A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20261 results in Negative / Null Result Report · page 538 of 676
Celik C, Celik MS · 2026 · Human psychopharmacology
Background and objective Isotretinoin is a systemic agent widely used in the treatment of severe acne vulgaris. Previous studies have reported that isotretinoin use may be associated with depression, anxiety, and sleep disorders. The aim…
Ayerbe L, Barbero-Pablos E, Foguet-Boreu Q et al. · 2026 · Journal of psychosomatic research
Introduction Evidence on the clinical outcomes of stroke for patients with psychiatric disorders is poor. It is also unclear if the prognosis of stroke has improved over the last two decades for those with mental health conditions. The…
Silberlust J, Roberts B, Leybov V et al. · 2026 · Journal of telemedicine and telecare
Virtual urgent care (VUC) has become an increasingly utilized resource for acute care delivery. Frequent utilization of VUC may reflect unmet longitudinal care needs and contribute to fragmented care. While high-utilizer patterns are well…
Song Z, Wang H, Jin M et al. · 2026 · Psychiatry research. Neuroimaging
This study investigates the pathogenic mechanisms underlying major depressive disorder (MDD) and the therapeutic mechanisms of vortioxetine in treatment-naive, first-episode MDD patients. 22 treatment -naive, first-episode MDD patients and…
de Lima Wachholz P, Bierhals ES, de Lima CM et al. · 2026 · Veterinary research communications
The aim of this study was to evaluate the tolerance and efficacy of ezetimibe in reducing cholesterol and/or triglycerides in dogs with hyperlipidemia. Twenty-three dogs with hyperlipidemia were randomly distributed into three groups:…
Berben PBQ, Smolders YL, de Vries IR et al. · 2026 · Acta obstetricia et gynecologica Scandinavica
Introduction Labor epidural analgesia (LEA) is widely used for intrapartum pain management, but its effects on uterine activity (UA) remain unclear. Electrohysterography (EHG) is a promising non-invasive method for intrapartum UA…
Olaleye AO, Kabir E, Khanam R · 2026 · Preprint
Abstract Background Breast cancer is a major global health concern, with substantial mortality and incidence rates. In Australia, breast cancer is prevalent, and policies have been implemented to enhance screening, including recent changes…
Song JM, Li SH, Peng WT et al. · 2026 · Journal of dairy science
The periparturient period in dairy cattle is characterized by significant metabolic stress, often involving a state of negative energy balance, heightened oxidative stress, and systemic inflammation. Supplementation with n-3 PUFA, such as…
Espinoza Ramirez J, Durango M, Santalo O et al. · 2026 · Journal of the American Pharmacists Association : JAPhA
Background Many organizations have developed criteria for pharmacy practice models; however, most of these models are not based on studies evaluating clinical outcomes. Currently, there is no consensus on the ideal pharmacy practice model.…
Chang YJ, Hsu TC, Chan CH et al. · 2026 · The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
ObjectiveTo evaluate 3-dimensional pharyngeal airway changes following 2-jaw orthognathic surgery in skeletal Class III patients and to assess their association with surgical movements.DesignRetrospective observational study.SettingSingle…
Shi K, Li J · 2026 · Psychological research
This study adopts the Think/No-Think (TNT) paradigm for the first time to examine whether activation of thematic semantic relation representations is intrusive. In Experiment 1, during the learning phase, participants memorized cue–target…
Suematsu Y, Minei A, Sumita Y et al. · 2026 · European journal of preventive cardiology
Aims Cardiac rehabilitation (CR) has been shown to improve the prognosis of patients with acute myocardial infarction (AMI). In Japan, the duration of hospitalization has shortened, resulting in a lower participation rate in CR among…
Omerovic E, Råmunddal T, Jha S et al. · 2026 · European heart journal. Cardiovascular pharmacotherapy
Two contemporary randomized trials of β-blocker therapy after myocardial infarction (MI) reached apparently conflicting conclusions. REBOOT, conducted in Spain and Italy, found no reduction in death or major cardiovascular events among…
Mittal H, Thattaruthody F, Akella M et al. · 2026 · Indian journal of ophthalmology
Abstract This experiment was designed to study the effect of mitomycin C (MMC) on conjunctival lymphatics and the lymphangiogenesis potential of synthetic retinoic acid (ec23) in rat eyes. This prospective animal experimental study…
Royo M, Jiménez Á, Molina-Martin A et al. · 2026 · European journal of ophthalmology
PurposeTo analyze the amplitude of accommodation and its changes at a 6-month follow-up in healthy subjects implanted with an anterior chamber pIOL, assessing whether accommodative function is affected. Additionally, changes in visual…
Temizel KA, Dursun P, Ikizoglu G · 2026 · Postepy dermatologii i alergologii
Introduction Chronic spontaneous urticaria (CSU) and urticarial vasculitis (UV) are chronic inflammatory skin disorders. Monoclonal anti-IgE therapy is widely approved for CSU and is increasingly investigated for its broader…
Siqueira RC, Pinho TS, Brandao CC · 2026 · Cureus
Objective The objective of this study was to evaluate the short-term ocular safety, feasibility, and exploratory functional signals associated with intravitreal adalimumab (ADA) in patients with retinitis pigmentosa (RP). Methods This…
Nelles D, Özkan N, Vogelhuber J et al. · 2026 · Heart and vessels
To assess the impact of functional tricuspid regurgitation (FTR) and transcatheter tricuspid valve repair (TTVR) on sympathetic nerve activity (SNA). Increased SNA is associated with adverse outcomes and reduced survival in patients with…
Nicolli A, Armani T, Buendía Arellano M et al. · 2026 · Preprint
Cryopreservation of ram semen induces structural and functional alterations that compromise sperm fertility. Since seminal plasma contributes to the regulation and preservation of sperm function, increasing attention has been directed…
Wahyono P, Ariesaka KM, Susetyarini E et al. · 2026 · Preprint
Background Limited male contraception choices have prompted the hunt for natural antifertility drugs. This experimental study investigates the antifertility effects of stigmasterol extracted from Pluchea indica leaves in male rats ( Rattus…
Sun G, Lin W, Peng Y et al. · 2026 · BMC anesthesiology
Postoperative fatigue is a prevalent complication delaying early recovery after gynecological laparoscopic surgery, with no proven effective interventions. To investigate the effect of continuous intraoperative low-dose esketamine on…
Ciccarelli G, Monaco E, Nasso V et al. · 2026 · Journal of experimental orthopaedics
Purpose The purpose of this study was to quantify return-to-play (RTP) time, post-operative performance and market-value trends after proximal hamstring repair in top-tier European league soccer players. It was hypothesized that surgery…
Deruelle P, Arcieri F, Martineau R · 2026 · Gynecologie, obstetrique, fertilite & senologie
Background Hyperemesis gravidarum (HG) remains one of the most disabling complications of the first trimester, with a high risk of recurrence after a prior episode that weighs heavily on family planning and on patients' mental health.…
Pak K, Yoon C, Sadda SR · 2026 · Eye (London, England)
Purpose To evaluate longitudinal change in hard exudate (HEs) volume over 5-years following anti-VEGF treatment for diabetic macular oedema (DMO). Methods This study was a post-hoc analysis of structural optical coherence tomography (OCT)…
Holgado D, Martínez-Pérez V, Martín-Arévalo E et al. · 2026 · Preprint
Inconsistent evidence regarding the cognitive effects of transcranial direct current stimulation (tDCS) highlights the need for more comprehensive approaches to assess its impact. This study aimed to investigate the effects of…
Kim HSW, Cha S, Choi JY et al. · 2026 · The Journal of craniofacial surgery
This study compared the upper airway dimensions following maxillomandibular advancement (MMA) surgery in adults with obstructive sleep apnea (OSA) with those of normal controls. Korean adult OSA patients who underwent conventional MMA…
Haflidadottir S, Helgadottir FD, Sighvatsson MB · 2026 · Scandinavian journal of psychology
The global burden of infertility and its associated psychological distress is substantial, yet many individuals face barriers to accessing psychological support. A scalable, low-cost online intervention presents a promising solution. A…
Yu C, Huang W, Yu B et al. · 2026 · Preprint
Synthetic 6-Br-Q0C10 has been shown to have a partial electron transfer activity of native coenzyme Q in the isolated mitochondria. It reduces energy coupling efficiency by 30 %, suggesting that it may be useful in the management of…
May R, Hernández Gómez MÁ, Aguirre Martínez JL et al. · 2026 · Preprint
One of the most notable impacts of wind energy is bird mortality due to collisions with wind turbines, making it necessary to adopt measures to prevent or mitigate this impact. In recent years, studies have been carried out to test the…
Leal Barbosa V, Westenhofen D, Scherdien Silva P et al. · 2026 · Lasers in medical science
Purpose To evaluate the efficacy of 8% arginine-based desensitizing toothpaste and photobiomodulation (PBM), used alone or in combination, in the treatment of dentin hypersensitivity (DH). Materials and methods This randomized,…