e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19893 results in Negative / Null Result Report · page 559 of 664

Negative / Null Result ReportMedicine

Face-to-face vs. telerehabilitation for thoracic hyperkyphosis in children- A randomized controlled pilot study.

Gözener Canbülbül S, Canbülbül B, Özcan Şİ et al. · 2026 · Journal of pediatric rehabilitation medicine

PurposeThis pilot study aimed to compare the effects of face-to-face and telerehabilitation approaches on thoracic hyperkyphosis, back extensor muscle strength, and discomfort in children.MethodsA randomized clinical trial was conducted in…

View details →DOI: 10.1177/18758894261446171
Negative / Null Result ReportMedicine

The John Charnley Award: A Randomized Controlled Trial of Dual Mobility and Single Bearings for Patients at High Risk of Dislocation Following Primary Total Hip Arthroplasty.

Potluri AS, Yadav AS, Weintraub MT et al. · 2026 · The Journal of arthroplasty

Introduction This multicenter randomized controlled trial (RCT) sought to determine if dual-mobility bearings (DM) reduce dislocations in patients at high-risk for instability undergoing primary total hip arthroplasty (THA) compared to…

View details →DOI: 10.1016/j.arth.2026.06.018
Negative / Null Result ReportMedicine

Nocturnal Hypoxemia and Incident Coronary Artery Disease in Obstructive Sleep Apnea: Results from the Sleep Apnea Patients in Skaraborg Study.

Peker Y, Hjälm HH, Glantz H et al. · 2026 · Balkan medical journal

Background The relationship between obstructive sleep apnea (OSA) and coronary artery disease (CAD) remains controversial. Although observational studies have suggested that OSA is associated with an increased risk of coronary events,…

View details →DOI: 10.4274/balkanmedj.galenos.2026.2026-3-213
Negative / Null Result ReportMedicine

Safety of drug-eluting stent in Chinese population with or without diabetes: a multi-center registry study.

Cao S, Ling M, Zhang X et al. · 2026 · BMC cardiovascular disorders

Background The safety of drug-eluting stents (DES) in patients undergoing percutaneous coronary intervention (PCI) remains largely lacking in China. This study aimed to determine the 1-year adverse outcomes in a large registry of patients…

View details →DOI: 10.1186/s12872-026-06060-9
Negative / Null Result Report

Association of Driver Oncogenic Alterations with SUVmax, Preoperative Serum Calcium, and Smoking Status in Surgically Resected Non-Small Cell Lung Cancer: A Retrospective Single-Center Study

Korodimos N, Wojtyś ME, Kostopanagiotou K et al. · 2026 · Preprint

Background: Non-small cell lung cancer (NSCLC) is driven by distinct oncogenic al-terations with important therapeutic and prognostic implications. Noninvasive bi-omarkers that predict molecular status in surgically resectable disease may…

View details →DOI: 10.20944/preprints202605.0394.v1
Negative / Null Result ReportOpen accessMedicine

Investigation of Contrast-Induced Neurotoxicity and the Effects of Sildenafil and <i>N</i>-Acetylcysteine on HIF-1α Levels in Wistar Rats.

Altintop I, Tatli M, Sarica ZS et al. · 2026 · Brain sciences

Background Contrast-induced encephalopathy (CIE) is an uncommon yet clinically significant complication associated with iodinated contrast media, with its mechanisms remaining unclear. Objective The aims of this study are to examine the…

View details →DOI: 10.3390/brainsci16040362
Negative / Null Result ReportMedicine

Comparison of esketamine combined with dexmedetomidine versus propofol combined with midazolam on drug-induced sleep endoscopy: a randomized controlled trial.

Jiang Y, Wang Z, Wen H et al. · 2026 · BMC anesthesiology

Background Drug-induced sleep endoscopy (DISE) is widely used to evaluate upper airway obstruction in patients with obstructive sleep apnea syndrome (OSAS). We aimed to compare the sedative efficacy and safety of esketamine combined with…

View details →DOI: 10.1186/s12871-026-03987-6
Negative / Null Result ReportMedicine

Prognostic Value of BUN-Based Ratios for Mortality and Prolonged Hospitalization in Acute Upper Gastrointestinal Bleeding: Comparison with Established Risk Scores.

İnan B, Erdoğan Ç, Keskin ET et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : This study investigated the prognostic value of two simple blood urea nitrogen (BUN)-based ratios, BUN/hemoglobin (Hb) and BUN/Albumin, for predicting in-hospital mortality and prolonged hospitalization in…

View details →DOI: 10.3390/medicina62061210
Negative / Null Result ReportMedicine

Direct Maxillary Sinus Tissue Analysis for <i>TAS2R38</i> Polymorphisms: Establishing a Tissue-Based Translational Framework in Odontogenic Rhinosinusitis.

Greța-Oanță AL, Roman A, Berindan-Neagoe I et al. · 2026 · Journal of clinical medicine

Background/Objectives: Bitter taste receptors (T2Rs), specifically T2R38, are present in the respiratory epithelium and react with bacterial quorum-sensing molecules to induce an innate immunity response. Although TAS2R38 polymorphisms…

View details →DOI: 10.3390/jcm15124836
Negative / Null Result ReportMedicine

Inhibitory Control and Creativity in Children With Mild Intellectual Disabilities.

Japundža-Milisavljević M, Buha N, Milanović-Dobrota B · 2026 · Journal of applied research in intellectual disabilities : JARID

Background The study is based on the Dual Pathway to Creativity Model and explores the relationship between inhibitory control and creativity in children with mild intellectual disabilities. Method The sample consisted of 58 children with…

View details →DOI: 10.1111/jar.70213
Negative / Null Result ReportMedicine

Evaluation of corneal aberrations and meibomian gland function after botulinum toxin A in blepharospasm/hemifacial spasm.

Doganay D, Ismayilov AS, Sevınc D et al. · 2026 · Cutaneous and ocular toxicology

Purpose To evaluate the changes in aberrometry values on corneal topography and the function of the meibomian glands following therapeutic Botulinum toxin type A injections in patients with blepharospasm and hemifacial spasm. Materials and…

View details →DOI: 10.1080/15569527.2026.2673150
Negative / Null Result ReportMedicine

Modulation of oxidative stress mediates kaempferol induced enhancement of bovine oocyte In Vitro maturation developmental efficiency.

Wang H, Wang W, Li Y et al. · 2026 · Animal reproduction science

This study aimed to examine the protective effects of kaempferol on the in vitro maturation (IVM) of bovine oocytes and their subsequent embryonic development, and to investigate the underlying mechanisms. Bovine oocytes were cultured with…

View details →DOI: 10.1016/j.anireprosci.2026.108252
Negative / Null Result ReportMedicine

Tasting beer based on the tactile thickness of the glass lip

Ariga A, Kubo N, Koizumi T et al. · 2026 · Food Quality and Preference.

Multisensory research has demonstrated that the perceptual characteristics of a receptacle can influence how beverages are experienced, a phenomenon known as sensation transference. Previous studies have shown that the lip thickness of a…

Negative / Null Result Report

Do drugs with biliary toxicity cause cholangiocarcinoma?

Zong C, Lim K, Walker SA et al. · 2026 · Preprint

A bstract Many commonly used therapeutic drugs cause biliary toxicity, but it is unclear if they are directly responsible for the increasing incidence of cholangiocarcinoma (CCA). We tested experimentally and analyzed through a cohort…

View details →DOI: 10.64898/2026.03.31.715688
Negative / Null Result ReportMedicine

Incidence and associated factors of metachronous contralateral cryptorchidism after unilateral cryptorchidism: a retrospective cohort study.

Grande-Moreillo C, Pérez-López C, Vicente-Sánchez N et al. · 2026 · European journal of pediatrics

Acquired cryptorchidism is an increasingly recognized condition and may present bilaterally with a metachronous pattern. The objective of this study was to evaluate the incidence of acquired contralateral metachronous cryptorchidism and to…

View details →DOI: 10.1007/s00431-026-07154-4
Negative / Null Result ReportMedicine

Frequent Ambulatory Care Visits Predict Harmful Diagnostic Errors in High-Risk Hospitalized Patients: a Retrospective Cohort Study.

Goyal A, Konieczny K, Plombon S et al. · 2026 · Journal of general internal medicine

Background Diagnostic errors (DEs) are a major threat to hospital patient safety. Identifying admission-based predictors associated with harmful DEs may help improve diagnostic safety in high-risk populations. Objective To assess the…

View details →DOI: 10.1007/s11606-026-10527-y
Negative / Null Result ReportOpen accessMedicine

Effectiveness of Hyaluronic Acid Gel in Preventing Postoperative Intrauterine Adhesion Formation Following Operative Hysteroscopy.

Ciftci B, Karadag B · 2026 · International journal of women's health

Objective To evaluate the effectiveness of intrauterine hyaluronic acid (HA) gel application in preventing postoperative intrauterine adhesion formation following operative hysteroscopy. Methods This retrospective comparative study was…

View details →DOI: 10.2147/ijwh.s609095
Negative / Null Result ReportOpen accessMedicine

Trend and clinical outcomes of transcatheter aortic valve replacement in connective tissue disease from the national inpatient sample database (2016-2022).

Yasmin F, Rab AU, Asghar MS et al. · 2026 · Journal of cardiothoracic surgery

Purpose Given the systemic nature of connective tissue diseases (CTD), open surgical intervention for aortic stenosis is often considered high risk, making transcatheter aortic valve replacement (TAVR) a potentially preferable alternative.…

View details →DOI: 10.1186/s13019-026-04170-1
Negative / Null Result ReportMedicine

Factors Affecting the Quantitative Value of the Pivot Shift Test Using a Navigation System in Anterior Cruciate Ligament Injured Knees.

Nakamae A, Nekomoto A, Nakata K et al. · 2026 · The journal of knee surgery

Abstract This study aimed to identify factors associated with greater quantitative pivot shift in anterior cruciate ligament (ACL)-injured knees by quantitatively assessing the pivot shift under anesthesia using a navigation system prior…

View details →DOI: 10.1055/a-2865-3249
Negative / Null Result ReportMedicine

Evaluation of the Effect of Different Drilling Systems on Trabecular Bone Microarchitecture During Implant Cavity Preparation Using CBCT: Ex Vivo Study.

Cakir M, Buyuk C, Kan B · 2026 · The International journal of oral & maxillofacial implants

Purpose Achieving optimal primary stability is critical for dental implant success, particularly in low-density bone regions such as the posterior maxilla. Conventional high-speed drilling with irrigation may remove vital bone fragments…

View details →DOI: 10.11607/jomi.11740
Negative / Null Result ReportOpen accessMedicine

Dosimetric Impact of Artificial Intelligence (AI)-Based Autocontouring Software, OncoStudio, in High-Risk Prostate Cancer Treatment Planning: A Three-Group Comparative Study on the Slice Ranges of Seminal Vesicles.

Kawaguchi M, Hoshina M, Sugahara S et al. · 2026 · Cureus

Objective This pilot study investigated the dosimetric impact of artificial intelligence (AI)-generated seminal vesicle (SV) autocontouring (AC) compared with manual contouring (MC) in high-risk prostate cancer volumetric-modulated arc…

View details →DOI: 10.7759/cureus.103403
Negative / Null Result ReportMedicine

Real-World Outcomes of Total Neoadjuvant Therapy Versus Standard Neoadjuvant Chemoradiotherapy in Stage II-III Locally Advanced Rectal Cancer: A Comparative Cohort Study.

Erken AA, Dincer ST · 2026 · Asia-Pacific journal of clinical oncology

Aim Total neoadjuvant therapy has been adopted to improve systemic disease control in locally advanced rectal cancer, yet long-term real-world outcomes, particularly in non-Western populations, remain incompletely defined. We compared…

View details →DOI: 10.1111/ajco.70118
Negative / Null Result ReportMedicine

Inflammatory Biomarkers and Their Associations with Arrhythmic Burden Following SGLT2-I Treatment in Chronic Heart Failure-A Subanalysis of the ERASe Trial.

Benedikt M, Herrmann M, Aziz F et al. · 2026 · Journal of clinical medicine

Background : Sodium glucose-linked transport 2 inhibitors (SGLT2-Is) are well known to exert beneficial effects in chronic heart failure (CHF) independent of left ventricular ejection fraction (LVEF). As inflammation plays a key role in…

View details →DOI: 10.3390/jcm15124681
Negative / Null Result ReportOpen accessMedicine

Two versus three cannulated screws in pediatric Delbet type II femoral neck fractures: a retrospective comparative study.

Erdoğan F, Cengiz T, Şimşek ŞA et al. · 2026 · Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES

Background Pediatric femoral neck fractures are rare but carry a high risk of complications such as avascular necrosis (AVN), premature physeal closure, and coxa vara. Although stable internal fixation is essential, the optimal number of…

View details →DOI: 10.14744/tjtes.2026.97273
Negative / Null Result ReportMedicine

Outcome of preterm newborns admitted with respiratory distress in relation to time of initiation of CPAP.

Pandey K, Choubey B, Gupta N et al. · 2026 · Journal of neonatal-perinatal medicine

BackgroundRespiratory distress is a frequent complication in preterm infants, often requiring respiratory support. Respiratory distress syndrome (RDS), caused by surfactant deficiency in the immature lung, is the predominant etiology in…

View details →DOI: 10.1177/19345798261443957