A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19893 results in Negative / Null Result Report · page 556 of 664
Lopes FM, Bantounas I, Sarov A et al. · 2026 · Nephron
Introduction Human fetal kidneys contain macrophages, innate immune cells postulated to enhance their development. Macrophages have also been implicated in the pathobiology of human kidney malformations and Wilms tumour. Human pluripotent…
Prins PJ, Buga A, Storoschuk K et al. · 2026 · Journal of the American Nutrition Association
Background Exogenous ketone supplementation acutely elevates circulating beta-hydroxybutyrate ( R -BHB), but the impact of chronic repeated dosing on exercise performance, cognition, mood, and cardiometabolic health remains unclear.…
Lee HW, Harris AN, Wall SM et al. · 2026 · American journal of physiology. Renal physiology
Hypokalemia activates intercalated cell acid secretion, but because hypokalemia is typically associated with metabolic alkalosis, this activation cannot be ascribed to extracellular pH. Metabolic acidosis induces responses similar to those…
King JL, Effinger DP, Basquez-Pfeifer C et al. · 2026 · Translational psychiatry
The head-twitch response (HTR) is widely used as a preclinical assay for the hallucinogenic potential of compounds, with its utility based on 5HT 2A R activation. Here, we examine how the polypharmacological agonists lisuride and lysergic…
Donate APG, Cousijn J, Rømer Thomsen K · 2026 · Psychopharmacology
Rationale People who use cannabis often report using it to improve sleep and/or manage mental health symptoms. Cannabis products differ in their typical cannabinoid composition, particularly in their relative THC and CBD content, which may…
Brown KA, Max LNF, Struble SE et al. · 2026 · American journal of veterinary research
Objective Determine the acute effects of xylazine and detomidine on concentrations of selected growth factors, cytokines, and α2-macroglobulin (A2M) in platelet-rich plasma (PRP) and autologous protein solution (APS) and the long-term…
Calder AE, Diehl VJ, Lietz MP et al. · 2026 · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Preclinical studies suggest that lysergic acid diethylamide (LSD) may induce lasting changes in brain function and learning ability, but evidence in humans is uncertain. Motor learning, in particular, has clinical relevance but has not…
Uenishi R, Kawata R, Manabe T et al. · 2026 · Preprint
Neuroinflammation is a central driver of tauopathy, yet the precise chemokines that orchestrate the inflammatory microenvironment remain elusive. Here, we report C-X-C motif chemokine ligand 10 (CXCL10) is markedly upregulated in the…
Dachille GP, Zuanna AD, Paiella M et al. · 2026 · Preprint
Abstract We quantify how the employment expansion accompanying Italy’s post-pandemic recovery mitigated the distributional consequences of the contemporaneous surge in prices, which disproportionately affected households at the bottom of…
Cárdenas SA · 2026 · Preprint
Objective(s): Strategic overcharging involves threatening disproportionately harsh punishment to widen the differential between the potential sentence if convicted at trial (PTS) and the plea sentence. Though larger discounts increase plea…
Enciso-Pablo Ó, Sierra-Ramírez F, Sotres-Bayon F · 2026 · Psychopharmacology
Rationale Benzodiazepines are widely used to treat anxiety; however, their influence on defensive behavior when threats compete with rewards remains unclear. Objectives Here, we tested the effects of diazepam on reactive avoidance (no…
Ben-Chetrit E, Zilberstein Z, Levin PD · 2026 · Preprint
Abstract Background Obtaining blood cultures at IV insertion is common practice, but is probably associated with greater contamination. Whether use of first-aliquot-diversion (diversion) reduces contamination in this context is not clear.…
Abrahams M, Bunting BP, Frewer LJ et al. · 2026 · Food & function
Although personalised nutrition is more effective than generic approaches to dietary health promotion, effect sizes tend to be small. Behaviour change theory implies the importance of goal setting to successful health intervention. This…
Ben-Zeev T, Levi C, Ratamess NA et al. · 2026 · Hormones and behavior
This study examined the effects of resistance training (RT) and supraphysiological nandrolone decanoate (ND) administration on hippocampal neurogenesis, neurotrophic signaling, and behavior. Forty 3-month-old male C57BL/6 J mice were…
dela Cruz PC, Benson B, Jayavelu ND et al. · 2025 · Preprint
ABSTRACT Background Rhinovirus (RV) is the most common trigger of viral-induced pediatric asthma exacerbations. The impact of IL-13-driven inflammation, common in pediatric asthma, on airway epithelial antiviral and inflammatory responses…
Ceccatto Andrade VP, Araujo Júnior E, Callado GY et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology
Objective The transdermal administration of testosterone is a promising alternative to improve sexual health in postmenopausal women with decreased sexual desire, although its use remains off-label in Brazil and several other countries.…
Miftakhov R, Fortygina P, Zuzina A et al. · 2026 · Scientific reports
Astrocytes communicate bidirectionally with neurons by releasing various signaling molecules. This astrocyte-neuron "dialogue" is essential for long-term processes in the nervous system, and its disruption correlates with various…
Lalunio H, Goodman CA, Stupka N et al. · 2026 · Preprint
Abstract Aims Chronic inflammation and oxidative stress are key components in Duchenne muscular dystrophy (DMD) pathology. Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional protein involved in…
Wu J, Li G, Pen J et al. · 2026 · Journal of environmental management
Saline-alkali grassland ecosystems are essential methane (CH 4 ) sinks, playing a significant role in global CH 4 budgets. However, our understanding of the CH 4 uptake potential in saline-alkali grasslands and its response to climate…
Pirillo V, Barca F, Bruno D et al. · 2026 · Preprint
Insects offer promising opportunities for organic waste bioconversion; however, they cannot efficiently degrade synthetic polymers such as polyethylene terephthalate (PET). Here, we generated transgenic Drosophila melanogaster lines to…
Fang YJ, Gonzalez K, Konecny F et al. · 2026 · American journal of physiology. Heart and circulatory physiology
Maternal exercise may influence long-term cardiovascular health in offspring, yet its effects on intrinsic myocardial performance and mitochondrial metabolism remain incompletely defined. We investigated whether maternal voluntary wheel…
Nutter NA, Costa-Terryll A, Miller LM et al. · 2026 · Preprint
Streptococcus pneumoniae ( Spn ) asymptomatically colonizes the upper respiratory tract (URT), a niche from which it can transmit to another host or cause invasive disease in the same host. The in vivo transcriptional adaptations that Spn…
DiLeone R, Trinko JR, Atangana E et al. · 2026 · Preprint
Binge eating disorder (BED) is characterized by episodic overconsumption of palatable food and involves dysregulated motivational and arousal processes. The orexin (hypocretin) system, through its widespread projections to mesolimbic…
Plouhinec L, Maresca M, Saget J et al. · 2026 · Applied microbiology and biotechnology
As demand for sustainable and welfare-conscious food production increases, reducing the environmental and health impacts of animal feed has become a key challenge. Soybean meal (SBM) is widely used in poultry diets for its high protein…
Pearson AL, Tomaszewska MA, Brown CD et al. · 2026 · Preprint
Abstract Exposure to heat in urban settings is a significant and growing public health concern. Yet, few studies have longitudinally measured everyday heat exposure using GPS-derived activity space data, paired with fine resolution…
Ki SY, Jeong YT · 2026 · Biochemical and biophysical research communications
Peripheral sensory nerve injury triggers Wallerian degeneration, a process characterized by axonal fragmentation, myelin breakdown, and robust macrophage infiltration. While macrophages are widely implicated in debris clearance and repair…
Schmid JA, Hogue M, Aguilar-Cardoza J et al. · 2026 · Environmental toxicology and chemistry
Agricultural run-off is one of the leading sources of environmental pollution in the United States. Insecticides and neonicotinoids have become the most used insecticide class across the world and act as an agonist on the nicotinic…
Riviere JC, Marty V, Cavaillé J et al. · 2026 · Preprint
Prader-Willi syndrome (PWS) is a neurodevelopmental disorder caused by the loss of paternally expressed genes within the imprinted 15q11-q13 locus, which includes clusters of box C/D small nucleolar RNAs (SNORDs), notably the SNORD115 and…
Alshammari AK, Maina M, Alsuwat MA et al. · 2026 · Preprint
Respiratory viral-bacterial co-infections cause severe disease across species, yet the molecular mechanisms underlying enhanced pathogenesis remain poorly understood. This study characterised H3N8 equine influenza A virus (IAV) and…
Saiz-Gonzalo G, Drouin G, Rao Y et al. · 2026 · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Non-nutritive sweeteners (NNS) are increasingly consumed during pregnancy, yet their distinct metabolic fates obscure a unified mechanism for developmental programming. We tested whether maternal NNS exposure acts upstream of metabolism by…