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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20261 results in Negative / Null Result Report · page 552 of 676

Negative / Null Result ReportMedicine

Luspatercept and thrombotic events in patients with myelodysplastic syndrome: a target trial emulation framework using TriNetX database.

Vojjala N, Nassar M, Nanjareddy S et al. · 2026 · Leukemia & lymphoma

Myelodysplastic syndrome (MDS) is an identified risk for both venous and arterial thromboembolism (ATE). The thrombotic risk of drugs used in MDS, such as Luspatercept and Erythropoietin-stimulating agents (ESAs), has yielded conflicting…

View details →DOI: 10.1080/10428194.2026.2684311
Negative / Null Result ReportMedicine

A pilot study of a sexual health workshop for oncology staff: feasibility, impact, and gaps in addressing young adult breast cancer survivorship needs.

Rick TJ, Girard A, Topalian A et al. · 2026 · Journal of cancer survivorship : research and practice

Purpose Sexual health concerns are highly prevalent and distressing among adolescent and young adult (AYA) breast cancer survivors, yet are rarely addressed in routine oncology care. Lack of provider training remains a key barrier to…

View details →DOI: 10.1007/s11764-026-01985-8
Negative / Null Result ReportMedicine

Osteoarticular Infections in MIMIC-IV, A Clinical and Microbiological Analysis.

Azarpira M, Gascoin JC · 2026 · Studies in health technology and informatics

Osteoarticular infections (OAIs) remain challenging, particularly in the context of rising antimicrobial resistance. Using the MIMIC-IV database, this study applies a structured informatics workflow to characterize inflammatory marker (IM)…

View details →DOI: 10.3233/shti260147
Negative / Null Result ReportMedicine

Exploring unconventional antimicrobial stewardship models: options beyond traditional prospective audit and feedback.

Christensen AB, Cochran GL, Avedissian SN et al. · 2026 · Infection control and hospital epidemiology

Background Prospective audit and feedback (PAF) is a core antimicrobial stewardship strategy. Discontinuing PAF in favor of alternative interventions has not been previously evaluated. Methods This descriptive study assessed changes in…

View details →DOI: 10.1017/ice.2026.10500
Negative / Null Result ReportMedicine

Cytotoxic and Genotoxic Stress Transiently Increase the Contribution of Platelet-Biased Hematopoietic Stem Cells to Platelet Production.

Meng Y, Ren X, Li R et al. · 2026 · Experimental hematology

Platelets are produced via a canonical pathway emanating from multilineage hematopoietic stem cells (ML-HSCs) and a faster, direct pathway used by platelet-biased (P-) HSCs where the latter circumvents progenitors intermediate between HSCs…

View details →DOI: 10.1016/j.exphem.2026.105456
Negative / Null Result Report

ADHD is not a risk factor for service-related PTSD in Israeli military conscripts: Evidence from a population-based cohort study of 1.4 million recruits

Porat DB, Abuhasira S, Ekka-Zohar A · 2026 · Preprint

Abstract Background Attention-deficit/hyperactivity disorder (ADHD) has been hypothesized to increase vulnerability to post-traumatic stress disorder (PTSD) due to emotional dysregulation, impulsivity, and executive function deficits. Most…

View details →DOI: 10.21203/rs.3.rs-9741341/v1
Negative / Null Result Report

Community-level Monitoring of Antimicrobial Resistance following Mass Administration of Azithromycin to Reduce Child Mortality in Côte d’Ivoire: Results from Two Rounds of Surveillance

Dulli L, Gbonon V, Touré F et al. · 2026 · Preprint

Background Mass Drug Administration (MDA) of azithromycin for the elimination of trachoma and, more recently, for the reduction of child mortality, are public health strategies shown, with mixed results, to contribute to the development of…

View details →DOI: 10.12688/gatesopenres.16385.1
Negative / Null Result ReportMedicine

Heat treatment combined with hybrid exercises retraining mitigates cellular markers of protein turnover after hindlimb suspension in male mice: A pilot study.

Normand-Gravier T, Solsona R, Bertrand-Gaday C et al. · 2026 · Experimental physiology

Recent evidence suggests that heat treatment (HT) and resistance training can limit skeletal muscle mass loss during immobilization. However, the effects of repeated HT sessions combined with hybrid exercises (EX), which promote both…

View details →DOI: 10.1113/ep093111
Negative / Null Result ReportMedicine

Non-tuberculous mycobacteria in primary ciliary dyskinesia: a national multicenter cohort study.

Bar-On O, Less Elazari S, Ben-Zvi H et al. · 2026 · Respiration; international review of thoracic diseases

Introduction The prevalence and clinical significance of non-tuberculous mycobacteria (NTM) in individuals with primary ciliary dyskinesia (PCD) remain unclear, with most data extrapolated from cystic fibrosis. This first national…

View details →DOI: 10.1159/000552722
Negative / Null Result ReportMedicine

Effects of providing access to a cycling exergaming platform on cardiorespiratory fitness and cardiometabolic health in adolescents: a randomised, controlled trial.

Berg J, Wang AI, Madssen E et al. · 2026 · Scientific reports

Insufficient physical activity (PA) among adolescents has deleterious consequences for their health. Exergaming, which combines exercise with gaming, is enjoyable, but the long-term effects of exergaming on adolescent health remain poorly…

View details →DOI: 10.1038/s41598-026-48327-3
Negative / Null Result ReportMedicine

Effects of reduced metabolizable protein diets supplemented with rumen-protected His under adequate Met and Lys supply on production, nutrient digestibility, N utilization, and manure ammonia emissions in lactating cows.

Park K, Kim J, Hu H et al. · 2026 · Journal of dairy science

Balancing for limiting AA may prevent reduced production when deficient MP is provided. The objective of the study was to determine the effects of rumen-protected (RP) His supplementation at different levels of MP when Lys and Met supplies…

View details →DOI: 10.3168/jds.2025-27548
Negative / Null Result ReportMedicine

Are gaps in the time of submissions and approvals of new drugs between Health Canada and the Food and Drug Administration related to therapeutic value? A cross-sectional study.

Lexchin J · 2026 · Health policy (Amsterdam, Netherlands)

Background Health Canada is proposing to use decisions by foreign regulators in approving new drugs to speed up their marketing. Objectives To investigate the length of gaps in submissions to and approvals by Health Canada compared to the…

View details →DOI: 10.1016/j.healthpol.2026.105631
Negative / Null Result ReportMedicine

Do potentially traumatic events experienced by people in one's social circle affect one's own mental health and emotional support? Findings from a prospective population-based study.

van der Velden PG, Contino C, Kempe S et al. · 2026 · Acta psychologica

Background Adults may have individuals in their social circle who were recently exposed to potentially traumatic events (PTEs). The present study aims to examine if these adults are at increased risk for mental health problems and reduced…

View details →DOI: 10.1016/j.actpsy.2026.107136
Negative / Null Result ReportMedicine

Impact of concomitant cholecystectomy during gastrectomy for gastric cancer on the postoperative quality of life.

Shimonosono M, Arigami T, Okubo K et al. · 2026 · Surgery today

PURPOSE: This study aimed to evaluate the impact of concomitant prophylactic cholecystectomy during gastrectomy for gastric cancer on the postoperative quality of life (QOL) and nutritional outcomes. METHODS: A retrospective analysis was…

View details →DOI: 10.1007/s00595-026-03294-0
Negative / Null Result Report

Similarity of Major Life-Event Perceptions and Relationship Satisfaction among Romantic Couples: The Case of Moving in Together

Fliedner K, Buehler JL, Wrzus C et al. · 2026 · Preprint

This study examined the similarity of partners’ event perceptions of a major life event (i.e., moving in together as couple) and how similarity relates to relationship satisfaction. Considering event perceptions from multiple individuals…

View details →DOI: 10.31234/osf.io/8h6yb_v1
Negative / Null Result ReportMedicine

Optimizing Necrotizing Otitis Externa Management: The Role of PET-CT in Antibiotic Stewardship.

Zammit M, Davies T, Youssef A · 2026 · Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

Objective To optimize antibiotic regimens in necrotizing otitis externa (NOE) and skull base osteomyelitis (SBO) and evaluate the role of positron emission tomography-computed tomography (PET-CT) in disease monitoring. Study design A…

View details →DOI: 10.1097/mao.0000000000004777
Negative / Null Result ReportMedicine

Work-related Well-Being, Turnover Intention, and Completed Turnover in a Cohort of U.S. Patient Care Workers.

Boden LI, Peters SE, McTernan M et al. · 2026 · Journal of occupational and environmental medicine

Objective To determine whether burnout and thriving from work affect turnover intention and actual turnover. Methods This study used multivariable logistic regression to estimate the impact of burnout and thriving from work on turnover…

View details →DOI: 10.1097/jom.0000000000003713
Negative / Null Result ReportMedicine

Tolerability and effectiveness of definitive chemoradiotherapy in locally advanced lung cancer patients with combined pulmonary fibrosis and emphysema.

Fujimoto K, Kogo M, Kobayashi H et al. · 2026 · Cancer treatment and research communications

Background This study evaluated the efficacy and safety of definitive chemoradiotherapy (CRT) for lung cancer in patients with combined pulmonary fibrosis and emphysema (CPFE), focusing on radiation pneumonitis (RP). Materials and methods…

View details →DOI: 10.1016/j.ctarc.2026.101262