A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20261 results in Negative / Null Result Report · page 529 of 676
Celik B, Kaya M, Emre S · 2026 · Parasite immunology
Chronic spontaneous urticaria (CSU) is a mast cell driven multifactorial disorder with complex pathogenesis. While the association between CSU and internal parasites has been investigated, the association of ectoparasites such as Demodex…
Vaisman TM, Koller J · 2025 · Preprint
Abstract Background: Family accommodation (FA) consists of changes in behavior or routines made by family members of people with psychological or developmental disorders, to reduce child distress associated with the disorder. Preliminary…
Bajaj JS, Kamath PS, Wong F et al. · 2026 · Clinical and molecular hepatology
Background/aims Infections with drug-resistant organisms (DROs) are associated with poor outcomes in cirrhosis. Rifaximin, widely used for hepatic encephalopathy (HE) could promote cross-resistance, but data regarding clinical impact are…
Prada-Rey N, Samal L, Rodriguez JA · 2026 · Journal of general internal medicine
Rationale & objective To describe kidney health evaluation rates in patients with type 2 diabetes mellitus overall and compare outcomes by language preference. Study design Retrospective cohort analysis. Setting & participants Adult…
Schott P, Enser K, Weiß M · 2026 · Preprint
Interpersonal emotion regulation depends not only on specific strategies, but also on the choice of regulation partner. While previous research suggests that individuals select regulation partners based on their perceived competence in…
Mahar JH, Wayda B, Weng Y et al. · 2026 · American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Donor heart left ventricular hypertrophy (LVH) is a common reason for organ discard in the United States, despite limited contemporary data on its impact on transplant outcomes. Using Scientific Registry of Transplant Recipients data…
Liu C · 2026 · Reproductive biology and endocrinology : RB&E
Arkfeld et al. reported that AMH predicts miscarriage in non-PCOS but not in PCOS ART cycles. We raise concerns regarding the biological plausibility and data interpretation of their findings. Extremely low AMH (<1 ng/mL) is…
Wu P, Li L, An G et al. · 2026 · Ocular immunology and inflammation
Background Multiple studies have associated PTGER4 polymorphisms with susceptibility to several autoimmune diseases, particularly ankylosing spondylitis (AS)-a condition strongly linked to the onset of acute anterior uveitis (AAU). Given…
Lucas A, Novebri NA, Heros PAI et al. · 2026 · Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
Background Biliary atresia (BA) is a serious condition and the leading cause for liver transplantation in children. The exact cause for BA is currently unknown, with one suggested mechanism being a viral infection. Cytomegalovirus (CMV) is…
Athanasiadou A, Kroos S, van de Wetering R et al. · 2026 · Arthritis & rheumatology (Hoboken, N.J.)
Objective Rheumatoid arthritis (RA) is characterized by anti-modified protein antibodies (AMPAs), including anti-citrullinated (ACPA), anti-carbamylated (anti-CarP), and anti-acetylated (AAPA) protein antibodies. In contrast to other…
Öztürk Ü, Üremiş MM, Kurutaş EB · 2026 · Journal of clinical medicine
Background: Hypertension (HTN) is a multifactorial condition involving alterations in vascular signaling, inflammation, and oxidative stress. Women during the menopausal transition may experience increased cardiovascular risk due to…
de Oliveira RG, Fujii T, Younus I et al. · 2026 · Spine deformity
Purpose To evaluate the early postoperative relationship between changes in distal and proximal lumbar lordosis and the L1-pelvic angle in adult spinal deformity surgery. Methods A retrospective review was performed of 120 adult spinal…
Avelar-Pereira B, Spotorno N, Orduña Dolado A et al. · 2026 · Preprint
Alzheimer’s disease (AD) neuropathological changes can be detected with blood-based biomarkers during the long preclinical phase that precedes clinical diagnosis. Tau phosphorylated at threonine 217 (p-tau217) has been found to closely…
Binnie T, Smith A, Ng L et al. · 2026 · Gait & posture
Background Reduced knee confidence is common in people with knee osteoarthritis and may influence how they engage with physical activity. A lack of confidence may lead an individual to adopt compensatory movement strategies, such as…
Hakimi S, Kirkwood R, Phillips SM et al. · 2026 · The international journal of behavioral nutrition and physical activity
Background Mobility is a cornerstone of healthy ageing typically assessed using self-report and performance-based measures. Recent research suggests these measures are poor proxies for real-world mobility. Device-derived measures of…
Cagli F, Yetkin MO, Gulseren V et al. · 2026 · Preprint
Abstract Background Polycystic ovary syndrome (PCOS) is associated with chronic anovulation and prolonged unopposed estrogen exposure, which may contribute to endometrial dysfunction. Trefoil factor 3 (TFF3) is an estrogen-responsive…
Gómez-Barrado JJ, Porras-Ramos Y, Romero-Castro MJ et al. · 2026 · Journal of clinical lipidology
Background Despite optimal lipoprotein cholesterol control, patients with chronic coronary syndrome (CCS) exhibit substantial residual cardiovascular risk. Lipoprotein(a) (Lp[a]) is an independent cardiovascular risk factor, primarily…
Lisa T, Maria CA, Luca BB et al. · 2026 · European journal of ophthalmology
PurposeThis study assessed retinal non-perfusion areas (RNPAs) and vascular density (VD) in the superficial (SCP) and deep (DCP) capillary plexuses of diabetic patients across three stages of diabetic retinopathy (DR): no DR (stage 0),…
Celik B, Kaya M, Emre S · 2025 · Preprint
Introduction: Chronic spontaneous urticaria (CSU) is a mast cell driven multifactorial disorder with complex pathogenesis. While association between CSU and internal parasites investigated, the association of ectoparasites such as Demodex…
Dogan E, Sevinc N, Ozdemir M et al. · 2026 · Nutricion hospitalaria
Background it is known that aflatoxin M1 can be transmitted to newborns through breast milk and may cause serious health problems. We aimed to determine whether the presence of aflatoxin M1 in breast milk has a role in the etiology of…
Mustamir AA, Lacante SA, Mizuno T et al. · 2026 · Preprint
Abstract Background Endolimax nana is a common intestinal archamoebid within Evosea (Amoebozoa), alongside genera such as Entamoeba , Iodamoeba , and Mastigamoeba . Despite its frequent colonization of humans, it has received limited…
Akkurt B, Bülez A · 2025 · Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine
Objective: This study aimed to investigate the association between infant gender and both postpartum depression and breastfeeding duration at multiple time points during the postpartum period. Methods: A prospective longitudinal study was…
Nemes A, Ambrus N, Lengyel C · 2026 · Journal of clinical medicine
Introduction. Left ventricular (LV) function can be characterized by numerous parameters, the most well-known being the ejection fraction (EF), derived from LV end-systolic and end-diastolic volumes (ESV and EDV, respectively) throughout…
Tine A, Diallo MA, Gaye A et al. · 2026 · Preprint
Abstract Background: Artemisinin-based combination therapies (ACTs) remain the cornerstone of malaria treatment in Africa. However, the emergence of Plasmodium falciparum artemisinin partial resistance associated with mutations in the…
Santiago MV, Olmedillas H, Sáinz J et al. · 2026 · Stress and health : journal of the International Society for the Investigation of Stress
Chronic stress, common in university students and particularly pronounced in women, negatively impacts health. Heart Rate Variability (HRV), an autonomic balance measure, is influenced by stress, physical activity (PA), and the menstrual…
Gil P, Rojo C, Martín ML et al. · 2026 · Journal of pediatric gastroenterology and nutrition
Objectives Owing to the regulatory effect of the immune response associated with Helicobacter pylori (H. pylori) a protective role for this infection in the development of atopic conditions in children has been postulated. We aim to study…
Sharma AK, Huda RK, Alam SP et al. · 2026 · Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine
Background Non-communicable diseases (NCDs) are the fastest-growing global health burden, and air pollution is a major threat to human health. Growing evidence suggests that air pollution especially PM 2.5 is associated with diabetes…
Wolfram C, Vogl TJ, Eichler K et al. · 2026 · Preprint
Abstract Purpose To evaluate therapeutic effectiveness and safety of lipiodol-based conservative transpedal lymphangiography in sealing persistent inguinal lymphatic fistulas after lymphadenectomy, and to determine whether therapeutic…
Khabbazi A, Askari L, Faramarzi E et al. · 2026 · Clinical rheumatology
Aim Palindromic rheumatism (PR) is a periodic rheumatic disease characterized by recurrent attacks of pain and swelling, affecting articular and periarticular structures. Despite the evidence supporting the association between overweight…
Kharouf F, Mehta P, Carrizo Abarza V et al. · 2025 · Rheumatology (Oxford, England)
Objectives Evidence for the association between MTX use and liver fibrosis in PsA remains inconclusive. We aimed to explore the frequency of liver fibrosis in PsA and identify associated factors including cumulative MTX dose and metabolic…