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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20261 results in Negative / Null Result Report · page 530 of 676

Negative / Null Result ReportMedicine

1-(1-naphthylmethyl)-piperazine Inhibition assay successfully rules out efflux pump overexpression in Acinetobacter baumannii.

Zosim V, Mullie C, Peltier F et al. · 2025 · Molecular biology reports

Background Antimicrobial resistance (AMR) in Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. (ESKAPE pathogens), notably in carbapenem-resistant…

View details →DOI: 10.1007/s11033-025-10826-3
Negative / Null Result ReportOpen accessMedicine

Characteristics of healthcare workers and health facilities associated with inaccurate recording of malaria rapid diagnostic test results: a multi-country study.

Atobatele S, Mpimbaza A, Ngufor C et al. · 2025 · Malaria journal

Background Malaria rapid diagnostic tests (RDTs) have improved case management and surveillance across sub-Saharan Africa by reducing presumptive treatment and enhancing diagnostic specificity. However, healthcare workers' (HCWs) concerns…

View details →DOI: 10.1186/s12936-025-05674-2
Negative / Null Result ReportMedicine

Retrospective Evaluation of the Correlation Between Somatostatin Receptor PET/CT and Histopathology in Patients with Suspected Intracranial Meningiomas.

Ebner R, Braach J, Rübenthaler J et al. · 2025 · Journal of nuclear medicine : official publication, Society of Nuclear Medicine

The aim of this retrospective study was to evaluate the correlation between findings from somatostatin receptor (SSTR) PET/CT and histopathology in patients with suspected intracranial meningiomas. Methods: We conducted a retrospective…

View details →DOI: 10.2967/jnumed.125.270115
Negative / Null Result Report

Characteristics of healthcare workers associated with inaccurate recording of malaria rapid diagnostic test results: a multi-country study

Atobatele S, Mpimbaza A, Ngufor C et al. · 2025 · Preprint

Abstract Background Malaria rapid diagnostic tests (RDTs) have improved case management and surveillance across sub-Saharan Africa by reducing presumptive treatment and enhancing diagnostic specificity. However, healthcare workers’ (HCWs)…

View details →DOI: 10.21203/rs.3.rs-7194605/v1
Negative / Null Result ReportOpen accessMedicine

Evaluation of standard and modified two-tiered testing algorithms using well-characterized early Lyme disease samples.

Horn EJ, Menefee B, Schotthoefer AM et al. · 2026 · Journal of clinical microbiology

Current laboratory testing for Lyme disease (LD) relies on serology. We evaluated the performance of standard two-tiered testing (STTT) and modified two-tiered testing (MTTT) algorithms using samples obtained from well-characterized…

View details →DOI: 10.1128/jcm.01187-25
Negative / Null Result ReportMedicine

Assessing the risk of venous thromboembolism in trans masculine persons on gender-affirming hormone therapy: A literature review.

Hugueny J, de Ricolfis A, Johnson N et al. · 2025 · Thrombosis research

Objective This review aimed to synthesize recent data on venous thromboembolism (VTE) risk in the context of masculinizing hormone therapy with testosterone. Methods An electronic search was performed in MEDLINE/PubMed without date…

View details →DOI: 10.1016/j.thromres.2025.109516
Negative / Null Result ReportMedicine

Cortico-cortical paired associative stimulation increases SMA-M1 facilitation in tremor-dominant Parkinson's disease.

Tan J, Rurak BK, Helmich RC et al. · 2026 · Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

Objective Tremor is a common motor symptom of Parkinson's disease (PD) that reduces quality of life. Cortico-cortical paired associative stimulation (ccPAS) is a transcranial magnetic stimulation protocol that induces connective…

View details →DOI: 10.1016/j.clinph.2026.2111928
Negative / Null Result ReportMedicine

Interactive Alignment After Communication Partner Training in Adults With Traumatic Brain Injury.

Bode-Akinboye E, Rietdijk R, Dale R et al. · 2026 · American journal of speech-language pathology

Purpose Adults with moderate-severe traumatic brain injury (TBI) often have significant communication challenges, particularly in interpersonal conversations. Most research aiming to understand these challenges has used static measures of…

View details →DOI: 10.1044/2025_ajslp-25-00226
Negative / Null Result ReportMedicine

Acetaminophen inhibits denitrification in Paracoccus denitrificans: Bioenergetic constraint and periplasmic electron transfer impairment.

Dong ZH, Zhang Y, Lu J et al. · 2026 · Journal of hazardous materials

Acetaminophen (APAP) is frequently detected in municipal wastewater, yet its effect on heterotrophic denitrification remains insufficiently resolved. Here, Paracoccus denitrificans was exposed to 0.5 and 7.5 ppm APAP, representing lower…

View details →DOI: 10.1016/j.jhazmat.2026.142260
Negative / Null Result ReportMedicine

Topical Cetirizine in Androgenetic Alopecia: A Preliminary Study.

Dhurat RS, Sharma R, Shetty C et al. · 2025 · Skin appendage disorders

Introduction Prostaglandin D2 (PGD2) is elevated in the bald scalp of men with androgenetic alopecia (AGA) and inhibits hair growth. Cetirizine, an H1-antihistamine, reduces PGD2 production and has anti-inflammatory effects, making it a…

View details →DOI: 10.1159/000550279
Negative / Null Result ReportMedicine

Calm in the Chaos: A Mixed-Methods Pilot Study Using a Mobile Mindfulness App to Manage Stress and Burnout Among Emergency Department Nurses.

Kober M, Livingston JA, Barrick C et al. · 2026 · Journal of holistic nursing : official journal of the American Holistic Nurses' Association

Background: Emergency department (ED) nurses are routinely exposed to high-stress clinical environments, increasing their risk for burnout and emotional exhaustion. In holistic nursing, self-care is viewed as a professional and ethical…

View details →DOI: 10.1177/08980101261424557
Negative / Null Result ReportMedicine

The effect of discharge education provided with two different teaching techniques on nursing students' knowledge, self-efficacy and satisfaction: A randomized controlled trial.

Kayin Y, Oztas B · 2026 · Nurse education in practice

Aim This study examined the effects of PechaKucha and Teach-Back teaching techniques on nursing students' knowledge, self-efficacy and satisfaction regarding discharge education. Background Effective discharge education requires strategies…

View details →DOI: 10.1016/j.nepr.2026.104807
Negative / Null Result Report

Current Evidence on the Effects of Non-Nutritive Sweeteners on the Gut Microbiota-Incretin Axis and Metabolic Outcomes in Adult Human Populations: A Scoping Review

Sharma V, Verma Y · 2026 · Preprint

Abstract Non‑nutritive sweeteners (NNS) are widely consumed under the assumption of metabolic inertness, but emerging evidence suggests they may affect the gut microbiome, incretin hormones, and glucose homeostasis. This scoping review…

View details →DOI: 10.21203/rs.3.rs-10106611/v1
Negative / Null Result ReportOpen accessMedicine

Deficit irrigation and grafting effects on soil attributes, vegetative growth, yield components, and quality of 'Crimson Seedless' grapevines under a semiarid region.

Salama AM, Al-Obeed RS, Helmy A et al. · 2026 · Frontiers in plant science

This study evaluated the combined effects of grafting and deficit irrigation (DI) on soil attributes, vegetative growth, yield components, fruit quality, and water productivity of 'Crimson Seedless' grapevines under semiarid conditions. It…

View details →DOI: 10.3389/fpls.2026.1785340
Negative / Null Result ReportOpen accessMedicine

Fiber-to-stone distance and fragment size with holmium laser lithotripsy.

Glienke L, Hall TL, Ghani KR et al. · 2026 · Urolithiasis

Control of fragment size during laser lithotripsy has taken on increasing importance with adoption of ureteroscopic aspiration technologies. The objective of this study was to characterize the relationship between laser-fiber-to-stone…

View details →DOI: 10.1007/s00240-026-01970-x
Negative / Null Result ReportMedicine

Effect of ulnar positive variance on outcomes after arthroscopic transosseous repair of palmer 1B TFCC foveal tears.

Won JH, Shin JW, Kwon J et al. · 2026 · Journal of orthopaedic surgery and research

Purpose To determine whether ulnar positive variance (UPV) and relative ulnar positive variance (RUPV) affect clinical outcomes following arthroscopic transosseous repair of triangular fibrocartilage complex (TFCC) foveal tears. Methods…

View details →DOI: 10.1186/s13018-026-07010-z
Negative / Null Result ReportMedicine

Influence of surface treatment and cement type on the bond strength of additively manufactured permanent resin materials.

Diken Türksayar AA, Öztemel N, Yeşil Kurt İB et al. · 2026 · Odontology

This study evaluated the shear bond strength (SBS) of two dual-cure resin cements to a stereolithography-fabricated 3D-printed permanent crown material after various surface pretreatment protocols. Disc-shaped specimens were fabricated…

View details →DOI: 10.1007/s10266-026-01464-7
Negative / Null Result ReportMedicine

Comparison of the efficacy of posterior lumbar interbody fusion and transforaminal lumbar interbody fusion in the treatment of double-level lumbar spondylolisthesis combined with spinal stenosis: a retrospective comparative study.

Ma Z, Luan H, Abulimiti K et al. · 2026 · BMC surgery

Objective To compare the clinical and radiographic outcomes of posterior lumbar interbody fusion (PLIF) and transforaminal lumbar interbody fusion (TLIF) in the treatment of double-level lumbar spondylolisthesis combined with spinal…

View details →DOI: 10.1186/s12893-026-03917-w
Negative / Null Result ReportMedicine

Correlation between swallowing and diaphragmatic functions in stroke patients with hemiplegia: a cross-sectional observational study.

Liu X, Zhao J, Wu Y et al. · 2026 · Scientific reports

Swallowing and diaphragmatic functions share neural regulatory pathways and require synchronous assessment. Patients who have had a stroke are susceptible to many complications, of which dysphagia and diaphragmatic dysfunction are…

View details →DOI: 10.1038/s41598-026-50341-4
Negative / Null Result ReportMedicine

The Effect of Preoperative Tranexamic Acid on Blood Transfusions in Geriatric Hip Fracture Surgery: A Randomized Controlled Trial.

Sullivan M, Perea LL, Bradburn E et al. · 2026 · Journal of orthopaedic trauma

Objectives To evaluate whether preoperative intravenous tranexamic acid (TXA) reduces postoperative blood transfusion rates in geriatric patients undergoing operative treatment for hip fracture. Methods Design Prospective, double-blinded,…

View details →DOI: 10.1097/bot.0000000000003172
Negative / Null Result ReportOpen accessMedicine

A comparative study of clinical efficacy, electrophysiological outcomes, and perioperative parameters between endoscopic carpal tunnel release and open carpal tunnel release for carpal tunnel syndrome.

Zhang Z, Liu Y, Yang H et al. · 2026 · Frontiers in cellular neuroscience

Purpose To compare the clinical efficacy of endoscopic (ECTR) and open (OCTR) carpal tunnel release for carpal tunnel syndrome (CTS) and provide evidence-based surgical guidance. Methods A retrospective cohort study was conducted including…

View details →DOI: 10.3389/fncel.2026.1845917
Negative / Null Result ReportOpen accessMedicine

Comparison of the Bond Strength of Silane-Treated Glass Fiber Posts at Different Solvent Evaporation Times: An In Vitro Study.

Ramos-Ramos V, Dextre-Herrera S, Ramírez-Vargas G et al. · 2026 · Journal of clinical and experimental dentistry

Background Silane is used as a coupling agent on glass fiber posts to enhance chemical interaction at the post-resin cement interface. This in vitro study evaluated the bond strength of silane-treated glass fiber posts at different solvent…

View details →DOI: 10.4317/jced.63939
Negative / Null Result ReportOpen accessMedicine

Association of central α-klotho with dopaminergic and melanocortin receptors on feed intake regulation in chicken.

Hassania Y, Hassanpour S, Zendehdel M et al. · 2026 · Poultry science

This study aimed to detemine association of central α-klotho with dopaminergic and melanocortin receptors on feed intake regulation in chicken. 264 meat-type chicken were included 6 experiments, each containing 4 groups. In experiment 1,…

View details →DOI: 10.1016/j.psj.2026.107042
Negative / Null Result ReportMedicine

Capsular management in posterolateral total hip arthroplasty: impact on proprioception, balance, functional outcomes, and complications.

Guven S, Veizi E, Nazligul AS et al. · 2026 · Journal of orthopaedic surgery and research

Background The role of capsular management in total hip arthroplasty (THA) performed via the posterolateral approach remains debated, particularly regarding its effects on proprioception, balance, and postoperative stability. While…

View details →DOI: 10.1186/s13018-026-07020-x