántara-Obando MO, Caycho-Rodríguez T et al. · 2026 · The International journal of social psychiatry

The aim of this study was to analyze whether exposure to esthetic content aligned with beauty standards on social media mediates the relationship between a history of childhood/adolescent sexual abuse and bulimic symptomatology in…

View details →DOI: 10.1177/00207640261438840
Negative / Null Result ReportMedicine

Effect of Continuous Theta-Burst Stimulation on Postoperative Delirium in Older Patients Who Undergo Cardiac Surgery.

Zhang J, Zhu Y, Yin Y et al. · 2026 · Neuromodulation : journal of the International Neuromodulation Society

Objectives Postoperative delirium (POD) is a common complication after cardiac surgery in older patients, associated with higher mortality and prolonged stays. Continuous theta-burst stimulation (cTBS), a noninvasive neuromodulation…

View details →DOI: 10.1016/j.neurom.2026.03.003