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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19885 results in Negative / Null Result Report · page 531 of 663

Negative / Null Result ReportMedicine

Comparative Evaluation of Unilateral Recession-Plication Versus Bilateral Three-Muscle Surgery for Large-Angle Exotropia.

Anand K, Nagpal V, Dutta P et al. · 2026 · Journal of pediatric ophthalmology and strabismus

Purpose To evaluate and compare unilateral recession-plication versus bilateral three-muscle surgery for large-angle exotropia. Methods A prospective interventional non-randomized comparative study was conducted involving 66 patients with…

View details →DOI: 10.3928/01913913-20260521-01
Negative / Null Result ReportOpen accessMedicine

Precision in Medial pivot total knee arthroplasty: A retrospective study on mechanical axis alignment and functional outcomes with CT-guided patient-specific instrumentation.

Mat Salleh F, Nizam I · 2026 · SICOT-J

Background Total Knee Arthroplasty (TKA) is the standard treatment for end-stage osteoarthritis, with optimal outcomes dependent on precise mechanical alignment and accurate implant positioning. Patient-specific instrumentation (PSI),…

View details →DOI: 10.1051/sicotj/2026034
Negative / Null Result ReportOpen accessMedicine

Types of physical activity and applied outcome measures in physical activity interventions among patients with inflammatory bowel disease: a scoping review.

Fromberg EB, Brink MT, Villumsen M et al. · 2026 · BMC gastroenterology

BACKGROUND: While pharmacological treatments remain essential in inflammatory bowel disease (IBD), complementary approaches such as physical activity are increasingly being explored for their potential benefits. This scoping review aimed…

View details →DOI: 10.1186/s12876-026-04792-8
Negative / Null Result ReportMedicine

Supporting incarcerated autistic individuals: evaluation of an autism awareness training for prison staff.

Maljaars J, De Roo L, Van der Paelt S et al. · 2026 · International journal of prison health

Purpose Prison environments are particularly challenging for autistic people experiencing incarceration due to a lack of knowledge and awareness of autism among prison staff. The study aimed to evaluate the level of satisfaction and…

View details →DOI: 10.1108/ijoph-09-2025-0081
Negative / Null Result ReportMedicine

Bridging the Gap from "Paper" to "Patient": An Overview and Quality Assessment of PET/CT-Based Radiomics for Prostate Cancer Using the Updated RQS 2.0.

Bian S, Yang Y, Wang Z et al. · 2026 · Academic radiology

Rationale and objectives To apply the updated Radiomics Quality Score (RQS 2.0) and the Radiomics Readiness Level (RRL) framework to systematically evaluate the methodological quality and clinical translation maturity of Positron-emission…

View details →DOI: 10.1016/j.acra.2026.05.016
Negative / Null Result ReportMedicine

Explorative investigation on effects of multi-day neurofeedback with implanted electrodes in patients with Parkinson's disease.

Rohr-Fukuma M, Stieglitz LH, Bujan B et al. · 2026 · Neuroscience

Neurofeedback, which consists of recording and visualizing neural activity in real-time, is a method currently being investigated as a supplementary treatment for Parkinson's disease (PD). By using implanted deep brain stimulation (DBS)…

View details →DOI: 10.1016/j.neuroscience.2026.06.016
Negative / Null Result ReportMedicine

Comparison of the Efficacy of Intra-Articular Polyacrylamide Hydrogel and the Cross-Linked Hyaluronic Acid/Chondroitin Sulfate Combination in Treating Advanced-Stage Knee Osteoarthritis.

Altıntaş M, Ateş O, Soy F et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Polyacrylamide hydrogel (PAAG) is still underresearched, and few human studies have validated its efficacy in knee osteoarthritis (OA), particularly in advanced stages. The aim of this study was to compare the…

View details →DOI: 10.3390/medicina62061091
Negative / Null Result ReportMedicine

Improving Operative Note Documentation in Vascular Surgery: A Two-Cycle Closed-Loop Audit Following Introduction of Standardised Procedure-Specific Templates.

Mersal M, Amin A, Embaby OM et al. · 2026 · Annals of vascular surgery

Objective To evaluate completeness of operative note documentation in a vascular surgery service and to assess whether introduction of standardised procedure-specific templates was associated with improved documentation in a repeat audit…

View details →DOI: 10.1016/j.avsg.2026.06.008
Negative / Null Result ReportMedicine

Evaluation of text- and image-based generative artificial intelligence for simulating impacted third molar extraction.

Hamada M, Nishiyama K, Ichiyama S et al. · 2026 · Journal of stomatology, oral and maxillofacial surgery

Background Recent advances in generative artificial intelligence (AI) have opened new opportunities in procedural simulation. However, its clinical accuracy for simulating impacted mandibular third molar extraction remains unclear.…

View details →DOI: 10.1016/j.jormas.2026.102863
Negative / Null Result ReportMedicine

The effects of hyperbaric oxygen dosing on the delayed neuropsychiatric sequalae of carbon monoxide poisoning.

Gur I, Safrai A, Nov Y · 2026 · Clinical toxicology (Philadelphia, Pa.)

Introduction A paucity of evidence exists as to the comparative effectiveness of various hyperbaric oxygen regimens in preventing delayed neuropsychiatric sequelae. We aimed to compare the effect of four such treatment regimens: (1) P O 2…

View details →DOI: 10.1080/15563650.2026.2666318
Negative / Null Result ReportMedicine

A critical analysis of the Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2) and the European Carotid Surgery Trial (ECST)-2.

Paraskevas KI, Zeebregts CJ, Blecha M et al. · 2026 · Seminars in vascular surgery

The Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2) concluded that addition of transfemoral carotid artery stenting to intensive medical therapy (IMT) among patients with high-grade…

View details →DOI: 10.1053/j.semvascsurg.2026.03.008
Negative / Null Result ReportMedicine

Percutaneous thoracolumbar burst-fracture fixation - does additional anterior support offer significant benefit?

Urbaneja A, Martin Laez R, López Gomez P · 2026 · British journal of neurosurgery

Purpose Percutaneous pedicle screw fixation has become a widely adopted technique for treating thoracolumbar burst fractures without neurological deficit, though optimal strategies - particularly regarding anterior support - remain…

View details →DOI: 10.1080/02688697.2026.2643667
Negative / Null Result ReportMedicine

Chitosan-fibrinogen-thrombin matrix accelerates re-epithelialization and cornification in a rat wound healing model.

Lerhcha H, Chevrier A, Lavertu M · 2026 · NPJ Regenerative medicine

This study evaluated a chitosan-fibrinogen-thrombin (CFT) matrix enriched with autologous skin cells and a fatty acid sodium salt (FASS) to enhance wound closure and regeneration. A rat excisional wound model compared six treatments: CFT…

View details →DOI: 10.1038/s41536-026-00486-7
Negative / Null Result ReportMedicine

Exploring the Gut Microbiome's Association in Psoriasis and Psoriatic Arthritis: A Scoping Review.

Kent J, Chao J, Liao W et al. · 2026 · Journal of psoriasis and psoriatic arthritis

Introduction Psoriasis (PsO) and psoriatic arthritis (PsA) are chronic inflammatory conditions treated with primarily immune-modulating medication. However, interest is growing in gut microbiome therapies. Studies have reported altered gut…

View details →DOI: 10.1177/24755303261464171
Negative / Null Result ReportOpen accessMedicine

Clinical impact of the angiosome concept: is it applicable in femoropopliteal bypasses, limb salvage, and wound healing in critical pathologic limb-threatening ischemia?

Mazurova T, Sengul I, Sengul D et al. · 2026 · Revista da Associacao Medica Brasileira (1992)

Introduction The global burden of peripheral artery disease is increasing worldwide. A subset of 5% of these patients ultimately reach the final stage with trophic defects, a condition clinically defined as critical limb-threatening…

View details →DOI: 10.1590/1806-9282.20252069
Negative / Null Result ReportMedicine

Round Window Drill-Out in Advanced Otosclerosis.

Aragon KE, Vrabec JT · 2026 · Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

Objective To discuss the effect of round window drill-out for otosclerosis cases with radiographic evidence of round window obliteration. Patients Four adult patients (5 ears) were included with audiometric findings of a mixed hearing loss…

View details →DOI: 10.1097/mao.0000000000004989
Negative / Null Result Report

Age-dependent Effects of Titrating Anodal Transcranial Direct Current Stimulation (tDCS) Intensity on Motor Sequence Learning

Frese AM, Ungureanu R, Ghasemian-Shirvan E et al. · 2026 · Preprint

Optimising the currently heterogenous efficacy of transcranial direct current stimulation (tDCS) interventions for motor learning requires identifying stimulation parameters facilitating performance while accounting for age-related…

View details →DOI: 10.64898/2026.06.09.731079
Negative / Null Result ReportMedicine

Right vagus nerve stimulation promotes motor cortical plasticity.

Welch HF, Rajendran M, Thorn CA · 2026 · Scientific reports

Stimulation of the left cervical vagus nerve (l-VNS) paired with motor training is FDA-approved to improve upper limb function after stroke. However, recent preclinical studies have revealed a striking asymmetry in engagement of the…

View details →DOI: 10.1038/s41598-026-52474-y
Negative / Null Result ReportMedicine

Ordering Practices and Utilization of a Next-Generation Sequencing Panel for Myeloproliferative Neoplasms.

Cooke T, Soderquist CR, Mansukhani MM et al. · 2026 · The journal of applied laboratory medicine

Background JAK2, CALR, and MPL mutations are defining features of myeloproliferative neoplasms (MPNs). Molecular testing for variants in these genes is standard of care in the diagnosis of MPNs. A high reimbursement denial rate led to…

View details →DOI: 10.1093/jalm/jfaf197
Negative / Null Result ReportMedicine

Use of rebamipide solution as a submucosal injection material to prevent esophageal stricture after endoscopic submucosal dissection: Animal study.

Hirai Y, Fujimoto A, Sasaki M et al. · 2026 · Endoscopy international open

Background and study aims It is desirable to develop a safe, cost-effective, and easy approach to prevent strictures after esophageal endoscopic submucosal dissection (ESD). We explored use of a novel rebamipide solution, an anti-ulcer…

View details →DOI: 10.1055/a-2820-3721
Negative / Null Result ReportMedicine

Addition of High-Dose Cytarabine to Fludarabine, Busulfan, and Melphalan Conditioning for Cord Blood Transplantation in Adult Acute Myeloid Leukemia.

Yamaguchi K, Watanabe O, Mitsuki T et al. · 2026 · Transplantation and cellular therapy

The clinical benefit of adding high-dose cytarabine (HDCA) to fludarabine (FLU), busulfan (BU), and melphalan (MEL)-based conditioning for cord blood transplantation (CBT) in acute myeloid leukemia (AML) remains unclear. We aimed to…

View details →DOI: 10.1016/j.jtct.2026.05.038
Negative / Null Result ReportMedicine

Sarcopenia modifies the survival benefit of triple therapy versus TACE alone in elderly patients with unresectable hepatocellular carcinoma: A multicenter retrospective cohort study.

Ye L, Yue W, Lin K et al. · 2026 · Scientific reports

Triple therapy combining transarterial chemoembolisation (TACE), tyrosine kinase inhibitors (TKIs), and immune checkpoint inhibitors (ICIs) has shown efficacy in unresectable hepatocellular carcinoma (HCC), but evidence in elderly patients…

View details →DOI: 10.1038/s41598-026-57283-x
Negative / Null Result ReportMedicine

Clinical Characteristics and Long-Term Outcomes of Atypical Choroid Plexus Papillomas: A Single-Center Experience of 40 Cases.

Zuo P, Jiang K, Zou W et al. · 2026 · Neurosurgery

Background and objectives Atypical choroid plexus papillomas (ACPPs) are exceedingly uncommon. The treatment strategies for managing this condition remain a topic of debate. The main aim of this study was to elucidate the clinical features…

View details →DOI: 10.1227/neu.0000000000004026
Negative / Null Result ReportMedicine

Effectiveness and safety of REVIVENT-TC system for the left ventricular reconstruction in ischaemic heart failure. A literature review.

Kakoudaki T, Poon SS, Kumar P · 2026 · Cardiovascular revascularization medicine : including molecular interventions

Background Surgical ventricular reconstruction (SVR) is not always feasible in patients with ischaemic cardiomyopathy and left ventricular (LV) aneurysm, due to high surgical risk. The Revivent-TC Transcatheter Ventricular Enhancement…

View details →DOI: 10.1016/j.carrev.2026.04.002
Negative / Null Result ReportMedicine

Is Adjuvant Chemotherapy Necessary for All Patients with pT3N0 Rectal Cancer after Upfront Surgery? A Multicenter Retrospective Study.

Kang KM, Lee HY, Ahn HM et al. · 2026 · Cancer research and treatment

Purpose The role of adjuvant chemotherapy (ACT) in pathologic T3N0 (pT3N0) rectal cancer, which has a favorable prognosis, remains controversial because high-risk groups for recurrence are not well defined. This study investigated…

View details →DOI: 10.4143/crt.2025.1308