A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19885 results in Negative / Null Result Report · page 529 of 663
Baştuğ O, Canpolat A, Kafadar D et al. · 2026 · American journal of perinatology
Objective This study aimed to evaluate the renal effects and safety of adjunct aminophylline therapy in neonates with hypoxic-ischemic encephalopathy (HIE) undergoing therapeutic hypothermia (TH). Study design This retrospective cohort…
Kasai N, Ihara H, Iemitsu M et al. · 2026 · Experimental physiology
Prolonged sitting disrupts lower-limb endothelial and microvascular function, likely via reduced shear stress and blunted microvascular reactivity. We examined whether Tabata-style high-intensity interval training (HIIT) mitigates this…
Ganss C, Jung K · 2026 · Journal of dentistry
Objectives To investigate Hawthorne-like research participation effects on toothbrushing-related plaque outcomes. The data source was a longitudinal flossing study without toothbrushing instruction. Methods This secondary analysis used…
Nakamura S, Tajima S, Hirota T et al. · 2026 · International journal of hematology
Tacrolimus (TAC) is a pivotal immunosuppressant used to prevent graft-versus-host disease (GVHD) following hematopoietic stem cell transplantation (HSCT). However, because lymphocytes express P-glycoprotein (P-gp), which actively effluxes…
Hauken MA, Gjestad R, Sekse RJT et al. · 2026 · The journal of sexual medicine
Background Hyperbaric oxygen therapy (HBOT) is an established treatment for pelvic late radiation tissue injuries (LRTIs) in cancer survivors, yet its impact on sexual health outcomes has previously not been examined. Aim To investigate…
Keesing F, LaDeau SL, Canham CD et al. · 2026 · The Journal of animal ecology
Pulsed resources, including mast production by forest trees, often have knock-on effects on consumer populations and their prey, predators, parasites and mutualists. Response by small rodents to fluctuating acorn production in temperate…
Pechanova O, Bulkova R, Vrankova S et al. · 2025 · Physiological research
Short-term fructose exposure may perturb the nitric oxide (NO)/reactive oxygen species (ROS) balance before hemodynamic changes development. Male Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR) rats received 10 % fructose in…
Adjekum R, Small SA, Chan S et al. · 2026 · American journal of audiology
Purpose Narrowband (NB) chirps have recently been of great interest in audiology for the electrophysiological assessment of hearing in infants, but clinicians have little information about these new stimuli and how they compare to more…
Short C, Semple T, Abkir M et al. · 2026 · Thorax
Introduction The current cystic fibrosis (CF) care era, while hugely welcome, raises new challenges, particularly the need for more sensitive pulmonary outcome measures. Seeking further optimisation, we previously developed a Short…
Mol BM, de Bresser CJM, de Kleijn PV et al. · 2026 · European stroke journal
Carotid endarterectomy (CEA) is performed to lower the long-term risk of stroke in patients with carotid stenosis. Data evaluating long-term outcomes after CEA are scarce, but crucial for accurately determining long-term benefits. We aimed…
Langeskov-Christensen M, Nygaard MKE, Eskildsen SF et al. · 2026 · Neurorehabilitation and neural repair
Objectives Medical disease-modifying treatments are lacking in Parkinson's disease (PD). Physical exercise is potentially an inexpensive and easily accessible disease-modifying therapy, but this remains to be studied using recent promising…
Anderson M, Bodén R, Wass CE et al. · 2026 · Journal of affective disorders
Background Impaired plasticity has been implicated in major depressive disorder (MDD), which is reflected in impaired automatic sensory detection as measured using mismatch negativity (MMN). Intermittent theta-burst stimulation (iTBS) is…
van Houten P, van de Ven AC, van Herwaarden AE et al. · 2026 · Journal of clinical & translational endocrinology
Endogenous Cushing's syndrome (CS) is characterized by chronic hypercortisolism. After achieving remission, morbidity remains increased and quality of life remains impaired. Moreover, the incidence of inflammatory disorders increases after…
Ould Ismail AA, Pettus JR, Tafe LJ et al. · 2026 · Head & neck
Purpose To evaluate whether comprehensive sampling of cervical lymphadenectomy tissue increases lymph node yield (LNY) and improves staging adequacy beyond standard grossing practice. Methods At a single academic center, a comprehensive…
Söylemez E, Dağ M · 2026 · Applied neuropsychology. Adult
This study examined how smartphone-related cognitive load interferes with motor control during static balance and mobility tasks. Excessive smartphone use has been associated with attentional shifts and divided cognitive resources,…
Shvetsova AA, Zakirjanova GF, Ostapchuk KP et al. · 2026 · Pflugers Archiv : European journal of physiology
The beneficial effects of statins for cardiovascular system were widely described in various pathologies. However, much less is known about the effects of statins in healthy organism, especially in systemic resistance arteries. We aimed to…
Hansen ESH, Håkansson KEJ, Brustad N et al. · 2026 · Respiratory medicine
Background After puberty asthma is more common and often more severe in females, indicating a potential role of sex steroids. Observational and genetic studies suggest that higher testosterone levels are associated with improved lung…
Michienzie C, Galgiani J, Fitzwater SP · 2026 · Pediatrics
Objective Coccidioidomycosis (CM) is not as well described in children as it is in adults. The Kaiser Permanente Southern California (KPSC) system provides care within an endemic region for CM, affording the opportunity to describe the…
Gilbert SJ, Vazquez SR, Gouripeddi R et al. · 2026 · Journal of thrombosis and thrombolysis
Increasing use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) raises concern for interactions with warfarin. Although GLP-1 RAs do not affect warfarin pharmacokinetics, their appetite-reducing effects may decrease vitamin K…
Liu GN, Chen C, Xu L et al. · 2026 · Microcirculation (New York, N.Y. : 1994)
Background Impaired opisthenar microvessel area (OMA) has been associated with adverse cardiac outcomes in acute myocardial infarction (AMI) patients. Here, we compared the characteristics of OMA of ischemic stroke (AIS) patients, National…
Sönmez M, Alemdaroğlu E, Ata AM et al. · 2026 · Acta cardiologica
Background Cardiac rehabilitation (CR) has been shown to be beneficial in preventing and treating sarcopenia in those with cardiovascular disease. The aim of the study is to compare the effects of high intensity intermittent aerobic…
Jonkers J, Elderman M, Salas M · 2026 · Zoo biology
Research on positive animal welfare has prompted exploration and implementation of methods to stimulate the behavioral repertoires of zoo-housed species. We investigated the impact of a modified feeding method on the behavioral diversity,…
Gao X, Xiao Z, Huard M et al. · 2026 · Preprint
Segmental bone defects and age-related osteoarthritis (OA) are clinically challenging in terms of treatment. Although preclinical studies have demonstrated efficacy for bone defect healing and OA using ex vivo gene therapy or biomaterial…
Sancler-Silva YFR, Albino MV, Freitas MS et al. · 2026 · Journal of equine veterinary science
Background The use of cryopreserved semen in donkey jennies induces an exacerbated post-insemination uterine inflammatory response, resulting in low fertility rates. Aims/objectives This study aimed to investigate the effects of different…
Pradhan A, Hughes RPJ, Woodman-Pieterse EC et al. · 2026 · Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)
Purpose To determine how accommodation affects lens shape in myopic and non-myopic children. Methods Participants included 76 non-myopic (spherical equivalent refraction (SER): 0.00 to +1.75 D) and 18 myopic children (SER = -3.50 to -0.75…
Cayden L, Chandrasagran RA, Adam C et al. · 2026 · Preprint
Abstract Introduction: The majority of spinal injuries occur secondary to blunt trauma and patients with significant blunt trauma must be assumed to have an unstable spinal injury until complete radiological and clinical assessment. MRI…
Hoekstra SP, Leicht CA, Kellogg D Jr et al. · 2026 · Experimental physiology
Passive heat therapy can improve cardiometabolic health outcomes in some clinical populations, making it a potential therapeutic tool for individuals with spinal cord injury (SCI), who exhibit elevated cardiometabolic disease risk and face…
Wenk MJ, Rademacher N, Liedl B et al. · 2026 · Urologia internationalis
Introduction The aim of the study was to prospectively evaluate patient and clinician reported outcomes of voiding function, pain levels and patient satisfaction of transgender women preoperatively (t0), 6 months (t1), and 12 months (t2)…
Tyrell E, Lau KGY, Bednorz M et al. · 2026 · Acta obstetricia et gynecologica Scandinavica
Introduction To assess longitudinal changes in serum sFlt-1 and PLGF in women with newly diagnosed hypertension in pregnancy before and after commencing antihypertensive therapy, aiming at tight BP control ( Material and methods This was a…
Yokoyama K, Shimokihara S, Miyajima R et al. · 2026 · Community mental health journal
This study examined whether overall and domain-specific self-disclosure to peers at baseline was prospectively associated with changes in personal recovery over one-year among community-dwelling adults with mental disorders in Japan. A…