A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19885 results in Negative / Null Result Report · page 532 of 663
Klaiman T, Ianotte L, Josephs M et al. · 2023 · Preprint
Abstract Background : Heart failure (HF) is one of the most common reasons for hospital admission and is a major cause of morbidity, mortality, and increasing health care costs. The EMPOWER study was a randomized trial that used remote…
Leger K, Dong J, DeBruine LM et al. · 2023 · Scientific reports
Perceptions of the trustworthiness of faces predict important social outcomes, including economic exchange and criminal sentencing decisions. However, the specific facial characteristics that drive trustworthiness perceptions remain poorly…
Yoon S, Rottenberg J · 2025 · BMC psychology
Background Does what a person desires to feel (affect valuation) predict their future affective reaction to salient life events? We tested this idea in the context of an exam, a key achievement-oriented event for college students. Methods…
Singstock M, Abdul Khader AHS, Wayant C et al. · 2026 · The oncologist
Background Oncology clinical trials, regardless of success in meeting their primary endpoint, often suffer from spin-the misrepresentation of research findings. Despite dramatic improvements in myeloma outcomes, numerous recent myeloma…
Cusimano C, Kim J, Wong J · 2025 · Proceedings of the National Academy of Sciences of the United States of America
It is common to say that people feel entitled to rewards-they think they have earned or deserve them-based on their effort and achievement. However, effort and achievement draw on different principles to justify reward. They can also…
Nakata Y, Watanabe Y, Ozaki A · 2026 · Cureus
Background The purpose of this study was to evaluate whether the workstyle reform, aimed at improving physician health and safety, achieved a secondary goal of enhancing surgical productivity by applying the Malmquist Index (MI) model. We…
Xu H, He Y · 2026 · BMC psychology
BACKGROUND: Interparental relationship quality and attachment are theorized to be associated with young adults’ marital attitudes, yet evidence in Chinese cultural contexts is mixed. We tested whether interparental conflict versus divorce…
Weilnhammer V · 2024 · Neuroscience of consciousness
The neurobiology of conscious experience is one of the fundamental mysteries in science. New evidence suggests that transcranial magnetic stimulation of the parietal cortex does not modulate bistable perception. What does this mean for the…
Ramaswamy A, Yamamori Y, Vivekananda U et al. · 2026 · Computational psychiatry (Cambridge, Mass.)
Anhedonia, a transdiagnostic symptom marked by diminished reward sensitivity, is often linked to impairments in reinforcement learning (RL). Standard tasks (e.g., the 4-arm bandit) can place substantial demands on participants and may blur…
Burkard T, Holmberg D, Thorell A et al. · 2022 · Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
Background Obesity is considered a risk factor for cataracts. The association between weight loss and a cataract among patients with obesity has not been assessed to date. Objectives To assess the association between weight loss following…
Cassar A, Hobbs A, Anttila-Hughes J et al. · 2026 · PNAS nexus
A consistent finding regarding human societies is that higher temperatures lead to antisocial behavior, including more crime, violence, aggression, and civil conflict. A large body of research documents this relationship at the societal…
Li ZL, Zou YW, Jia PW et al. · 2026 · Food science & nutrition
Growing research implicates the diet-microbiota-joint axis plays a key role in joint health. The Dietary Index for Gut Microbiota (DI-GM) is a novel metric evaluating dietary effects on microbial communities, yet its potential link to…
Wu J, Hang R, Xin P et al. · 2026 · Brain sciences
Background: Proficient second language (L2) reading relies on complex neurocognitive processes. Neuroimaging studies have identified key brain regions recruited during L2 reading, including the left inferior parietal lobule (LIPL) and the…
Kırkgeçit M, Türkoğlu H, Yüzbaşı MF et al. · 2026 · Medicina (Kaunas, Lithuania)
Background and Objectives : We aimed to determine whether preoperative systemic inflammatory markers derived from complete blood count differ between patients with intradural spinal tumors and healthy controls, and whether any such…
Ezquina SAM, Jones M, Dicks E et al. · 2025 · American journal of epidemiology
Common genetic variation throughout the genome and rare coding variants identified to date explain about half of the inherited genetic component of epithelial ovarian cancer risk. It is likely that rare variation in the noncoding genome…
Tsay JS, Najafi T, Schuck L et al. · 2022 · Preprint
Our ability to enact successful goal-directed actions involves multiple learning processes. Among these processes, implicit motor adaptation ensures that the sensorimotor system remains finely tuned in response to changes in the body and…
Pawel S, Heyard R, Micheloud C et al. · 2024 · eLife
In several large-scale replication projects, statistically non-significant results in both the original and the replication study have been interpreted as a 'replication success.' Here, we discuss the logical problems with this approach:…
Farhan MA, Makkiyah FA, Hadiwiardjo YH et al. · 2025 · BMC medical education
Objective This study examines the relationship among medical students' academic achievement, self-regulated learning, and critical thinking ability. Methods This study employed a cross-sectional analytical design involving 120 medical…
Sangroungrai A, Atipiboonsin V, Sukhonthamarn K et al. · 2025 · Arthroplasty (London, England)
Background Intraoperative periprosthetic femur fracture is a serious complication in hip arthroplasty, affecting patient outcomes. This study explored the biomechanical properties of the proximal femur, specifically comparing prophylactic…
Yang W, Li Z, Chen X et al. · 2026 · Clinics (Sao Paulo, Brazil)
Background Diet plays a key role in regulating the gut microbiota. This study aimed to investigate the association between the Dietary Index of the Gut Microbiome (DI-GM) ‒ a score designed to reflect the potential of a diet to support a…
Hamilton F, Mitchell R, Constantinescu A et al. · 2022 · Preprint
Introduction Severe malaria remains a deadly disease for many young children in low- and middle-income countries. Levels of Interleukin-6 (IL-6) have been shown to identify cases of severe malaria and associate with severity, but it is…
Rajaraman R, Kassaye I, Sharma SS et al. · 2026 · Antimicrobial agents and chemotherapy
The aim of this study was to determine the antiamoebic efficacy of povidone-iodine when used as an adjunct to topical biguanide therapy for Acanthamoeba keratitis. Patients with smear- or culture-positive Acanthamoeba keratitis received…
Makin AD, Rahman A, Bertamini M · 2020 · Preprint
Previous work has shown that symmetrical or regular stimuli are judged as lasting longer than asymmetrical or irregular ones, even when actual duration is matched. This effect has been replicated with different methods and stimuli types,…
Pinto R, Ferreira R, Alves P et al. · 2025 · Healthcare (Basel, Switzerland)
Background : Healthcare-associated infection drives morbidity and unplanned hospital use in haemodialysis. We aimed to determine whether an adapted British Renal Society Infection Risk Screening Tool, applied during a nurse-led vascular…
Andrade G, Gamboa L, Campo-Redondo M · 2026 · Frontiers in psychology
Background Beliefs about free will are central to philosophical and scientific conceptions of agency, and experimental work suggests that weakening such beliefs can reduce honesty, self-control, and helping. Yet little is known about how…
Chen C, Zhang W, Chu C et al. · 2026 · Gland surgery
Background Thyroid malignancies pose a significant global health burden, especially in women. Sex hormones are crucial for thyroid function, but their relationship with thyroid malignancy remains unclear. This study investigates the causal…
Hamilton F, Mitchell RE, Constantinescu A et al. · 2023 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Objectives Severe malaria remains a deadly disease for many young children in low- and middle-income countries. Levels of interleukin (IL)-6 have been shown to identify cases of severe malaria and associate with severity, but it is unknown…
Oda T, Houshmand Chatroudi A, Yotsumoto Y · 2026 · Journal of vision
Flicker-induced time dilation refers to the robust illusion whereby temporally modulated visual stimuli are perceived as lasting longer than static stimuli. Although flicker-induced time dilation has been consistently demonstrated, it…
Xu X, Zang X, Liu H et al. · 2026 · The Journal of international medical research
ObjectiveTo assess the causal effects of specific eating habits on ischemic stroke risk and functional outcomes using Mendelian randomization.MethodsThis two-sample Mendelian randomization study used genetic variants associated with 32…
Lin WT, Yang JL, Lin CY et al. · 2026 · JAC-antimicrobial resistance
Objectives Among patients with daptomycin-resistant and vancomycin-resistant Enterococcus faecium bloodstream infection (BSI), the optimal definitive therapy is uncertain. We estimated the dose effect of daptomycin (≥11 mg/kg versus 8 to…