Negative / Null Result Report
Yanagihara K, Nagata K, Yamakawa T et al. · 2025 · Preprint
Backgrounds: . Programmed death-ligand 1 (PD-L1) immunohistochemistry (IHC) is a critical predictive biomarker for immune checkpoint inhibitor (ICI) therapy in triple-negative breast cancer (TNBC). However, prolonged storage of…
View details →DOI: 10.20944/preprints202508.1544.v1 Negative / Null Result ReportOpen accessMedicine
Obeidat A, Sabbah BN, Mandourah H et al. · 2025 · Annals of medicine and surgery (2012)
Introduction Testicular sperm extraction (TESE) is a common procedure for retrieving sperm in men with azoospermia. However, the success rates of a second TESE following an initial unsuccessful attempt remain low. This study aims to…
View details →DOI: 10.1097/ms9.0000000000003560 Negative / Null Result ReportMedicine
Olaniyan H, Beckman J, Crosby E et al. · 2026 · Clinica chimica acta; international journal of clinical chemistry
Objectives Timely and locally relevant drug testing is helpful for overdose assessment; however, immunoassay (IA)-based urine drug screens (UDS) often fail to detect emerging substances. This study assesses fentanyl screen utilization and…
View details →DOI: 10.1016/j.cca.2026.120948 Negative / Null Result ReportMedicine
Wang J, Jiang B · 2026 · Journal of infection in developing countries
Introduction Postoperative central nervous system (CNS) infections in craniotomy patients diagnosed through clinical signs and cerebrospinal fluid (CSF) bacterial culture, pose a challenge due to the morbidity and mortality of bacterial…
View details →DOI: 10.3855/jidc.21771 Negative / Null Result ReportMedicine
Nardy T, Rondinaud E, Dessajan J et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Objectives This study assessed the clinical significance of negative BioFire® FilmArray® Pneumonia Panel (FA-PP) results in ICU patients with suspected hospital-acquired (HAP) or ventilator-associated pneumonia (VAP), evaluating its impact…
View details →DOI: 10.1016/j.ijid.2026.108665 Negative / Null Result ReportMedicine
Saito T, Namera A, Yamamoto R et al. · 2026 · The Journal of toxicological sciences
Zopiclone (ZOP) and eszopiclone (EZOP) are hypnotics belonging to the cyclopyrrolone class, which are metabolized to zopiclone-N-oxide (ZOPNO) and N-desmethylzopiclone (NDZOP), respectively, and finally to 2-amino-5-chloropyridine (2A5C)…
View details →DOI: 10.2131/jts.51.173 Negative / Null Result ReportMedicine
Pottenger LH, Banton M, Barranco WT et al. · 2026 · Journal of environmental science and health. Part C, Toxicology and carcinogenesis
Recent studies investigating mutagenic/cytogenetic effects of styrene and styrene-7,8-oxide (SO) were reviewed to update published critical evaluations of these data from 2019. Transcriptomics studies relevant to styrene/SO genotoxicity…
View details →DOI: 10.1080/26896583.2026.2623381 Negative / Null Result ReportMedicine
Monteiro T, Romeiro K, Brisson-Suárez K et al. · 2026 · European endodontic journal
Objective This study compared the accuracy of digital periapical radiography (DPR) and cone beam computed tomography (CBCT) in detecting extruded filling material, using a human cadaver model. Micro-computed tomography (Micro-CT) served as…
View details →DOI: 10.65717/eej.2026.25090 Negative / Null Result ReportMedicine
Nguyen AQ, Nguyen HTN, Ho NT et al. · 2026 · Allergy and asthma proceedings
Background: Nonsteroidal anti-inflammatory drugs (NSAID) are the second most frequent cause of drug-induced hypersensitivity after β-lactam antibiotics. Diagnosing cross-intolerance reactions to NSAIDs remains challenging because…
View details →DOI: 10.2500/aap.2026.47.260013 Negative / Null Result Report
Bedia-Tanoh VA, Konaté-Touré A, Kouakou OMK et al. · 2025 · Preprint
Abstract Background Accurate malaria diagnosis and reporting are critical for effective case management and surveillance. In sub-Saharan Africa, rapid diagnostic tests (RDTs) are widely used to support clinical decision-making. However,…
View details →DOI: 10.21203/rs.3.rs-7334541/v1 Negative / Null Result ReportMedicine
Yang YJ, Lee MR, Chung CL et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Objectives Despite the availability of rapid tuberculosis (TB) nucleic acid amplification (NAA) testing, prevention of TB transmission within healthcare facilities remains a challenge due to ongoing difficulties in promptly isolating…
View details →DOI: 10.1016/j.ijid.2026.108538 Negative / Null Result ReportMedicine
Wu M, Bukowski BR, Hickman JA et al. · 2026 · The Journal of arthroplasty
Background Accurate diagnosis of periprosthetic joint infection (PJI) remains suboptimal. Of the tests used, one is the alpha defensin lateral flow assay (ADLFA). This study assessed ADLFA for the diagnosis of PJI in total hip…
View details →DOI: 10.1016/j.arth.2026.02.026 Negative / Null Result ReportMedicine
Ismail A, Abunasser S, Salameh IM et al. · 2026 · Microorganisms
Fourth-generation immunoassays are widely used for HIV and syphilis screening; however, false-reactive results may increase confirmatory testing and operational burden in high-throughput laboratories. This study evaluated the comparative…
View details →DOI: 10.3390/microorganisms14061302 Negative / Null Result ReportMedicine
Greenfield PT, Phillips BB, Throckmorton TW et al. · 2026 · Journal of surgical orthopaedic advances
Despite studies highlighting magnetic resonance imaging (MRI)/magnetic resonance angiogram (MRA) accuracy in diagnosing shoulder pathologies, there remains a paucity of data regarding false negative results of these tests. The authors…
Negative / Null Result ReportMedicine
Burleigh-Flayer H, Canatsey R, Jean PA et al. · 2026 · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Cyclo-di-Badge (CdB) is a by-product of epoxy resin coatings applied to the inside of food cans. By-products are non-intentionally added substances (NIAS) with potential to migrate into food. Due to the lack of data on CdB, studies were…
View details →DOI: 10.1016/j.fct.2026.115952 Negative / Null Result Report
Mousavi SS, Karimi S, Hassannia MS et al. · 2025 · Preprint
Objective Electrocardiography and blood pressure (BP) measurement are two widely used tools for diagnosis and monitoring cardiovascular diseases. While the electrocardiogram (ECG) and BP have been considered complementary modalities, there…
View details →DOI: 10.1101/2025.07.25.25332198 Negative / Null Result ReportOpen accessMedicine
Al Ayoubi O, Aldakak MA, Ibrahim B et al. · 2026 · Clinical case reports
Pleural tuberculosis is a common manifestation of extrapulmonary tuberculosis; however, its diagnosis remains challenging in paucibacillary disease, where clinical presentation may be atypical and microbiological tests frequently yield…
View details →DOI: 10.1002/ccr3.72205 Negative / Null Result ReportMedicine
Nielsen SM, Russell EM, Ellsworth RE et al. · 2025 · Journal of the National Comprehensive Cancer Network : JNCCN
Background The presence of variants of uncertain significance (VUS) should not influence clinical management; however, prior studies on breast cancer-related health care utilization in women with VUS versus negative germline genetic test…
View details →DOI: 10.6004/jnccn.2025.7011 Negative / Null Result ReportMedicine
Salman E · 2026 · Indian journal of medical microbiology
Background The primary reason for increased lab use is inappropriate or needless test requests. Our study examined the benefits of repeated antinuclear antibody (ANA) testing and the reasons for ANA test requests in accordance with…
View details →DOI: 10.1016/j.ijmmb.2025.101035 Negative / Null Result ReportMedicine
Watanabe K, Takahashi H, Narumi R et al. · 2025 · The journal of obstetrics and gynaecology research
Non-invasive prenatal testing (NIPT) is a screening method that analyzes cell-free DNA (cfDNA) in maternal plasma to detect major aneuploidies. However, NIPT can fail to identify subtle chromosomal aberrations. We report a case in which…
View details →DOI: 10.1111/jog.70168 Negative / Null Result ReportOpen accessMedicine
Sridapan T, Jaturapaktrarak C, Rujirawat T et al. · 2026 · Journal of fungi (Basel, Switzerland)
Pythiosis is an emerging infectious disease caused by the oomycete Pythium insidiosum , affecting humans and animals primarily in subtropical and tropical regions. The pathogen is commonly found in swampy environments, and exposure can…
View details →DOI: 10.3390/jof12050351 Negative / Null Result ReportOpen accessMedicine
Meng S, Zhao W, Zhang H et al. · 2026 · EJHaem
Objective To retrospectively analyze the early efficacy and safety of azacitidine plus lisaftoclax in patients with acute myeloid leukemia (AML) and myelodysplastic syndrome with increased blasts (MDS-IB), providing a reliable clinical…
View details →DOI: 10.1002/jha2.70305 Negative / Null Result ReportMedicine
Castle PE, Befano B, Hyer M et al. · 2026 · Journal of the National Cancer Institute
Background We demonstrated that cervical cancer risk following any screening result is lower if there is a known prior negative screening history vs an unknown screening history. We extended these findings to look at how screening performs…
View details →DOI: 10.1093/jnci/djaf317 Negative / Null Result ReportMedicine
Çubuk F, Öksüz C, Öz M · 2026 · Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
Objective A substantial proportion of urine cultures in patients with suspected urinary tract infections (UTIs) yield negative results. This study aimed to evaluate whether parameters from automated urinalysis could predict the likelihood…
View details →DOI: 10.1016/j.jiac.2026.102904 Negative / Null Result ReportOpen accessMedicine
Sato R, Takasaka N, Hosaka Y et al. · 2025 · BMC infectious diseases
Background The T-SPOT.TB assay is widely used for the adjunctive diagnosis of tuberculosis (TB). However, clinicians often encounter false-negative T-SPOT.TB results. The extent of TB spread may influence host immune functions, which can…
View details →DOI: 10.1186/s12879-025-10777-x Negative / Null Result ReportOpen accessMedicine
Sripa J, Suebsamran P, Pangjit K · 2026 · BMC infectious diseases
Background Opisthorchiasis remains an important public health problem in Southeast Asia and is strongly associated with cholangiocarcinoma. Although stool-based diagnosis is widely used, its sensitivity is limited in light infections,…
View details →DOI: 10.1186/s12879-026-13445-w Negative / Null Result ReportOpen accessMedicine
Unubol N, Ayaş M, Uyar NY et al. · 2025 · Microorganisms
In recent years, the World Health Organization has highlighted biofilm-derived multidrug-resistant bacteria as a critical threat to both global health and the environment. Although various testing methods are available, crystal violet and…
View details →DOI: 10.3390/microorganisms14010021 Negative / Null Result Report
AL-Saeedi A, Abdulamir AS, Aufi IM et al. · 2025 · Preprint
Abstract Background The widespread use of accurate real-time RT-PCR tests for community individuals is a critical approach to managing the disease and reducing COVID-19 transmission effectively. In addition, serological ELISA assays are…
View details →DOI: 10.21203/rs.3.rs-8233598/v1 Negative / Null Result ReportOpen accessMedicine
Mukherjee S, Fujiwara Y, Fountzilas C et al. · 2025 · Cancer medicine
Background Preoperative chemoradiation (CRT) followed by surgery for localized esophageal and gastroesophageal junction adenocarcinoma (EGAC) is a standard of care with a pathologic complete response (pCR) rate of 20%. We evaluated a novel…
View details →DOI: 10.1002/cam4.70835 Negative / Null Result ReportMedicine
Fu Q, Chen Y, Huang D et al. · 2023 · Annals of surgical oncology
Background Folinic acid, fluorouracil, irinotecan, and oxaliplatin (FOLFIRINOX) or modified FOLFIRINOX (mFFX) is the first-line standard of care for metastatic pancreatic adenocarcinoma; effective and safe treatment strategies are needed…
View details →DOI: 10.1245/s10434-023-13383-w 