Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
O. A. Saygina, T. S. Sukhinina, M. A. Terenicheva et al. · 2026 · Рациональная фармакотерапия в кардиологии
Aim. To study the safety of using the intravenous beta-blocker (BB) esmolol in the early stages of ST-segment elevation myocardial infarction (STEMI) before primary percutaneous coronary intervention (PCI) based on an analysis of the incidence and clinical significance of adverse events (acute heart failure, hypotension, bradycardia, disorders of atrioventricular conduction (AV conduction), etc.) compared with the control group.Material and methods. The presented study is part of the randomized controlled trial ESMO-VASCMI (ClinicalTrials.gov NCT number 06376630) on the study of the cardioprot
View details →DOI: 10.20996/1819-6446-2025-3241 Negative / Null Result ReportOpen accessMedicine
Shurong Huang, Zhe Su, Huiping Su et al. · 2022 · Scientific Reports
Abstract Estrogen can promote the acceleration of bone maturation and phthalate esters (PAEs) have estrogen-mimicking effects. We investigated whether PAEs are associated with the acceleration of bone age (BA) in girls with early onset of puberty (EOP). This case–control study enrolled 254 girls with EOP from the Endocrinology Department at Shenzhen Children’s Hospital between December 2018 and August 2019. Ultra-performance liquid chromatography and tandem mass spectrometry were used to analyze the 10 metabolites of PAEs (mPAEs) in urine samples. BA was measured using an artificial intelligen
View details →DOI: 10.1038/s41598-022-19470-4 Negative / Null Result ReportOpen accessDiseases of the blood and blood-forming organs
Edvan de Queiroz Crusoe, Fabiana Higashi, Maria Paula Nalesso Camargo Padilha et al. · 2014 · Revista Brasileira de Hematologia e Hemoterapia
Background: Induction therapy followed by high-dose chemotherapy and autologous transplantation is the standard treatment for suitable patients with multiple myeloma. Objective: The aim of this study was to assess whether induction therapy with thalidomidecontaining regimens was associated with improved results compared to vincristine, doxorubicin, and dexamethasone, and whether cyclophosphamide, thalidomide, and dexamethasone were associated with better results than thalidomide and dexamethasone. Methods: The records of 152 patients who underwent autologous transplantation at this institution
View details →DOI: 10.5581/1516-8484.20140008 Negative / Null Result ReportOpen accessSpecial aspects of education
Élida de Fátima Diniz Souza, Ana Paula Ramos Machado, José Danúzio Leite de Oliveira et al. · 2025 · BMC Medical Education
Abstract Background In Brazil, residency programmes in Family and Community Medicine (FCM) and Multiprofessional Residency in Family Health (MRFH) are two-year specialisation courses, funded by the federal government, which aim to train professionals to work in Primary Health Care (PHC). The aim of this study was to draw up an inventory of the assessed competences of the residency programmes in the state of Paraíba, Brazil. Our study’s hypothesis is that self-assessment of competences can be a useful tool for monitoring the development of competences in the training of health professionals, co
View details →DOI: 10.1186/s12909-025-07521-z Negative / Null Result ReportOpen accessMedicine
Christine B. French, Sharon L. McDonnell, Reinhold Vieth · 2019 · Journal of Medical Case Reports
Abstract Background Vitamin D nutrition research requires accurate measures of circulating 25-hydroxyvitamin D. Our objectives were to test whether a diurnal fluctuation in blood-spot concentrations of 25-hydroxyvitamin D can be demonstrated statistically in a single individual, and whether such fluctuation is affected by the pre-dose versus post-dose timing of the blood draw. Case presentation The participant in this case study was a generally healthy Caucasian woman in her 40s who has taken 5000 IU vitamin D3 supplement at midday for over 1 year. Each blood sample was drawn individually from
View details →DOI: 10.1186/s13256-018-1948-9 Negative / Null Result ReportOpen accessSpecial aspects of education
Wei Han Hong, Jamunarani Vadivelu, Esther Gnanamalar Sarojini Daniel et al. · 2015 · Medical Education Online
Background: Studies have shown the importance of metacognition in medical education. Metacognitive skills consist of two dimensions: knowledge of metacognition and regulation of metacognition. Aim: This study hypothesizes that the knowledge and regulation of metacognition is significantly different at the beginning and end of the academic year, and a correlation exists between the two dimensions of metacognitive skills with academic performance. Methods: The Metacognitive Skills Inventory comprising 52 Likert-scale items was administered to 159 first-year medical students at the University of
View details →DOI: 10.3402/meo.v20.27561 Negative / Null Result ReportOpen accessOrthopedic surgery
Steven M. Hadley BA, John J. Peabody MD, Sarah Westvold MPH et al. · 2024 · Foot & Ankle Orthopaedics
Category: Ankle; Trauma Introduction/Purpose: It remains unclear whether ankle fracture pattern as described by the Weber classification—a reproducible method describing the level of fracture with respect to the distal tibiofibular syndesmosis—impacts outcomes. Patient Reported Outcome Measurement Information System (PROMIS) is a validated measure of outcomes after foot and ankle surgery. To our knowledge, no study has compared PROMIS scores between Weber subtypes. Our study thus examines whether Weber fracture subtype impacts surgical outcomes as measured by PROMIS scores. We hypothesize that
View details →DOI: 10.1177/2473011424s00255 Negative / Null Result ReportOpen accessPublic aspects of medicine
Zeynab Arbabi, Abdolali Banaiefar, Sajjad Arshadi et al. · 2023 · پیاورد سلامت
Background and Aim: Metabolic syndrome refers to a set of metabolic disorders related to obesity, such as abdominal obesity, increased body fat mass, lipid disorders, hypertension, increased blood glucose, and insulin resistance. The present study was conducted with the aim of determining the effect of 8 weeks of CXWORX exercises combined with inulin consumption on some indicators of oxidative stress in obese women with metabolic syndrome. Materials and Methods: Forty eight obese women with metabolic syndrome in the age range of 30 to 40 years were randomly divided into Control, inulin, CX exe
Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Ibrahim Halil YASAK, Mustafa YILMAZ, Murat GÖNEN et al. · 2020 · Arquivos de Neuro-Psiquiatria
ABSTRACT Objective: Ubiquitin C-terminal Hydrolase-L1 (UCH-L1) enzyme levels were investigated in patients with epilepsy, epileptic seizure, remission period, and healthy individuals. Methods: Three main groups were evaluated, including epileptic seizure, patients with epilepsy in the non-seizure period, and healthy volunteers. The patients having a seizure in the Emergency department or brought by a postictal confusion were included in the epileptic attack group. The patients having a seizure attack or presenting to the Neurology outpatient department for follow up were included in the non-se
View details →DOI: 10.1590/0004-282x20200040 Negative / Null Result ReportOpen accessFermentation industries. Beverages. Alcohol
Antika Boondaeng, Sumaporn Kasemsumran, Kraireuk Ngowsuwan et al. · 2022 · Fermentation
Pineapples are a tropical fruit with high nutritional value and high vitamin and sugar contents. In this study, low-grade pineapples were fermented to produce vinegar using surface culture fermentation (SCF), which involved the addition of dragon fruit juice, to compare the quality and antioxidant activity of different preparations of vinegar. The highest acetic acid concentration (7.35%) was obtained from pineapple vinegar after 20 days of incubation. Vinegar made from mixed pineapple and dragon fruit juice without peel and vinegar with pineapple and dragon fruit juice with peel had acetic ac
View details →DOI: 10.3390/fermentation8110597 Negative / Null Result ReportOpen accessPublic aspects of medicine
Xiaohang Chen, Xin Zhou, Yan Xu et al. · 2024 · Frontiers in Public Health
BackgroundThe current rate of organ donation in China falls significantly below the global average and the actual demand. Nursing students play a crucial role in supporting and promoting social and public welfare activities. This study primary aims to analyze the levels of knowledge, attitudes, willingness toward organ donation, and attitudes toward death among nursing students, and investigate the mediating role of attitude in the relationship between knowledge and willingness. The secondary aims to identify factors that may influence the willingness.MethodsA convenience sample of nursing stu
View details →DOI: 10.3389/fpubh.2024.1370635 Negative / Null Result ReportOpen accessMedicine
ZHANG Yanan, MAO Chuanwu, XIONG Chenglong et al. · 2022 · Shanghai yufang yixue
ObjectiveTo explore the effects of different dietary induction models of inulin， resistant starch RS3 and their complexes on the body weight and intestinal flora in mice.MethodsA total of 64 C57BL/6 mice were randomly divided into low-fat control group， low-fat inulin group， low-fat resistant starch RS3 group， low-fat composite group and high-fat control group， high-fat inulin group， high-fat resistant starch RS3 group and high-fat composite group for dietary intervention. The mice were weighed and fresh feces were collected weekly. Diet intervention was continued until the weight of the high-
View details →DOI: 10.19428/j.cnki.sjpm.2022.21054 Negative / Null Result ReportMedicine
Vermot-Desroches V, Rezkallah A, Kodjikian L et al. · 2026 · Journal francais d'ophtalmologie
Purpose The goal of the present study was to compare the effect of nasal versus temporal placement of the iStent Inject W® during phacoemulsification on intraocular pressure (IOP). Design and participants Over 5 consecutive years, 389 eyes…
View details →DOI: 10.1016/j.jfo.2026.104888 Negative / Null Result ReportOpen accessGynecology and obstetrics
Bingqian Zhang, Lianbao Cao, Lingling Ding et al. · 2017 · Gynecology and Minimally Invasive Therapy
Objective: To evaluate the effects of different treatment methods for previous ectopic pregnancies (EP) on cryopreserved embryo transfer (CET) outcomes. Materials and Methods: This was a retrospective cohort study. Patients with EP histories were divided into four groups based on their previous EP treatments: Group 1—unilateral tubal removal; Group 2—bilateral tubal removal or unilateral tubal removal with contralateral tubal ligation; Group 3—conservative surgery group; and Group 4—conservative medication group. A total of 1333 women with previous histories of being admitted to the hospital f
View details →DOI: 10.1016/j.gmit.2017.01.001 Negative / Null Result ReportOpen accessMedicine (General)
Rui Ping Peng, Zi Qian Zhu, Hong Yi Shen et al. · 2022 · Frontiers in Medicine
ObjectiveThis study aimed to observe vascular and neuroretinal alterations in people with prediabetes [impaired fasting glucose (IFG) and impaired glucose tolerance (IGT)] and normal glucose metabolism.MethodsA total of 21 patients with prediabetes (42 eyes) and 20 healthy controls (40 eyes) participated in our study. All patients underwent a complete eye examination [including fundus fluorescein angiography (FFA) and optical coherence tomography (OCT)] and a related general examination (complete biochemical analysis, routine blood tests, and glycosylated hemoglobin).ResultsOn FFA, no patients
View details →DOI: 10.3389/fmed.2022.777646 Negative / Null Result ReportOpen accessMedical emergencies. Critical care. Intensive care. First aid
Alexandra Skovran, Mason Hinke, Shelly N. B. Sloan et al. · 2022 · Emergency and Critical Care Medicine
Abstract. Background. Sepsis is the leading cause of death in hospitalized patients and significant effort has been made to facilitate early diagnosis and management. However, aggressive treatment can have negative effects, especially in patients with unstable volume status, such as those with congestive heart failure. Methods. We used electronic medical records to perform a retrospective study looking at hospital outcomes in patients from Southwest Missouri who were admitted with sepsis and had a comorbid diagnosis of hypertensive heart failure. Our primary outcome was in-hospital mortality.
View details →DOI: 10.1097/ec9.0000000000000033 Negative / Null Result ReportOpen accessDentistry
Utku Böcüoğlu, Esra Ateş Yıldırım, Selma Erdoğan Düzcü et al. · 2026 · BMC Oral Health
Abstract Objectives This in vitro study aimed to evaluate the effect of laser photobiomodulation on the structural integrity and degradation resistance of two types of platelet-rich fibrin membranes: Leukocyte- and Platelet-Rich Fibrin (L-PRF) and Titanium-Prepared Platelet-Rich Fibrin (T-PRF). Structural changes in the fibrin network were assessed using Scanning Electron Microscopy (SEM) and light microscopy. Materials and methods Our study was performed on 15 systemically healthy individuals and four L-PRF and four T-PRF membranes obtained from each individual, totaling 120 samples. L-PRF wa
View details →DOI: 10.1186/s12903-026-07974-8 Negative / Null Result ReportOpen accessMedical physics. Medical radiology. Nuclear medicine
Zhu Guo-Pei, Lu Jiade, Xiong Xiao-Peng et al. · 2011 · Radiation Oncology
Abstract Background High-precision radiation therapy techniques such as IMRT or sterotactic radiosurgery, delivers more complex treatment fields than conventional techniques. The increased complexity causes longer dose delivery times for each fraction. The purpose of this work is to explore the radiobiologic effect of prolonged fraction delivery time on tumor response and survival in vivo. Methods 1-cm-diameter Lewis lung cancer tumors growing in the legs of C57BL mice were used. To evaluate effect of dose delivery prolongation, 18 Gy was divided into different subfractions. 48 mice were rando
View details →DOI: 10.1186/1748-717x-6-4 Negative / Null Result ReportOpen accessSurgery
Eiji Nomura, Takatoshi Seki, Kentaro Yatabe et al. · 2024 · World Journal of Surgical Oncology
Abstract Background Elderly gastric cancer patients (EGCPs) require treatment according to not just the stage of their cancer, but also to their general condition and organ function, and rather than full treatment, the appropriate amount of treatment is necessary. Methods A total of 425 patients who underwent gastrectomy for primary gastric cancer in our institution between April 2013 and March 2020 were classified by age into two groups: elderly patients (EP, age ≥ 80 years, n = 89); and younger patients (YP, age < 80 years, n = 336). The preoperative, intraoperative, and postoperative condit
View details →DOI: 10.1186/s12957-024-03488-1 Negative / Null Result ReportOpen accessMedicine
Falcão MG, Suarez MA, Ferreira ACOP et al. · 2026 · Acta ortopedica brasileira
Objective To analyze the outcomes related to partial and total hip arthroplasties in elderly patients with femoral neck fractures at a hospital in the city of São Paulo. Material and methods We reviewed the medical records of patients…
View details →DOI: 10.1590/1413-785220263403e299827 Negative / Null Result ReportOpen accessDentistry
Muhammad Zubair Ahmad · 2024 · International Journal of Dentistry
Objectives. Rotary single-file endodontic systems are commonly used for root canal treatment. However, very few studies have evaluated the apical extrusion of debris generated by these systems during canal preparation at normal body temperature in laboratory conditions. The aim of this study was to evaluate the amount of apically extruded debris caused by seven different single-file endodontic instrumentation systems at body temperature in mandibular molar teeth with curved root canals. Methods. One hundred forty mandibular first permanent molars were randomly divided into seven groups (n = 20
View details →DOI: 10.1155/2024/8367693 Negative / Null Result ReportOpen accessBiotechnology
Cai Wang, Cai Wang, Dongyuan Xin et al. · 2023 · Frontiers in Bioengineering and Biotechnology
Introduction: Interleukin-6 (IL-6) is a multifunctional polypeptide cytokine composed of two glycoprotein chains, which plays an important role in many cellular reactions, pathological processes, diagnosis and treatment of diseases and so on. The detection of IL-6 plays a promising role in the cognition of clinical diseases.Methods: 4-mercaptobenzoic acid (4-MBA) was immobilized on the gold nanoparticles modified platinum carbon (PC) electrode with the linker IL-6 antibody, and finally formed an electrochemical sensor that specifically recognized IL-6. Through the highly specific antigen-antib
View details →DOI: 10.3389/fbioe.2023.1128934 Negative / Null Result ReportOpen accessDiseases of the digestive system. Gastroenterology
Olga Maria Nardone, Giulio Calabrese, Alessia La Mantia et al. · 2025 · Therapeutic Advances in Gastroenterology
Background: Managing extraintestinal manifestations (EIMs) in inflammatory bowel disease (IBD) patients remains challenging due to considerable heterogeneity in diagnostic criteria and the lack of a standardised definition and validated diagnostic pathways. Delays in recognising and treating EIMs can lead to significant disease progression. Therefore, early detection and treatment are crucial. Objectives: We aimed to assess the effectiveness of a dedicated immune-mediated inflammatory diseases (IMIDs) clinic in reducing EIM diagnostic delays and improving patients’ outcomes. Design: A single-c
View details →DOI: 10.1177/17562848251323529 Negative / Null Result ReportOpen accessMedicine
Qina Ye, Shaodan Sun, Jian Deng et al. · 2023 · Scientific Reports
Abstract To investigate the gut microbiota distribution and its functions in children with avoidant/restrictive food intake disorder (ARFID). A total of 135 children were enrolled in the study, including 102 children with ARFID and 33 healthy children. Fecal samples were analyzed to explore differences in gut microbiota composition and diversity and functional differences between the ARFID and healthy control (HC) groups via 16S rDNA and metagenomic sequencing. The gut microbiota composition and diversity in children with ARFID were different from those in heathy children, but there is no diff
View details →DOI: 10.1038/s41598-023-47760-y Negative / Null Result ReportOpen accessAnimal culture
R. Shi, D. Liu, J. Sun et al. · 2015 · Czech Journal of Animal Science
Iron (Fe) is an essential mineral for animal development and function. The present study was carried out to evaluate the effect of replacing FeSO4 with iron glycine chelate (Fe-Gly) in the equal Fe level in diets on broiler chickens. The broilers were randomly allotted to 6 dietary treatments with 5 replicate pens and 10 birds per pen. The treatments consisted of: Control group (100 mg Fe from FeSO4/kg diet), Experimental group 1 (80 mg Fe from FeSO4 + 20 mg Fe from Fe-Gly/kg diet), Experimental group 2 (60 mg Fe from FeSO4 + 40 mg Fe from Fe-Gly/kg diet), Experimental group 3 (40 mg Fe from F
View details →DOI: 10.17221/8173-cjas Negative / Null Result ReportOpen accessBanking
Suripto, Arif Sugiono, Havid Dasuki · 2023 · Banks and Bank Systems
This study aims to analyze the comparison of the resilience of Islamic and conventional banking in the Association of Southeast Asian Nations (ASEAN) during the COVID-19 pandemic. Comparison of banking resilience was proxied by the Capital Adequacy Ratio (CAR) and Loan-to-Deposit Ratio (LDR) factors, Return on Assets (ROA) and Non-Performing Loans (NPL) with the Multiple Discriminant Analysis test. In this case, the emphasis is placed on the patterns by which Islamic and conventional banking in ASEAN weathered the recent financial crisis during the COVID-19 pandemic. The explanatory and quanti
View details →DOI: 10.21511/bbs.18(3).2023.16 Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Davies Isabel R, Gavrilovic Jelena, Baugh Mark D et al. · 2003 · Cardiovascular Diabetology
Abstract Background Coronary plaque rupture may result from localised over expression of matrix metalloproteinases (MMPs) within the plaque by infiltrating monocyte – macrophages. As MMP expression can be promoted by the modified lipoproteins, oxidative stress and hyperglycaemia that characterises Type 2 diabetes, we hypothesised that peripheral monocytes in these patients, exposed to these factors in vivo, would demonstrate increased MMP production compared to controls. Methods We examined peripheral venous monocyte expression of MMP and tissue inhibitor of metalloproteinase-1 (TIMP-1) in 18
View details →DOI: 10.1186/1475-2840-2-3 Negative / Null Result ReportOpen accessMedicine (General)
F Ansari, L Akbari, SH Kohan · 2021 · Armaghane Danesh Bimonthly Journal
Background & aim: Background and Aim: Among working women, health professionals are more exposed to environmental factors and unfavorable working conditions than working women. A large group of health professionals consists of nurses and operating room staff who provide services in hospitals. For this purpose, the present study was conducted to determine the effect of unfavorable working conditions on the incidence of spontaneous abortion in operating room staff and nurses of teaching hospitals in Isfahan. Methods: This was a retrospective analytical study. The statistical population included
Negative / Null Result ReportOpen accessSurgery
Nguyen Tai Thu, Pham Dang Hai, Nguyen Thi Kieu Ly et al. · 2024 · Egyptian Liver Journal
Abstract Background Cirrhosis is associated with chronic cardiovascular dysfunction termed cirrhotic cardiomyopathy (CCM), characterized by myocardial hypertrophy and diastolic dysfunction. Detecting early cardiac changes is crucial, especially in patients undergoing liver transplantation. Objective: This study aims to evaluate left ventricular systolic function in cirrhotic patients undergoing liver transplantation using speckle-tracking echocardiography. Methods A prospective observational study was conducted involving 54 cirrhotic patients who underwent liver transplantation, along with 28
View details →DOI: 10.1186/s43066-024-00397-6 Negative / Null Result ReportOpen accessPediatrics
Mohaddeseh Badpeyma, Roghayeh Molani-Gol, Fatemeh Sistanian et al. · 2024 · Iranian Journal of Neonatology
Background: This study aims to determine the effect of different GnRH agonist brands on body mass index (BMI), weight, and height in patients referred to the pediatric endocrinology clinic of Akbar Hospital.Methods: In this cohort study, 80 girls aged 5-8 years diagnosed with precocious puberty cases were included according to the Tanner staging and at the second puberty stage. The patients were classified into three groups of GnRH agonists, A, B, and C, receiving Diphereline, Microrelin, and Variopeptyl, respectively. Height, weight, and BMI were calculated every three months.Results: In grou
View details →DOI: 10.22038/ijn.2024.74125.2433 