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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20261 results in Negative / Null Result Report · page 547 of 676

Negative / Null Result ReportMedicine

High dose methyl donor nutrient supplementation fails to prevent the adverse effects of a maternal Western-style diet on depression-related behavior and results in stress-dependent effects on learning.

Farber C, Jackson C, Renteria K et al. · 2026 · Nutrition (Burbank, Los Angeles County, Calif.)

Background Exposure to a Western diet during gestation and lactation adversely impacts offspring mood, learning, and memory. We determined if high dose maternal methyl donor nutrient (MDN) supplementation ameliorated the effects of a high…

View details →DOI: 10.1016/j.nut.2026.113149
Negative / Null Result ReportMedicine

Platelet-derived mitochondrial preparation did not alter early inflammatory markers in a bilateral lipopolysaccharide-induced model of equine synovitis.

Khaliji E, Marycz K, Horna M et al. · 2025 · American journal of veterinary research

Objective To evaluate IA autologous platelet-derived mitochondrial preparation versus vehicle control in a bilateral lipopolysaccharide (LPS)-induced model of equine synovitis. Methods 2 ng of LPS was injected into bilateral intercarpal…

View details →DOI: 10.2460/ajvr.25.05.0187
Negative / Null Result ReportMedicine

Effects of dietary alpha-ketoglutaric acid on growth performance and intestinal barrier function in Lateolabrax maculatus fed a high soybean meal diet

Quan F, Ma J, Zhao Y et al. · 2025 · Aquaculture international

This study investigated the effects of supplementing high soybean meal diets with alpha-ketoglutaric acid (AKG) on the intestinal health and growth performance of spotted sea bass (Lateolabrax maculatus). A total of 270 fish (average…

Negative / Null Result ReportMedicine

Opposing Effects of Dietary Nitrate on Muscle Contractile Function in Fast and Slow Human Muscles.

Zoughaib WS, Fry MJ, Singhal A et al. · 2026 · Medicine and science in sports and exercise

Purpose Increasing nitric oxide bioavailability via nitrate (NO 3- ) ingestion enhances muscle contractility, which may be due to phosphorylation of the regulatory light chain of myosin. If so, there should be an interaction between NO 3-…

View details →DOI: 10.1249/mss.0000000000003932
Negative / Null Result Report

Functional and evolutionary evidence from a widely used molluscan model reveals the absence of ecdysone signaling in lophotrochozoans

Svigruha R, Yañez-Guerra LA, Caña-Bozada VH et al. · 2025 · Preprint

Abstract Ecdysone-controlled pathways regulate ecdysozoan development through both a nuclear (nEcR) and a membrane receptor (mEcR). Ecdysone signaling was long thought to be exclusive to ecdysozoans; however, studies since 2010 have…

View details →DOI: 10.21203/rs.3.rs-8193722/v1
Negative / Null Result ReportMedicine

Heparin in peripherally inserted central catheters did not alter elective removal and complication rates in preterm infants.

Wackernagel D, Gavelli V, Nydert P · 2025 · Clinical nutrition ESPEN

Background & aims In preterm and sick newborn infants, peripherally inserted central catheters (PICC) are used for the delivery of concentrated parenteral nutrition and other high risk drugs. Despite the precaution issued by the ESPGHAN…

View details →DOI: 10.1016/j.clnesp.2025.03.024
Negative / Null Result ReportMedicine

Vacuolar Protein Sorting 35 Controls Hepatocellular Proliferation Through SRC Signaling and Promotes Diethyl Nitrosamine-Induced Tumor Initiation.

Barbosa MG, Vos DY, Verzijl CRC et al. · 2026 · Cellular and molecular gastroenterology and hepatology

Background & aims Hepatocellular carcinoma is the third leading cause of cancer-related mortality worldwide. Therapeutic options for hepatocellular carcinoma remain limited, and the mechanisms underlying hepatocellular carcinoma are not…

View details →DOI: 10.1016/j.jcmgh.2026.101788
Negative / Null Result ReportMedicine

Effects of percussive massage vs. foam rolling on hamstring function: a comparative study using shear wave elastography, tensiomyography, and MyotonPro.

Fischer J, Seguel JM, Drole K et al. · 2026 · BMC sports science, medicine & rehabilitation

Background This study investigated the comparative acute effects of 3 × 30 s of vibration foam rolling (VFR) or percussive massage (PM) on the hamstring muscles, specifically range of motion (ROM), maximum voluntary isometric contraction…

View details →DOI: 10.1186/s13102-026-01732-7
Negative / Null Result ReportMedicine

Core Temperature Estimation Using Wearable Earbud-Type Thermometer and Machine Learning During Light-Intensity Cycling Under Varying Indoor Ambient Temperatures.

Fujii N, Katagiri A, Nakagome K et al. · 2026 · Scandinavian journal of medicine & science in sports

Continuous monitoring of core temperature is crucial for optimizing exercise performance, promoting health, and ensuring safety. Here, we evaluated the validity of a machine learning-based earbud-type core temperature sensor during…

View details →DOI: 10.1111/sms.70315
Negative / Null Result ReportMedicine

Development and validation of the OMERACT juvenile idiopathic arthritis MRI- sacroiliac joint score (OMERACT JAMRIS-SIJ): Phase 3.

Maksymowych WP, Weiss PF, Francavilla ML et al. · 2026 · Seminars in arthritis and rheumatism

Objective The OMERACT JAMRIS working group has defined a spectrum of MRI lesions in the sacroiliac joint (SIJ) in pediatric cases with spondyloarthritis (SpA) that match domains for inflammation and structural damage. We aimed to assess…

View details →DOI: 10.1016/j.semarthrit.2026.153018
Negative / Null Result ReportMedicine

Efficacy of Adjunct PRObiotics as Compared to the Standard Care in Moderate Unipolar Depression Among Geriatric Patients: A Randomized Double-Blind Placebo-Controlled Pilot Multi-Center Trial (PRODG).

Sinha P, Chatterjee P, Kathiresan P et al. · 2026 · Journal of the American Geriatrics Society

Objective To evaluate the efficacy of adjunct probiotic supplementation (Lactobacillus helveticus and Bifidobacterium longum) alongside standard care compared to placebo in older adults with moderate unipolar depression. Methods A…

View details →DOI: 10.1111/jgs.70530
Negative / Null Result ReportMedicine

A Predictive Model of Duodenal Atrophy in Adults With Celiac Disease: Could Diagnostic Endoscopy Be Avoided?

Pontet Y, Aguirrezábal P, Pintos J et al. · 2026 · Journal of clinical gastroenterology

Background In adults, the diagnosis of celiac disease (CeD) relies on the presence of disease-specific antibodies and the confirmation of duodenal atrophy. This study aimed to develop a diagnostic model to predict duodenal atrophy in…

View details →DOI: 10.1097/mcg.0000000000002315
Negative / Null Result ReportMedicine

ADAMDEC1 is not a driver of intestinal fibrosis but a marker of the inflammation-stromal niche in Crohn's disease.

Tanabe H, Watanabe D, Agawa M et al. · 2026 · Biochemical and biophysical research communications

Objectives Intestinal fibrosis is a severe complication of Crohn's disease (CD). While ADAMDEC1 has been identified as a marker for specific fibroblast subsets, its functional role in fibrogenesis remains unclear. This study aimed to…

View details →DOI: 10.1016/j.bbrc.2026.153749
Negative / Null Result ReportMedicine

Antibacterial resin infiltrants containing DMAHDM and NACP: Effects on antibacterial activity, cytotoxicity, and remineralization potential - an in vitro study.

Souza AF, Fraga MAA, Correr AB et al. · 2026 · Dental materials : official publication of the Academy of Dental Materials

Objectives To evaluate the effects of incorporating the antibacterial monomer dimethylaminohexadecyl methacrylate (DMAHDM; 2.5% and 5% wt%) and amorphous calcium phosphate nanoparticles (NACP; 2 wt%) on the antibacterial activity,…

View details →DOI: 10.1016/j.dental.2026.05.014
Negative / Null Result Report

Beyond Taste: Unpacking Consumer Perceptions of Plant-Based Cheese Alternatives in Uruguay Through Sensory, Information, and Expectation Analysis

Varghese C, Sosa C, Maique J et al. · 2026 · Preprint

Abstract Plant-based cheese alternatives (PBCAs) are considered sustainable substitutes for dairy-based cheese (DB); however, their consumer acceptance remains limited, particularly in dairy-dominant cultural contexts such as Uruguay,…

View details →DOI: 10.21203/rs.3.rs-8703177/v1
Negative / Null Result ReportMedicine

The relationship between fall risk, trochanteric soft tissue thickness, and hip fracture risk in older adults.

Johannesdottir F, Aspelund T, Mahar S et al. · 2026 · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Current fracture risk assessment does not directly include fall probability, despite the fact that most hip fractures resulting from falls. Additionally, the role of trochanteric soft tissue thickness (TST) in hip fracture risk remains…

View details →DOI: 10.1093/jbmr/zjaf161
Negative / Null Result ReportMedicine

Preharvest application of Meyerozyma guilliermondii LMA-Cp01 biofungicide combined with sodium benzoate for eco-friendly management of anthracnose disease on mango fruit.

López-Cruz R, Ragazzo-Sánchez JA, Calderón-Santoyo M · 2026 · Archives of microbiology

In this study, mango fruit trees cv. Kent (Mangifera indica L.) grown in Nayarit, Mexico, during the 2024 and 2025 seasons were preharvest-treated with four applications of microencapsulated Meyerozyma guilliermondii LMA-Cp01 (0.4 g L⁻¹),…

View details →DOI: 10.1007/s00203-026-04816-7
Negative / Null Result ReportMedicine

Protective effects of hydrogen-rich water against acute lead-induced hepatic, renal, and testicular toxicity in rats.

Kharazmi K, Saroughi M, Khoshniat MT et al. · 2026 · Naunyn-Schmiedeberg's archives of pharmacology

Lead exposure is linked to various adverse effects on human health, including toxicity to multiple organs such as the kidneys, liver, and reproductive system. Lead induces its toxic effects through complex pathways, including mitochondrial…

View details →DOI: 10.1007/s00210-026-05422-6
Negative / Null Result ReportMedicine

Full-fat meal, defatted meal, oil and chitin from black soldier fly in low and high soybean-based diets on growth performance and nutrient retention of rainbow trout

Riesenbach IC, Tsomik G, Chiasson M et al. · 2026 · Aquaculture.

Insects, such as black soldier flies (BSF), have garnered attention in the aquaculture industry as a sustainable protein and lipid alternative to fishmeal and fish oil. However, research is lacking on which components of BSF improve fish…

Negative / Null Result Report

Endozoochory by Goats and White-Tailed Deer: Type of Ruminant Affect Recovery and Germination of Neltuma pallida Seeds

Salinas-Marcos J, Cruz-Luis J, Aguirre L · 2025 · Preprint

The “algarrobo”, Neltuma pallida is a key tree species in the seasonally dry tropical forests in Equatorial Pacific South America, currently at risk. Its regeneration depends on endozoochorous seed dispersal, in which seeds are ingested…

View details →DOI: 10.20944/preprints202511.1812.v1