A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20261 results in Negative / Null Result Report · page 536 of 676
Miler K, Gorący I, Łoniewska B et al. · 2026 · Genes
Background The correlation between renal volume (or mass) and nephron number in newborns allows the use of the total kidney volume (TKV) at birth as a surrogate for congenital nephron number. Previously, the wide variation in final nephron…
Justice J, Burnette H, Irlmeier R et al. · 2025 · Cancers
Background/objectives Immune checkpoint inhibitors (ICIs) have revolutionized outcomes for patients with melanoma. As such, it is important to understand factors that may influence response as well as toxicity to these therapies. Impaired…
Singh V, Banumathy N, Palla S et al. · 2025 · Pediatric blood & cancer
Background The chemotherapy regimen comprising carboplatin, vincristine, and etoposide (JOE) is commonly used to treat retinoblastoma. Carboplatin-induced ototoxicity is infrequently reported. Extended high-frequency hearing loss may…
Akbari T, Mach L, Hammersley DJ et al. · 2025 · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
Background Serial perfusion cardiovascular magnetic resonance (CMR) in symptomatic patients undergoing coronary artery bypass grafting (CABG) may provide mechanistic insight into dynamic abnormalities of the myocardium. Objectives To…
Ueland T, Traaen GM, Hunt TE et al. · 2025 · Sleep medicine
Study objectives Obstructive sleep apnea (OSA) and atrial fibrillation (AF) are highly prevalent conditions sharing multiple risk factors including obesity. Adipokines secreted from adipose tissue could modify pathways affecting atrial…
Penrod S, Forgit D, Griffin L · 2025 · American journal of speech-language pathology
Purpose The purpose of this study was to investigate whether the implementation of the Green Light Tool for the evaluation and treatment of tracheostomy patients hospitalized at Maine Medical Center affects the time to initiating oral…
Androvičová R, Jahn K, Engel J et al. · 2026 · Behavioural brain research
Rationale The compulsive sexual behaviour disorder (CSBD) is a recent addition to the ICD-11 diagnostic manual under the chapter of impulse control disorders. Though there is a wealth of different theoretical viewpoints regarding the…
Wang F, Wang C, Wang T et al. · 2025 · Preprint
Genotype-phenotype associations can be context-dependent and dynamic in nature leading to heterogeneity of genetic effects across different parts of the phenotype distribution. Quantile regression, an alternative to linear regression for…
Xiang H, Lin C, Chen S et al. · 2025 · Current HIV research
Introduction Peripheral blood lymphocyte subsets have been shown to influence prognosis in HIV-associated Diffuse Large B-Cell Lymphoma (HIV-DLBCL), a rare and highly aggressive form of non-Hodgkin's lymphoma linked to immunosuppression…
Bitran AM, Kleiman EM, Rizvi SL · 2026 · Archives of suicide research : official journal of the International Academy for Suicide Research
Objective Suicidal communications (SCs)-also known as suicide threats or "gestures," whereby an individual verbally or behaviorally signals suicidal intent-present a serious challenge to clinicians and loved ones, who may struggle to…
Mehta R, Sah R · 2025 · Cerebral circulation - cognition and behavior
•SDMT drop at baseline linked to higher Fazekas (WMH) scores.•No follow-up MoCA/SDMT association after multiple correction.•Practice effects likely inflated cognitive test recovery scores.•High attrition biased against fatigue and…
Liampas I, Tsirelis D, Dastamani M et al. · 2024 · Journal of molecular neuroscience : MN
Background and objectives Data on the association between BDNF rs6265 and multiple sclerosis (MS) are scarce and heterogeneous. Materials and methods We undertook a case-control study design. Newly diagnosed individuals with MS based on…
Yin Q, Shu T, Chen Z et al. · 2025 · Preprint
Abstract Background To investigate the relationship between emotional dysregulation, as measured by the emotional go/nogo task, and the multidimensional profile of borderline personality disorder (BPD). Methods Eighty-two participants (32…
Normann SS, Andersen HR, Lund LC et al. · 2025 · Environmental research
Background Over the past decade, the use of organophosphate insecticides including chlorpyrifos has faced increasing restrictions due to health concerns, leading to a rise in use of pyrethroids. Concerns about neurodevelopmental insults…
Razeghi M, Abdoli S, Mardanian Dehkordi L · 2024 · Applied nursing research : ANR
Aim Identify the relationship between a sense of belonging and psychosocial well-being in individuals with type 1 diabetes (T1D) in Iran. Background Understanding this relationship is vital for tailored nursing interventions to enhance…
Gao Y, Hsu V, Kil A et al. · 2026 · The Journal of clinical endocrinology and metabolism
Context Previous animal studies show association between osteocalcin (OC) and type 2 diabetes-related quantitative traits (QTs), with some suggesting these effects being mediated by adipokines. Replication in humans has been inconsistent.…
Fitzgerald M · 2024 · Trends in Food Science & Technology.
The messaging around processed food recently is that it is unhealthy and associated with the onset of chronic disease. However, food is processed for many reasons that range from preservation to safety, and then more recently in response…
Dousset J, Curnock MI, Wang JZ et al. · 2026 · Environmental management
As the Great Barrier Reef (GBR, the Reef) faces unprecedented threats, reducing anthropogenic pressures and fostering stewardship within coastal communities are among the strategic priorities identified in the Australian and Queensland…
Huh K, Kang M, Jung J · 2023 · European heart journal
Background and aims An increased risk of aortic aneurysm and aortic dissection (AA/AD) has been reported with fluoroquinolone (FQ) use. However, recent studies suggested confounding factors by indication. This study aimed to investigate…
Hecht S, Rojas-Ruiz A, Boucher M et al. · 2025 · Lung
Introduction A recent study on BALB/c and C57BL/6 mice demonstrated a clear lack of association between the in vivo response to nebulized methacholine and the degree of airway narrowing ex vivo in a model of asthma induced by a daily…
Chang RC, Olbrich H, Wang YF et al. · 2026 · JID innovations : skin science from molecules to population health
Bullous pemphigoid (BP) is an autoimmune blistering disease caused by autoantibodies to collagen type 17 ( COL17A1 ) and is a recognized immune-related adverse event in patients receiving immune checkpoint inhibitors (ICIs). We…
Goldenholz DM, Cheng JC, Chang C et al. · 2025 · Preprint
ABSTRACT Importance Medication adherence is widely emphasized in epilepsy management, with a belief that missing even single doses can trigger seizures. However, scientific evidence supporting this specific claim is limited, particularly…
Simonin EM, Switkowski KM, Rifas-Shiman SL et al. · 2026 · Frontiers in pediatrics
Introduction There are currently no known biomarkers associated with the diagnosis of infant colic, a common early disorder of gut brain interaction (DGBI) that has been found to predict adverse health outcomes, including atopy, migraines…
Soltanizadeh A, Tirgar A, Zamanian Y et al. · 2025 · Frontiers in oncology
Background Apelin, a peptide implicated in various physiological processes, has been shown to be involved in cancer development and progression. However, its role in breast cancer remains unclear. This study aimed to investigate serum…
McEvoy LK, Zhang B, Nguyen S et al. · 2026 · Aging
Epigenetic clocks of biological aging have been associated with cognitive impairment and dementia. Less is known about whether they are associated with an older-appearing brain or with an atrophy pattern associated with dementia. We…
Cristiani R, Hansson F, Senorski EH et al. · 2025 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
Purpose To evaluate factors associated with revision anterior cruciate ligament reconstruction (ACLR) within 5 years of primary ACLR in children and adolescents. Methods Children and adolescents (age Results A total of 1888 patients (mean…
Silva MJA, Figueira LRT, Sardinha DM et al. · 2025 · Frontiers in genetics
Coronavirus disease 2019 (COVID-19) is a multisystemic disease caused by SARS-CoV-2 that can lead to several pulmonary illnesses according to the immunological contexts of the individual. Haplotypes consist of single-nucleotide…
Ma Y, Mayes MD, Guo X et al. · 2024 · Scientific reports
This study aimed to examine whether a reported SSc-associated SNP rs2841277 in the PLD4 gene identified in an Asian population was also associated with SSc in European American (EA). The EA cohort consisting of 1005 SSc patients and 961…
Reveley M, Owen GR, Tumba N et al. · 2026 · Developmental neurobiology
Autism spectrum disorder (ASD) has recently been described as a synaptopathy where dysregulation at the level of the synapse is thought to evoke an excitation-inhibition (E/I) imbalance implicated in its pathogenesis. The mechanisms…
Plischuk M, Garizoain G, Mancuso RG · 2025 · International journal of paleopathology
Objective This study examines how age at death, sex, and socio-historical context relate to the frequency, location, and severity of Schmorl's nodes. Materials The sample comprised thoracic and lumbar vertebrae of 192 skeletons from two…