A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19885 results in Negative / Null Result Report · page 518 of 663
Zhou G, Dael N, Verweij S et al. · 2026 · Pharmaceuticals (Basel, Switzerland)
Background: The rapid emergence of immune-evasive SARS-CoV-2 variants necessitates the identification of accessible, low-cost prophylactic strategies. While drug repurposing offers a time-efficient alternative to novel drug development,…
Brent DA · 2026 · Journal of the American Academy of Child and Adolescent Psychiatry
In this issue of JAACAP, Asarnow and colleagues report the results of their innovative, elegantly conducted clinical trial that assessed the added value of stratified, stepped care (SSC) for youth at risk for suicidal behavior in a health…
Haroon A, Almuhaideb A, Adeleke S et al. · 2026 · Nuclear medicine communications
Objective To assess the accuracy of 18F choline PET/magnetic resonance (MR) when compared with the reference standard MRI-guided template mapping (TPM) biopsies for evaluation of biochemical relapse of prostate cancer in patients with…
Goldstein EL, Marcelo KR, Harjes WR et al. · 2025 · Emergency radiology
Purpose Controversy exists regarding analgesia premedication prior to right upper quadrant ultrasound (RUQUS) in the setting of abdominal pain when evaluating for acute cholecystitis (AC). The purpose of this study was to examine the…
Bafaraj SM · 2025 · Current problems in diagnostic radiology
The primary aim of this study is to assess how well ultrasonography and 99mTc-sestamibi scintigraphy perform as diagnostic tools for hyperparathyroidism (HPT) when compared to the clinical measurements of parathyroid hormone (PTH) levels.…
Kwatra D, Wakeford W, Ally M et al. · 2026 · BMC endocrine disorders
BACKGROUND: To evaluate the concordance of the NBCL CONNECT Point-of-Care (POC) Intraoperative Parathyroid Hormone (IOPTH) assay with a Central Laboratory standard, with a focus on percentage drops and the usefulness of POC testing in…
Saucedo M, Chamorro MF, Passler T et al. · 2026 · Journal of the American Veterinary Medical Association
Objective This study aimed to compare the most accurate sample type, test, and timing for detecting bovine viral diarrhea virus (BVDV) in persistently infected (PI) calves at different time points following birth and colostrum intake.…
Badelita SN, Sandu HM, Coriu D et al. · 2026 · Frontiers in oncology
Bone marrow hemodilution could compromise next generation flow cytometry based measurable residual disease evaluation in multiple myeloma and may cause false negative results. This review summarizes definitions, markers, indices,…
Behjatnia H, Couto P, Castillo Y et al. · 2026 · The American journal of case reports
BACKGROUND Fungal endocarditis constitutes up to 3% of diagnosed infective endocarditis cases, and Histoplasma spp. cause approximately 10% of fungal endocarditis cases. Histoplasma infection occurs through inhalation of spores typically…
Shi H, Li W, Guo L et al. · 2025 · Journal of thoracic disease
Background Both amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) and next-generation sequencing (NGS) are able to identify sensitizing epidermal growth factor receptor ( EGFR ) mutations of non-small cell lung…
Ceran Serdar C · 2026 · The Turkish journal of pediatrics
Background Biotinidase deficiency is a core condition in newborn screening programs worldwide. While fluorometric enzyme activity assays from dried blood spots (DBS) are the standard first-tier test, their accuracy can be susceptible to…
Guerrero-Tánori DM, Martínez-Guerrero A, Müller MF et al. · 2026 · MethodsX
The Mozart effect has been the subject of lively but also controversial debate in literature during the last decades. Positive as well as negative results have been reported, using different musical stimuli as well as cognitive tasks. In…
Orciari LA, Wicker V, Bonaparte S et al. · 2025 · Preprint
Point-of-care, immunochromatographic tests have not reliably detected rabies virus and have not utilized a consistent diagnostic protocol. International diagnostic standards established by the World Organization for Animal Health require…
Loomba R, Sanyal AJ, Nakajima A et al. · 2024 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Background & aims Pegbelfermin is a polyethlene glycol-conjugated analog of human fibroblast growth factor 21, a nonmitogenic hormone that regulates energy metabolism. This phase 2b study evaluated 48-week pegbelfermin treatment in…
Yanagihara K, Nagata K, Yamakawa T et al. · 2025 · Preprint
Backgrounds: . Programmed death-ligand 1 (PD-L1) immunohistochemistry (IHC) is a critical predictive biomarker for immune checkpoint inhibitor (ICI) therapy in triple-negative breast cancer (TNBC). However, prolonged storage of…
Obeidat A, Sabbah BN, Mandourah H et al. · 2025 · Annals of medicine and surgery (2012)
Introduction Testicular sperm extraction (TESE) is a common procedure for retrieving sperm in men with azoospermia. However, the success rates of a second TESE following an initial unsuccessful attempt remain low. This study aims to…
Olaniyan H, Beckman J, Crosby E et al. · 2026 · Clinica chimica acta; international journal of clinical chemistry
Objectives Timely and locally relevant drug testing is helpful for overdose assessment; however, immunoassay (IA)-based urine drug screens (UDS) often fail to detect emerging substances. This study assesses fentanyl screen utilization and…
Wang J, Jiang B · 2026 · Journal of infection in developing countries
Introduction Postoperative central nervous system (CNS) infections in craniotomy patients diagnosed through clinical signs and cerebrospinal fluid (CSF) bacterial culture, pose a challenge due to the morbidity and mortality of bacterial…
Nardy T, Rondinaud E, Dessajan J et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Objectives This study assessed the clinical significance of negative BioFire® FilmArray® Pneumonia Panel (FA-PP) results in ICU patients with suspected hospital-acquired (HAP) or ventilator-associated pneumonia (VAP), evaluating its impact…
Saito T, Namera A, Yamamoto R et al. · 2026 · The Journal of toxicological sciences
Zopiclone (ZOP) and eszopiclone (EZOP) are hypnotics belonging to the cyclopyrrolone class, which are metabolized to zopiclone-N-oxide (ZOPNO) and N-desmethylzopiclone (NDZOP), respectively, and finally to 2-amino-5-chloropyridine (2A5C)…
Pottenger LH, Banton M, Barranco WT et al. · 2026 · Journal of environmental science and health. Part C, Toxicology and carcinogenesis
Recent studies investigating mutagenic/cytogenetic effects of styrene and styrene-7,8-oxide (SO) were reviewed to update published critical evaluations of these data from 2019. Transcriptomics studies relevant to styrene/SO genotoxicity…
Monteiro T, Romeiro K, Brisson-Suárez K et al. · 2026 · European endodontic journal
Objective This study compared the accuracy of digital periapical radiography (DPR) and cone beam computed tomography (CBCT) in detecting extruded filling material, using a human cadaver model. Micro-computed tomography (Micro-CT) served as…
Nguyen AQ, Nguyen HTN, Ho NT et al. · 2026 · Allergy and asthma proceedings
Background: Nonsteroidal anti-inflammatory drugs (NSAID) are the second most frequent cause of drug-induced hypersensitivity after β-lactam antibiotics. Diagnosing cross-intolerance reactions to NSAIDs remains challenging because…
Bedia-Tanoh VA, Konaté-Touré A, Kouakou OMK et al. · 2025 · Preprint
Abstract Background Accurate malaria diagnosis and reporting are critical for effective case management and surveillance. In sub-Saharan Africa, rapid diagnostic tests (RDTs) are widely used to support clinical decision-making. However,…
Yang YJ, Lee MR, Chung CL et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Objectives Despite the availability of rapid tuberculosis (TB) nucleic acid amplification (NAA) testing, prevention of TB transmission within healthcare facilities remains a challenge due to ongoing difficulties in promptly isolating…
Wu M, Bukowski BR, Hickman JA et al. · 2026 · The Journal of arthroplasty
Background Accurate diagnosis of periprosthetic joint infection (PJI) remains suboptimal. Of the tests used, one is the alpha defensin lateral flow assay (ADLFA). This study assessed ADLFA for the diagnosis of PJI in total hip…
Ismail A, Abunasser S, Salameh IM et al. · 2026 · Microorganisms
Fourth-generation immunoassays are widely used for HIV and syphilis screening; however, false-reactive results may increase confirmatory testing and operational burden in high-throughput laboratories. This study evaluated the comparative…
Greenfield PT, Phillips BB, Throckmorton TW et al. · 2026 · Journal of surgical orthopaedic advances
Despite studies highlighting magnetic resonance imaging (MRI)/magnetic resonance angiogram (MRA) accuracy in diagnosing shoulder pathologies, there remains a paucity of data regarding false negative results of these tests. The authors…
Burleigh-Flayer H, Canatsey R, Jean PA et al. · 2026 · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Cyclo-di-Badge (CdB) is a by-product of epoxy resin coatings applied to the inside of food cans. By-products are non-intentionally added substances (NIAS) with potential to migrate into food. Due to the lack of data on CdB, studies were…
Mousavi SS, Karimi S, Hassannia MS et al. · 2025 · Preprint
Objective Electrocardiography and blood pressure (BP) measurement are two widely used tools for diagnosis and monitoring cardiovascular diseases. While the electrocardiogram (ECG) and BP have been considered complementary modalities, there…