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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19885 results in Negative / Null Result Report · page 513 of 663

Negative / Null Result ReportOpen accessMedicine

An analytical observational study for diagnostic accuracy of volume, conductivity & scatter (VCS) indices of neutrophils for diagnosis of sepsis in an emergency hospital setting.

Bharti A, Palta A, Bedi RK et al. · 2024 · The Indian journal of medical research

Background & objectives The newer technique using an innovative volume conductivity scatter (VCS) technology is emerging as a surrogate for sepsis diagnosis. The VCS technology offers a more objective method to measure cell volume (V),…

View details →DOI: 10.25259/ijmr_1898_23
Negative / Null Result ReportOpen accessMedicine

In Vitro Assessment of the Potential Effect of Vertical Peri-Implant Soft Tissue Thickness on Nonsurgical and Surgical Implant Surface Decontamination Methods.

Rahner A, Eickholz P, Gueth JF et al. · 2025 · Clinical oral implants research

Objectives In vitro analysis of the influence of vertical peri-implant soft tissue thickness (STT) on nonsurgical and surgical implant surface decontamination efficacy. Material and methods A total of 360 implants were dipped in indelible…

View details →DOI: 10.1111/clr.14415
Negative / Null Result ReportMedicine

Comparison of computed tomography findings between perianal tumors originating from the anal sacs and perianal glands in dogs.

Jeong J, Goh J, Nam C et al. · 2025 · Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association

Tumors originating from the anal sacs and perianal glands are common tumors of the perianal region. However, differentiation of perianal tumors based on CT findings remains challenging because perianal tumors can show overlapping CT…

View details →DOI: 10.1111/vru.13453
Negative / Null Result ReportOpen accessMedicine

A ubiquitous organophosphate flame retardant disrupts energy and glucose homeostasis in mice.

Sewell KM, Oriakhi K, Ngo Tenlep SY et al. · 2026 · Ecotoxicology and environmental safety

Organophosphate flame retardants (OPFRs) are used in many consumer products, and their presence in our environment raises concerns about potential health dangers. In humans, exposure to OPFRs, such as tris(1,3-dichloro-2-propyl) phosphate…

View details →DOI: 10.1016/j.ecoenv.2026.119827
Negative / Null Result ReportOpen accessMedicine

An Observational Study on Clinical Insights and Outcome Prediction of Lupus Enteritis in Indian Systemic Lupus Erythematosus Patients.

Kotha S, Baisya R, Yerram KV et al. · 2025 · Mediterranean journal of rheumatology

Background Lupus enteritis (LE) is the most common serious gastrointestinal manifestation of SLE. Indian literature on LE is limited, while most of the data comes from China and Western series with recent efforts on developing prediction…

View details →DOI: 10.31138/mjr.300924.ioe
Negative / Null Result ReportOpen accessMedicine

An atypical manifestation of Giant cell arteritis (GCA): constitutional symptoms & lingual ulcer in a 78-Year-Old male with negative temporal artery biopsies.

Gow J, Roofeh D · 2025 · BMC rheumatology

Background Giant cell arteritis (GCA) is a large vessel vasculitis characterized by granulomatous inflammation classically affecting the carotid artery branches. GCA most often presents with one or more classic clinical features which…

View details →DOI: 10.1186/s41927-025-00505-y
Negative / Null Result ReportMedicine

Robotic carotid artery stenting: a multicenter, propensity score-matched analysis of clinical outcomes and cost-effectiveness.

Patel SA, Roy JM, Musmar B et al. · 2024 · Neurosurgical focus

Objective Preclinical studies suggest that robotic carotid artery stenting (CAS) could be superior to manual CAS. However, very limited comparative data exist for patients who have undergone robotic versus manual CAS. In addition, no data…

View details →DOI: 10.3171/2024.9.focus24479
Negative / Null Result ReportMedicine

The level of agreement between the numerical rating scale and visual analogue scale for assessing pain intensity in adults with chronic pain.

Goudman L, Pilitsis JG, Billet B et al. · 2024 · Anaesthesia

The numerical rating scale and visual analogue scale are used to quantify pain intensity. However, it has not yet been explored whether these scores are interchangeable in adults with chronic pain. Data from the prospective multicentre…

View details →DOI: 10.1111/anae.16151
Negative / Null Result ReportMedicine

Long-term impact of posterior reconstruction urethrovesical anastomosis during robot-assisted prostatectomy A secondary analysis of a randomized cohort.

Millan B, Hoogenes J, Uy M et al. · 2025 · Canadian Urological Association journal = Journal de l'Association des urologues du Canada

Introduction We aimed to assess early and late continence rates post-robot-assisted radical prostatectomy (RARP), comparing posterior reconstruction (PR) urethrovesical anastomosis (UVA) to conventional urethrovesical anastomosis (C-UVA).…

View details →DOI: 10.5489/cuaj.9121
Negative / Null Result ReportOpen accessMedicine

Children with Dyslexia Benefit from Short Combined Reading and Motor Training: Objective Measures Assessed by Eye Movements and Postural Sway Recordings.

Caldani S, Khoury E, Delorme R et al. · 2025 · Brain sciences

Background/Objectives: Children with dyslexia report poor motor control; several studies have shown poor eye movements control during reading and important body instability in these children. The present study aimed to test in children…

View details →DOI: 10.3390/brainsci15111218
Negative / Null Result ReportMedicine

Sensory Stimulation and Robot-Assisted Arm Training After Stroke: A Randomized Controlled Trial.

Egger M, Bergmann J, Krewer C et al. · 2024 · Journal of neurologic physical therapy : JNPT

Background and purpose Functional recovery after stroke is often limited, despite various treatment methods such as robot-assisted therapy. Repetitive sensory stimulation (RSS) might be a promising add-on therapy that is thought to…

View details →DOI: 10.1097/npt.0000000000000486
Negative / Null Result ReportMedicine

Chapter 2: Rate Versus Rhythm Control.

Deering TF, Reiffel JA, Solomon AJ et al. · 2023 · The American journal of cardiology

Atrial fibrillation (AF) is a potentially serious health risk, both because of its symptoms and because of its association with an increased risk for heart failure, hospitalization, thromboembolism, and death. Chapter 2 discusses selection…

View details →DOI: 10.1016/j.amjcard.2023.08.022
Negative / Null Result ReportOpen accessMedicine

Prognosis and treatment of plasmablastic lymphoma in the United States: a multicenter retrospective study.

Hamby M, Egleston BL, Frosch ZAK et al. · 2026 · Blood cancer journal

Plasmablastic lymphoma (PBL) is a rare, aggressive AIDS-related lymphoma observed in patients with immunosuppressed states as well as in immunocompetent individuals. We sought to determine survival outcomes, prognostic factors, and optimal…

View details →DOI: 10.1038/s41408-026-01457-3
Negative / Null Result ReportMedicine

The current role of adjuvant radiotherapy in management of medullary thyroid carcinoma: A single institute analysis.

Bhuvana J, Shivhare V, Rath S et al. · 2025 · Journal of cancer research and therapeutics

Objectives Medullary thyroid carcinoma (MTC) accounts for only about 5% of total thyroid cancers. It usually presents as an advanced disease carrying a poor prognosis than well-differentiated thyroid cancers. While the treatment of choice…

View details →DOI: 10.4103/jcrt.jcrt_1174_23
Negative / Null Result ReportOpen accessMedicine

Pharmacological management of agitation in dementia: An evidence-based review with expert consensus.

Cheng CM, Tsai MJ, Tseng CC et al. · 2026 · Journal of the Chinese Medical Association : JCMA

Agitation is a frequently occurring and challenging neuropsychiatric symptom of Alzheimer's disease (AD) that substantially affects quality of life, caregiver burden, and healthcare utilization. Nonpharmacological interventions, especially…

View details →DOI: 10.1097/jcma.0000000000001342
Negative / Null Result ReportMedicine

Real-World Tocilizumab Use in Pediatric Inpatients.

Stitt GA, Hall MW, Diliberto MA et al. · 2025 · The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG

Objectives Primary objective: to quantify tocilizumab (TCZ) use in pediatric inpatients. Secondary objectives: to explore safety and clinical outcomes. Methods This retrospective cohort study took place in a free-standing, 564-bed…

View details →DOI: 10.5863/jppt-24-00130
Negative / Null Result ReportOpen accessMedicine

Lack of association between the brain penetrance of calcium channel blockers and the incidence of neuropsychiatric outcomes: a retrospective, multidatabase cohort study.

Kern DM, Bohn J, Maher MP et al. · 2026 · BMJ open

Objective To use best practices in pharmacoepidemiology to assess the association between new use of brain-penetrant calcium channel blockers (BP-CCBs) compared with use of non-brain-penetrant CCBs (NP-CCBs) and the incidence of…

View details →DOI: 10.1136/bmjopen-2025-100282
Negative / Null Result ReportMedicine

Correlations between Visual Temporal Resolution and Individual Alpha Peak Frequency: Evidence that Internal and Measurement Noise Drive Null Findings.

Deodato M, Melcher D · 2024 · Journal of cognitive neuroscience

The brain organizes the continuous flow of sensory input by parsing it into discrete events. In the case of two flashes separated by a brief ISI, for example, perception may be of a single flash or two distinct flashes, depending on the…

View details →DOI: 10.1162/jocn_a_01993
Negative / Null Result ReportOpen accessMedicine

Thyroid testing in primary hypothyroidism.

Ambasta A, Grenet G, Otte J et al. · 2025 · African journal of primary health care & family medicine

Thyroid hormones regulate essential metabolic processes and development. The hypothalamic-pituitary-thyroid axis regulates hormone production, with thyroid-stimulating hormone (TSH) levels being a key indicator of thyroid function in…

View details →DOI: 10.4102/phcfm.v17i1.5043
Negative / Null Result ReportOpen accessMedicine

Antiarrhythmic Treatment in Heart Failure.

Könemann H, Güler-Eren S, Ellermann C et al. · 2024 · Current heart failure reports

Purpose of review Arrhythmias are common in patients with heart failure (HF) and are associated with a significant risk of mortality and morbidity. Optimal antiarrhythmic treatment is therefore essential. Here, we review current approaches…

View details →DOI: 10.1007/s11897-023-00642-w
Negative / Null Result ReportOpen accessMedicine

Laparoscopic Salpingectomy Regulates The Expression of Endometrial Homeobox Genes ( HOXA9, HOXA10, HOXA11, HOXD10 ) and HOX Transcript Antisense Intergenic RNA in Women with Communicating Hydrosalpinx: A Prospective Study.

Zafarani F, Soleimani Mehranjani M, Ghaffari F et al. · 2024 · International journal of fertility & sterility

Background This study aimed to determine the alteration of endometrial expression levels of HOXA9/HOXA10/ HOXA11/HOXD10 genes and HOX transcript antisense intergenic RNA (HOTAIR) in mid-luteal phase endometrium in patients with…

View details →DOI: 10.22074/ijfs.2024.2026081.1655
Negative / Null Result ReportOpen accessMedicine

Effectiveness of strenghtning oropharyngeal myofunctional therapy combined with cervical spine exercises in mild to moderate obstructive sleep apnoea.

Díaz de Terán T, Bolado J, Palomo P et al. · 2025 · Sleep & breathing = Schlaf & Atmung

Objective To assess the effectiveness of an intervention programme combining Oropharyngeal Myofunctional Therapy (OMT) and cervical spine exercises in the general population with mild to moderate Obstructive Sleep Apnoea (OSA), analysing…

View details →DOI: 10.1007/s11325-025-03487-w
Negative / Null Result ReportMedicine

Quantitative EEG for the Monitoring of Walking Recovery in Chronic Stroke Patients Receiving Action Observation Training.

Shamsi F, Aligholi H, Karimi MT et al. · 2024 · Journal of motor behavior

The current study aimed to evaluate the effects of action observation on the walking ability and oscillatory brain activity of chronic stroke patients. Fourteen chronic stroke patients were allocated randomly to the action observation (AO)…

View details →DOI: 10.1080/00222895.2024.2320904
Negative / Null Result ReportOpen accessMedicine

Osteoporosis independent of traditional risk factors in hyperthyroid patients in a resource-limited setting: An observational study.

Tadesse M, Tesfaye BA, Taye B et al. · 2026 · Medicine

Hyperthyroidism accelerates bone turnover and increases the risk of secondary osteoporosis. However, evidence from sub-Saharan Africa remains scarce. This study assessed the prevalence and predictors of osteoporosis among hyperthyroid…

View details →DOI: 10.1097/md.0000000000048715