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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20261 results in Negative / Null Result Report · page 543 of 676

Negative / Null Result ReportOpen accessMedicine

Shear Bond Strength of a Light-Cured and a Dual-Cured Universal Adhesive to Primary and Permanent Dentin: An In Vitro Study.

Fousekis E, Arhakis A, Arapostathis K et al. · 2026 · Biomimetics (Basel, Switzerland)

The aim of the study was to evaluate the immediate and aged shear bond strength (SBS) of a dual-cured and a light-cured universal adhesive to primary and permanent dentin. Twenty caries-free primary molars and twenty permanent third molars…

View details →DOI: 10.3390/biomimetics11050358
Negative / Null Result ReportOpen accessMedicine

Intraperitoneal Polypropylene Mesh in Clean, Potentially Septic, and Controlled Contamination Fields: An Experimental Rat Study.

Makrantonakis A, Mantzoros I, Ioannidis O et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Intraperitoneal onlay mesh (IPOM) reduces ventral/incisional hernia recurrence but raises concern for adhesions and infection, particularly when the operative field is not strictly clean. We aimed to determine…

View details →DOI: 10.3390/medicina62050803
Negative / Null Result ReportOpen accessMedicine

Prognostic Value of the Platelet-to-Lymphocyte Ratio in Patients With Acute Coronary Syndrome and Its Correlation With Angiographic Findings.

Seetharama DB, Prasad K, Prakash VR et al. · 2026 · Cureus

Introduction Acute coronary syndrome (ACS) is a major manifestation of coronary heart disease and is associated with significant morbidity and mortality. Inflammatory and thrombotic mechanisms play an important role in its pathogenesis.…

View details →DOI: 10.7759/cureus.105558
Negative / Null Result ReportMedicine

The effect of three different root canal filling materials on postoperative pain in teeth with irreversible pulpitis: a randomized clinical trial.

Eminsoy Avcı AT, Yavuz B, Karakaya B et al. · 2026 · BMC oral health

Background This randomized clinical trial aimed to compare postoperative pain (PP) and analgesic consumption following single-visit root canal treatment using two calcium silicate-based sealers (BioMTA + and Well-Root PT) and one epoxy…

View details →DOI: 10.1186/s12903-026-08525-x
Negative / Null Result ReportOpen accessMedicine

Translating Evidence into Obstetric Care: Developing a Best Practice-Informed Stepped-Care Clinical Algorithm for the Management of Gestational Insomnia.

Zhao FY, Yue LP, Ho YS et al. · 2026 · Nature and science of sleep

Background and aims Insomnia during pregnancy is potentially associated with adverse outcomes, including gestational diabetes mellitus, pre-eclampsia, cesarean delivery, preterm birth, and depression. This study aimed to synthesize…

View details →DOI: 10.2147/nss.s607896
Negative / Null Result ReportMedicine

Electroacupuncture for essential hypertension: Mechanistic insights, current clinical evidence, and translational challenges.

Zhou Y, Qin S, Ma Y · 2026 · Clinical and experimental hypertension (New York, N.Y. : 1993)

Background Essential hypertension (EH) remains a leading modifiable risk factor for cardiovascular morbidity and mortality worldwide. Electroacupuncture (EA), combining traditional acupuncture with pulsed electrical stimulation at specific…

View details →DOI: 10.1080/10641963.2026.2685125
Negative / Null Result ReportOpen accessMedicine

Artemisinin-Related Therapeutic Strategies for Autoimmune Thyroiditis: Chemokine-Receptor Networks, Spatial Thyroid Biology, and Molecular Mechanisms.

Sun Y, Yang X, Zhu Q et al. · 2026 · Drug design, development and therapy

Autoimmune thyroiditis (AIT) is a chronic immune-mediated thyroid disorder characterized by lymphocytic infiltration, follicular epithelial injury, autoantibody production, and variable progression to thyroid dysfunction. Because current…

View details →DOI: 10.2147/dddt.s614133
Negative / Null Result ReportMedicine

Why evidence struggles to shape musculoskeletal health care and surgical practice in Australia: insights from an Australian clinician survey.

Yu J, Eyles JP, Moreti Cabral Silveira A et al. · 2026 · BMC health services research

Background Evidence based medicine is a critical cornerstone in contemporary medicine, yet uptake and adoption of evidence remain suboptimal. This is prominent in many fields of healthcare, including musculoskeletal health and surgery.…

View details →DOI: 10.1186/s12913-026-14843-1
Negative / Null Result ReportMedicine

Assessing the foundations of forensic identification evidence: A critical examination of proficiency test design and results.

Scurich N, Albright TD · 2026 · Proceedings of the National Academy of Sciences of the United States of America

Proficiency testing is widely used to assess expertise in medicine, engineering, and other high-stakes fields. In forensic science, such tests are often cited in court as evidence that pattern-comparison methods are accurate and reliable.…

View details →DOI: 10.1073/pnas.2528192123
Negative / Null Result ReportOpen accessMedicine

Weak economic evidence for WHO's essential cancer medicines for Africa.

van der Steege AE, Humuza J, Shyirambere C et al. · 2026 · BMJ global health

Introduction The WHO Model Lists of Essential Medicines (MLEM and MLEMc) guide national medicine selection, particularly in low-income and lower middle-income countries (LMICs). Concerns exist about the adequacy and transferability of…

View details →DOI: 10.1136/bmjgh-2025-022533
Negative / Null Result ReportMedicine

The Role of Buspirone in Antishivering Protocols for Post-Cardiac Arrest Targeted Temperature Management: What Evidence Supports Its Use?

Ganguly A, Bhowmik S, Hajra A · 2026 · Therapeutic hypothermia and temperature management

Shivering is a common complication of targeted temperature management (TTM), which could undermine its neuroprotective benefits by increasing cerebral oxygen consumption and metabolic demand. Buspirone, a 5-HT1A receptor partial agonist,…

View details →DOI: 10.1177/21537658261464859
Negative / Null Result ReportMedicine

Comprehensive review of the evidence informing the standard of care penicillin treatment of congenital syphilis.

Simone J, Cooke C, Lee S et al. · 2026 · Sexually transmitted infections

Congenital syphilis (CS) has been rapidly re-emerging as a public health crisis across North America. The present standard of care treatment for CS involves a 10-day hospitalisation for intravenous penicillin G, which is costly for…

View details →DOI: 10.1136/sextrans-2025-056692
Negative / Null Result ReportMedicine

Managing auditory hallucination symptoms in patients with schizophrenia in China: a best practice implementation project.

Jin X, Shen T, Wang Y et al. · 2026 · JBI evidence implementation

Introduction Auditory hallucinations, persistent and distressing symptoms in patients with schizophrenia, are often poorly controlled by antipsychotics. Structured non-pharmacological interventions remain limited in routine clinical…

View details →DOI: 10.1097/xeb.0000000000000595
Negative / Null Result ReportMedicine

Immune checkpoint inhibitors and chemotherapy versus chemotherapy for early triple-negative breast cancer.

Gao Y, Liu M, Li L et al. · 2026 · The Cochrane database of systematic reviews

Background Triple-negative breast cancer (TNBC), an aggressive subtype lacking oestrogen and progesterone receptors and amplification of HER2 receptors, accounts for 12% to 17% of breast cancers. Adjuvant and neoadjuvant chemotherapy…

View details →DOI: 10.1002/14651858.cd015072.pub3
Negative / Null Result ReportMedicine

Exploring the State of the Literature on Teaching Evidence-Based Practice to Speech-Language Pathology Students: A Scoping Review.

Brock AS · 2026 · American journal of speech-language pathology

Purpose The objective of this review article is to examine and describe the literature on training speech-language pathology students on the principles of evidence-based practice (EBP). Method A scoping literature review was undertaken in…

View details →DOI: 10.1044/2026_ajslp-25-00227
Negative / Null Result ReportOpen accessMedicine

Virtual Reality and Gamification for Assessing Technical Aptitude, Cognitive Abilities, and Personality Characteristics in Surgical Residency Selection: Validation Study.

Gazit N, Ben-Gal G, Eliashar R · 2026 · JMIR medical education

Background Assessment of technical aptitude, cognitive abilities, and personality characteristics is important in selecting candidates for surgical training. Currently, the selection of surgical training candidates does not systematically…

View details →DOI: 10.2196/82515
Negative / Null Result ReportOpen accessMedicine

Clinical Outcomes and Safety of Stem Cell Therapy for Diabetic Foot Ulcers: A Cross-Sectional Analysis of Overlapping Meta-Analyses.

Du Y, Xu Z, Wen T et al. · 2026 · Diabetes, metabolic syndrome and obesity : targets and therapy

Purpose The care of diabetic foot ulcers (DFU) continues to be a notable clinical challenge. The efficacy and safety of stem cell therapies versus conventional treatments for DFU are debated. Cross-sectional analyses of meta-analyses…

View details →DOI: 10.2147/dmso.s593437
Negative / Null Result ReportMedicine

Herbal Products and Dietary Supplements in Radiation Oncology: Evidence, Safety, and Practical Patient Counseling.

Hou YN, Gubili J, Mao JJ · 2026 · Seminars in radiation oncology

Studies show that patients with cancer use herbal products more often than the general population. Lowering the risk of disease recurrence, symptom control, and improving quality of life are often the reasons cited for such use. However, a…

View details →DOI: 10.1016/j.semradonc.2026.151035
Negative / Null Result ReportOpen accessMedicine

Nurse Practitioner Opioid Prescribing Authority: A Comparative Policy Analysis of New Zealand, United States, and Australia.

Kyei EF, Kyei GK, Forson MM et al. · 2026 · Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing

Aim To examine nurse practitioner opioid prescribing authority across three countries, analyzing safety outcomes, workforce distribution patterns, access equity, and service to vulnerable populations using integrated nursing policy and…

View details →DOI: 10.1111/jnu.70109
Negative / Null Result ReportOpen accessMedicine

Sport Participation and Nutrition in Students: A Scoping Review of Neuroendocrine and Autonomic Mechanisms Linking Lifestyle Behaviors to Cognitive and Academic Outcomes.

Tafuri MG, Monda V, La Marra M et al. · 2026 · Nutrients

Background/Objectives: Sport participation and nutrition are increasingly recognized as key determinants of cognitive function and academic achievement in student populations. However, the biological mechanisms underpinning these…

View details →DOI: 10.3390/nu18111651
Negative / Null Result ReportMedicine

From Framework to Practice: Evaluating the Uptake of Sensitivity Analyses in The National Institute for Health and Care Excellence Real-World External Control Arm Evidence.

Leahy TP, Keenan C, Robertshaw E et al. · 2026 · Value in health regional issues

Objectives Growing reliance on single-arm trials (SATs) is driving increased real-world external control arm (RW-ECA) use in health technology assessment submissions. However, concerns over residual confounding and unmeasured bias often…

View details →DOI: 10.1016/j.vhri.2026.101651