A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20261 results in Negative / Null Result Report · page 554 of 676
Leech J, Sauer BM, Baduashvili A et al. · 2025 · Neurology. Clinical practice
Background and objectives The presence of oligoclonal bands (OCBs) indicates an augmented immune response within the CNS and is integral to the diagnosis of multiple sclerosis (MS). Expert consensus panels recommend OCB testing for…
Wezenberg BN, Koster M, van Wingen G et al. · 2025 · Schizophrenia research
Objective Sleep disturbances and brain alterations are common in psychotic disorders and individuals at clinical high risk for psychosis (CHR-P). It remains unclear whether gray matter volume changes are inherent to psychosis or partly…
Bolterstein E, Mungre S, Nuss K et al. · 2025 · microPublication biology
WRNexo and Blm , Drosophila orthologs of human WRN and BLM RecQ helicases, play crucial roles in DNA replication and repair. Using a Course-based Undergraduate Research Experience (CURE) in an introductory Biology course, we investigated…
Uedo N, Gotoda T, Takizawa K et al. · 2026 · The American journal of gastroenterology
Introduction The recommendation to discontinue low-dose aspirin (LDA) during the periprocedural period of endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) remains controversial in patients at low thrombotic risk. If…
Zabir MOH, Habib MA, Monalisa et al. · 2026 · IJID regions
Objectives Acute respiratory infections (ARIs) such as influenza-like illness (ILI) and severe acute respiratory infection (SARI) are leading causes of morbidity among children aged under 5 years (under-5) in Bangladesh. In Cox's Bazar,…
Ericson JE, Natukwatsa D, Ssenyonga P et al. · 2025 · Preprint
Objective We previously identified Paenibacillus species in the cerebrospinal fluid of 44% of infants presenting for neurosurgical evaluation with findings consistent with postinfectious hydrocephalus (PIH) in Eastern Uganda. Here we…
Fróes LAR Júnior, Sotto MN, Avancini J et al. · 2026 · Anais brasileiros de dermatologia
Early diagnosis of leprosy remains primarily clinical, based on recognition of skin lesions with altered sensation and peripheral nerve involvement. However, complementary tests play crucial roles in confirming uncertain cases, guiding…
Sauerwein HL, Hermsen DF, KIndgen-Milles D et al. · 2025 · Preprint
Background: /Objectives: Clinical experience indicates that determination of interleukin 6 (IL-6) in human blood can vary depending on time span between sample collection and centrifugation. Here, we have evaluated that confounding effect…
Zhao G, Jiao Z, Dai P et al. · 2023 · Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
Objective To explore the cause for a twin pregnancy with false negative result for 22q11.2 deletion syndrome by expanded non-invasive prenatal testing (NIPT-plus). Methods A pregnant woman with twin pregnancy through in-vitro fertilization…
Vega-Gonzalez J, Toro JAC, García EL et al. · 2025 · Genes, chromosomes & cancer
According to the 5th edition of the WHO Classification of Soft Tissue and Bone Tumors, the diagnosis of synovial sarcoma relies on morphology, immunohistochemistry, and the detection of a specific fusion involving the SS18 gene with a…
Taechikantaphat M, Kongchareon A, Julapanthong P et al. · 2026 · Veterinary and animal science
This prospective, randomized clinical trial compared the therapeutic efficacy and rate of platelet recovery of doxycycline 10 mg/kg once daily (SID) (Group A, n=17) versus 5 mg/kg twice daily (BID) (Group B, n=12) in 29 dogs naturally…
Pimentel V, Becker J · 2025 · Arquivos de neuro-psiquiatria
Neuromyelitis optica spectrum disorder (NMOSD) is a severe autoimmune demyelinating disease characterized by a high risk of relapse and disability. In cases positive for aquaporin 4-immunoglobulin G (AQP4-IgG), long-term immunosuppression…
Mazzotta E, Natale A, Bellinati L et al. · 2025 · Animals : an open access journal from MDPI
Equid milk (donkey or mare) has traditionally been consumed raw or fermented due to its distinctive chemical composition, which closely resembles human milk, and its nutritional benefits. Nowadays, interest in it is increasing, despite…
Bai M, Li Y, Gao Q et al. · 2025 · Virology journal
Purpose Present study aimed to compare the boiling and magnetic bead nucleic acid extraction method for HPV genotypes detection. Methods By mixing hemoglobin with HPV positive quality control products, the anti-interference ability of two…
Limaye AP, Crespo M, Kamar N et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Background QuantiFERON-cytomegalovirus (QFT-CMV) is a standardized assay for the evaluation of cytomegalovirus-specific cell-mediated immunity (CMV-CMI). Objectives The purpose of this study was to assess the evolution of CMV-CMI…
Wang X, Fan Z, Huo L et al. · 2025 · Breast care (Basel, Switzerland)
Background In sentinel node biopsy (SNB) procedure for breast cancer patient, whether the abnormal node was excised is uncertain. The impact of abnormal node on the accuracy of SNB results is unknown. Methods In this prospective study,…
Russo F, Chatterjee D, DeMaria N et al. · 2024 · Journal of community genetics
DNA-based population screening for adult-onset diseases holds promise for advancing personalized medicine and improving public health. Yet as most individuals pursuing such screening receive negative results, the return of results process…
Roman TS, Gray SM, Sneddon TP et al. · 2026 · HGG advances
The impact of clinical exome and genome sequencing (ES/GS) depends on the clinical setting. In the sequencing arm of a multifactor randomized clinical trial to evaluate broadening access, we assessed the diagnostic and inconclusive…
Bölük S, Bölük S · 2025 · Cureus
Background In breast cancer surgery, sentinel lymph node biopsy (SLNB) is routinely utilized for axillary assessment. Frozen section examination of the sentinel lymph node (SLN) is used to guide the decision for axillary dissection.…
Chunkul S, Sathirapatya T, Dangklao P et al. · 2025 · Forensic science international. Synergy
Sexual assault is a terrible crime that demands a comprehensive and skilled investigation to gather the perpetrator's biological material. To collect all possible physical and biological evidence, forensic investigation is crucial and…
Liu Q, Liu X, Chang L et al. · 2025 · Clinica chimica acta; international journal of clinical chemistry
Introduction Accurate and early HIV detection is crucial for improving outcomes and controlling transmission. This study compares HIV marker patterns and evaluates detection assay performance in general screening and ART-treated…
Ma F, Hu J, Bai M et al. · 2024 · Clinical laboratory
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection typically relies on reverse transcription-polymerase chain reaction (RT-PCR) technology. However, there is a certain rate of missed detection of SARS-CoV-2…
Lauffer P, van Weelden W, van Haelst MM et al. · 2025 · Journal of community genetics
Polygenic risk scores (PRS) have emerged as a potential tool for predicting complex genetic traits and disorders, which may complement traditional rare variant testing. As genome-wide association studies (GWAS) expand, PRS predictive…
Cassileth LB, Killeen K, York A et al. · 2026 · Aesthetic surgery journal. Open forum
Background Mastectomy skin flap necrosis (MSFN) is a critical postoperation complication in postmastectomy breast reconstruction. High replacement tissue expander fill volume and large mastectomy specimen size are commonly assumed to…
Akella JS, Onken BD, Sedore CA et al. · 2026 · microPublication biology
The Caenorhabditis Intervention Testing Program aims to identify lifespan-extending interventions that are effective across diverse genetic backgrounds. Previous studies identified a role for anticonvulsants in lifespan extension in the…
Jones GT, Bennett AN, Sengupta R et al. · 2025 · Arthritis care & research
Objective Imaging evidence of active sacroiliitis is important for diagnosis, classification, and monitoring of axial spondyloarthritis (axSpA). However, there is no consistent guidance on whether patients should temporarily stop…
Karlsen KL, Clausen CL, Kahiyah RAS et al. · 2026 · Open forum infectious diseases
Background Adults hospitalized with respiratory syncytial virus (RSV) face mortality risks comparable to or higher than those with influenza A or B. However, studies on the impact of bacterial co-infections on mortality are inconsistent.…
Kocaaslan H, Ceylan C, Sümer F et al. · 2026 · BMC surgery
PURPOSE: In non-metastatic advanced gastric cancer, gastrectomy with D2 lymph node dissection is the main curative treatment. The clinical benefit of omentectomy in gastric cancer surgery is still controversial. We planned to investigate…
Sobhi A, Hegazy RM, Zolfakar DS et al. · 2026 · Preprint
Abstract Purpose Ovarian lesions are common diseases nowadays that should be diagnosed accurately. The Ovarian-Adnexal Reporting and Data System (O-RADS) classification helps to a great extent in categorizing the type of ovarian lesions,…
Mayorga AP, Peña CO, Muñoz DB et al. · 2026 · Preprint
Abstract Background The rapid urease test (RUT) is widely used for Helicobacter pylori (H. pylori) diagnosis, but its diagnostic performance in advanced gastric atrophy remains poorly characterized. Aims To evaluate RUT accuracy against…