Negative / Null Result ReportOpen accessMedicine
Shanshan Shi, Xiuchun Zhang, M Alejandra Mandel et al. · 2017 · PLoS ONE
Cassava (Manihot esculenta) is an important tropical subsistence crop that is severely affected by cassava brown streak disease (CBSD) in East Africa. The disease is caused by Cassava brown streak virus (CBSV) and Ugandan cassava brown streak virus (UCBSV). Both have a (+)-sense single-stranded RNA genome with a 5' covalently-linked viral protein, which functionally resembles the cap structure of mRNA, binds to eukaryotic translation initiation factor 4E (eIF4E) or its analogues, and then enable the translation of viral genomic RNA in host cells. To characterize cassava eIF4Es and their potent
View details →DOI: 10.1371/journal.pone.0181998 Negative / Null Result ReportOpen accessDentistry
Ramtin Azar, Hassan Semyari, Mohamad Javad Kharazifard · 2020 · Frontiers in Dentistry
Objectives: This study aimed to compare the oral health related quality of life (OHRQoL) of patients using conventional dentures versus implant-supported overdentures. Materials and Methods: This study evaluated the OHRQoL of 90 patients between 35 to 75 years who were selected from several public and private dental clinics in Tehran in 2018. Of all, 45 had conventional dentures of both jaws, and 45 had a mandibular overdenture supported by two implants at the site of mandibular canine teeth and a conventional maxillary denture. The OHRQoL of patients was determined using the Oral Health Impac
View details →DOI: 10.18502/fid.v17i1.3964 Negative / Null Result ReportOpen accessMedicine
Linh Tran, Jeah Jung, Roger Feldman et al. · 2022 · PLoS ONE
Purpose Chronic hepatitis C virus (HCV) infection is an important public health concern. Limited information exists on disparities in the quality of HCV care. We examine disparities in genotype or quantitative HCV ribonucleic acid testing before and after starting HCV treatment, and screening for hepatocellular carcinoma (HCC) in HCV patients with cirrhosis. Methods This national study included Medicare beneficiaries with HCV between 2014 and 2017. We used bivariate probit to estimate the probability of receiving recommended tests before and after HCV treatment by patient race/ethnicity, urban
View details →DOI: 10.1371/journal.pone.0263913 Negative / Null Result ReportOpen accessMedicine
F. E. Kocak, M. Yöntem, Ö. Yücel et al. · 2013 · Biochemia Medica
Introduction: Today, the pneumatic tube transport system (PTS) is used frequently because of its advantages related to timing and speed. However, the impact of various types of PTS on blood components is unknown. The aim of this study was…
View details →DOI: 10.11613/bm.2013.024 Negative / Null Result ReportOpen accessMedicine
Sigrid Børte, Bendik S Winsvold, Synne Øien Stensland et al. · 2017 · PLoS ONE
Background There is little knowledge about how factors early in life affect the development of migraine and tension-type headache. We aimed to examine whether growth restriction in utero is associated with development of migraine and frequent tension-type headache in adults. Methods The population-based Nord-Trøndelag Health Study (HUNT 3) contained a validated headache questionnaire, which differentiated between migraine and tension-type headache. These data were linked to information on weight and gestational age at birth from the Norwegian Medical Birth Registry. In total 4557 females and 2
View details →DOI: 10.1371/journal.pone.0175908 Negative / Null Result ReportOpen accessInternal medicine
Katherine Rieke, Ramon Durazo-Arvizu, Kiang Liu et al. · 2014 · Journal of Obesity
Objective. To examine the association between anxiety and weight change in a multiethnic cohort followed for approximately 10 years. Methods. The study population consisted of participants of the multiethnic study of atherosclerosis who met specified inclusion criteria (n = 5,799). Weight was measured at baseline and four subsequent follow-up exams. Anxiety was analyzed as sex-specific anxiety quartiles (QANX). The relationship between anxiety level and weight change was examined using a mixed-effect model with weight as the dependent variable, anxiety and time as the independent variables, an
View details →DOI: 10.1155/2014/894627 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Ganeshgouda Majigoudra, Ashish K Duggal, Debashish Chowdhury et al. · 2023 · Annals of Indian Academy of Neurology
Background: Myasthenia Gravis (MG) is a chronic fluctuating illness, due to the dysfunction of neuromuscular junction which is autoimmune in nature. The disease severely affects the Quality Of Life (QOL). Objective: The primary objective of our study was to assess the QOL in patients with MG using Short Form 36 (SF 36) and MGQOL 15 R (Hindi translated).The secondary objective was to assess the correlation of age, sex, illness duration, clinical characteristics, severity, and treatment with the QOL in MG patients. Methodology: A cross sectional study of 55 MG patients was done to analyse and ev
View details →DOI: 10.4103/aian.aian_945_22 Negative / Null Result ReportOpen accessDiseases of the blood and blood-forming organs
adel abd elhaleim hagag · 2015 · Mediterranean Journal of Hematology and Infectious Diseases
Abstract Background: Acute myeloid leukemia (AML) accounts for 25%-35% of the acute leukemia in children. BAALC (Brain and Acute Leukemia, Cytoplasmic gene) is a recently identified gene on chromosome 8q22.3 that has prognostic significance in AML. The aim of this work was to study the impact of BAALC gene expression on prognosis of AML in Egyptian children. Patients and methods: This study was conducted on 40 patients of newly diagnosed AML who were subjected to the following: Full history taking, clinical examination, laboratory investigations including: complete blood count, LDH, bone marro
View details →DOI: 10.4084/mjhid.2015.033 Negative / Null Result ReportOpen accessMedicine (General)
Achim Grünewaldt, Gernot Rohde · 2024 · Frontiers in Medicine
BackgroundThe incidence of adverse events during endobronchial ultrasound is low. Nevertheless, it is unclear, whether patients with impaired pulmonary function have an increased risk of respiratory events during the intervention.MethodsA monocentric prospective observational study was performed at the Department of Respiratory Medicine, University Hospital Frankfurt/Main, Germany. Adult patients undergoing an endobronchial ultrasound examination with propofol-sedation were included. Pre-interventional screening included pulmonary function testing, laboratory tests and electrocardiogram. The o
View details →DOI: 10.3389/fmed.2024.1409160 Negative / Null Result ReportOpen accessPublic aspects of medicine
Bolte John, Schipper Maarten, Kelfkens Gert et al. · 2011 · BMC Public Health
Abstract Background Evidence about a possible causal relationship between non-specific physical symptoms (NSPS) and exposure to electromagnetic fields (EMF) emitted by sources such as mobile phone base stations (BS) and powerlines is insufficient. So far little epidemiological research has been published on the contribution of psychological components to the occurrence of EMF-related NSPS. The prior objective of the current study is to explore the relative importance of actual and perceived proximity to base stations and psychological components as determinants of NSPS, adjusting for demograph
View details →DOI: 10.1186/1471-2458-11-421 Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Asher Shafrir, Asher Shafrir, Asher Shafrir et al. · 2022 · Frontiers in Pharmacology
Background and Aims: There is conflicting evidence regarding the association between proton pump inhibitors (PPI) and the risk of acquisition and severity of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.Aim: To evaluate the association between PPI exposure and infection and development of severe disease in patients infected with SARS-CoV2in a large population-based historical cohort.Methods: Data were extracted from a health maintenance organization database in Israel that insures over 1,200,000 individuals from across the country. All patients who underwent SARS-CoV-2 testi
View details →DOI: 10.3389/fphar.2022.791074 Negative / Null Result ReportOpen accessMedicine
Rob Janssen, Jef Serré, Ianthe Piscaer et al. · 2020 · ERJ Open Research
Background Vitamin D supplementation lowers exacerbation frequency in severe vitamin D-deficient patients with COPD. Data regarding the effect of vitamin D on elastin degradation are lacking. Based on the vitamin's anti-inflammatory properties, we hypothesised that vitamin D supplementation reduces elastin degradation, particularly in vitamin D-deficient COPD patients. We assessed the effect of vitamin D status and supplementation on elastin degradation by measuring plasma desmosine, a biomarker of elastin degradation. Methods Desmosine was measured every 4 months in plasma of 142 vitamin D-na
View details →DOI: 10.1183/23120541.00128-2019 Negative / Null Result ReportOpen accessPediatrics
Karl Ove Hufthammer, Trond Markestad, Claus Klingenberg et al. · 2022 · BMJ Paediatrics Open
Objective To compare outcome after less invasive surfactant administration (LISA) and primary endotracheal intubation (non-LISA) in infants born before gestational age (GA) 28 weeks.Setting All neonatal intensive care units (NICUs) in Norway during 2012–2018.Methods Defined population-based data were prospectively entered into a national registry. We compared LISA infants with all non-LISA infants and with non-LISA infants who received surfactant following intubation. We used propensity score (PS) matching to identify non-LISA infants who were similar regarding potential confounders.Main outco
View details →DOI: 10.1136/bmjpo-2022-001527 Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Takehiro Sugiyama, Takashi Furuno, Yuichi Ichinose et al. · 2024 · Journal of Diabetes Investigation
ABSTRACT Aims/Introduction A recent US Food and Drug Administration report highlighted concerns over nitrosamine (7‐nitroso‐3‐(trifluoromethyl)‐5,6,7,8‐tetrahydro[1,2,4] triazolo‐[4,3‐a]pyrazine [NTTP]) impurities in sitagliptin, prompting investigations into its safety profile. The present study aimed to determine if the use of NTTP‐contaminated sitagliptin, in comparison with other dipeptidyl peptidase‐4 (DPP‐4) inhibitors, is associated with an increased cancer risk. Materials and Methods This retrospective cohort study secondarily used the National Database of Health Insurance Claims and S
View details →DOI: 10.1111/jdi.14281 Negative / Null Result ReportOpen accessMedicine
Luis M. Pérez-Belmonte, José David Torres-Peña, María D. López-Carmona et al. · 2020 · BMC Medicine
Abstract Background Limited evidence exists on the role of glucose-lowering drugs in patients with COVID-19. Our main objective was to examine the association between in-hospital death and each routine at-home glucose-lowering drug both individually and in combination with metformin in patients with type 2 diabetes mellitus admitted for COVID-19. We also evaluated their association with the composite outcome of the need for ICU admission, invasive and non-invasive mechanical ventilation, or in-hospital death as well as on the development of in-hospital complications and a long-time hospital st
View details →DOI: 10.1186/s12916-020-01832-2 Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Pankaj Puar, Nikhil Mistry, Kim A. Connelly et al. · 2023 · ESC Heart Failure
Abstract Aims Given recent suggestions that serum levels of insulin‐like growth factor‐binding protein 7 (IGFBP7) may identify patients who derive greater cardiorenal benefits from treatment with sodium‐glucose transport 2 inhibitors (SGLT2i), this exploratory sub‐analysis of the EMPA‐HEART CardioLink‐6 randomized controlled trial evaluated the association between serum levels of IGFBP7 and empagliflozin‐mediated left ventricular mass regression. Methods and results The EMPA‐HEART CardioLink‐6 trial used gold‐standard cardiac magnetic resonance imaging to detect change in left ventricular mass
View details →DOI: 10.1002/ehf2.14335 Negative / Null Result ReportOpen accessMedicine
Mina Niusha, Seyed Ali Rahmani, Leila Kohan et al. · 2023 · Asian Pacific Journal of Reproduction
Objective: To detect common chromosomal aneuploidy variations in embryos from couples undergoing assisted reproductive technology and preimplantation genetic screening and their possible associations with embryo quality. Methods: In this study, 359 embryos from 62 couples were screened for chromosomes 13, 21, 18, X, and Y by fluorescence insitu hybridization. For biopsy of blastomere, a laser was used to remove a significantly smaller portion of the zona pellucida. One blastomere was gently biopsied by an aspiration pipette through the hole. After biopsy, the embryo was immediately returned to
View details →DOI: 10.4103/2305-0500.365228 Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Baravan Al-Kassou, Hasanin Al-Shaikh, Adem Aksoy et al. · 2023 · International Journal of Cardiology: Heart & Vasculature
Background: Vascular injury and bleeding complications remain frequent after transcatheter aortic valve replacement (TAVR). Whether the access-site of preprocedural coronary angiography (CAG) affects TAVR-related complications is not known. The aim of this study was to evaluate the impact of transradial (TRA) versus transfemoral access (TFA) for preprocedural CAG on outcomes in patients undergoing subsequent TAVR. Methods: The study cohort included 1002 patients undergoing transfemoral TAVR, of whom 39.4% (395/1002) had undergone radial and 60.6% (607/1002) femoral access for pre-TAVR CAG. The
View details →DOI: 10.1016/j.ijcha.2023.101205 Negative / Null Result ReportOpen accessBusiness
Choudhury Mousumi, Singh Ranjit · 2016 · Acta Universitatis Sapientiae: Economics and Business
Bancassurance has evolved as a strong distribution channel in India. Bancassurance means that the insurance company and the bank come together to offer insurance products from the counter of the banks to the bank’s customer. The present study attempts to analyse customers’ perception regarding assurance of bancassurance channel in providing insurance-related services. The study also tries to find out the impact of various demographic variables on customers’ perception regarding assurance of bancassurance channel. The study finds that customers consider bancassurance channel having high assuran
View details →DOI: 10.1515/auseb-2016-0005 Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Shih-Wei Lai, Shih-Wei Lai, Cheng-Li Lin et al. · 2017 · Frontiers in Pharmacology
Background/Objectives: Previous studies showed that zolpidem use could be associated with increased cancer risk, but the role of zolpidem on hepatocellular carcinoma (HCC) risk remains undetermined. The study purpose was to examine the association between HCC risk and zolpidem use in Taiwan.Methods: Using the database from the Taiwan National Health Insurance Program, we designed a case-control study which consisted of 77986 subjects aged 20 years or older with newly diagnosed HCC as the case group, and 77986 subjects without HCC as the control group, from 2000 to 2011. Ever use of zolpidem wa
View details →DOI: 10.3389/fphar.2017.00767 Negative / Null Result ReportOpen accessPublic aspects of medicine
Sonia Oveisi, Roghaye Keshavarz Sadegh, Sina Hosainzade et al. · 2025 · Discover Social Science and Health
Abstract Background Parenting self-efficacy (PSE) describes the beliefs and attitudes of parents on their capabilities to perform well on parenting tasks. Considering its direct relation to the physical and mental development of the children, we evaluated PSE in Iranian parents and investigated its potential effects on children's growth as a reflection of their self-regulation. Methods This investigation was conducted in 2019 in Takestan, Iran, and aimed to assess PSE in 300 parents of children under 2 years old. Families filled out a demographic questionnaire and a PSE questionnaire containin
View details →DOI: 10.1007/s44155-025-00196-3 Negative / Null Result ReportOpen accessMedicine
Zainab Almussa · 2021 · The Medical Journal of Basrah University
Abstract: Introduction: Low birth weight is the best indicator of the impact in the health system and the best predictor of mortality and morbidity in the neonatal, post neonatal and childhood periods. Objectives: This study was planned to study the association between birth weight and selected risk factors in Basrah governorate with special reference to: Socio demographic factors, Present obstetric history, Past obstetric history, History of Ante Natal Care, and Medical history. Methods: This is hospital- based cross sectional study was conducted on 362 infants delivered and /or admitted to A
View details →DOI: 10.33762/mjbu.2021.129962.1070 Negative / Null Result ReportOpen accessPublic aspects of medicine
Sanjay B Tripathi, Vishakha K Kapadia · 2015 · National Journal of Community Medicine
Objectives: To evaluate the clinical profile and the factors influencing treatment outcome of TB patients co-infected with HIV attending DOT centers of Southeast area of Ahmedabad, Gujarat Methodology: A Prospective observation study was conducted to assess the treatment outcome of TB in TB-HIV co-infected patients on DOTs conducted at L.G. Hospital and tuberculosis units (TUs) of south and east region of Ahmedabad. TB patients started DOTS were registered and were followed till treatment outcome was declared. Results: The treatment success rate was found to be 84.17% (101 of 120 patients). Tr
Negative / Null Result ReportOpen accessMedicine
Artha Falentin Putri Susilo, Hanom Husni Syam, Hartanto Bayuaji et al. · 2024 · Scientific Reports
Abstract Vitamin D and calcium in follicular fluid play an important role in modulating steroidogenesis, folliculogenesis, and oocyte quality determination. Both collaborate to produce top-quality embryos (TQE) during in vitro fertilization (IVF). In this study, we compared free 25(OH)D3 and calcium levels in follicular fluid between TQE and non-TQE groups. This cross-sectional study included women who underwent IVF procedures at tertiary hospitals in Bandung, Indonesia. Ovarian follicular fluid was collected during the ovum pick-up procedure. The examination of 25(OH)D3 levels, vitamin d-bind
View details →DOI: 10.1038/s41598-024-71769-6 Negative / Null Result ReportOpen accessMedicine
Sarah Moreira de Sousa Gomes, Paulo César Apolinário de Souza, Cassiane Freitas Rodrigues et al. · 2026 · DST
Introduction: Women living with HIV/AIDS (WLHA) are more vulnerable to human papillomavirus (HPV) infection, particularly by high-risk oncogenic subtypes, due to HIV-associated immunosuppression. Objective: To assess the prevalence and distribution profile of HPV subtypes in WLHA, correlating findings with CD4 levels and age group. Methods: A cross-sectional study was conducted with 184 WLHA receiving care at a public referral center in Juiz de Fora, Minas Gerais, from May 2021 to May 2022. Self-collected vaginal samples were analyzed by RT-PCR to detect HPV subtypes. Associations between HPV
View details →DOI: 10.5327/dst-2177-8264-1457 Negative / Null Result ReportOpen accessGeriatrics
Socheat Cheng, Tahreem Ghazal Siddiqui, Michael Gossop et al. · 2020 · BMC Geriatrics
Abstract Background Central nervous system depressant medications (CNSDs) such as opioid analgesics and sedative-hypnotics are commonly prescribed to older patients for the treatment of chronic pain, anxiety and insomnia. Yet, while many studies reported potential harms, it remains unknown whether persistent use of these medications is beneficial for older patients’ self-reported health-related quality of life (HRQoL). The present study clarified this knowledge gap through comparing HRQoL of hospitalized older patients with versus without using CNSD drugs for ≥4 weeks. Moreover, we explored th
View details →DOI: 10.1186/s12877-020-01838-8 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Karthikeyan R, Marimuthu G, Ramasubramanian C et al. · 2014 · Neuropsychiatric Disease and Treatment
Ramanujam Karthikeyan,1 Ganapathy Marimuthu,1 Chellamuthu Ramasubramanian,2 Gautham Arunachal,2 Ahmed S BaHammam,3 David Warren Spence,4 Daniel P Cardinali,5 Gregory M Brown,6 Seithikurippu R Pandi-Perumal7 1Department of Animal Behaviour and Physiology, School of Biological Sciences, Madurai Kamaraj University, Madurai, India; 2MS Chellamuthu Trust and Research Foundation, KK Nagar, Madurai, India; 3University Sleep Disorders Center, College of Medicine, National Plan for Science and Technology, King Saud University, Riyadh, Saudi Arabia; 4Independent researcher, Toronto, Ontario, C
Negative / Null Result ReportOpen access
Padma B Prabha, Jyothi P T · 2022 · Journal of Education Technology in Health Sciences
Structured interactive lectures (SIL) and Flipped classroom methods (FCM) are newer teaching learning methods which utilise pedagogical way of teaching. This study intends to compare efficacy of both methods in the understanding of…
View details →DOI: 10.18231/j.jeths.2021.019 Negative / Null Result ReportOpen accessVeterinary medicine
K. Wojdak-Maksymiec, M. Kmiec, J. Ziemak · 2006 · Veterinární Medicína
The study included 124 Polish Black-and-White dairy cows of various share of the Holstein-Friesian (HF) breed. Lactoferrin (LTF) gene polymorphism was obtained with PCR-RFLP method using EcoRI enzyme. Two alleles of LTF, A and B, were found in the studied population. Their frequencies were 67.74% and 32.56%, respectively. The alleles controlled the occurrence of three genotypes: AA, BB and AB, of frequencies equal to 37.90%, 2.42% and 59.68%, respectively. It was established that statistically significant associations exist between the somatic cell count (SCC) and LTF genotype, lactation month
View details →DOI: 10.17221/5512-vetmed Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Sofya Ilmer, Rubab Sohail, Sharon Hyman · 2026 · Frontiers in Endocrinology
IntroductionThis retrospective chart review investigated the relationship between 25-hydroxyvitamin D levels and the initial clinical and biochemical presentation of type 1 diabetes mellitus (T1DM) in children under 18 years of age, specifically: (1) presence or absence of diabetic ketoacidosis and the severity of diabetic ketoacidosis (DKA) - among those with DKA, and (2) beta-cell function.MethodsThis study included 99 children with new-onset Type 1 Diabetes Mellitus (T1DM). Patients were diagnosed at our pediatric endocrinology practice at Northwell Health between June 2023 and February 202
View details →DOI: 10.3389/fendo.2026.1814563 