A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20261 results in Negative / Null Result Report · page 528 of 676
SUN X, GODJE ISG, HU H et al. · 2024 · Preprint
Despite breakthroughs in care and treatment, the consequences of a subarachnoid hemorrhage (SAH) are still associated with morbidity and mortality. Early brain injury is still a major source of clinical deterioration in people with SAH.…
Vicario-Feliciano R, Zil-E-Ali A, Aziz F · 2025 · Annals of vascular surgery
Introduction Predictors of sac behavior after endovascular aortic aneurysm repair (EVAR) and the impact of sac behavior on long-term survival are not well known. There are limited multicenter trials studying the impact of beta blockers…
Maines E, Franceschi R, Candia FD et al. · 2025 · Diabetes/metabolism research and reviews
Definitive prevention for type 1 diabetes (T1D) is not yet available, but we are now entering a new era where disease-modifying therapies are becoming available in T1D to halt disease progression. In this review, we present up-to-date…
Reboul A, Claidière N, Dautriche I et al. · 2025 · PloS one
This study investigates whether baboons are capable of semantic compositionality, specifically, whether they can apply compositional rules to new situations (generalization). In language, semantic compositionality is linked to…
Chen Y, He M, Zhao S et al. · 2024 · Preprint
Objective: To investigate the clinical value of adding on Jin-gu-lian Capsule (JGL) in rheumatoid arthritis (RA) treatment on disease activity and quality of life (QoL) by a real world study (RWS). Methods A RWS was conducted to compare…
Ghosh R · 2024 · Preprint
Abstract Background: Consolidation therapy with high dose cytarabine (HIDAC) for Acute Myeloid Leukemia (AML)is associated with significant neutropenia , resultant infections and associated morbidities. In this prospective study on de novo…
Baker JF · 2026 · Hip & pelvis
Purpose Surgeons are both interested in the relationship between spinopelvic parameters and acetabular orientation since concomitant diseases of the spine and hip are common. Spondylolysis of L5 is common in 4% to 8% of the population. L5…
Könemann H, Güler-Eren S, Ellermann C et al. · 2024 · Current heart failure reports
Purpose of review Arrhythmias are common in patients with heart failure (HF) and are associated with a significant risk of mortality and morbidity. Optimal antiarrhythmic treatment is therefore essential. Here, we review current approaches…
Zafarani F, Soleimani Mehranjani M, Ghaffari F et al. · 2024 · International journal of fertility & sterility
Background This study aimed to determine the alteration of endometrial expression levels of HOXA9/HOXA10/ HOXA11/HOXD10 genes and HOX transcript antisense intergenic RNA (HOTAIR) in mid-luteal phase endometrium in patients with…
Gandhi A, Parhizgar A · 2025 · Frontiers in endocrinology
Initially developed for type 2 diabetes and obesity, glucagon-like peptide-1 receptor agonists (GLP-1RAs) are now emerging as promising candidates for modifying the course of neurodegenerative diseases. This potential stems from the…
Aragón-Sánchez J, Víquez-Molina G, López-Valverde ME et al. · 2023 · Diabetic medicine : a journal of the British Diabetic Association
Aims We hypothesize that microbiology- and pathology-confirmed positive bone margins after the resection of diabetes-related foot osteomyelitis are associated with worse outcomes. Methods We conducted a prospective study consisting of a…
Ahmed N, Russo L, Kuo YH · 2024 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Objectives To compare levetiracetam and phenytoin as prophylaxis for the short-term development of status epilepticus (SE) during care of pediatric patients with acute severe traumatic brain injury (TBI). Design Nonprespecified secondary…
Shefner JM, Cudkowicz ME, Genge A et al. · 2025 · JAMA neurology
Importance Treatment options for amyotrophic lateral sclerosis (ALS) remain suboptimal. Results from a phase 2 study of reldesemtiv in ALS suggested that it may slow disease progression. Objective To assess the effect of reldesemtiv vs…
Apivatgaroon A, Sukkarnkosol S, Pukrittayakamee NC et al. · 2025 · JSES international
Background Suspension stabilization is a commonly used surgical method for acute acromioclavicular (AC) joint dislocation. However, a failure rate of around 26% caused various emerging surgical techniques and recommendations. We aimed to…
Rannikko EH, Pajula S, Suominen SH et al. · 2025 · Plastic and reconstructive surgery
Background Breast cancer-related lymphedema is a common complication lacking medical treatment. Lymfactin is an adenovirus type 5-based gene therapy and prolymphangiogenic growth factor vector that induces vascular endothelial growth…
Kim S, Shin MJ, Krauss RM · 2025 · Current atherosclerosis reports
Purpose of review This paper reviews the effects of major macronutrients and specific dietary interventions on atherogenic dyslipidemia, a common trait characterized by increased concentrations of triglyceride-rich and small, dense LDL…
Idani D, Mashhadi SM, Babaei H et al. · 2024 · Preprint
Purpose: To evaluate vascular changes in patients with diabetic macular ischemia (DMI) after systemic oxygen therapy using Optical coherence tomography angiography (OCTA). Methods: : This interventional before-after study included 26 eyes…
Cavalcante FP, Cardoso A, Antonini M et al. · 2025 · Translational breast cancer research : a journal focusing on translational research in breast cancer
Background Neoadjuvant chemotherapy (NAC) is widely accepted as standard treatment in breast cancer, particularly in cases of tumors with aggressive biology. NAC has increased the rates of breast-conserving surgery (BCS) and the conversion…
Díaz de Terán T, Bolado J, Palomo P et al. · 2025 · Sleep & breathing = Schlaf & Atmung
Objective To assess the effectiveness of an intervention programme combining Oropharyngeal Myofunctional Therapy (OMT) and cervical spine exercises in the general population with mild to moderate Obstructive Sleep Apnoea (OSA), analysing…
Shamsi F, Aligholi H, Karimi MT et al. · 2024 · Journal of motor behavior
The current study aimed to evaluate the effects of action observation on the walking ability and oscillatory brain activity of chronic stroke patients. Fourteen chronic stroke patients were allocated randomly to the action observation (AO)…
Tadesse M, Tesfaye BA, Taye B et al. · 2026 · Medicine
Hyperthyroidism accelerates bone turnover and increases the risk of secondary osteoporosis. However, evidence from sub-Saharan Africa remains scarce. This study assessed the prevalence and predictors of osteoporosis among hyperthyroid…
Makino M, Shishikura D, Kusumoto H et al. · 2026 · Cardiovascular diagnosis and therapy
Background The micro-axial intravascular flow pump (mAFP) may potentially improve the prognosis of cardiogenic shock (CS). Despite its advanced hemodynamic profile, efficacy remains undetermined. Safety and mid-term outcomes were compared…
Serwer T, Wahid M, Imtiaz F et al. · 2024 · JPMA. The Journal of the Pakistan Medical Association
Objective To identify the mutation in codon 201 of the deleted in colorectal cancer gene in colorectal cancer, and to correlate that mutation to the histopathological grading of colorectal cancer. Methods The cross-sectional study was…
Dureha R, Navit S, Khan SA et al. · 2024 · International journal of clinical pediatric dentistry
Aim The aim of this study was to evaluate the antimicrobial efficacy and minimum inhibitory concentration (MIC) of commercially available pediatric dentifrices containing different compositions against Streptococcus mutans and…
Martinez-Canton M, Gallego-Selles A, Galvan-Alvarez V et al. · 2024 · Free radical biology & medicine
Calcium (Ca 2+ )/calmodulin-dependent protein kinase II (CaMKII) is activated during exercise by reactive oxygen species (ROS) and Ca 2+ transients initiating muscle contraction. CaMKII modulates antioxidant, inflammatory, metabolic and…
O'Leary RM, Zavlun N, Kinney A et al. · 2025 · Frontiers in psychology
Pupil dilation has become a well-established physiological index of cognitive effort. Here we examined the often-cited finding of an inverted U-shaped function of pupil size across the continuum from highly degraded to clear speech. Unlike…
Funaki R, Nomura S, Ushima A et al. · 2024 · Biological & pharmaceutical bulletin
Commercially available so-called sanitizers in Japan are often touted as having remarkable "sanitizing (jokin)" effect, "virus-removal" capabilities, and "99.99%" removal rate of microbes and pathogens. In this study, we investigated the…
Bukhari SS, Saeed F, Tahir I et al. · 2023 · Preprint
Abstract Background: The standard of care for gliomas includes maximum safe resection of the tumor. This may lead to inadvertent damage to tissue directly or vasculature supplying normal brain tissue. This may result in perilesional brain…
Karra DA, Suchodolski JS, Newman SJ et al. · 2025 · Journal of veterinary internal medicine
Background Chronic enteropathies (CE) are common in cats, and alterations of the intestinal microbiota might be involved in the pathogenesis. Hypothesis/objectives To evaluate the efficacy of a single enema fecal microbiota transplantation…
Rivera D, Robinson T, King AC · 2024 · Perceptual and motor skills
In this investigation, we examined the influence of two approaches of motor skill learning (differential learning and repetition-based) for an explosive motor skill. Twenty-seven individuals completed four training sessions of a standing…