Negative / Null Result ReportOpen accessEnvironmental Science
Brent B. Hughes, M. D. Levey, Monique C. Fountain et al. · 2015 · Proceedings of the National Academy of Sciences
Coastal ecosystems provide numerous important ecological services, including maintenance of biodiversity and nursery grounds for many fish species of ecological and economic importance. However, human population growth has led to increased…
View details →DOI: 10.1073/pnas.1505815112Cited by 81 Negative / Null Result ReportOpen accessNeuroscience
Frieder M. Paulus, Johannes Bedenbender, Sören Krach et al. · 2013 · Human Brain Mapping
BACKGROUND: Genome-wide association studies have identified the rs1006737 single nucleotide polymorphism (SNP) in the CACNA1C gene as a susceptibility locus for schizophrenia and bipolar disorder. On the neural systems level this…
View details →DOI: 10.1002/hbm.22244Cited by 81 Negative / Null Result ReportAgricultural and Biological Sciences
Albert B. Phillimore, Sandra Stålhandske, R. Smithers et al. · 2012 · The American Naturalist
Phenology affects the abiotic and biotic conditions that an organism encounters and, consequently, its fitness. For populations of high-latitude species, spring phenology often occurs earlier in warmer years and regions. Here we apply a…
View details →DOI: 10.1086/667893Cited by 81 Negative / Null Result ReportOpen accessMedicine
Catherine Townsend, Julie Laffy, Bryan Wu et al. · 2016 · Frontiers in Immunology
Antibody variable regions are composed of a heavy and a light chain, and in humans, there are two light chain isotypes: kappa and lambda. Despite their importance in receptor editing, the light chain is often overlooked in the antibody literature, with the focus being on the heavy chain complementarity-determining region (CDR)-H3 region. In this paper, we set out to investigate the physicochemical and structural differences between human kappa and lambda light chain CDR regions. We constructed a dataset containing over 29,000 light chain variable region sequences from IgM-transcribing, newly f
View details →DOI: 10.3389/fimmu.2016.00388Cited by 81 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Nicholas F. Evageliou, Michelle Haber, Annette Vu et al. · 2016 · Clinical Cancer Research
PURPOSE: Deregulated MYC drives oncogenesis in many tissues yet direct pharmacologic inhibition has proven difficult. MYC coordinately regulates polyamine homeostasis as these essential cations support MYC functions, and drugs that…
View details →DOI: 10.1158/1078-0432.ccr-15-2539Cited by 81 Negative / Null Result ReportOpen accessMedicine
Yoshimi Kubota, Hiroyasu Iso, Chigusa Date et al. · 2011 · Stroke
BACKGROUND AND PURPOSE: Only a few reports have dealt with the association of antioxidant vitamin intakes with mortality or morbidity from cardiovascular disease in Asia. We investigated the relation of dietary vitamins A, E, and C intake…
View details →DOI: 10.1161/strokeaha.110.601526Cited by 81 Negative / Null Result ReportOpen accessMedicine
Selma Kronsteiner-Gicevic, Audrey J. Gaskins, Teresa T. Fung et al. · 2018 · PLoS ONE
BACKGROUND: Dietary diversity scores (DDS) are considered as metrics for monitoring the implementation of the UN's Sustainable Development Goals, but they need to be rigorously evaluated. OBJECTIVE: To examine two DDS, the Food Groups Index (FGI), and the Minimum Dietary Diversity-Women (MDD-W), alongside two dietary quality scores, the Alternate Healthy Eating Index (AHEI-2010) and the Prime Diet Quality Score (PDQS), with risks of gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDPs). DESIGN: The analysis included 21,312 (GDM) and 19,917 (HDPs) singleton births r
View details →DOI: 10.1371/journal.pone.0195103Cited by 81 Negative / Null Result ReportOpen accessMedicine
Katherine Andrinopoulos, Gretchen Clum, Debra A. Murphy et al. · 2011 · AIDS Education and Prevention
In this study HIV health-related quality of life (HIV-HRQOL) is examined among 179 behaviorally infected adolescent and young adult women. Modifiable psychosocial variables including depression, stigma, social support, and illness…
View details →DOI: 10.1521/aeap.2011.23.4.367Cited by 81 Negative / Null Result ReportOpen accessMaterials Science
Mathilde Hunault, T. Leguay, Xavier Thomas et al. · 2010 · Haematologica
BACKGROUND: The prognosis of acute lymphoblastic leukemia in the elderly is poor. The GRAALL-SA1 phase II, randomized trial compared the efficacy and toxicity of pegylated liposomal doxorubicin versus continuous-infusion doxorubicin in…
View details →DOI: 10.3324/haematol.2010.027862Cited by 81 Negative / Null Result ReportOpen accessMedicine
Marcos Hortes Nisihara Chagas, José Alexandre S. Crippa, Antônio Waldo Zuardi et al. · 2013 · Journal of Psychopharmacology
UNLABELLED: Cannabidiol (CBD) is one of the main components of Cannabis sativa and has a wide spectrum of action, including effects in the sleep-wake cycle. OBJECTIVE: The objective of this paper is to assess the effects on sleep of acute…
View details →DOI: 10.1177/0269881112474524Cited by 81 Negative / Null Result ReportOpen accessMedicine
Davide Castagno, Mark C. Petrie, Brian Claggett et al. · 2012 · European Heart Journal
AIMS: The importance of heart rate in the pathophysiology of heart failure with reduced LVEF has recently attracted attention. In particular, the findings of the Systolic Heart failure treatment with the I(f) inhibitor ivabradine Trial…
View details →DOI: 10.1093/eurheartj/ehs004Cited by 81 Negative / Null Result Report
Christina Brock, Christian Stevns Hansen, Jesper Karmisholt et al. · 2019 · British Journal of Clinical Pharmacology
Aims Type 1 diabetes can be complicated with neuropathy that involves immune‐mediated and inflammatory pathways. Glucagon‐like peptide‐1 receptor agonists such as liraglutide, have shown anti‐inflammatory properties, and thus we…
View details →DOI: 10.1111/bcp.14063Cited by 81 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Anne J. M. R. Geijsen, Stefanie Brezina, Pekka Keski‐Rahkonen et al. · 2019 · International Journal of Cancer
Colorectal cancer is known to arise from multiple tumorigenic pathways; however, the underlying mechanisms remain not completely understood. Metabolomics is becoming an increasingly popular tool in assessing biological processes. Previous metabolomics research focusing on colorectal cancer is limited by sample size and did not replicate findings in independent study populations to verify robustness of reported findings. Here, we performed a ultrahigh performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS) screening on EDTA plasma from 268 colorectal cancer
View details →DOI: 10.1002/ijc.32146Cited by 81 Negative / Null Result ReportOpen accessSocial Sciences
Raquel Álvarez-Urdiola, David García, Yamir Moreno et al. · 2015 · EPJ Data Science
Recent grassroots movements have suggested that online social networks might play a key role in their organization, as adherents have a fast, many-to-many, communication channel to help coordinate their mobilization. The structure and dynamics of the networks constructed from the digital traces of protesters have been analyzed to some extent recently. However, less effort has been devoted to the analysis of the semantic content of messages exchanged during the protest. Using the data obtained from a microblogging service during the brewing and active phases of the 15M movement in Spain, we per
View details →DOI: 10.1140/epjds/s13688-015-0042-4Cited by 80 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jason Yao, Anna Pilko, Roy Wollman · 2016 · Molecular Systems Biology
The heterogeneity in mammalian cells signaling response is largely a result of pre-existing cell-to-cell variability. It is unknown whether cell-to-cell variability rises from biochemical stochastic fluctuations or distinct cellular states. Here, we utilize calcium response to adenosine trisphosphate as a model for investigating the structure of heterogeneity within a population of cells and analyze whether distinct cellular response states coexist. We use a functional definition of cellular state that is based on a mechanistic dynamical systems model of calcium signaling. Using Bayesian param
View details →DOI: 10.15252/msb.20167137Cited by 80 Negative / Null Result ReportOpen accessPhysics and Astronomy
C. Schaefer, Mario Geiger, T. Kuntzer et al. · 2017 · Astronomy and Astrophysics
Context. Future large-scale surveys with high-resolution imaging will provide us with approximately 10 5 new strong galaxy-scale lenses. These strong-lensing systems will be contained in large data amounts, however, which are beyond the…
View details →DOI: 10.1051/0004-6361/201731201Cited by 80 Negative / Null Result ReportOpen accessMedicine
Konstantinos A. Toulis, Brian H Willis, Tom Marshall et al. · 2017 · The Journal of Clinical Endocrinology & Metabolism
Context: Empagliflozin was found to decrease mortality in patients with type 2 diabetes mellitus (T2DM) and a prior cardiovascular disease (CVD) event. Objectives: To establish whether these benefits can be replicated in a real-world…
View details →DOI: 10.1210/jc.2016-3446Cited by 80 Negative / Null Result ReportOpen accessMedicine
Sushmita Pamidi, Isabelle Marc, Gabrielle Simoneau et al. · 2016 · Thorax
OBJECTIVE: It is unclear whether objectively measured maternal sleep-disordered breathing (SDB) leads to poor fetal outcomes. In this study, we prospectively assessed whether polysomnography-based diagnosis of SDB in the third trimester is…
View details →DOI: 10.1136/thoraxjnl-2015-208038Cited by 80 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Joonho Suh, Yun‐Sil Lee · 2020 · Journal of Bone Metabolism
Myostatin, also known as growth differentiation factor 8 (GDF8), is a transforming growth factor-β (TGF-β) family member that functions to limit skeletal muscle growth. Accordingly, loss-of-function mutations in myostatin result in a…
View details →DOI: 10.11005/jbm.2020.27.3.151Cited by 80 Negative / Null Result ReportMedicine
Oded Zmora, Khaled Madbouly, Hagit Tulchinsky et al. · 2010 · Diseases of the Colon & Rectum
PURPOSE: Urinary bladder drainage for several days after pelvic surgery is a common surgical practice, despite insufficient evidence supporting its routine use. The aim of this study was to prospectively evaluate the utility of urinary…
View details →DOI: 10.1007/dcr.06013e3181c7525cCited by 80 Negative / Null Result ReportMedicine
Murat Gedikoğlu, Levent Oğuzkurt, Serkan Gür et al. · 2013 · Catheterization and Cardiovascular Interventions
OBJECTIVES: To compare the success and complication rates of ultrasound-guided or palpation-guided punctures of the common femoral artery in a prospective randomized study. BACKGROUND: Percutaneous femoral arterial access is sometimes…
View details →DOI: 10.1002/ccd.24955Cited by 80 Negative / Null Result ReportEnvironmental Science
Eric E. Knapp, J. Morgan Varner, Matt D. Busse et al. · 2011 · International Journal of Wildland Fire
Mechanical mastication converts shrub and small tree fuels into surface fuels, and this method is being widely used as a treatment to reduce fire hazard. The compactness of these fuelbeds is thought to moderate fire behaviour, but whether…
View details →DOI: 10.1071/wf10110Cited by 80 Negative / Null Result ReportDentistry
Panagiotis A. Koromantzos, Konstantinos Makrilakis, Xanthippi Dereka et al. · 2011 · Journal of Periodontology
BACKGROUND: It is well accepted that glycemic control in patients with diabetes mellitus (DM) is affected by systemic inflammation and oxidative stress. The effect of periodontal therapy on these systemic factors may be related to…
View details →DOI: 10.1902/jop.2011.110148Cited by 80 Negative / Null Result ReportOpen accessPsychology
Oren Contreras‐Rodríguez, Jesús Pujol, Iolanda Batalla et al. · 2013 · Social Cognitive and Affective Neuroscience
Psychopaths show a reduced ability to recognize emotion facial expressions, which may disturb the interpersonal relationship development and successful social adaptation. Behavioral hypotheses point toward an association between emotion…
View details →DOI: 10.1093/scan/nst014Cited by 80 Negative / Null Result ReportMedicine
Jan Krhút, Vladimír Borovička, Karolína Bílková et al. · 2018 · Neurourology and Urodynamics
AIMS: To assess the efficacy and safety of mirabegron in the treatment of neurogenic detrusor overactivity. METHODS: This prospective, multicenter, randomized, double-blind, placebo-controlled study was conducted in three tertiary centers,…
View details →DOI: 10.1002/nau.23566Cited by 80 Negative / Null Result ReportOpen accessMedicine
Mary Carmelle Philogene, Serena M. Bagnasco, Edward S. Kraus et al. · 2016 · Transplantation
BACKGROUND: This is a cross-sectional study designed to evaluate the histologic characteristics of graft injury in the presence of anti-angiotensin II type 1 receptor antibody (AT1R-Ab) and anti-endothelial cell antibody (AECA). METHODS:…
View details →DOI: 10.1097/tp.0000000000001231Cited by 80 Negative / Null Result ReportSocial Sciences
Daniel Tinkelman, Daniel Neely · 2010 · Nonprofit and Voluntary Sector Quarterly
Several econometric issues arise in using nonprofit data. After controlling for unduly influential observations and heteroskedasticity, regression analysis performed on National Center for Charitable Statistics “digitized data” from 2001…
View details →DOI: 10.1177/0899764010371010Cited by 79 Negative / Null Result ReportOpen accessMedicine
Christopher M. Jackson, Christina M. Kochel, Christopher J. Nirschl et al. · 2015 · Clinical Cancer Research
PURPOSE: Immune responses to antigens originating in the central nervous system (CNS) are generally attenuated, as collateral damage can have devastating consequences. The significance of this finding for the efficacy of tumor-targeted…
View details →DOI: 10.1158/1078-0432.ccr-15-1516Cited by 79 Negative / Null Result ReportOpen accessMedicine
Boulos Nassar, Mary Vaughan‐Sarrazin, Lan Jiang et al. · 2014 · JAMA Internal Medicine
IMPORTANCE: Intensive care unit (ICU) telemedicine (TM) programs have been promoted as improving access to intensive care specialists and ultimately improving patient outcomes, but data on effectiveness are limited and conflicting.…
View details →DOI: 10.1001/jamainternmed.2014.1503Cited by 79 Negative / Null Result ReportOpen accessMedicine
Patrick M. Honoré, Rita Jacobs, Inne Hendrickx et al. · 2015 · Annals of Intensive Care
Sepsis-induced acute kidney injury (SAKI) remains an important challenge in critical care medicine. We reviewed current available evidence on prevention and treatment of SAKI with focus on some recent advances and developments. Prevention of SAKI starts with early and ample fluid resuscitation preferentially with crystalloid solutions. Balanced crystalloids have no proven superior benefit. Renal function can be evaluated by measuring lactate clearance rate, renal Doppler, or central venous oxygenation monitoring. Assuring sufficiently high central venous oxygenation most optimally prevents SAK
View details →DOI: 10.1186/s13613-015-0095-3Cited by 79 