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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21339 results · page 518 of 712

Negative / Null Result ReportMedicine

Evaluation of Clitoral Artery Doppler Parameters After Brachytherapy and Its Effects On Sexual Functions.

Özdemir BG, Agakishiyeva L, Bilgi A et al. · 2026 · Journal of lower genital tract disease

Objectives Assessment of clitoral artery flow parameters (eg, pulsation and resistance indices) is important for individual patient evaluation of sexual function quality. Selected hormonal treatments may also influence these vascular…

View details →DOI: 10.1097/lgt.0000000000000955
Negative / Null Result Report

Safety of transglutaminase-induced corneal collagen cross-linking on the central cornea thickness and intraocular pressure in vivo

Sitorasmi PH, Ningtiyas YS, Wahyuni I et al. · 2026 · Preprint

Background Corneal collagen cross-linking (CXL) is a procedure for making bonds that connect polymer chains to one another. Corneal CXL aims to slow or stop the progression of keratoconus by using photooxidative therapy so as to increase…

View details →DOI: 10.12688/f1000research.129694.2
Negative / Null Result ReportOpen accessMedicine

Fecal microbiota composition concerning body mass index and early-life factors in Mexican preschool-aged children: a cross-sectional study.

Hernández-Rodríguez D, Contreras A, Melgar Lalanne G et al. · 2026 · PeerJ

Background The gut microbiota maturation extends beyond the first two years of life. Early perinatal and postnatal factors may influence the child's nutritional status, which, in turn, can affect the composition of their gut microbiota.…

View details →DOI: 10.7717/peerj.21253
Failed Experiment ReportMedicine

Clinical Outcomes of First-Line Immune Checkpoint Inhibitor-Based Therapy for Postoperative Recurrence After Adjuvant Nivolumab in Esophageal Cancer.

Sugase T, Kanemura T, Matsuura N et al. · 2026 · Annals of surgical oncology

Background Adjuvant nivolumab has become a standard treatment after curative resection for locally advanced esophageal cancer; however, postoperative recurrence remains common. The efficacy of immune checkpoint inhibitor (ICI)-based…

View details →DOI: 10.1245/s10434-026-19818-4
Negative / Null Result ReportOpen accessMedicine

Effect of a One-Week Lubricant Pretreatment on Post-LASIK Dry Eye: Single-Center Randomized, Single-Masked Study With 1-Month Follow-Up.

Cañones-Zafra R, Allendes-Urquiza G, Muñiz C et al. · 2026 · Journal of ophthalmology

Purpose Our purpose is to report the results of a prospective study on ocular discomfort and objective tear film parameters (osmolarity and NIKBUT), in myopic patients, and observe the possible differences at 1 month between randomized…

View details →DOI: 10.1155/joph/6643075
Negative / Null Result ReportMedicine

Could Autism Spectrum Disorder Be Associated With Craniosynostosis?

Still MEH, Alberts A, Nagda P et al. · 2026 · The Journal of craniofacial surgery

Introduction Craniosynostosis is a common pediatric condition that results in variable symptoms that range from asymptomatic cosmetic deformities to severe signs of intracranial hypertension. Little is understood about the relationship…

View details →DOI: 10.1097/scs.0000000000012817
Negative / Null Result ReportOpen accessMedicine

Tomato drought-responsive transcription factor TINY1 suppresses embryonic growth.

Azriel M, Shohat H, Blinderman D et al. · 2026 · Journal of experimental botany

Dehydration-responsive element-binding (DREB) transcription factors play an important role in plant responses to drought. DREB subfamily A4 contains a subgroup named TINY. Previous studies in Arabidopsis suggest that TINYs suppress plant…

View details →DOI: 10.1093/jxb/erag054
Negative / Null Result ReportMedicine

Preoperative Gabapentin for Vaginal Prolapse Procedures: A Randomized Trial.

Johnson CM, Kenne KA, Bradley CS et al. · 2026 · Urogynecology (Philadelphia, Pa.)

Importance Perioperative gabapentin is widely used in gynecology ERAS protocols, but evidence for its use for vaginal prolapse procedures is very limited. Objective The objective of this study was to evaluate the effect of preoperative…

View details →DOI: 10.1097/spv.0000000000001746
Negative / Null Result ReportMedicine

Longitudinal Development of Macular Ganglion Cell Layer Thickness in Children: The Copenhagen Child Cohort 2000 Eye Study.

Bendtsen AW, Lykkebirk L, Behrens CM et al. · 2026 · Ophthalmic epidemiology

Purpose To examine changes in macular ganglion cell layer (GCL) thickness over five years in a community-based birth cohort of children without ophthalmic disease. Methods This prospective study included 660 children without ophthalmic…

View details →DOI: 10.1080/09286586.2026.2693522
Negative / Null Result ReportMedicine

Immersive Haptic Simulation for Psychomotor Skill Acquisition in Preclinical Prosthetic Dentistry: A Randomized Study.

Bandiaky ON, Volteau C, Bihan A et al. · 2026 · The International journal of prosthodontics

Purpose The aim of this study was to evaluate the effect of using the VirTeaSy Dental simulator in conjunction with a virtual reality headset on student performance in conventional fixed prosthodontics simulations. Material and methods The…

View details →DOI: 10.11607/ijp.9731
Negative / Null Result ReportOpen accessMedicine

Does closed suction drainage reduce postoperative hematoma and muscle swelling after total hip arthroplasty? A retrospective comparative study using computed tomography.

Asano T, Uemura K, Higuchi R et al. · 2026 · Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs

Purpose Closed suction drainage has been used after total hip arthroplasty (THA) to prevent hematoma, muscle swelling, and complications, but its effectiveness remains controversial. This study evaluated the effects of drains on…

View details →DOI: 10.1007/s10047-026-01561-y
Negative / Null Result ReportMedicine

Constrained acetabular liner total hip arthroplasty versus conventional hemiarthroplasty for unstable comminuted femoral intertrochanteric fractures in elderly patients with neurological disorders.

Dong M, Liu Y, Wei C · 2026 · BMC surgery

Background To evaluate whether constrained acetabular liners (CAL) used in total hip arthroplasty (THA) reduce the risk of dislocation and related complications in patients with neuromuscular disorders and unstable comminuted femoral…

View details →DOI: 10.1186/s12893-026-03973-2
Negative / Null Result ReportMedicine

Clinical outcomes of conventional Vs. transepithelial photorefractive keratectomy: A prospective contralateral eye study.

Marchi MB, Al Harami A, Maher A et al. · 2026 · European journal of ophthalmology

PurposeTo compare the clinical outcomes of conventional photorefractive keratectomy (PRK) and transepithelial PRK (TransPRK) for the correction of myopic refractive errors.MethodsThis prospective, paired-eye comparative study included 48…

View details →DOI: 10.1177/11206721261461914
Negative / Null Result ReportMedicine

Comparison of Nasal Tip Projection and Rotational Stability between Structural Rhinoplasty with Strut Graft and Preservation Rhinoplasty with Pitanguy Ligament Graft.

Farhadi F, Ahmadpour F, Nezafati S et al. · 2026 · Aesthetic plastic surgery

Background and aim The nasal tip plays a central role in facial aesthetics, and achieving long-term tip stability is a key objective in rhinoplasty. This study compared postoperative tip stability between structural rhinoplasty using a…

View details →DOI: 10.1007/s00266-026-05847-7
Negative / Null Result ReportOpen accessMedicine

Impact of sport disciplines on gut microbiota in elite athletes: evidence from Taekwondo and diving athletes.

Chen X, Xie L, Li B · 2026 · Frontiers in microbiology

Objective Gut microbiota is closely associated with athletic performance, but differences between sport disciplines have rarely been reported. This study collected gut microbiota samples from athletes across different sport disciplines to…

View details →DOI: 10.3389/fmicb.2026.1770499
Negative / Null Result ReportOpen accessMedicine

A chlorine releasing solution as an alternative for dental biofilm control.

Telles PYV, Oliveira VC, Geng Vivanco R et al. · 2026 · Scientific reports

To evaluate the antibiofilm activity of a chlorine-releasing solution (CRS) and its in vitro effects on enamel color stability, surface roughness, and microhardness. A mixed biofilm composed of Staphylococcus aureus, Candida albicans, and…

View details →DOI: 10.1038/s41598-026-49642-5
Negative / Null Result ReportOpen accessMedicine

Comparison of Postoperative Analgesic Efficacy of Two Intrathecal Morphine Doses (75 μg vs 100 μg) for Cesarean Delivery: A Double-Blind Randomized Study.

Veraza JA, Martinez MA, Angulo P et al. · 2026 · Cureus

Background Intrathecal morphine remains a cornerstone of post-cesarean analgesia due to its prolonged spinal effect; however, its use is limited by dose-dependent adverse effects. Contemporary practice trends favor dose minimization, yet…

View details →DOI: 10.7759/cureus.107761
Negative / Null Result ReportOpen accessMedicine

Do the Pre-Existing Class III and Class V Composite Restorations Affect the Sealing Ability and Integrity of 3D-Printed Laminate Veneer Margins? An In Vitro Study.

Qaraghuli AM, Cagidiaco EF, Ferrari M · 2026 · Journal of functional biomaterials

Background: The application of veneer restorations over previously composite-restored anterior teeth presents significant clinical challenges, particularly in achieving optimal marginal sealing. Aim: This in vitro study aimed to evaluate…

View details →DOI: 10.3390/jfb17050249
Negative / Null Result ReportOpen accessMedicine

Current status of 5-aminosalicylic acid in Crohn's disease treatment: a nationwide survey and analysis of perspectives and practice patterns among inflammatory bowel disease physicians.

Li Y, Chen C, Wang C · 2026 · Frontiers in gastroenterology (Lausanne, Switzerland)

Objective To investigate the perspectives and clinical practice patterns of inflammatory bowel disease (IBD) physicians regarding the use of 5-aminosalicylic acid (5-ASA) in Crohn's disease (CD). Methods A 21-item questionnaire was…

View details →DOI: 10.3389/fgstr.2026.1783772
Negative / Null Result ReportMedicine

Acute effects of the FIFA 11 + kids warm-up program compared with a judo-specific warm-up on explosive and functional performance in youth judo athletes: a randomized crossover study.

Mor H, Şar H, Arslan T et al. · 2026 · BMC sports science, medicine & rehabilitation

Background The FIFA 11 + Kids (FIFA 11+) warm-up program is effective for injury prevention and to enhance sports performance, including vertical jump (VJ), sprint, balance, and agility. However, no previous study has examined the acute…

View details →DOI: 10.1186/s13102-026-01751-4
Negative / Null Result Report

Validation of a novel indirect Swept-source optical coherence tomography method for assessing internal fit and marginal adaptation: An in vitro study

Zeng C, Tabata T, Takahashi R et al. · 2026 · Preprint

Abstract Background Adaptation of indirect restorations is critical for clinical success. Although the conventional silicone replica method is destructive, direct in-situ Swept-source optical coherence tomography (SS-OCT) can be used to…

View details →DOI: 10.21203/rs.3.rs-9841824/v1
Negative / Null Result ReportOpen accessMedicine

Clinicopsychological stratification of recovery outcomes in cerebral aneurysm patients following cluster analysis.

Reder SR, Hardt J, Brockmann MA et al. · 2026 · PNAS nexus

The aim of this present study was to investigate the multifactorial determinants of recovery outcomes in cerebral aneurysm patients by identifying subgroups based on clinical and psychological factors. A cross-sectional approach was used (…

View details →DOI: 10.1093/pnasnexus/pgag157