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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19885 results in Negative / Null Result Report · page 523 of 663

Negative / Null Result ReportMedicine

Preoperative posterior pelvic tilt is associated with residual low back pain and inferior patient-reported outcomes after total hip arthroplasty.

Ito K, Fujii M, Oba Y et al. · 2026 · International orthopaedics

Purpose To determine changes in low back pain (LBP) after total hip arthroplasty (THA), identify preoperative factors associated with residual LBP and LBP improvement, and clarify the association between residual LBP and patient-reported…

View details →DOI: 10.1007/s00264-026-06885-1
Negative / Null Result Report

Association of body composition, daily physical activity and handgrip strength with mortality, cardiovascular events and cancers in Japanese patients with diabetes

Hamasaki H, Taxiarchi V · 2026 · Preprint

Aims Sarcopenia and sarcopenic obesity are associated with increased risks of cardiovascular (CV) disease and mortality. This study examined the associations of body composition and daily physical activity with mortality, CV events and…

View details →DOI: 10.64898/2026.06.09.26355239
Negative / Null Result ReportMedicine

Water intake, switching between bites and sips, and drinking behavior are associated with food intake across meals varying in spiciness: A secondary analysis of two randomized crossover studies.

Cunningham PM, Hayes JE · 2026 · Appetite

Widespread nutrition advice instructs consumers to drink water with meals to increase fullness and reduce energy intake. However, recent data indicates greater water intake is associated with more food intake at a meal, not less. Switching…

View details →DOI: 10.1016/j.appet.2026.108698
Negative / Null Result ReportMedicine

High daily fructose intake and late-evening fruit consumption are associated with ultrasonographically assessed hepatic steatosis in family medicine outpatients.

Ediz E, Küçükdağ HN, Özel MA · 2026 · Scientific reports

Although high fructose consumption is known to be associated with metabolic disorders, specific intake thresholds and consumption patterns related to hepatic steatosis have not been fully defined. This study aimed to quantify daily…

View details →DOI: 10.1038/s41598-026-57356-x
Negative / Null Result ReportMedicine

Investigating patterns of long-term opioid usage in 11,771 trauma survivors with up to 6 years follow-up in Denmark.

Millarch AS, Schøning J, Hjulmand VG et al. · 2026 · The journal of trauma and acute care surgery

Background Opioids have a well-known capacity to induce long-term dependency with related increased morbidity and mortality. Usage patterns following traumatic injury are, however, not well studied. We investigated long-term opioid usage…

View details →DOI: 10.1097/ta.0000000000004892
Negative / Null Result ReportMedicine

Longitudinal analysis of 15-year health outcomes after combat-related lower limb amputation: A retrospective study.

Melcer T, Robinson MI, Jurick S et al. · 2026 · The journal of trauma and acute care surgery

Background Limited longitudinal research has been conducted on health outcomes during the first 15 years after combat-related lower limb amputation. Methods This retrospective analysis of Departments of Defense and Veterans Affairs health…

View details →DOI: 10.1097/ta.0000000000004900
Negative / Null Result ReportMedicine

Psychological safety and perceived risk are associated with emergency nurses' intention to use AI-augmented triage systems.

Jiang Y, Kong M, Feng T et al. · 2026 · Scientific reports

Emergency department overcrowding places sustained pressure on triage workflows and patient prioritization. Artificial intelligence (AI)-augmented triage systems have been introduced to support emergency decision-making, but frontline…

View details →DOI: 10.1038/s41598-026-56833-7
Negative / Null Result ReportMedicine

Oyster-derived peptide DLAGRDLTDYLM attenuates dexamethasone-induced osteoporosis in rats: associations with lipid metabolism and bone remodeling signatures.

Yang W, Tan M, Lin H et al. · 2026 · Food & function

Oyster-derived peptides have shown potential for bone protection; yet, the anti-osteoporotic activity of defined sequences remains insufficiently characterized in glucocorticoid-induced osteoporosis (GIOP). Here, DLAGRDLTDYLM (OP4),…

View details →DOI: 10.1039/d6fo00926c
Negative / Null Result ReportMedicine

Sub-Minimum Inhibitory Concentrations of Amoxicillin Modulate Biofilm Formation and the Expression of Biofilm-Associated Genes in <i>Enterococcus faecalis</i>.

Tegegne DT, Banaszkiewicz S, Bania J et al. · 2026 · Molecules (Basel, Switzerland)

Background: Enterococcus faecalis is one of the most frequent causes of catheter-associated urinary tract infections, largely due to its ability to form biofilms on indwelling urinary catheter surfaces, which enhance bacterial persistence…

View details →DOI: 10.3390/molecules31121986
Negative / Null Result ReportOpen accessMedicine

Isolated Peripheral Nervous System Presentation in Ma/Ma2-Associated Autoimmunity.

Vilaseca A, Villagrán-García M, Farina A et al. · 2026 · Neurology(R) neuroimmunology & neuroinflammation

Objectives Ma/Ma2-associated neurologic autoimmunity is characterized by CNS involvement. However, isolated peripheral nervous system (PNS) presentations have been rarely reported. We aimed to describe the frequency and syndromes of…

View details →DOI: 10.1212/nxi.0000000000200623
Negative / Null Result ReportOpen accessMedicine

VSIG2 is associated with an immune-cold microenvironment and reduced response to PD-1 blockade in bladder cancer.

Wu J, Liang P, He Y et al. · 2026 · Frontiers in cellular and infection microbiology

Background Bladder cancer is one of the most common malignancies worldwide, and only a subset of patients derives durable benefit from immune checkpoint blockade. An immune-cold tumor microenvironment, characterized by limited immune…

View details →DOI: 10.3389/fcimb.2026.1859986
Negative / Null Result ReportMedicine

Prognostic Value of Bronchoalveolar Lavage in Systemic Autoimmune Rheumatic Diseases-Associated Interstitial Lung Disease.

Gysan MR, Kastrati K, Pochepnia S et al. · 2026 · Journal of clinical medicine

Background: Systemic autoimmune rheumatic diseases-associated interstitial lung disease (SARD-ILD) presents with varied disease courses, emphasizing the need for reliable predictors of progression. The prognostic utility of bronchoalveolar…

View details →DOI: 10.3390/jcm15124834
Negative / Null Result ReportOpen accessMedicine

An analysis of succinate dehydrogenase B in pleural mesothelioma.

Jennings CJ, Marciniak SJ, Pinton G et al. · 2026 · Discover oncology

Aim To investigate the expression of succinate dehydrogenase B and its potential as a therapeutic target in pleural mesothelioma (PM). Methods The expression of succinate dehydrogenase B was examined in cell lines using PCR. The expression…

View details →DOI: 10.1007/s12672-026-04961-x
Negative / Null Result ReportMedicine

Monotherapy versus combination therapy for treatment of carbapenem-resistant Acinetobacter baumannii complex infections: results from an observational study.

Bertholdi Filho SU, Telles JP, Melo IM et al. · 2026 · Critical care science

Objective To evaluate the efficacy of monotherapy versus combination therapy in the treatment of carbapenem-resistant Acinetobacter baumannii infections. Methods A retrospective observational study was conducted in two tertiary hospitals…

View details →DOI: 10.62675/2965-2774.20260352
Negative / Null Result ReportMedicine

Non-Coding RNAs as Emerging Biomarkers in HPV-Associated Cervical Precancer and Cancer: Molecular Mechanisms and Clinical Perspectives.

Terrinoni M, Caputo V, Palisciano M et al. · 2026 · Genes

Background/Objectives: Cervical cancer is mainly driven by persistent infection with high-risk human papillomaviruses (HPV), particularly HPV16 and HPV18. Despite advances in cytology, HPV-DNA testing and vaccination, challenges remain in…

View details →DOI: 10.3390/genes17060714
Negative / Null Result ReportMedicine

Exosomal MALAT1 expression associated with the cardioprotective effects of carvacrol in acute doxorubicin-induced cardiac injury: Potential involvement of Nrf2/Keap1-related signaling.

Ahmadi T, Ghorbanzadeh V, Hosseinnejad E et al. · 2026 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Doxorubicin remains an indispensable component of many chemotherapy regimens; however, its clinical use is limited by dose-dependent cardiotoxicity that may progress to dilated cardiomyopathy and heart failure. In the present study, we…

View details →DOI: 10.1016/j.biopha.2026.119606
Negative / Null Result ReportMedicine

Thyroid Autoimmunity in Polycystic Ovary Syndrome: Phenotype Distribution, HDL-Cholesterol, and Data-Driven Clusters in a Retrospective Cohort Study.

Mogoș RA, Carauleanu A, Vasilache IA et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Autoimmune thyroiditis (AIT) is often reported patients with PCOS, and may co-occur with altered metabolic risk markers. The aims of this study were to assess baseline differences according to thyroid…

View details →DOI: 10.3390/medicina62061184
Negative / Null Result ReportMedicine

Abdominal massage improves intestinal barrier function via the TLR4/MyD88/NF-κB signaling pathway in obesity-associated T2DM rats.

Han Y, Zhong C, Lu Z et al. · 2026 · Scientific reports

Abdominal massage (AM), a traditional Chinese medicine treatment, is gradually being recognized in clinical practice for its ability to improve the symptoms of obesity and type 2 diabetes mellitus (T2DM) in clinical practice. This study…

View details →DOI: 10.1038/s41598-026-57589-w
Negative / Null Result Report

Inflammation-Driven Epithelial Plasticity in Oral Mucosa Adjacent to Long-Term Restorative Materials: A Retrospective Histopathological and Immunohistochemical Study

Mehedinti R, Earar K, Stefanescu A et al. · 2026 · Preprint

Background: and Objectives: Long-standing contact between oral mucosa and restorative materials may be associated with adaptive epithelial and stromal remodeling. This study evaluated non-dysplastic epithelial plasticity and cumulative…

View details →DOI: 10.20944/preprints202606.1076.v1
Negative / Null Result ReportMedicine

Urate-lowering therapy adherence among gout patients in Southwest China: A cross-sectional study of determinants and regional disparities.

Tang Z, Huang C, Qiu G et al. · 2026 · Clinical rheumatology

Objective Gout is directly associated with hyperuricemia. This study aims to investigate the adherence rate to urate-lowering therapy (ULT) and its influencing factors among patients with gout in Southwest China. Methods A cross-sectional…

View details →DOI: 10.1007/s10067-026-08232-6
Negative / Null Result ReportMedicine

Incidence and risk factors of acute blood pressure drops during circular-array pulsed-field ablation for pulmonary vein isolation.

Hashimoto S, Ishiguchi H, Yoshiga Y et al. · 2026 · Heart rhythm

Background Data regarding acute blood pressure (BP) drops during pulsed-field ablation (PFA) for pulmonary vein isolation (PVI) are limited. Objective This study aimed to determine the incidence and risk factors of acute BP drops during…

View details →DOI: 10.1016/j.hrthm.2026.02.050
Negative / Null Result ReportMedicine

EXPRESS: Exaggerated Self-Referencing in Body Dysmorphic Disorder.

Richards-Brown M, Castiello de Obeso S, Dennison R et al. · 2026 · Quarterly journal of experimental psychology (2006)

The self-prioritisation effect demonstrates that people have a bias to learn and process self-relevant compared to other-relevant information. This tendency may provide a tool to understand how body image and perception become disrupted in…

View details →DOI: 10.1177/17470218261465670
Negative / Null Result ReportMedicine

Predictors of Ageism among Social Work Students and Practitioners in Greece: The Role of Aging Anxiety and Experiential Factors.

Micheli K, Koutra K, Markakis G · 2026 · International journal of aging & human development

This study examines whether aging anxiety (based on terror management theory) or demographic and experiential factors better explain attitudes toward older adults among social work students and professionals. Cross-sectional data were…

View details →DOI: 10.1177/00914150261456748
Negative / Null Result ReportMedicine

Genetically predicted gut bacteria, circulating bacteria-associated metabolites and liver cancer: A Mendelian randomisation study.

Daniel N, Papadimitriou N, Chatziioannou AC et al. · 2026 · Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

Background and aims Recent data suggest a role for the gut microbiome in the development of hepatocellular carcinoma. We investigated associations of gut microbiome abundances and concentrations of circulating bacteria-associated…

View details →DOI: 10.1016/j.dld.2026.05.008