Negative / Null Result ReportOpen accessInfectious and parasitic diseases
Adediwura Oladunni Arowosegbe, Iyabode Olabisi Dedeke, Olufunke Bolatito Shittu et al. · 2023 · Annals of Global Health
Background: In resource-poor settings, perinatal infections contribute significantly to maternal and neonatal deaths, and the use of clean delivery kits (CDKs) has been proposed as a tool to reduce the risk of infection-related deaths. This study aims to assess the acceptability and effectiveness of CDKs in preventing infections in deliveries attended by traditional birth attendants (TBAs) in Abeokuta, Nigeria. Methods: The study was a cluster-randomized trial with 67 birth centres/clusters, 453 births/mothers, and 457 babies randomized to intervention or control arms; intervention involved su
View details →DOI: 10.5334/aogh.4015 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Naoya Hasegawa, Masafumi Fukuda · 2020 · Epilepsy & Behavior Reports
We investigated the efficacy of lacosamide (LCM) polytherapy in improving seizure outcomes and psychiatric symptoms in patients with epilepsy with psychiatric comorbidities. We retrospectively collected data from medical records of outpatients of the Department of Psychiatry of Nishiniigata Chuo Hospital Epilepsy Center in Japan. We extracted data from all patients with epilepsy and psychiatric comorbidities who had been treated with LCM. We evaluated seizure prognosis and changes in psychiatric symptoms after LCM polytherapy. After LCM administration, 19 (47.5%) patients had improvements in s
View details →DOI: 10.1016/j.ebr.2020.100402 Negative / Null Result ReportOpen accessMedicine
Onyinyechi Bede-Ojimadu, Nwakasi Nnamah, Jude A. Onuegbu et al. · 2025 · Scientific Reports
Abstract The ability of selenium to both prevent and induce cancer at varying biological concentrations has been reported in previous studies. We studied the associations between selenium exposure and prostate diseases such as prostate cancer (PCa) and benign prostatic hyperplasia (BPH), and estimated the optimal range of selenium concentrations that may be needed to prevent these diseases among Nigerian men. Blood and urine samples from men with histologically diagnosed PCa (n = 90), BPH (n = 97), and controls (n = 98) were analyzed for trace elements, including selenium. The associations bet
View details →DOI: 10.1038/s41598-025-32341-y Negative / Null Result ReportOpen accessAccounting. Bookkeeping
Itzhak David Simão Kaveski, Antonio Maria da Silva Carpes, Roberto Carlos Klann · 2015 · Revista Catarinense da Ciência Contábil
O presente artigo tem por objetivo identificar os fatores que explicam o nível de divulgação relativo ao CPC 27 – Ativo Imobilizado, por empresas listadas no segmento do Novo Mercado de Governança Corporativa da BM&FBovespa, considerando como seus prováveis determinantes as variáveis tamanho, imobilizado total, endividamento e rentabilidade do imobilizado. O estudo caracteriza-se como descritivo, conduzido por meio de análise documental e abordagem quantitativa. A população é composta de 109 empresas em 2011, abrangendo uma amostra de 106 empresas. Para coleta dos dados foi elaborado um check
View details →DOI: 10.16930/2237-7662/rccc.v14n41p33-45 Negative / Null Result ReportOpen accessGenetics
Sabrina E.M. Almeida, Luciana B.S. Santos, Daniel T. Passos et al. · 2008 · Genetics and Molecular Biology
The genetic diversity of a single nucleotide polymorphism (SNP) at the exon 20 (T945M) of the leptin receptor gene (LEPR) and of three short tandem repeats (STRs BM7225, BMS694, and BMS2145) linked to LEPR was investigated in three beef cattle herds (Brangus Ibagé, Charolais, and Aberdeen Angus). A cheap and effective new method to analyze the T945M polymorphism in cattle populations was developed and the possible role of these polymorphisms in reproduction and weight gain of postpartum cows was evaluated. High levels of genetic diversity were observed with the average heterozygosity of STRs r
View details →DOI: 10.1590/s1415-47572008000400013 Negative / Null Result ReportOpen accessMedicine
Camila Salazar-Fernández, María José Baeza-Rivera, Diego Manríquez-Robles et al. · 2023 · Vaccines
The embrace of coronavirus disease 2019 (COVID-19) vaccine conspiracies has been linked to vaccine hesitancy. This study aimed to investigate the relationship between COVID-19 vaccine conspiracy theories and perceived vaccine effectiveness. The study utilized a longitudinal follow-up study in which adults in Chile completed surveys in December 2020 (T1) and May 2021 (T2). The psychometric properties of the five-item instrument on conspiracy theories for the COVID-19 vaccine were evaluated using data from T1 ( n = 578). A confirmatory one-factor structure with suitable indicators of reliability
View details →DOI: 10.3390/vaccines11071150 Negative / Null Result ReportOpen accessMedicine
Jihye Kim, Carol J. Boushey, Lynne R. Wilkens et al. · 2022 · BMC Medicine
Abstract Background Plant-based diets assessed by a priori indices are associated with health outcomes. This study investigated the associations between pre-defined indices of plant-based diets and risk of colorectal cancer (CRC) and evaluated whether the association varies by sex, race and ethnicity, and anatomic subsite of tumors. Methods A total of 79,952 men and 93,475 women who participated in the Multiethnic Cohort Study were included. Primary outcome was incidence of invasive CRC. Cox models were used to estimate the risk of CRC across quintiles of three plant-based diet scores: overall
View details →DOI: 10.1186/s12916-022-02623-7 Negative / Null Result ReportOpen accessMedicine
Fumi Irie, Ryu Matsuo, Satomi Mezuki et al. · 2024 · Scientific Reports
Abstract Smoking has detrimental effects on the cardiovascular system; however, some studies have reported better clinical outcomes after thrombolysis for ischemic stroke in smokers than in nonsmokers, a phenomenon known as the smoking paradox. Therefore, this study aimed to examine the smoking paradox in patients with ischemic stroke receiving reperfusion therapy. Data were collected from a multicenter hospital-based acute stroke registry in Fukuoka, Japan. The 1148 study patients were categorized into current and noncurrent smokers. The association between smoking and clinical outcomes, incl
View details →DOI: 10.1038/s41598-024-59508-3 Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Nuria Valdés, Nuria Valdés, Ana Romero et al. · 2024 · Frontiers in Endocrinology
IntroductionHistorically, Multiple Endocrine Neoplasia type 1 (MEN1)-related pituitary adenomas (PAs) were considered more aggressive and treatment-resistant than sporadic PAs. However, recent studies suggest similarities in their behavior. This study aimed to evaluate the long-term outcomes of MEN1 PAs and identify predictive factors.MethodsNationwide multicenter retrospective cohort study of MEN1-related PAs with a minimum 1-year follow-up, collecting patient demographics, germline MEN1 pathogenic variants (PV), PA size, secretory profile, radiological characteristics, treatments, and outcom
View details →DOI: 10.3389/fendo.2024.1427821 Negative / Null Result ReportOpen accessMedicine
Eman A Al Abdulsalam, Mohamed S Al-Hajjaj, Mohammad S Alanazi et al. · 2020 · Journal of Nature and Science of Medicine
Objectives: Several genes, including interleukin-13 (IL13), MS4A2, and IL 4 receptor alpha (IL4Rα), have been shown to associate with the inflammatory process in asthma. We investigated the possible association between asthma and five single-nucleotide polymorphisms (SNPs) in the IL13, IL4Rα, and MS4A2 gene in comparison with the level of the IL-13 protein in the Saudi asthmatics and controls. Subjects and Methods: The study group included 50 adult asthmatic patients and 50 normal healthy controls. Blood was extracted, and DNA was prepared. Genotyping was performed on DNA using direct sequenci
View details →DOI: 10.4103/jnsm.jnsm_67_19 Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Barrak Alahmad, Taofik Oyekunle, Claire Strohmeyer et al. · 2025 · Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Arrhythmia, particularly atrial fibrillation, is on the rise globally. While increased surveillance, aging populations, and other risk factors partially explain this rise, emerging risks such as extreme heat from climate change are underexplored. Methods We used Product Surveillance Registry by Medtronic (2016–2023) in the United States to examine patients with implantable cardioverter‐defibrillator or cardiac resynchronization therapy defibrillator devices. We identified first arrhythmic episodes (atrial tachycardia/fibrillation [AT/AF] or ventricular tachycardia/fibrillation) reco
View details →DOI: 10.1161/jaha.124.040352 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Kollipara Sumanth, Uma Sinharoy, Anindita Joardar et al. · 2026 · Annals of Indian Academy of Neurology
Background and Objectives: Epilepsy, with its complex interplay of neurobiological, genetic, and pharmacological factors, continues to challenge neurologists worldwide—particularly in managing drug resistance. This study aimed to evaluate the frequency of the SCN1A and SCN2A gene polymorphisms among patients with epilepsy (PWE) from Eastern India to assess their relationship with clinical profiles, electroencephalography (EEG) findings, and response to antiseizure medication. Methods: In this case–control genetic association study, a total of 110 PWE were assessed for demographic and clinical
View details →DOI: 10.4103/aian.aian_616_25 Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Muller Susan, Bouquot Jerry, Lou Yahuan et al. · 2007 · BMC Cancer
Abstract Background TRAIL plays an important role in host immunosurveillance against tumor progression, as it induces apoptosis of tumor cells but not normal cells, and thus has great therapeutic potential for cancer treatment. TRAIL binds to two cell-death-inducing (DR4 and DR5) and two decoy (DcR1, and DcR2) receptors. Here, we compare the expression levels of TRAIL and its receptors in normal oral mucosa (NOM), oral premalignancies (OPM), and primary and metastatic oral squamous cell carcinomas (OSCC) in order to characterize the changes in their expression patterns during OSCC initiation a
View details →DOI: 10.1186/1471-2407-7-108 Negative / Null Result ReportOpen accessDermatology
Raissa Massaia Londero Chemello, Elsa Regina Justo Giugliani, Renan Rangel Bonamigo et al. · 2011 · Anais Brasileiros de Dermatologia
FUNDAMENTOS: Não há consenso quanto ao efeito do aleitamento materno no desenvolvimento da dermatite atópica. É necessário aprofundar conhecimentos sobre possíveis fatores envolvidos nessa relação, como a influência do aleitamento materno na colonização do paciente atópico pelo Staphylococcus aureus (S. aureus). OBJETIVO: Avaliar uma potencial associação entre aleitamento materno e colonização pelo S. aureus nas crianças atópicas. MÉTODOS: Estudo transversal envolvendo 79 crianças atópicas de 4-24 meses, de ambos os sexos, em acompanhamento no Ambulatório de Dermatologia Sanitária de Porto Ale
View details →DOI: 10.1590/s0365-05962011000300002 Negative / Null Result ReportOpen accessOtorhinolaryngology
Fery Mai Rafanan, Eduard Alfanta, Romulus Roberto Peter Instrella · 2024 · Philippine Journal of Otolaryngology Head and Neck Surgery
Objective: To investigate the association between the time intervals of key clinical time points and tumor progression (increase in clinical staging) in head and neck cancer patients before and during the pandemic. Methods: Design: Retrospective Cohort Study Setting: Tertiary Government Training Hospital Participants: A total of 81 head and neck cancer patients who consulted at the OPD and underwent elective surgery between January 1, 2018, and December 31, 2022, under the Department of Otorhinolaryngology – Head and Neck Surgery of East Avenue Medical Center were included in the study; 40 pat
View details →DOI: 10.32412/pjohns.v39i1.2197 Negative / Null Result ReportOpen accessPsychology
Fahri Sezer, Aytekin Gürtepe · 2025 · BMC Psychology
Abstract The primary aim of this study was to investigate the relationships between attachment, social exclusion, and risky behaviors in adolescents. The sample comprised 463 adolescents, aged 13–18, attending various high schools in Turkey. Data were collected using three instruments: the Parent and Peer Attachment Inventory, the Ostracism (Social Exclusion) Scale for Adolescents, and the Risk Behaviors Scale. The results revealed a moderate negative correlation between attachment to mothers and risky behaviors, while a weaker negative correlation was observed between attachment to fathers an
View details →DOI: 10.1186/s40359-025-02822-w Negative / Null Result ReportOpen accessAgriculture
Nouraldin Moradi, Narges Nazifi, Qodrat Rahimi Miyanaji et al. · 2014 · مجله بیوتکنولوژی کشاورزی
Follicle stimulating hormone receptor (FSHR) and growth differentiation factor 9 (GDF9) both are the most important proteins that affect reproduction process in mammalian. Polymorphism in these genes and their possible relationship with twining trait in Zel (n=150) sheep are investigated in the present study. Blood samples were collected randomly via vein puncture. PCR-RFLP technique for FSHR marker site showed two A and B alleles with the frequency of 93.33 and 6.67 and two genotypes of AA and BB with the frequency of 93.33 and 6.67, respectively. However, the heterozygote AB genotype was not
View details →DOI: 10.22103/jab.2014.1319 Negative / Null Result ReportOpen accessChemical technology
Kyung Won Lee, Min-Sook Kang, Seung Jae Lee et al. · 2023 · Foods
This study aimed to identify major dietary patterns associated with abdominal obesity in middle-aged and older Korean adults. Data from the Korean Genome and Epidemiology Study were used. A total of 48,037 Korean adults aged ≥40 years without abdominal obesity at baseline were followed-up. Dietary assessment was conducted using a validated 106-item food-frequency questionnaire, and dietary patterns were identified using factor analysis. Abdominal obesity was defined as a waist circumference of ≥90 cm for men and ≥85 cm for women, according to the Korean Society for the Study of Obesity. Multiv
View details →DOI: 10.3390/foods12112148 Negative / Null Result ReportOpen accessMedicine
Alexandria Turner, Mieke L van Driel, Ben Mitchell et al. · 2025 · Family Practice
Abstract Background Inappropriate antibiotic prescription for self-limiting respiratory tract infections (RTIs) by general practitioner (GP) registrars (trainees) is less common than by established GPs but still exceeds evidence-based…
View details →DOI: 10.1093/fampra/cmaf005 Negative / Null Result ReportOpen accessDiseases of the respiratory system
Suzanne L. Pollard, John J. Lima, Karina Romero et al. · 2017 · Asthma Research and Practice
Abstract Background Prior evidence suggests that vitamin D deficiency may increase the risk of asthma and atopy and impair pulmonary function in children. Methods In this cross-sectional analysis nested in a case-control study, we analyzed serum 25(OH)D concentrations in 413 children with asthma and 471 children without asthma living in two geographically adjacent study communities (Pampas and Villa El Salvador). We measured total and antigen-specific IgE levels, pulmonary function, asthma control, and exhaled nitric oxide. Results Mean 25(OH)D concentrations were 25.2 ng/mL (SD 10.1) in child
View details →DOI: 10.1186/s40733-017-0033-2 Negative / Null Result ReportOpen accessGynecology and obstetrics
Ruiqi Wang, Yaqi Lin, Lixue Chen et al. · 2025 · Journal of Ovarian Research
Abstract Objective This multicenter retrospective study examines the impact of female COVID-19 infection on assisted reproductive technology (ART) outcomes, including clinical pregnancy rates, miscarriage rates, and live birth rates, and further evaluated potential influencing factors associated with these outcomes. Methods Our multicenter retrospective cohort study analyzed 10,140 cycles (2021–2023) from 10 Beijing ART centers, comparing 4,099 cycles from COVID-19-positive women with 6,041 age-matched (1:1.5) COVID-negative controls (pre-pandemic). Outcomes included pregnancy, miscarriage, an
View details →DOI: 10.1186/s13048-025-01749-5 Negative / Null Result ReportOpen accessMedicine
Lauren S. Keenan-Devlin, Ann E. B. Borders, Alexa Freedman et al. · 2023 · Scientific Reports
Abstract Exposure to traumatic events during pregnancy may influence pregnancy and birth outcomes. Growing evidence suggests that exposure to traumatic events well before pregnancy, such as childhood maltreatment (CM), also may influence the course of pregnancy and risk of adverse birth outcomes. We aimed to estimate associations between maternal CM exposure and small-for-gestational-age birth (SGA) and preterm birth (PTB) in a diverse US sample, and to examine whether common CM-associated health and behavioral sequelae either moderate or mediate these associations. The Measurement of Maternal
View details →DOI: 10.1038/s41598-023-36831-9 Negative / Null Result ReportOpen accessMedicine
Amir Mari, Wasef Na’amnih, Loay Ghantous et al. · 2023 · Scientific Reports
Abstract Gastro-esophageal reflux disease (GERD) can cause erosive esophagitis (EE) and compromise the quality of life (QoL). We examined differences in symptom severity and QoL according to EE severity grade. A follow-up study was conducted among GERD patients at the Nazareth Hospital in Israel. Patients underwent a baseline gastroscopy in 2014–2020 during which the EE grade was determined using the Los Angeles classification. Follow-up telephone interviews were conducted during 2019–2020 with a mean time interval of 18.9 months (SD = 14.9) after the baseline gastroscopy to assess GERD sympto
View details →DOI: 10.1038/s41598-023-41332-w Negative / Null Result ReportOpen accessShipment of goods. Delivery of goods
Theuns F.J. Oosthuizen · 2014 · Journal of Transport and Supply Chain Management
A lack of optimum selection and application of decision-making techniques, in conjunction with suitable decision-making practice and perception of employees in a transport work environment demands attention to improve overall performance. Although multiple decision-making techniques exist, five prevalent techniques were considered in this article, namely the Kepner-Tregoe, Delphi, stepladder, nominal group and brainstorming techniques. A descriptive research design was followed, using an empirical survey which was conducted among 210 workers employed in a transport work environment and studyin
View details →DOI: 10.4102/jtscm.v8i1.118 Negative / Null Result ReportOpen accessMedicine
Otobo I Ujah, Omojo C Adaji, Innocent A O Ujah et al. · 2025 · PLoS ONE
Food insecurity (FI) has been identified as a determinant of child development, yet evidence quantifying this association using the newly developed Early Childhood Development Index 2030 (ECDI2030) remains limited. Herein, we provide national estimates of early childhood development (ECD) risks using the ECDI2030 and examined to what extent FI was associated with ECD among children aged 24-59 months in Nigeria. This population based cross-sectional analyses used data from the UNICEF-supported 2021 Multiple Indicator Cluster Survey in Nigeria. The analytic sample comprised children aged 24-59 m
View details →DOI: 10.1371/journal.pone.0316381 Negative / Null Result ReportOpen accessNutritional diseases. Deficiency diseases
Rohith N. Thota, Shamasunder H. Acharya, Manohar L. Garg · 2019 · Lipids in Health and Disease
Abstract Background Lowering insulin resistance and dyslipidaemia may not only enhance glycaemic control but also preserve the β-cell function, reducing the overall risk of developing type 2 diabetes (T2D). The current study was aimed to evaluate the effects of curcumin and/or long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) supplementation on glycaemic control and blood lipid levels in individuals at high risk of developing T2D. Methods This was a 2 × 2 factorial, randomised, double-blinded, placebo-controlled study. Participants were allocated to either double placebo (PL) or curcu
View details →DOI: 10.1186/s12944-019-0967-x Negative / Null Result ReportOpen accessBiology (General)
Aviad Schnapp, Moria Harel, Dalit Cayam-Rand et al. · 2022 · Biomedicines
Autism spectrum disorder (ASD) is often associated with debilitating sleep disturbances. While anecdotal evidence suggests the positive effect of cannabinoids, randomized studies are lacking. Here, we report the effects of cannabinoid treatment on the sleep of 150 children and adolescents with ASD, as part of a double-blind, placebo-controlled study that assessed the impact of cannabinoid treatment on behavior (NCT02956226). Participants were randomly assigned to one of the following three treatments: (1) whole-plant cannabis extract, containing cannabidiol (CBD) and Δ9-Tetrahydrocannabinol (T
View details →DOI: 10.3390/biomedicines10071685 Negative / Null Result Report
Patrícia Fernandes Albeirice da Rocha, Luciano Marques dos Santos, Amanda J. Ullman et al. · 2025 · Revista da Sociedade Brasileira de Enfermeiros Pediatras
Objective To assess the feasibility of conducting a randomized clinical trial to evaluate the effectiveness of virtual reality on pain perception in children undergoing peripheral intravenous insertion, compared to traditional clinical…
View details →DOI: 10.31508/1676-3793202501i Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Christian Borel, Caroline Even, Christophe Le Tourneau et al. · 2023 · BMJ Oncology
Objective Salivary gland cancers (SGC) are rare cancers with currently no standard treatment for recurrent/metastatic disease. Based on checkpoint inhibitors benefit in a broad range of tumours, NIvolumab in Salivary gland CArcinoma of the Head and Neck (NISCAHN) evaluated nivolumab efficacy in SGC.Methods and analysis In this phase II single-stage Fleming design, patients with SGC with a progressive disease progression within 6 months prior to entering the study, were divided into ACC (adenoid cytic carcinoma) and non-ACC. All received nivolumab for a maximum of 12 months. The primary endpoin
View details →DOI: 10.1136/bmjonc-2023-000065 Negative / Null Result ReportOpen accessMicrobiology
José C. Segovia, Juan C. Ramírez, Paula Río et al. · 2025 · Microbiology Spectrum
ABSTRACT Two strains of the minute virus of mice (MVM) parvovirus (of the species Protoparvovirus rodent1), named i (immunosuppressive) and p (prototype), show disparate tropism and pathogenicity in mice. Unlike the virulent MVMi, the MVMp is attenuated and infection-restricted in primary mouse hematopoietic cells; however, it does infect human transformed, established, and stem cells. We thus seek here a putative MVMp natural tropism to humans compared to MVMi. Infectious purified MVMp virions suppress in vitro the clonogenic potential of human committed (erythroid and myeloid) and primitive
View details →DOI: 10.1128/spectrum.02339-25 