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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19885 results in Negative / Null Result Report · page 516 of 663

Negative / Null Result ReportMedicine

Diet Quality, Healthy Practices, and Psychosocial Functioning Across School Youth, Students, and Adults in Poland: A Cross-Sectional Online Survey.

Sochacka K, Kotowska A, Lachowicz-Wiśniewska S · 2026 · Nutrients

Background: This study aimed to compare a limited set of predefined diet-, lifestyle-, knowledge-, and psychosocial indicators across school youth, students, and adults in Poland, and to examine their associations with three predefined…

View details →DOI: 10.3390/nu18122022
Negative / Null Result ReportMedicine

Is outcome observed in performance of clinical tests associated with patient-reported outcome measures after patellofemoral pain treatment? Secondary analysis of data from a randomized clinical trial.

Machado EM, Matthews M, Rathleff MS et al. · 2026 · Brazilian journal of physical therapy

Background Clinical functional tests for patellofemoral pain (PFP), such as step-up, step-down and squat, are commonly used in clinic practice, although the extent to which changes in these tests reflect changes in patient-reported outcome…

View details →DOI: 10.1016/j.bjpt.2026.101593
Negative / Null Result ReportMedicine

Phenotypic Heterogeneity in Crohn's Disease-Associated Intestinal Strictures: An Exploratory Retrospective Cohort Study.

Fusco S, Nesseler J, Minn L et al. · 2026 · Diagnostics (Basel, Switzerland)

Background : Crohn's disease-associated intestinal strictures represent a major source of morbidity and frequently require endoscopic or surgical intervention. However, patients with stricturing Crohn's disease demonstrate substantial…

View details →DOI: 10.3390/diagnostics16121841
Negative / Null Result ReportMedicine

Long Term Growth and Rupture Risk, and Associated Factors of Splenic Artery Aneurysms in a Large Observational Cohort.

Larkio J, Söderström M, Holmström J et al. · 2026 · European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

Objective The aim of this retrospective observational study was to analyse imaging and patient related parameters of splenic artery aneurysms (SAAs) and their impact on SAA growth and rupture. Methods The term "aneurysm" was systematically…

View details →DOI: 10.1016/j.ejvs.2026.06.019
Negative / Null Result ReportMedicine

Maternal Microbial Reservoirs Are Associated with Early Bacterial and Archaeal Community Assembly in Neonatal Hu Lambs.

Huang B, Mao C, Xu T et al. · 2026 · Animals : an open access journal from MDPI

Early-life microbial community assembly is important for gastrointestinal development, immune maturation, and feed utilization in young ruminants, but the maternal reservoirs associated with neonatal lamb gut microbial profiles remain…

View details →DOI: 10.3390/ani16121862
Negative / Null Result ReportMedicine

Factors Associated with Infection Control Competency Among Infection Control Nurses and Physicians in Long-Term Care Hospitals: A Cross-Sectional Study.

Choi JS, Kim KM · 2026 · Healthcare (Basel, Switzerland)

Background The number of long-term care hospitals (LTCHs) in Korea has been increasing. Because LTCHs primarily care for older adults who are vulnerable to infection, strict infection control (IC) practices are essential. This study aimed…

View details →DOI: 10.3390/healthcare14121709
Negative / Null Result ReportMedicine

Preoperative hypoalbuminemia as a prognostic factor in patients with gastric cancer undergoing radical gastrectomy: Construction of a nomogram.

Qu ZW, Zhang Y, Guo MY · 2026 · The Journal of international medical research

ObjectiveTo investigate the association of preoperative hypoalbuminemia (serum albumin <35 g/L) with clinicopathological characteristics and survival outcomes in patients with gastric cancer undergoing radical gastrectomy and to construct…

View details →DOI: 10.1177/03000605261457301
Negative / Null Result ReportMedicine

Serum IDO1 and β-catenin levels in patients with multiple sclerosis with and without atherosclerosis: A case-control study.

Abdulridha GAO, Fadhel AS, Al-Kinany SQ et al. · 2026 · Journal of neuroimmunology

Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system characterized by leukocyte infiltration, immune activation, demyelination, and axonal injury. This case-control observational study aimed to investigate…

View details →DOI: 10.1016/j.jneuroim.2026.579013
Negative / Null Result ReportMedicine

Acetazolamide-induced metabolic acidosis in pediatric idiopathic intracranial hypertension: associations with bone mineral density, growth, and kidney function.

Baltu D, Taş N, Alıcı N et al. · 2026 · Pediatric nephrology (Berlin, Germany)

Background Although acetazolamide is the main medical treatment for idiopathic intracranial hypertension (IIH), data on acetazolamide-induced metabolic acidosis and its long-term outcomes are limited. This study aimed to investigate the…

View details →DOI: 10.1007/s00467-026-07431-2
Negative / Null Result ReportMedicine

Identification of Gait Patterns Associated with Paretic Propulsion and Velocity in Community-Dwelling Individuals with Stroke: A Multicenter Retrospective Study.

Mano N, Mori K, Kuwabara T et al. · 2026 · Annals of biomedical engineering

Purpose Diverse gait patterns in individuals with stroke require personalized rehabilitation to improve paretic propulsion (Pp), which reflects gait function. However, the gait characteristics associated with Pp have not been fully…

View details →DOI: 10.1007/s10439-026-04203-9
Negative / Null Result ReportOpen accessMedicine

Nature Connectedness and Work Engagement in the Relationship Between Emotional Exhaustion and Life Satisfaction Among Employees.

Jaime-Jorge S, García-Ael C, Azanza G et al. · 2026 · European journal of investigation in health, psychology and education

This paper analyses associations between psychological health at work and life satisfaction among employees. Specifically, it investigates the association between work stress and emotional exhaustion and explores whether connectedness to…

View details →DOI: 10.3390/ejihpe16060079
Negative / Null Result ReportMedicine

Aqueous PFOS exposure decouples gaseous carbon loss from mineral-associated carbon retention in controlled wetland-interface mesocosms.

Lu B, Wang P, Hu J et al. · 2026 · Environmental pollution (Barking, Essex : 1987)

Wetland interfaces regulate greenhouse-gas exchange and carbon retention, yet contaminant exposure may disrupt the relationship between these two processes. Whether aqueous perfluorooctane sulfonate (PFOS), a persistent aquatic…

View details →DOI: 10.1016/j.envpol.2026.128638
Negative / Null Result ReportMedicine

Factors associated with achieving knee flexion around one hundred and twenty five degrees and numerical rating scale around one at one year after posterior cruciate-retaining total knee arthroplasty.

Shioiri H, Takahashi T, Matsumoto T · 2026 · International orthopaedics

Purpose To investigate factors associated with achieving both postoperative knee flexion range of motion (ROM) ≥ 125° and Numerical Rating Scale (NRS) pain score ≤ 1 at one year after posterior cruciate-retaining total knee arthroplasty…

View details →DOI: 10.1007/s00264-026-06884-2
Negative / Null Result ReportMedicine

Climate Change Worry and Flourishing Among Chinese University Students: The Roles of Anxiety-Depressive Symptoms and Physical Activity.

Liu S, Tan Y, Zang L · 2026 · Healthcare (Basel, Switzerland)

Background/Objectives: Climate change worry is an emerging concern in youth mental health, but little is known about how it is associated with positive psychological functioning among university students. This study examined whether…

View details →DOI: 10.3390/healthcare14121624
Negative / Null Result ReportMedicine

Risk factors for multidrug resistance and mortality in healthcare-associated neonatal gram-negative bloodstream infections.

Turgut H, Özdemir R, Memişoğlu F · 2026 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

Purpose This study aimed to characterize pathogen distribution and antimicrobial resistance patterns of gram-negative bloodstream infections in a tertiary neonatal intensive care unit and to determine which factors were associated with…

View details →DOI: 10.1007/s10096-026-05565-7
Negative / Null Result ReportMedicine

Evaluating Three Routes of Tranexamic Acid Administration in Total Hip and Knee Arthroplasty: A Nationwide Database Analysis in Taiwan.

Hsu LI, Chen JW, Hsu HW et al. · 2026 · Anesthesiology

Background Tranexamic acid (TXA) reduces perioperative blood loss, but comparative effectiveness and safety across administration routes remain uncertain. The authors evaluated topical, IV, and oral TXA in unilateral total hip and knee…

View details →DOI: 10.1097/aln.0000000000006114
Negative / Null Result ReportMedicine

Risk factors and the effect of belimumab on flares during glucocorticoid tapering in systemic lupus erythematosus: A multicentre ANSWER-SLE cohort study.

Miyake H, Onishi A, Tsuji H et al. · 2026 · Modern rheumatology

To identify factors associated with flare after glucocorticoid (GC) reduction in systemic lupus erythematosus (SLE) and determine whether belimumab influences this risk. Using the ANSWER-SLE cohort, this retrospective multicentre study…

View details →DOI: 10.1093/mr/roag053
Negative / Null Result ReportMedicine

Structural and load-dependent arterial stiffness are differentially associated with cognition or biomarkers of Alzheimer's disease and related dementias: The healthy brain study.

Deconne TM, Suerken CK, Lipford ME et al. · 2026 · Journal of Alzheimer's disease : JAD

BackgroundArterial stiffness is an emerging risk factor for Alzheimer's disease (AD) and related dementias (ADRD) and is assessed by measuring pulse wave velocity (PWV). Recent mathematical modeling has allowed for the delineation of…

View details →DOI: 10.1177/13872877261458779
Negative / Null Result ReportMedicine

Transitioning to Adult Caregiving and Grandchild Care Are Associated With Mental and Physical Health Outcomes Among Middle-Aged and Older Adults: Longitudinal Evidence From South Africa, 2015-2022.

Pengpid S, Peltzer K, Hajek A · 2026 · Australasian journal on ageing

Objectives The aim of this study was to assess the longitudinal association between transitioning to adult caregiving, grandparent childcare and mental health outcomes (depressive symptoms, life satisfaction and cognitive functioning) and…

View details →DOI: 10.1111/ajag.70181
Negative / Null Result ReportOpen accessMedicine

Chronic kidney disease screening and associated factors among people living with HIV on anti-retroviral therapy in Dar Es Salaam, Tanzania: Hospital-based cross-sectional study.

Theophil M, Lyimo AA, Ambikile JS · 2026 · PloS one

Background Chronic Kidney Disease (CKD) is a significant global health challenge, particularly among people living with HIV (PLHIV) on antiretroviral therapy (ART). The combined effects of HIV infection, long-term ART exposure, and other…

View details →DOI: 10.1371/journal.pone.0352024
Negative / Null Result ReportMedicine

Quantitative Systems Toxicology Model Predicts Obeticholic Acid-Associated Liver Injury in Metabolic Dysfunction-Associated Steatotic Liver Disease.

Mayo AK, Beaudoin JJ, Woodhead JL et al. · 2026 · Clinical pharmacology and therapeutics

Obeticholic acid (OCA), a synthetic analog of chenodeoxycholic acid, was approved in 2016 for the treatment of primary biliary cholangitis. Early clinical trials revealed elevated liver biomarkers in healthy subjects receiving…

View details →DOI: 10.1002/cpt.70355
Negative / Null Result ReportOpen accessMedicine

Pulmonary Fibrosis and Pulmonary Function in Patients with Metastatic Testicular Cancer During and after Combination Chemotherapy: The BLEOTOX Study.

Frey L, Grunwald S, Ruckes C et al. · 2026 · European urology open science

Background and objective Metastatic testicular germ cell tumors (mTGCTs) are treated with combination chemotherapy (Cx) containing bleomycin (BEP [bleomycin, etoposide, and cisplatin]). Bleomycin-induced pulmonary toxicity (BPT) is a…

View details →DOI: 10.1016/j.euros.2026.04.004
Negative / Null Result ReportMedicine

Association between extubation timing and functional outcomes in patients with acute ischemic stroke after endovascular treatment.

Liang D, Tong Y, Li F et al. · 2026 · Cerebrovascular diseases (Basel, Switzerland)

Introduction General anesthesia (GA) with endotracheal intubation is standard during endovascular treatment (EVT) for acute ischemic stroke (AIS), but the optimal timing for post-procedural extubation remains unclear. Methods In this…

View details →DOI: 10.1159/000552953
Negative / Null Result ReportMedicine

Preoperative posterior pelvic tilt is associated with residual low back pain and inferior patient-reported outcomes after total hip arthroplasty.

Ito K, Fujii M, Oba Y et al. · 2026 · International orthopaedics

Purpose To determine changes in low back pain (LBP) after total hip arthroplasty (THA), identify preoperative factors associated with residual LBP and LBP improvement, and clarify the association between residual LBP and patient-reported…

View details →DOI: 10.1007/s00264-026-06885-1
Negative / Null Result Report

Association of body composition, daily physical activity and handgrip strength with mortality, cardiovascular events and cancers in Japanese patients with diabetes

Hamasaki H, Taxiarchi V · 2026 · Preprint

Aims Sarcopenia and sarcopenic obesity are associated with increased risks of cardiovascular (CV) disease and mortality. This study examined the associations of body composition and daily physical activity with mortality, CV events and…

View details →DOI: 10.64898/2026.06.09.26355239
Negative / Null Result ReportMedicine

Water intake, switching between bites and sips, and drinking behavior are associated with food intake across meals varying in spiciness: A secondary analysis of two randomized crossover studies.

Cunningham PM, Hayes JE · 2026 · Appetite

Widespread nutrition advice instructs consumers to drink water with meals to increase fullness and reduce energy intake. However, recent data indicates greater water intake is associated with more food intake at a meal, not less. Switching…

View details →DOI: 10.1016/j.appet.2026.108698