A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19893 results in Negative / Null Result Report · page 548 of 664
Kim CK, Lee YR, Ong L et al. · 2022 · Journal of Alzheimer's disease : JAD
Given the acknowledged lack of success in Alzheimer's disease (AD) drug development over the past two decades, the objective of this review was to derive key insights from the myriad failures to inform future drug development. A systematic…
Li W, Bunch CM, Zackariya S et al. · 2025 · Scientific reports
Disordered hemostasis associated with life-threatening hemorrhage commonly afflicts patients in the emergency department, critical care unit, and perioperative settings. Rapid and sensitive hemostasis phenotyping is needed to guide…
Shepard S, Anderson JM, Heigle B et al. · 2023 · Journal of orthopaedic surgery and research
Purpose To our knowledge, no study has quantified the rate of discontinuation and nonpublication of randomized controlled trials (RCTs) regarding upper and lower extremity fractures. Methods We searched ClinicalTrials.gov on September 9th,…
Bajwa MS, Jackson R, Dhanda J et al. · 2023 · Cancers
Objectives High-quality randomised controlled trials (RCT) to support the use of Fibrin Sealants (FS) in neck dissection (ND) are lacking. The DEFeND trial assessed critical pilot/feasibility questions and signals from clinical outcomes to…
Howland RH · 2015 · Journal of psychosocial nursing and mental health services
Seven topics previously described in this column are revisited. The use of quantitative electroencephalography has been shown in a prospective study to be effective for predicting antidepressant treatment response. A novel antidepressant…
Ford KL, Sawyer MB, Ghosh S et al. · 2024 · ESMO open
Background Low muscle mass (MM) predicts unfavorable outcomes in cancer. Protein intake supports muscle health, but oncologic recommendations are not well characterized. The objectives of this study were to evaluate the feasibility of…
Wulff KC, Miller FG, Pearson SD · 2011 · Health affairs (Project Hope)
To attain the anticipated benefits of increased investments in comparative effectiveness research, the results must translate into improved medical practice and policy. In this article we present an analysis of a case study of percutaneous…
Komiya T, Huang CH · 2018 · Frontiers in oncology
Recent application of immunotherapy in clinical oncology revolutionized our management of advanced human cancers. Check point inhibitors targeting CTLA4 and PD-1/PD-L1 axis are immunotherapeutic agents currently available to treat a…
Ponizovsky AM, Rosca P, Aronovich E et al. · 2015 · Journal of substance abuse treatment
Background Limited clinical trials and case-reports yielded conflicting results regarding the efficacy of baclofen (a GABAB agonist) in the treatment of alcohol dependence. The aim of this study was to test the efficacy and tolerability of…
Park L, Furey M, Nugent AC et al. · 2019 · The international journal of neuropsychopharmacology
Background This randomized, placebo-controlled, crossover trial examined the antidepressant efficacy of the muscarinic antagonist scopolamine in major depressive disorder subjects with more severe and refractory forms of major depressive…
Wu CC, Wolfe JM · 2022 · Vision research
During a visual search for a target among distractors, observers do not fixate every location in the search array. Rather processing is thought to occur within a Functional Visual Field (FVF) surrounding each fixation. We argue that there…
Pramhas S, Thalhammer T, Terner S et al. · 2023 · The Lancet regional health. Europe
Background Painful knee osteoarthritis (KOA) is common, pharmacological treatment, however, is often hampered by limited tolerability. Cannabidiol, which preclinically showed anti-inflammatory, analgesic activity, could supplement…
Finlay CJ, Jackson MJ, Fisher R et al. · 2024 · Journal of Parkinson's disease
Background Increased activity across corticostriatal glutamatergic synapses may contribute to L-DOPA-induced dyskinesia in Parkinson's disease. Given the weak efficacy and side-effect profile of amantadine, alternative strategies to reduce…
Ghomrawi HMK, Marx RG, Pan TJ et al. · 2018 · Contemporary clinical trials communications
Publication of 2 (negative) randomized clinical trials (RCTs) in 2002 and 2008 demonstrating inefficacy of arthroscopic debridement of the knee (ADK) for osteoarthritis, and a 2004 national non-coverage Medicare determination, have…
Pochon C, Laroye C, Kimmoun A et al. · 2023 · Frontiers in medicine
Background The COVID-19 pandemic caused a wave of acute respiratory distress syndrome (ARDS) with a high in-hospital mortality, especially in patients requiring invasive mechanical ventilation. Wharton Jelly-derived Mesenchymal Stromal…
Goudman L, Jansen J, Vets N et al. · 2021 · Journal of clinical medicine
The increased awareness of discrepancies between self-reporting outcome measurements and objective outcome measurements within the field of neuromodulation has accelerated the search towards more objective measurements. The aim of this…
Sanderson C, Hardy J, Spruyt O et al. · 2013 · Journal of pain and symptom management
Placebo and nocebo effects are known to contribute significantly to the response to symptom control, including analgesia. Clinical trial methodologies using placebo controls are designed to identify the magnitude of these effects in the…
Farooqi AS, Guadagnolo BA, Mitra D et al. · 2023 · Current oncology (Toronto, Ont.)
Locoregional recurrence (LRR) is the predominant pattern of relapse and often the cause of death in patients with retroperitoneal sarcomas (RPS). As a result, reducing LRR is a critical objective for RPS patients. However, unlike soft…
Ou SL, Luo J, Wei H et al. · 2023 · Frontiers in pharmacology
Background: Evidence of efficacy and safety of programmed cell death 1 (PD-1) and programmed death ligand-1 (PD-L1) checkpoint inhibitors in oesophageal cancer (EC), gastric cancer (GC) and colorectal cancer (CRC) was inconsistent,…
Petrylak DP, Ratta R, Matsubara N et al. · 2025 · Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Purpose The standard of care for metastatic castration-resistant prostate cancer (mCRPC) after second-generation androgen receptor pathway inhibitor (ARPI) therapy is still docetaxel. The randomized, double-blind, phase III KEYNOTE-921…
Mitting RB, Ray S, Raffles M et al. · 2019 · PloS one
Background Methylprednisolone remains a commonly used ancillary therapy for paediatric acute respiratory distress syndrome (PARDS), despite a lack of level 1 evidence to justify its use. When planning prospective trials it is useful to…
Brustad N, Garland J, Thorsen J et al. · 2020 · JAMA pediatrics
Importance Studies suggest an association between maternal vitamin D status during pregnancy and offspring anthropometry and bone mineralization, but investigations are few and with mixed results. Objective To investigate the effect of a…
Wu Y, Tan KC, Shiu SW et al. · 2022 · Journal of diabetes investigation
Aims/introduction To examine the association between cholesterol efflux capacity (CEC) of serum high-density lipoprotein (HDL) and cognitive function and brain structures in older people with diabetes mellitus. Materials and methods…
Genis C, Torun Ozel C, Selmanoglu A et al. · 2025 · Allergy and asthma proceedings
Background: Ondansetron is a common antiemetic that rarely causes hypersensitivity. Skin-prick testing (SPT) and intradermal testing (IDT) may assist in diagnosing ondansetron hypersensitivity; however, their sensitivity, specificity, and…
Felländer M, Grandi G, Juremalm M et al. · 2026 · Veterinary parasitology, regional studies and reports
Infections with Fasciola hepatica are most prevalent in south-western Sweden, but climate change may facilitate further spread, as both the parasite and its snail host thrive in humid, mild conditions. Sheep are particularly susceptible,…
Yi P, Ou ZY, Wang MM et al. · 2026 · Zhongguo shi yan xue ye xue za zhi
Objective To explore the simplest scheme for detection of "Asian-type" DEL in clinical blood transfusion and its application effectiveness. Methods 100 pregnant women who tested Rh(D) negative by the saline method were selected. Their…
Iimura S, Nishaat A · 2025 · Preprint
The current study explored the associations between different levels of developmental plasticity factors—specifically, prenatal androgen exposure and the personality trait related to environmental sensitivity. We recruited participants…
Galata Z, Limoncu O, Tunakan Dalgıc C et al. · 2026 · Allergy and asthma proceedings
Introduction: Local anesthetics (LAs) are commonly used to provide regional insensitivity in dentistry, minor surgical procedures, and general anesthesia but may rarely cause allergic reactions. Methods: The file data of 101 patients who…
Staley I · 2026 · Preprint
Quantum-like models of cognition account for order effects, conjunction and disjunction fallacies, and contextuality in human decision data using the Hilbert-space formalism without claiming literal quantum processes in the brain. Two…
Horita V, Yuan L · 2026 · Preprint
Commercial inoculants based on associative diazotrophs and methylotrophic bacteria, and bios-timulant programs, are marketed for broad use in cereal and fiber production, yet most field deployment occurs over already adequate mineral…