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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20261 results in Negative / Null Result Report · page 533 of 676

Negative / Null Result ReportOpen accessMedicine

Molecular investigation of Neospora caninum in cattle in the Khomas region of Namibia.

Samkange A, Chitanga S, Mbiri P et al. · 2025 · The Onderstepoort journal of veterinary research

Neosporosis is a leading cause of bovine abortions worldwide, with a substantial economic impact because of reproductive losses, costing the cattle industry billions of dollars annually. Despite the global significance of Neospora caninum,…

View details →DOI: 10.4102/ojvr.v92i1.2237
Negative / Null Result ReportMedicine

Evaluation of dried blood spot testing for serological monitoring of epizootic and zoonotic pathogens in domestic pigs.

Steinhauer R, Kübler E, Gaugler S et al. · 2026 · Journal of virological methods

Dried blood spots (DBS) constitute a stable, cost-efficient sampling matrix that can be collected in a minimally invasive manner. Although widely adopted in human medicine, their use in veterinary diagnostics remains limited. This study…

View details →DOI: 10.1016/j.jviromet.2025.115336
Negative / Null Result ReportMedicine

Radiation dosimetry of <sup>15</sup>O-water based on dynamic large axial field of view PET.

Lubberink M, Åhlström A, Tolvanen T et al. · 2026 · Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

Purpose Previously published effective dose coefficient estimates for 15 O-water are around 1 μSv/MBq, resulting in an effective dose of around 0.4 mSv for a typically injected activity of 400 MBq in clinical cardiac scans. These estimates…

View details →DOI: 10.1016/j.nuclcard.2026.102775
Negative / Null Result ReportMedicine

Application and Evaluation of a Formative Feedback Rubric on Nontechnical Skills Using Retrospective SIMPL App Data in General Surgery Residents.

Cloonan MR, Maginot ER, Tieken KR et al. · 2026 · Journal of surgical education

To determine the frequency of nontechnical skills (NTS) feedback provided by attending surgeons through narrative comments and assess its effectiveness using a validated formative feedback rubric. This retrospective cross-sectional study…

View details →DOI: 10.1016/j.jsurg.2026.104035
Negative / Null Result ReportOpen accessMedicine

Economic evaluation of the second-line regimen of liposome irinotecan (II) combined with 5-FU/LV versus placebo combined with 5-FU/LV for locally advanced or metastatic pancreatic ductal adenocarcinoma in China.

Huang J, Ye H, Lin J et al. · 2026 · PloS one

Background The cost-effectiveness of liposome irinotecan (II) (HR070803) in combination with 5-fluorouracil and leucovorin as a treatment for patients with locally advanced or metastatic pancreatic ductal adenocarcinoma offering a…

View details →DOI: 10.1371/journal.pone.0351853
Negative / Null Result ReportMedicine

Clinical efficacy of portable, cost-effective manual thermal pulsation for obstructive meibomian gland dysfunction and factors associated with therapeutic efficacy.

Cheng X, Huang H, Fan Z et al. · 2026 · BMJ open ophthalmology

Objective To evaluate the efficacy and safety of portable, cost-effective manual thermal pulsation as a single therapy for meibomian gland dysfunction (MGD) and to compare the microbiota and lipid composition in subjects with different…

View details →DOI: 10.1136/bmjophth-2026-002769
Negative / Null Result ReportMedicine

Chronic toxicity and uptake of 10 Per- and Polyfluoroalkyl Acids to marine species Americamysis bahia and Atherinops affinis.

Hayman NT, Pandelides Z, Colvin MA et al. · 2026 · Environmental toxicology and chemistry

A lack of marine specific data results in challenges to assessing site-specific ecological risks and developing marine water quality criteria for per- and polyfluoroalkyl substances (PFAS). Here, the toxicity and bioaccumulation of…

View details →DOI: 10.1093/etojnl/vgag168
Negative / Null Result ReportMedicine

Effective Coverage of Rehabilitation for Adults with Chronic Primary Low Back Pain in Uganda.

De Groote W, Taremwa Y, Duttine A et al. · 2026 · International journal of environmental research and public health

In Uganda, in 2019, 6.8 million people experienced health conditions that are amenable to rehabilitation. This is largely due to musculoskeletal disorders such as low back pain (LBP). Measuring effective coverage of rehabilitation means…

View details →DOI: 10.3390/ijerph23060693
Negative / Null Result ReportMedicine

National medical occupational radiation dose monitoring in Saudi Arabia.

Aljuaid M, Alsiraj K · 2026 · Annals of the ICRP

This is a national study about the occupational Radiation doses for medical workers in the Kingdom of Saudi Arabia which covers the period since the establishment of the Nuclear and Radiological Regulatory Commission (NRRC). The study aims…

View details →DOI: 10.1177/01466453251411988
Negative / Null Result ReportOpen accessMedicine

Awareness of Effective Communication Skills Among Paediatric Dentists in Turkey.

Büyüksefil M, Çimen Ü, Şimşek Derelioğlu S et al. · 2026 · Oral health & preventive dentistry

Purpose Effective communication with paediatric patients is one of the cornerstones of paediatric dentistry. Strong communication skills play a critical role in reducing dental anxiety, enhancing patient satisfaction, and facilitating the…

View details →DOI: 10.3290/j.ohpd.c_2680
Negative / Null Result ReportMedicine

Comparison of effective phacoemulsification times used in cataract surgery between the Veritas Vision System and the Centurion Vision System.

Choi JY, Song WS, Won YK et al. · 2026 · Korean journal of ophthalmology : KJO

Purpose To compare the effective phacoemulsification time used in cataract surgery and postoperative outcomes between the Veritas and the Centurion Vision System. Methods A retrospective analysis was conducted on 90 eyes from 82 patients…

View details →DOI: 10.3341/kjo.2025.0196
Negative / Null Result ReportMedicine

Effective population size and N e /N ratio for two populations of Northern chamois (Rupicapra rupicapra) on the edge of the species' distribution range.

Jacobs S, Edelhoff H, Ebert C et al. · 2026 · BMC ecology and evolution

Effective population size (Ne) is a fundamental parameter in conservation genetics, providing relevant information on the adaptability and long-term viability of populations. In contrast, wildlife management strategies, particularly for…

View details →DOI: 10.1186/s12862-026-02543-7
Negative / Null Result ReportMedicine

Missed Opportunities for Timely Diagnosis and Effective Therapeutic Management of Prolonged Fever: A Case Study of Confirmed Lassa Fever in N'Zérékoré, Guinea, 2022.

Cherif IS, Essis EML, Diallo MA et al. · 2026 · Case reports in infectious diseases

Background Lassa fever is a potentially fatal viral hemorrhagic disease caused by a ribonucleic acid (RNA) virus of the Arenaviridae family, endemic in West Africa. It is highly virulent and contagious in several countries, with a…

View details →DOI: 10.1155/crdi/2672939
Negative / Null Result ReportMedicine

Unfolding prion misfolding and the challenge of identifying effective therapeutics: is there hope on the horizon?

Sabzehei S, Innocenti N, Rigoli M et al. · 2026 · Expert opinion on drug discovery

Introduction Prion diseases are rare, fatal neurodegenerative disorders caused by the conformational conversion of cellular prion protein (PrP) into a pathogenic counterpart called PrP Sc , that replicates by templated misfolding. The…

View details →DOI: 10.1080/17460441.2026.2688321
Negative / Null Result ReportOpen accessMedicine

Vessel diameter as a potential predictor of pulsed dye laser response in port wine stain: a retrospective exploratory reflectance confocal microscopy study.

Ran X, Shang Y, Yang X et al. · 2026 · Lasers in medical science

To investigate whether noninvasive reflectance confocal microscopy (RCM)-derived vascular parameters can serve as objective predictors of therapeutic response to pulsed dye laser (PDL) treatment in patients with port wine stain (PWS),…

View details →DOI: 10.1007/s10103-026-04906-4
Negative / Null Result ReportOpen accessMedicine

The Median Effective Dose of Phenylephrine Infusion for Prevention of Spinal-Induced Hypotension During Cesarean Delivery in the 15° Left-Tilt vs. Supine Positions: A Randomised Control Study.

Yu XQ, Drzymalski DM, Qian J et al. · 2026 · Drug design, development and therapy

Background Left uterine displacement is presumed to decrease vasopressor requirements during cesarean delivery due to decreased aortocaval compression, but studies have been equivocal. Our primary aim was to determine the median effective…

View details →DOI: 10.2147/dddt.s591446
Negative / Null Result ReportMedicine

Investigating the evidence for effective digital skin surveillance methods.

Fabbri F, Albusaidi I, Ntani G et al. · 2026 · Occupational medicine (Oxford, England)

Background Hand dermatitis is a common occupational skin disease and is particularly prevalent among healthcare workers. Aims To identify which digital skin surveillance methods are effective for detecting hand dermatitis. Methods A…

View details →DOI: 10.1093/occmed/kqag028
Negative / Null Result ReportOpen accessMedicine

Drug supply shortages and their perceived consequences for patients: a questionnaire survey of German and Austrian physicians.

Rotter JM, Seifert R · 2026 · European journal of clinical pharmacology

Purpose Drug supply shortages are a recurring issue in developed countries, with consequences for patients even before the COVID-19 pandemic. Questions arise regarding the effectiveness and tolerability of alternative treatments chosen by…

View details →DOI: 10.1007/s00228-026-04052-4
Negative / Null Result ReportOpen accessMedicine

Cost-Effectiveness of Anticoagulation Treatment for Subclinical Device-Detected Atrial Fibrillation.

Winstén AK, Langén V, Airaksinen KEJ et al. · 2026 · JAMA network open

Importance Anticoagulation for stroke prevention in subclinical, device-detected atrial fibrillation (AF) remains an area of clinical equipoise, and its cost-effectiveness is unknown. Objective To evaluate the cost-effectiveness of direct…

View details →DOI: 10.1001/jamanetworkopen.2026.17213
Negative / Null Result ReportOpen accessMedicine

Pre-TIPS Liver and Spleen Volumetry Are Not Associated With Liver-Related Outcomes After TIPS Placement for Refractory Ascites.

Bedoya JU, Wagner M, Malézieux E et al. · 2026 · Liver international : official journal of the International Association for the Study of the Liver

Background & aims Transjugular intrahepatic portosystemic shunt (TIPS) improves survival in refractory ascites. A careful patient's selection is mandatory as TIPS can lead to complications. Liver volumetry is predictive of outcomes before…

View details →DOI: 10.1111/liv.70691
Negative / Null Result ReportMedicine

Early Endoscopic Retrograde Cholangiopancreatography is Associated With Improved Health Care Resource Utilization in Acute Biliary Pancreatitis Without Cholangitis.

Chu BK, Abdelbaki A, Nikahd M et al. · 2026 · Journal of clinical gastroenterology

Background The optimal timing for endoscopic retrograde cholangiopancreatography (ERCP) in managing uncomplicated acute biliary pancreatitis (ABP) remains unclear. This population-based study assessed the impact of ERCP timing on outcomes…

View details →DOI: 10.1097/mcg.0000000000002341
Negative / Null Result ReportMedicine

Genetic Association and Clinical Relevance of TNFSF13B/BAFF and PADI4 Polymorphisms in ANCA-Associated Vasculitis: A Case-Control Study with Genetic Model Analysis in Guangxi Population.

Lu J, Huang S, Wei S et al. · 2026 · Genes

Objective: TNFSF13B , which encodes B-cell-activating factor ( BAFF ) and peptidylarginine deiminase 4 ( PADI4 ), plays crucial roles in the pathogenesis of ANCA-associated vasculitis (AAV). This study investigated the associations of…

View details →DOI: 10.3390/genes17060710