A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20261 results in Negative / Null Result Report · page 559 of 676
Boffetta P, Zaridze D, Świątkowska B et al. · 2026 · Frontiers in oncology
Introduction Exposure to arsenic, cadmium, chromium (VI) and nickel increases the risk of lung cancer; whereas humans are exposed to mixtures, epidemiology studies refer to individual metals/metalloids. Methods We analysed the data of a…
Shi C, Wu L, Yang Q et al. · 2026 · Preprint
Abstract Background Orientation impairment is an early and clinically meaningful marker of cognitive vulnerability in older adults and is associated with subsequent functional decline, dementia, and mortality. Although stroke is a…
Bevilacqua K, Gemmill A, Jackson D et al. · 2026 · Journal of immigrant and minority health
Latina/e women in the United States (US) experience intimate partner violence (IPV) at similar or lower rates than other women but worse IPV-related health outcomes, perhaps due to barriers to help-seeking. IPV reporting to police is one…
Martineau AR · 2026 · Current opinion in infectious diseases
Purpose of review This review summarizes findings of recent Phase 3 randomized controlled trials (RCTs) and meta-analyses investigating effectiveness of vitamin D supplementation for prevention and treatment of tuberculosis or acute…
Yang NY, Ke TM, Huang Y et al. · 2026 · Life (Basel, Switzerland)
Background/Objectives : Pancreatic cancer is one of the most lethal malignancies, with poor survival and few established modifiable risk factors. While Helicobacter pylori ( H. pylori ) infection is a known cause of gastric cancer, its…
Xu S, Sy LS, Hong V et al. · 2026 · Preprint
Background The Vaccine Safety Datalink (VSD) detected a statistical signal for ischemic events (ischemic stroke or transient ischemic attack) following bivalent mRNA COVID-19 vaccination through prospective surveillance during 2022-2023.…
Bar Or M, Schonberg T · 2025 · Preprint
Understanding habit formation in humans remains a fundamental challenge, partly due to the constraints of laboratory-based studies. Thus, this study investigated whether prolonged, real-world engagement with a novel smartphone-based task…
Binder M, Blankenberg AK, Nickel J · 2025 · Ecological economics
A positive relationship between pro-environmental behavior and subjective well-being has been used to argue for a “double dividend”, i.e. the narrative that pro-environmental behavior is beneficial for both environment and individual, when…
Wang Y, Sha S, Gwenzi T et al. · 2026 · Clinical nutrition (Edinburgh, Scotland)
Background & aims Vitamin D insufficiency and deficiency are common worldwide and linked to adverse health outcomes, including higher all-cause mortality. Two large randomized controlled trials (VITAL and D-Health), conducted in mostly…
Braun D, Olmer A · 2026 · Frontiers in psychiatry
Background and hypothesis Toxoplasma gondii (TG) exposure and host immunogenetic variation have been implicated in psychosis. Interferon-gamma (IFN-γ) is central to TG control; the IFN-γ +874T/A polymorphism has been linked to variability…
Vinceti M, Vicentini M, Ottone M et al. · 2026 · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
Background Consistent evidence from randomized controlled trials has shown that overexposure to selenium induces type 2 diabetes. However, uncertainties remain about the specific species and doses of selenium that trigger such diabetogenic…
Arza A, Gong Y, Shu J et al. · 2026 · Physical review letters
Millicharged particles are well-motivated dark matter candidates arising in many extensions of the standard model. We show that, despite their tiny coupling e_{m} to photons, millicharged dark matter (mDM) in the Earth's geomagnetic field…
Ishaqui AA, Alsaleh EA, Khalil AAA et al. · 2026 · Naunyn-Schmiedeberg's archives of pharmacology
Heart failure (HF) hospitalization is a high-risk transition period with frequent early post-discharge events; we evaluated whether oral metoprolol exposure during the index HF hospitalization is associated with lower all-cause death…
Liu Y, Sorace A, Smith K · 2025 · Preprint
Previous research has proposed that bilinguals would rather be redundant than ambiguous. To test this hypothesis, we conducted an experiment examining lexical ambiguity in spoken Mandarin at the tonal, segmental, and orthographical levels.…
Kashihara J, Kunisato Y, Sugawara D et al. · 2025 · Preprint
The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP) has gained popularity as an alternative to traditional disorder-specific psychotherapies, and its detailed treatment process remains unaddressed empirically. We…
Castellano Bueno J, Paraskevopoulou A, Miller CW et al. · 2025 · Preprint
Fluid control protocols are widely used in neuroscience to motivate laboratory macaques to engage with behavioural tasks. Despite strong evidence that the physiology of the animals is not compromised by such protocols, fluid control…
Ward J, Agbude R, Smees R et al. · 2025 · Hearing research
This study examined the concentrations of excitatory and inhibitory neurotransmitters (glutamate and GABA respectively) in two regions of interest (auditory and insular cortices) and a control region (visual cortex) to test the hypothesis…
Trotter D, Pariz A, Hutt A et al. · 2025 · Frontiers in synaptic neuroscience
Introduction Non-invasive brain stimulation techniques, widely used to manipulate neural excitability and behavior, are well studied at the meso- and macroscopic scales. However, less is known about their specificity at the level of…
Makin A, Taylor A, Macpherson L · 2025 · Psychological reports
The attractiveness halo effect has been discussed for over a century. Physically attractive people are often judged more favourably and accrue many life advantages. Halo effects have been observed in university settings for decades, but…
Greenleaf AT · 2025 · Preprint
Plant cognition has progressed from anecdote to rigor, yet the field still lacks a quantitative test for when distributed plant activity crosses into unified—perhaps conscious—processing. I introduce Pattern–Temporal Synergy (PTS), a…
Lee P, Li J, Jones BC et al. · 2025 · Evolutionary psychology : an international journal of evolutionary approaches to psychology and behavior
Researchers have suggested that men with more masculine facial characteristics have stronger immune systems but are perceived to be less likely to invest resources in partners and offspring. How women resolve this putative trade-off…
Hornsby G, Pu C, Badamikar A et al. · 2025 · Preprint
ABSTRACT Introduction While improving water, sanitation, and hygiene (WASH) service delivery in schools supports the Sustainable Development Goals, rigorous trials have recently reported inconsistent effects of WASH in schools (WinS)…
Codino A · 2025 · Preprint
The notion of Dark Matter originates from the violation of Virial Theorem in galaxy clusters and the empirical evidence of flat or increasing rotation curves in disk galaxies. From novel advances on basic properties of cosmic rays it…
Stilp CE, Winn MB · 2026 · The Journal of the Acoustical Society of America
Identification of speech sounds is influenced by spectral contrast effects (SCEs), the perceptual magnification of spectral differences between successive sounds. SCEs result in the categorization of a target sound being biased away from…
Harding JF, Walzer J, Piatt R et al. · 2025 · Contraception
Objectives It is important to identify programs that can work in multiple contexts to support adolescent parents in achieving their reproductive health goals. A randomized controlled trial in Ohio in 2012 found that the Teen Options to…
Ward J, Agbude R, Smees R et al. · 2025 · Preprint
This study examined the concentrations of excitatory and inhibitory neurotransmitters (glutamate and GABA respectively) in two regions of interest (auditory and insular cortices) and a control region (visual cortex) to test the hypothesis…
Bar Or M, Schonberg T · 2025 · Preprint
Understanding habit formation in humans remains a fundamental challenge, partly due to the constraints of laboratory-based studies. Thus, this study investigated whether prolonged, real-world engagement with a novel smartphone-based task…
Guest H, Plack CJ, Munro KJ et al. · 2026 · International journal of audiology
Objective Adult auditory brainstem response (ABR) amplitudes are employed by both researchers and clinicians, but exhibit substantial between-subject variability, reducing their sensitivity as measures of underlying auditory health. One…
Bar Or M, Schonberg T · 2025 · Preprint
Understanding habit formation in humans remains a fundamental challenge, partly due to the constraints of laboratory-based studies. Thus, this study investigated whether prolonged, real-world engagement with a novel smartphone-based task…
Nielsen SP, Mathiesen L, Møller P · 2025 · Basic & clinical pharmacology & toxicology
This review examines the association between early life exposure to phthalates in human males and Leydig cell endocrine function. A systematic search was performed in PubMed and EMBASE, identifying 17 studies for analysis. Association…