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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19893 results in Negative / Null Result Report · page 542 of 664

Negative / Null Result ReportMedicine

Indocyanine green in intestinal endometriosis surgery: a multicenter evaluation of anastomotic safety.

Barretto R, Sonnenfeld MM, da Silva RCM et al. · 2026 · Journal of robotic surgery

Objective To evaluate whether the use of intraoperative indocyanine green (ICG) fluorescence impacts anastomotic safety and surgical outcomes in patients undergoing bowel endometriosis resection. Methods Retrospective, multicenter…

View details →DOI: 10.1007/s11701-025-03136-0
Negative / Null Result ReportMedicine

Clinical efficacy and safety of long-term treatment, discontinuation, and extended dosing intervals of denosumab treatment for solid cancer bone metastasis: A retrospective study.

Mihara A, Iwanaga R, Muramatsu K et al. · 2025 · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

Background Metastatic bone tumors in solid cancer often induce excessive local bone resorption leading to skeletal related events (SRE) which may impact patients' quality of life and survival of the primary cancer. Denosumab, a bone…

View details →DOI: 10.1016/j.jos.2025.04.012
Negative / Null Result ReportMedicine

Development and testing of implementation strategies to increase the use of midline catheters in a paediatric intensive care unit.

Weber MD, Frankenberger W, Ullman AJ et al. · 2026 · Australian critical care : official journal of the Confederation of Australian Critical Care Nurses

Background Paediatric critically ill patients are at risk of harm from central venous catheter overuse. We applied an implementation science approach to promote appropriate use of midline catheters. The aim of this study was to evaluate…

View details →DOI: 10.1016/j.aucc.2025.101514
Negative / Null Result ReportOpen accessMedicine

First report of bilateral Bronchial Rheoplasty for treating chronic bronchitis performed in a single procedure.

Jensen K, Secher EL, Libermann RH et al. · 2025 · European clinical respiratory journal

Introduction The RheOx system delivers brief, high-voltage electrical pulses to the airway lining, promoting the regeneration of healthy tissue and reducing mucus production in COPD patients with chronic bronchitis. The procedure, called…

View details →DOI: 10.1080/20018525.2025.2591506
Negative / Null Result ReportOpen accessMedicine

Extensive intraoperative peritoneal lavage (EIPL) for gastric cancer with positive peritoneal lavage and/or stamp cytology: An exploratory phase II study.

Tsujio G, Yashiro M, Miki Y et al. · 2026 · PloS one

Background Our group revealed that the combination of intra-operative stamp cytology and peritoneal lavage cytology (CY) improved the identification of individuals with high risk of peritoneal metastasis. In this exploratory Phase II…

View details →DOI: 10.1371/journal.pone.0347742
Negative / Null Result ReportMedicine

The Impact of Preoperative Positive Suggestions on Dreaming With Intravenous Sedation: A Randomized Controlled, Blinded Trial.

Lee D, Lee H, Lee C et al. · 2026 · Anesthesia and analgesia

Background Drug-induced dreams during intravenous sedation vary by pharmacological agent and influence patient experiences, yet the role of preoperative positive suggestions in modulating these dreams is unclear. This study aimed to…

View details →DOI: 10.1213/ane.0000000000007818
Negative / Null Result ReportMedicine

A Phase 1, Open-Label, Single Ascending Dose Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of ES-481 After Oral Administration in Healthy Volunteers.

Niecestro R, Foster EC, Millist L et al. · 2026 · European journal of drug metabolism and pharmacokinetics

Background and objectives ES-481 is a potent and selective antagonist of the transmembrane alpha-amino-3-hydroxy-5-methyl-4 isoxazolepropionic acid (AMPA) receptor regulatory protein (TARP)-y8-dependent AMPA receptor being developed for…

View details →DOI: 10.1007/s13318-025-00979-8
Negative / Null Result ReportMedicine

Manipulating attention during eating effects food intake and medial prefrontal cortex fNIRS response in women with cognitive restraint.

Albajri E, Ayaz H, Shewokis PA et al. · 2026 · Appetite

Objective To investigate how shifting the attention away from food being eaten (by women who are cognitively restrained) toward another food-related stimulus affects food intake and relative increases in neural activity from baseline (as…

View details →DOI: 10.1016/j.appet.2025.108416
Negative / Null Result ReportMedicine

Human chorionic gonadotropin inhibits locomotion but not food intake independently of the area postrema and the nucleus tractus solitarius in female mice.

Anan M, Kagawa K, Okamatsu-Ogura Y et al. · 2026 · Physiology & behavior

The nausea and vomiting of pregnancy (NVP) affect many pregnant women's quality of life, and the underlying mechanisms are still unclear. Human chorionic gonadotropin (hCG) is suspected to be a factor in exacerbating NVP due to its…

View details →DOI: 10.1016/j.physbeh.2025.115151
Negative / Null Result ReportMedicine

Spontaneous axon regeneration is preserved despite gut microbiota disruption after spinal cord injury in larval lampreys.

González-Llera L, Santos-Durán GN, Vences A et al. · 2026 · Scientific reports

Spinal cord injuries (SCIs) often result in permanent disabilities in humans. One major reason for the lack of recovery is the inability of adult mammalian descending neurons to regenerate their axons after injury. In contrast, several…

View details →DOI: 10.1038/s41598-026-56243-9
Negative / Null Result ReportMedicine

Action potential propagation in the rodent myelinated optic nerve does not trigger neurovascular coupling.

Suarez-Baquero DE, Boido D, Assali A et al. · 2026 · Nature communications

In brain gray matter, neurovascular coupling (NVC) maintains brain metabolism homeostasis by modulating blood flow according to neuronal activity. In white matter, the energy cost of information transmission along myelinated axons is…

View details →DOI: 10.1038/s41467-026-71656-w
Negative / Null Result ReportMedicine

Associations between paracetamol administration and delayed intravenous antibiotic administration among patients with in-hospital sepsis.

Senangkhanikorn S, Morapun N, Samansee A et al. · 2026 · Journal of hospital medicine

Background Timely antibiotic administration is crucial for improving sepsis outcomes, but delays are common and multifactorial. Fever, a key feature of sepsis, is often treated with paracetamol, which may mask the condition and contribute…

View details →DOI: 10.1002/jhm.70347
Negative / Null Result ReportMedicine

Effects of replacing porcine blood meal with rumen-protected lysine, while maintaining metabolizable methionine supply, on performance, nitrogen use efficiency, and nutrient partitioning in dairy cows.

Arshad U, Johnson SJ, Fukumori R et al. · 2026 · Journal of dairy science

The objectives of this experiment were to determine the effects of replacing metabolizable Lys from porcine blood meal (PBM) with rumen-protected (RP) Lys (RPL) on lactation performance, ECM/DMI, N use efficiency (NUE; milk N/N intake),…

View details →DOI: 10.3168/jds.2025-27475
Negative / Null Result ReportMedicine

COVID-19 infection prior to the onset of type 1 diabetes does not impair beta-cell function: a two-year nationwide follow-up study.

Bjerregaard-Andersen M, Hostrup PE, Kolnes KJ et al. · 2026 · BMC endocrine disorders

Background A possible association between infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and type 1 diabetes (T1D) development has been reported. Whether SARS-CoV-2 infection affects beta-cell loss in T1D…

View details →DOI: 10.1186/s12902-026-02358-z
Negative / Null Result ReportMedicine

Do Preoperative Intra-Articular Steroid Injections Affect the Choice of Surgical Procedures for Thumb Carpometacarpal Osteoarthritis?

Komura S, Hirakawa A, Hirose H et al. · 2026 · The Journal of hand surgery

Purpose This study investigated the influence of preoperative intra-articular steroid injections on surgical outcomes of trapeziectomy with ligament reconstruction and tendon interposition (LRTI) arthroplasty and arthrodesis and aimed to…

View details →DOI: 10.1016/j.jhsa.2026.01.024
Negative / Null Result ReportMedicine

Optimizing Risk Communication for Lynch Syndrome: Results of a Randomized Controlled Trial of Visual Arrays for Genetic Testing.

Keels JN, Babicheva V, McDonald IR et al. · 2026 · Cancers

Background/Objectives : We aimed to test two different visual arrays for helping individuals accurately interpret colorectal cancer risk in Lynch syndrome. We also sought to examine factors associated with intention to share genetic test…

View details →DOI: 10.3390/cancers18091369
Negative / Null Result ReportMedicine

Morphological, Physiological, and Metabolite Responses of Potato to Infestation by the Fall Armyworm (Spodoptera frugiperda) and the Potato Scab Bacterium (Streptomyces resiliuntiscabiei)

Ogugua UV, Maluleke S, Goszczynska T et al. · 2026 · Potato Res..

The effect of the fall armyworm (FAW) (Spodoptera frugiperda) and the pathogenic bacterium Streptomyces resiliuntiscabiei, in combination or singly, on the morphological and physiological (growth, yield, and gas exchange), and metabolite…

Negative / Null Result ReportMedicine

Unraveling effect pathways and biomagnification: The impact of a polyfluoroalkyl fungicide on an aquatic decomposer-detritivore system.

Arias M, Meyer M, Bundschuh M et al. · 2026 · Ecotoxicology and environmental safety

Leaf litter breakdown is a key ecosystem process in streams driven by detritivorous macroinvertebrates and microbial decomposers, but it can be disrupted by anthropogenic stressors. In this context, we examined the effects of the…

View details →DOI: 10.1016/j.ecoenv.2026.120205