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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19885 results in Negative / Null Result Report · page 533 of 663

Negative / Null Result ReportMedicine

Individualized Perioperative Blood Pressure and Fluid Therapy in Esophagectomy: A Prospective, Single-blind Randomized Controlled Trial.

Hovgaard HL, Vistisen ST, Enevoldsen J et al. · 2026 · Anesthesiology

Background Esophagectomy is a key treatment for esophageal cancer but carries a high risk of postoperative complications, some of which are potentially preventable through optimized hemodynamic management. Goal-directed fluid therapy…

View details →DOI: 10.1097/aln.0000000000005919
Negative / Null Result ReportMedicine

Effect of a Post-Discharge Telephone-Based Intervention Led by Social Workers to Reduce Heart Failure Readmissions.

Yan CL, Erben A, Sarmiento K et al. · 2025 · Quality management in health care

Background Heart failure (HF) readmission rates at our institution were often higher than the expected levels for our institution type. Social work post-discharge telephone calls were identified as an opportunity to address reasons for HF…

View details →DOI: 10.1097/qmh.0000000000000535
Negative / Null Result ReportMedicine

Antiseizure Effects of Mirtazapine in a Rat Model of Status Epilepticus Via Cannabinoid Receptor Modulation.

Vafaei A, Manavi MA, Toutounchian S et al. · 2025 · Neurochemical research

Status epilepticus (SE) is a severe neurological condition with high morbidity and mortality rates. Despite the availability of treatments, many cases remain refractory to standard therapies. In this study we investigated the possible…

View details →DOI: 10.1007/s11064-025-04584-8
Negative / Null Result ReportOpen accessMedicine

Germicidal UV Light and Incidence of Acute Respiratory Infection in Long-Term Care for Older Adults: A Randomized Clinical Trial.

Shoubridge AP, Brass A, Crotty M et al. · 2025 · JAMA internal medicine

Importance Infectious outbreaks of respiratory viruses within long-term care facilities (LTCFs) for older adults are associated with high rates of hospitalization and death. Despite evidence that airborne transmission contributes…

View details →DOI: 10.1001/jamainternmed.2025.3388
Negative / Null Result ReportOpen accessMedicine

Heavy gravity combined with light gravity local anesthetic in subarachnoid anesthesia for cesarean section did not reduce the incidence of intraoperative hypotension in maternal women: a prospective cohort study.

Qiao W, Liu L, Zhang X et al. · 2025 · BMC anesthesiology

Background Subarachnoid anesthesia is the primary anesthetic method for elective cesarean section surgery, characterized by rapidly taking effect and reliable analgesia. However, subarachnoid anesthesia is prone to cause a high block…

View details →DOI: 10.1186/s12871-025-02895-5
Negative / Null Result ReportOpen accessMedicine

Daily Chlorhexidine Bathing for the Prevention of Nosocomial Infections in Critically Ill Patients (CLEAN-IT): a multicentre, cluster-randomised, crossover trial.

Tomazini BM, Besen BAMP, Gales AC et al. · 2026 · Lancet regional health. Americas

Background Critically ill patients are at risk of nosocomial infections, acquisition of multidrug-resistant pathogens, and substantial antimicrobial consumption. We assessed whether bathing with chlorhexidine reduces these outcomes…

View details →DOI: 10.1016/j.lana.2026.101400
Negative / Null Result ReportMedicine

Bio-based polyurethane coatings for controlled-release phosphorus fertilizers: Synthesis, characterization and effect on P use efficiency.

Cancellier EL, Degryse F, da Silva RC et al. · 2025 · The Science of the total environment

The use of petroleum-based coatings in controlled-release fertilizers (CRFs) raises environmental concerns and it is unclear if, and to what extent, CRFs can improve P use efficiency. This study explored the synthesis of bio-based…

View details →DOI: 10.1016/j.scitotenv.2025.180403
Negative / Null Result ReportOpen accessMedicine

The effects of balanced crystalloid versus plasma on endothelial injury, systemic inflammation, and coagulation in experimental endotoxaemia: a randomised human volunteer study.

van den Brink DP, Hilderink BN, Kleinveld DJB et al. · 2026 · British journal of anaesthesia

Background During shock, neutrophil-mediated glycocalyx degradation can lead to exposure of the procoagulant endothelial surface and consequent organ injury. Resuscitation using crystalloid fluids may augment this endothelial damage, while…

View details →DOI: 10.1016/j.bja.2025.08.060
Negative / Null Result ReportMedicine

Allyl isothiocyanate as a natural fumigant for protecting soybean and bean grains against Aspergillus parasiticus growth and aflatoxin production

Lopes LF, Favoretto VR, Evangelista AG et al. · 2025 · European food research & technology.

This study evaluated the efficacy of gaseous allyl isothiocyanate (AITC) in inhibiting Aspergillus parasiticus growth and aflatoxin production in soybeans and beans stored at 85% relative humidity for 35d. Samples of 50 g of soybeans or…

Negative / Null Result ReportMedicine

Standard Monofocal Intraocular Lenses Versus Enhanced Monofocal Intraocular Lenses for Children 6 to 13 Years Old With Pediatric Cataract.

Elzawahry S, Elhilali H, Awadein A et al. · 2026 · Journal of pediatric ophthalmology and strabismus

Purpose To investigate whether using an enhanced monofocal intraocular lens (IOL) in the pediatric age group can improve the visual performance at varying distances in comparison to standard monofocal lenses. Methods Forty-five eyes of…

View details →DOI: 10.3928/01913913-20250530-03
Negative / Null Result ReportOpen accessMedicine

Systematic Notchplasty in Primary ACL Reconstruction Using Hamstring Autografts: A Prospective Cohort Study on the Rate of Secondary Arthrolysis.

Saint-Etienne A, Hardy A, Miele A et al. · 2025 · Journal of clinical medicine

Background: Arthrofibrosis requiring arthrolysis is a relevant complication after anterior cruciate ligament (ACL) reconstruction. It has been suggested that intercondylar notch impingement may contribute to this outcome. The aim of this…

View details →DOI: 10.3390/jcm14207285
Negative / Null Result ReportOpen accessMedicine

Psychological Impact of AI-Simplified Brain MRI Reports: A Randomized Trial of Patient Understanding, Anxiety, and Health Literacy.

Alarifi M, Luo J, Jabour A et al. · 2026 · Journal of clinical medicine

Background/Objectives : Immediate patient access to radiology reports has increased the need for communication that patients can understand, yet it remains unclear whether simplifying report language improves comprehension without…

View details →DOI: 10.3390/jcm15114158
Negative / Null Result ReportMedicine

Argipressin for prevention of blood loss in hepatic resection: a randomised, placebo-controlled, double-blind trial.

Wisén E, Pivodic A, Skagervik A et al. · 2026 · British journal of anaesthesia

Background Blood loss and blood transfusion are associated with negative short-term and long-term outcomes in hepatic resection. Vasopressin decreases portal blood flow and could reduce bleeding during liver surgery. We compared the…

View details →DOI: 10.1016/j.bja.2025.09.021
Negative / Null Result ReportMedicine

In adults with TBI and anemia, liberal vs. restrictive RBC transfusion did not reduce unfavorable neurologic outcomes by 10% at 6 mo.

Malik A, Martin GS · 2024 · Annals of internal medicine

Source citation Turgeon AF, Fergusson DA, Clayton L, et al; HEMOTION Trial Investigators on behalf of the Canadian Critical Care Trials Group, the Canadian Perioperative Anesthesia Clinical Trials Group, and the Canadian Traumatic Brain…

View details →DOI: 10.7326/annals-24-02456-jc
Negative / Null Result ReportMedicine

Association of Stepping Up to High-Dose Inhaled Corticosteroids and Risk of Future Asthma Exacerbations: Data From the United States.

Tran TN, Kerkhof M, Le TT et al. · 2026 · The journal of allergy and clinical immunology. In practice

Background Real-world data on the benefit of high-dose inhaled corticosteroid (ICS) after exacerbation are limited. Objective To investigate whether stepping up to high-dose ICS after severe exacerbation reduces future asthma exacerbation…

View details →DOI: 10.1016/j.jaip.2025.10.005
Negative / Null Result ReportOpen accessMedicine

Reducing Noise Induced by Cardiac Pulsatility in Brain Maps of R<sub>2</sub>* and Magnetic Susceptibility Using Tailored k-space Sampling.

Raynaud Q, Dardano T, Oliveira R et al. · 2026 · NMR in biomedicine

Maps of the transverse relaxation rate R 2 * and magnetic susceptibility (χ) are computed from gradient-echo data and are sensitive to signal instabilities induced by cardiac pulsation. Here, we introduce two k-space sampling strategies…

View details →DOI: 10.1002/nbm.70305
Negative / Null Result ReportMedicine

Common channel length and implications to the weight loss.

Santoro S, Mota FC, de Aquino CGG et al. · 2025 · Updates in surgery

To present and analyze the results of sleeve gastrectomy with transit bipartition (SG + TB) with three different lengths of common channel (CC) and its implications for the weight loss and signals of residual malabsorption. A total of 790…

View details →DOI: 10.1007/s13304-025-02343-6
Negative / Null Result ReportMedicine

Effect of albumin infusion in patients with predicted severe acute pancreatitis: A randomized controlled trial.

Shu W, Wan J, Xu H et al. · 2025 · Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]

Background Although previous studies have shown the potential advantages of albumin administration in critically ill patients, it has not been tested in patients with severe acute pancreatitis. Methods In this single-center trial, we…

View details →DOI: 10.1016/j.pan.2025.08.012
Negative / Null Result ReportMedicine

The Effect of Intraoperative Methadone During Spine Fusion Surgery on Postoperative Opioid Requirements: A Randomized Clinical Trial.

Uhrbrand CG, Carlé N, Valancius K et al. · 2025 · Spine

Study design A randomized blinded trial with three groups. Objective To evaluate whether a single intraoperative methadone dose reduces postoperative opioid requirements and pain intensity in patients undergoing lumbar fusion surgery.…

View details →DOI: 10.1097/brs.0000000000005477
Negative / Null Result ReportMedicine

Effect of alirocumab on postprandial hyperlipidaemia in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled, cross-over trial.

Cariou B, Thys A, Oliveira AR et al. · 2025 · Diabetes, obesity & metabolism

Aims Postprandial hyperlipidaemia (PPL), characterized by elevated triglyceride (TG) concentrations after a meal, is common in type 2 diabetes (T2D) and is often recognized as an independent cardiovascular risk factor. Here, we aimed to…

View details →DOI: 10.1111/dom.16305
Negative / Null Result ReportMedicine

Impact of an electronic clinical decision support algorithm (eCDSA) on antibiotic prescribing in primary care in Cambodia: A cluster randomised controlled trial.

Wynberg E, Mishra A, Liverani M et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Objectives Poorly targeted antibiotic use in primary care is a driver of antimicrobial resistance. Electronic clinical decision support algorithms (eCDSAs) integrating point-of-care tests may improve prescribing. We evaluated the impact of…

View details →DOI: 10.1016/j.ijid.2026.108382
Negative / Null Result ReportMedicine

Proactive versus standard support of labor in the latent phase - A randomized, controlled clinical trial.

Larsen M, Underdal M, Salvesen Ø et al. · 2025 · Sexual & reproductive healthcare : official journal of the Swedish Association of Midwives

Objective Long latent phase of labor with subsequent prolonged total labor duration increases the risk of obstetric interventions and complications. We explored whether Proactive Support of Labor (PSL) compared to Standard Support of Labor…

View details →DOI: 10.1016/j.srhc.2025.101144
Negative / Null Result ReportMedicine

Minimal Impact of Prophylactic Antibiotics in Pediatric Inguinal Hernia Surgery: Evidence From Real-World Data.

Fujii T, Kitadani Y, Tanaka A et al. · 2025 · Journal of pediatric surgery

Background The effectiveness of prophylactic antibiotics in pediatric inguinal hernia repair remains unclear. As the procedure is considered clean, the necessity of prophylactic antibiotics is debated. Methods We conducted a retrospective…

View details →DOI: 10.1016/j.jpedsurg.2025.162607
Negative / Null Result ReportOpen accessMedicine

Impact of electrocardiogram monitoring on the frequency of tracheal intubation at birth.

de Souza Freire T, Kawakami MD, de Almeida MF et al. · 2026 · Jornal de pediatria

Objective To determine whether the use of an electrocardiogram monitor in newborns receiving positive pressure ventilation (PPV) at birth affects the frequency of tracheal intubation in the delivery room. Methods Retrospective cohort of…

View details →DOI: 10.1016/j.jped.2026.101504
Negative / Null Result ReportOpen accessMedicine

Impact of Pre-Elite Anterior Cruciate Ligament (ACL) Reconstruction on Draft Outcomes and Reinjury Risk in Elite Australian Football Players: A Retrospective Cohort Study.

Veale JP, Shawdon A, D'Alessandro P et al. · 2025 · Sports (Basel, Switzerland)

A history of anterior cruciate ligament reconstruction (ACLR) during the Australian Football (AF) talent pathway may impact draft prospects and increase the risk of a second injury during a professional career. This study investigated…

View details →DOI: 10.3390/sports13090308