A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20261 results in Negative / Null Result Report · page 519 of 676
Mobarak A, Chatterjee U, Munoz J et al. · 2026 · Preprint
Abstract The Swachh Bharat Mission - Gramin (SBM-G) was launched by the Prime Minister of India in 2014 during his inaugural independence-day address, as a flagship program to eliminate open defecation in India by 2019. Touted as the…
Wang J, He B, Kuerban G et al. · 2026 · Pakistan journal of pharmaceutical sciences
Background Evidence from experimental and clinical studies suggests that anesthetic drugs may modulate tumor biology by influencing immune regulation, inflammation and intracellular calcium signaling. However, the extent to which…
Wang Y, Qu J, Wang T et al. · 2026 · Blood purification
The relationship between baseline serum creatinine (SCr) levels at the initiation of continuous renal replacement therapy (CRRT) and in-hospital mortality remains unclear. This study aimed to investigate this relationship in critically ill…
Sharma M, Kaur N · 2026 · Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes
The reproductive toxicity of nitrate in juvenile and adult female rats, and its amelioration with ascorbic acid, curcumin or their combination, was studied. Rats were classified into five groups: control, nitrate, nitrate + ascorbic acid,…
Egorova K, Maaniitty T, Kärpijoki H et al. · 2026 · Preprint
Peripheral physiological processes contribute to emotions; however, the extent of the influence of internal signals on subjective emotional experiences remains a subject of debate. Methods Here we investigated the bodily sensations induced…
Puga T, Haechten T, Cush C et al. · 2025 · Orthopaedic journal of sports medicine
Background Kickoffs in the National Football League (NFL) are historically one of the most dangerous plays during an NFL game, with high levels of injuries. In 2024, the NFL introduced new rules aimed at reducing injuries during kickoffs,…
Javaheri J, Asgari M, Mohaghegh P et al. · 2026 · Preprint
Abstract Background: Routine monitoring, identification, early diagnosis and screening of diseases caused by environmental and industrial pollutants by all physicians who will practice in large and polluted cities or areas affected, must…
Sliman H, Sliman RKA, Aker A et al. · 2026 · Preprint
Abstract Background: Emotional stress in conflict zones may impact cardiovascular health, particularly acute coronary syndrome incidence. This retrospective study assesses the Israel–Hamas conflict's impact on ST-elevation myocardial…
Zander C, Rau A, Lützen N et al. · 2026 · Fluids and barriers of the CNS
BACKGROUND: CSF loss in spontaneous intracranial hypotension (SIH) has been related to alterations in glymphatic flow, which is poorly understood in this disease. Advanced multi-shell diffusion-weighted MRI (dMRI) enables quantification of…
Berube M, Bortman JM, Law AC et al. · 2026 · Hip international : the journal of clinical and experimental research on hip pathology and therapy
Background The optimal threshold to blood transfusion in patients after hip fracture surgery is unclear. This study leveraged regression discontinuity to quantify blood transfusion practices across haemoglobin thresholds of 7.0, 8.0, and…
Li Y, Wang D, Liu B et al. · 2026 · Preprint
Abstract Background Pulsed field ablation (PFA) is a novel non-thermal technology for atrial fibrillation (AF) ablation, but its immediate systemic effects on electrolytes remain poorly characterized. Methods We prospectively enrolled 161…
Darch W, Soliman J, Higgins NC et al. · 2026 · Scientific reports
Vascular endothelial cells (VECs) play a critical role in tissue and organ homeostasis, wound healing, and immune function. VECs are commonly utilized for in vitro cell culture and in vivo tissue engineering applications which experience…
Almekaty K, Alhefnawy M, Ismael A et al. · 2026 · Urology
Objective To prospectively assess the clinical outcomes and safety of microsurgical denervation of the penis (MSDP) for treatment of lifelong premature ejaculation (LPE); and to examine the impact of transitioning from partial to more…
Salem AS, Albelasy NF, El-Bialy AA · 2026 · The Angle orthodontist
Objectives To compare the effectiveness of clear aligner (CA) vs removable inclined plane (RP) in improving the dentofacial changes and oral health-related quality of life (OHRQoL) in children with anterior crossbite in the mixed…
Erdem Altınyürek E, Öztürk VÖ · 2026 · BMC oral health
Background Gastritis is characterized by alterations in the gastric microbiota. This dysbiosis in the stomach may affect immune system regulation as well as influence the oral microbiota. Periodontal disease results from dysbiosis of…
Mamun AA · 2026 · 3 Biotech
Drought significantly alters soil microbial activity and carbon cycling, yet its effects across contrasting land-use systems remain insufficiently understood. This study investigated drought-induced changes in microbial communities and…
Tuncsoy M, Tuncsoy B · 2026 · Bulletin of environmental contamination and toxicology
Aluminum (Al) is a widely occurring element in nature and is the most abundant element in the earth's crust after oxygen and silicon. In this study, metal accumulation levels in the gills, liver and muscle tissues and liver SOD, CAT and…
Nersesyan A, Kundi M, Muradyan R et al. · 2026 · Mutagenesis
We investigated the impact of cigarette smoking, daily exposure to tar and nicotine, and the duration of smoking on genetic instability (chromosomal damage-micronuclei, MN, nuclear buds-gene amplification) as well as on disturbances in…
Bakir M, Sağmak S · 2026 · BMC oral health
Background This study aimed to evaluate the effects of different modeling resins on the surface roughness, surface gloss, and color stability of a nanohybrid resin composite. Methods Forty disk-shaped specimens (10 mm diameter × 2 mm…
Kaplan S, de Nascimento J, Contini A · 2026 · Drug safety
Background and objectives Concerns about modafinil and armodafinil use in pregnancy emerged from animal reproductive toxicity and limited human data, including a US registry suggesting increased risk of major congenital malformations…
Sahu SK, Nayak M, Samal A et al. · 2026 · Preprint
Abstract Hypothyroidism has been associated with cognitive disorders and high risk of neurodegenerative disorders like Alzheimer's disease (AD), which is caused by amyloid-β (Aβ) accumulation in brain. The aim of the study is to examine…
Kawahata D, Biber D · 2026 · Journal of health psychology
The purpose of this study was to evaluate the impact of the Mindless to Mindful (M2M) program on fat mass, executive function, exercise identity, and exercise habit strength. A total of 89 adults consented to participate in the M2M…
Chaudhry AS, Tian W, Adam TH et al. · 2026 · Aesthetic surgery journal
Background Biologic and targeted immune-modulating agents are increasingly used to manage autoimmune diseases like rheumatoid arthritis, psoriasis, and inflammatory bowel disease. As more patients receiving these therapies undergo elective…
Rahimi MR, Morton AB, Golpasandi H et al. · 2025 · BMC sports science, medicine & rehabilitation
Background Coenzyme Q10 (CoQ10), a vital mitochondrial antioxidant, may enhance cardiovascular recovery and delay fatigue in athletes. This double-blind, randomized, placebo-controlled trial investigated CoQ10's effects on cardiac stress…
Karaaslan O, Türkyılmaz G, Hacıoğlu L et al. · 2026 · Biomedicines
Background/Objectives: Therapeutic plasma exchange (TPE) is an extracorporeal treatment used in thrombotic microangiopathies (TMAs) and various autoimmune and neurological disorders. However, data regarding its use during early pregnancy…
Long L, Liu G, Gao G et al. · 2026 · Insects
The effects of substituting soybean meal with black soldier fly larvae (BSFL) meal on the growth performance, immunological response, intestinal morphology, and gut microbiota of Pekin ducks were assessed. A total of 150 one-day-old Pekin…
Lober A, Eaton CM, Burnette S et al. · 2026 · Nursing for women's health
Objective To evaluate the impact of an evidence-based respectful maternity care program on registered nurses' attitudes and beliefs about childbirth practices across multiple U.S. hospital maternity and neonatal units. Secondary objectives…
Yang F, Ma Y, Li X et al. · 2026 · Life (Basel, Switzerland)
This study aims to investigate the effects of cysteamine zinc supplementation on milk production, composition, amino acid profile, and metabolites in mares. Building on prior experimental findings, a dose of 7 mg/kg body weight of CS-Zn…
Schreiber R, Ousingsawat J, Kunzelmann K · 2026 · Cellular and molecular life sciences : CMLS
We previously reported a loss of T cell activation following knockdown of the phospholipid scramblase and ion channel ANO9 (TMEM16J) in human Jurkat lymphocytes. We have now analyzed in detail the role of ANO9 in Jurkat ANO9 knockout cells…
Hafeez A, Saleem U, Naz S et al. · 2026 · Veterinary medicine and science
The objective of this study was to investigate the ameliorative effect of betaine on the performance, blood biochemistry, intestinal lesion score and nutrient utilization of broiler chickens exposed to coccidian challenge. A total of 600…